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Author |
Macfadden, B.J. |
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Title |
Evolution. Fossil horses--evidence for evolution |
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Journal Article |
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Year |
2005 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
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Volume |
307 |
Issue |
5716 |
Pages |
1728-1730 |
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Keywords |
Animals; Body Size; DNA, Mitochondrial; Diet; *Equidae/anatomy & histology/classification/genetics; *Evolution; Feeding Behavior; *Fossils; *Horses/anatomy & histology/classification/genetics; Paleodontology; Phylogeny; Time; Tooth/anatomy & histology |
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Address |
Florida Museum of Natural History, University of Florida, Gainesville, FL 32611, USA. bmacfadd@flmnh.ufl.edu |
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English |
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ISSN |
1095-9203 |
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Notes |
PMID:15774746 |
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no |
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Call Number |
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Serial |
1892 |
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Author |
Crosby, M.B.; Svenson, J.L.; Zhang, J.; Nicol, C.J.; Gonzalez, F.J.; Gilkeson, G.S. |
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Title |
Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide |
Type |
Journal Article |
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Year |
2005 |
Publication |
The Journal of pharmacology and experimental therapeutics |
Abbreviated Journal |
J Pharmacol Exp Ther |
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Volume |
312 |
Issue |
1 |
Pages |
69-76 |
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Keywords |
Animals; Cell Line; Gene Expression/drug effects; Macrophages/drug effects/metabolism; Mice; Mice, Inbred C57BL; Nitric Oxide/*metabolism; Nitric Oxide Synthase/*metabolism; Nitric Oxide Synthase Type II; PPAR delta/metabolism; PPAR gamma/*agonists/deficiency; Thiazolidinediones/pharmacology |
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Abstract |
Peroxisome proliferation-activated receptor (PPAR)gamma agonists inhibit inducible nitric-oxide synthase (iNOS), tumor necrosis factor-alpha, and interleukin-6. Because of these effects, synthetic PPARgamma agonists, including thiazolidinediones, are being studied for their impact on inflammatory disease. The anti-inflammatory concentrations of synthetic PPARgamma agonists range from 10 to 50 microM, whereas their binding affinity for PPARgamma is in the nanomolar range. The specificity of synthetic PPARgamma agonists for PPARgamma at the concentrations necessary for anti-inflammatory effects is thus in question. We report that PPARgamma is not necessary for the inhibition of iNOS by synthetic PPARgamma agonists. RAW 264.7 macrophages possess little PPARgamma, yet lipopolysaccharide (LPS)/interferon (IFN)gamma-induced iNOS was inhibited by synthetic PPARgamma agonists at 20 microM. Endogenous PPARgamma was inhibited by the transfection of a dominant-negative PPARgamma construct into murine mesangial cells. In the transfected cells, synthetic PPARgamma agonists inhibited iNOS production at 10 microM, similar to nontransfected cells. Using cells from PPARgamma Cre/lox conditional knockout mice, baseline and LPS/IFNgamma-induced nitric oxide levels were higher in macrophages lacking PPARgamma versus controls. However, synthetic PPARgamma agonists inhibited iNOS at 10 microM in the PPARgamma-deficient cells, similar to macrophages from wild-type mice. These results indicate that PPARgamma is not necessary for inhibition of iNOS expression by synthetic PPARgamma agonists at concentrations over 10 microM. Intrinsic PPARgamma function, in the absence of synthetic agonists, however, may play a role in inflammatory modulation. |
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Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA |
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ISSN |
0022-3565 |
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PMID:15356214 |
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no |
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Call Number |
refbase @ user @ |
Serial |
73 |
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Author |
Flack, J.C.; Krakauer, D.C.; de Waal, F.B.M. |
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Title |
Robustness mechanisms in primate societies: a perturbation study |
Type |
Journal Article |
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Year |
2005 |
Publication |
Proceedings. Biological sciences / The Royal Society |
Abbreviated Journal |
Proc Biol Sci |
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Volume |
272 |
Issue |
1568 |
Pages |
1091-1099 |
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Keywords |
Aggression/physiology; Animals; *Conflict (Psychology); Female; *Hierarchy, Social; Macaca nemestrina/*physiology; Male; *Models, Theoretical; Observation; *Social Behavior |
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Abstract |
Conflict management mechanisms have a direct, critical effect on system robustness because they mitigate conflict intensity and help repair damaged relationships. However, robustness mechanisms can also have indirect effects on system integrity by facilitating interactions among components. We explore the indirect role that conflict management mechanisms play in the maintenance of social system robustness, using a perturbation technique to 'knockout' components responsible for effective conflict management. We explore the effects of knockout on pigtailed macaque (Macaca nemestrina) social organization, using a captive group of 84 individuals. This system is ideal in addressing this question because there is heterogeneity in performance of conflict management. Consequently, conflict managers can be easily removed without disrupting other control structures. We find that powerful conflict managers are essential in maintaining social order for the benefit of all members of society. We show that knockout of components responsible for conflict management results in system destabilization by significantly increasing mean levels of conflict and aggression, decreasing socio-positive interaction and decreasing the operation of repair mechanisms. |
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Address |
Santa Fe Institute, NM 87501, USA. jflack@santafe.edu |
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ISSN |
0962-8452 |
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Notes |
PMID:16024369 |
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no |
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Call Number |
refbase @ user @ |
Serial |
165 |
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Author |
Brosnan, S.F.; Schiff, H.C.; de Waal, F.B.M. |
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Title |
Tolerance for inequity may increase with social closeness in chimpanzees |
Type |
Journal Article |
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Year |
2005 |
Publication |
Proceedings. Biological sciences / The Royal Society |
Abbreviated Journal |
Proc Biol Sci |
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Volume |
272 |
Issue |
1560 |
Pages |
253-258 |
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Keywords |
Analysis of Variance; Animals; *Attitude; Group Processes; Pan troglodytes/*psychology; Reward; *Social Behavior; Socioeconomic Factors |
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Abstract |
Economic decision-making depends on our social environment. Humans tend to respond differently to inequity in close relationships, yet we know little about the potential for such variation in other species. We examine responses to inequity in several groups of chimpanzees (Pan troglodytes) in a paradigm similar to that used previously in capuchin monkeys (Cebus apella). We demonstrate that, like capuchin monkeys, chimpanzees show a response to inequity of rewards that is based upon the partner receiving the reward rather than the presence of the reward alone. However, we also found a great amount of variation between groups tested, indicating that chimpanzees, like people, respond to inequity in a variable manner, which we speculate could be caused by such variables as group size, the social closeness of the group (as reflected in length of time that the group has been together) and group-specific traditions. |
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Address |
Yerkes National Primate Research Center, Emory University, 954 North Gatewood Drive, Atlanta, GA 30329, USA. sbrosna@emory.edu |
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English |
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0962-8452 |
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Notes |
PMID:15705549 |
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no |
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Call Number |
refbase @ user @ |
Serial |
169 |
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Author |
Ward, M.P.; Ramsay, B.H.; Gallo, K. |
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Title |
Rural cases of equine West Nile virus encephalomyelitis and the normalized difference vegetation index |
Type |
Journal Article |
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Year |
2005 |
Publication |
Vector Borne and Zoonotic Diseases (Larchmont, N.Y.) |
Abbreviated Journal |
Vector Borne Zoonotic Dis |
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Volume |
5 |
Issue |
2 |
Pages |
181-188 |
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Keywords |
Animals; Biomass; Cluster Analysis; Disease Outbreaks/veterinary; Ecology; *Geographic Information Systems; Horse Diseases/*epidemiology; Horses; Indiana/epidemiology; Plants; Population Surveillance; Rural Health; Seasons; Topography, Medical/*methods; West Nile Fever/epidemiology/*veterinary |
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Abstract |
Data from an outbreak (August to October, 2002) of West Nile virus (WNV) encephalomyelitis in a population of horses located in northern Indiana was scanned for clusters in time and space. One significant (p = 0.04) cluster of case premises was detected, occurring between September 4 and 10 in the south-west part of the study area (85.70 degrees N, 45.50 degrees W). It included 10 case premises (3.67 case premises expected) within a radius of 2264 m. Image data were acquired by the Advanced Very High Resolution Radiometer (AVHRR) sensor onboard a National Oceanic and Atmospheric Administration polar-orbiting satellite. The Normalized Difference Vegetation Index (NDVI) was calculated from visible and near-infrared data of daily observations, which were composited to produce a weekly-1km(2) resolution raster image product. During the epidemic, a significant (p < 0.01) decrease (0.025 per week) in estimated NDVI was observed at all case and control premise sites. The median estimated NDVI (0.659) for case premises within the cluster identified was significantly (p < 0.01) greater than the median estimated NDVI for other case (0.571) and control (0.596) premises during the same period. The difference in median estimated NDVI for case premises within this cluster, compared to cases not included in this cluster, was greatest (5.3% and 5.1%, respectively) at 1 and 5 weeks preceding occurrence of the cluster. The NDVI may be useful for identifying foci of WNV transmission. |
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Address |
Department of Veterinary Pathobiology, Purdue University School of Veterinary Medicine, West Lafayette, Indiana, USA. mward@cvm.tamu.edu |
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English |
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ISSN |
1530-3667 |
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Notes |
PMID:16011435 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2627 |
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Author |
de Waal, F.B.M.; Dindo, M.; Freeman, C.A.; Hall, M.J. |
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Title |
The monkey in the mirror: hardly a stranger |
Type |
Journal Article |
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Year |
2005 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
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Volume |
102 |
Issue |
32 |
Pages |
11140-11147 |
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Keywords |
Analysis of Variance; Animals; Cebus/*physiology; *Discrimination (Psychology); Empathy; Female; Male; Observation; *Recognition (Psychology); *Self Concept; Sex Factors |
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Abstract |
It is widely assumed that monkeys see a stranger in the mirror, whereas apes and humans recognize themselves. In this study, we question the former assumption by using a detailed comparison of how monkeys respond to mirrors versus live individuals. Eight adult female and six adult male brown capuchin monkeys (Cebus apella) were exposed twice to three conditions: (i) a familiar same-sex partner, (ii) an unfamiliar same-sex partner, and (iii) a mirror. Females showed more eye contact and friendly behavior and fewer signs of anxiety in front of a mirror than they did when exposed to an unfamiliar partner. Males showed greater ambiguity, but they too reacted differently to mirrors and strangers. Discrimination between conditions was immediate, and blind coders were able to tell the difference between monkeys under the three conditions. Capuchins thus seem to recognize their reflection in the mirror as special, and they may not confuse it with an actual conspecific. Possibly, they reach a level of self-other distinction intermediate between seeing their mirror image as other and recognizing it as self. |
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Address |
Living Links Center, Emory University, Atlanta, GA 30322, USA. dewaal@emory.edu |
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0027-8424 |
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Notes |
PMID:16055557 |
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no |
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Call Number |
refbase @ user @ |
Serial |
164 |
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Author |
Hoy, R. |
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Title |
Animal awareness: The (un)binding of multisensory cues in decision making by animals |
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Journal Article |
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Year |
2005 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
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Volume |
102 |
Issue |
7 |
Pages |
2267-2268 |
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Keywords |
Animals; Anura/physiology; *Awareness; *Behavior, Animal; Decision Making; Female; Male; Perception; Sensation |
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Department of Neurobiology and Behavior, 215 Mudd Hall, Cornell University, Ithaca, NY 14850, USA. rrh3@cornell.edu |
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ISSN |
0027-8424 |
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Notes |
PMID:15703288 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2821 |
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Author |
Whiten, A.; Horner, V.; de Waal, F.B.M. |
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Title |
Conformity to cultural norms of tool use in chimpanzees |
Type |
Journal Article |
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Year |
2005 |
Publication |
Nature |
Abbreviated Journal |
Nature |
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Volume |
437 |
Issue |
7059 |
Pages |
737-740 |
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Keywords |
Aging/physiology; Animals; Culture; Feeding Behavior/physiology; Female; Pan troglodytes/*physiology/*psychology; *Social Conformity; Technology; Time Factors |
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Abstract |
Rich circumstantial evidence suggests that the extensive behavioural diversity recorded in wild great apes reflects a complexity of cultural variation unmatched by species other than our own. However, the capacity for cultural transmission assumed by this interpretation has remained difficult to test rigorously in the field, where the scope for controlled experimentation is limited. Here we show that experimentally introduced technologies will spread within different ape communities. Unobserved by group mates, we first trained a high-ranking female from each of two groups of captive chimpanzees to adopt one of two different tool-use techniques for obtaining food from the same 'Pan-pipe' apparatus, then re-introduced each female to her respective group. All but two of 32 chimpanzees mastered the new technique under the influence of their local expert, whereas none did so in a third population lacking an expert. Most chimpanzees adopted the method seeded in their group, and these traditions continued to diverge over time. A subset of chimpanzees that discovered the alternative method nevertheless went on to match the predominant approach of their companions, showing a conformity bias that is regarded as a hallmark of human culture. |
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Address |
Centre for Social Learning and Cognitive Evolution, School of Psychology, University of St Andrews, St Andrews, Fife, KY16 9JP, UK. a.whiten@st-and.ac.uk |
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1476-4687 |
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Notes |
PMID:16113685 |
Approved |
no |
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Call Number |
refbase @ user @ |
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163 |
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Author |
Whiten, A. |
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Title |
The second inheritance system of chimpanzees and humans |
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Journal Article |
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Year |
2005 |
Publication |
Nature |
Abbreviated Journal |
Nature |
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Volume |
437 |
Issue |
7055 |
Pages |
52-55 |
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Keywords |
Animals; Animals, Wild/physiology/psychology; Behavior, Animal/*physiology; *Culture; Female; Humans; Imitative Behavior; Learning/*physiology; Pan troglodytes/*physiology/psychology; *Social Behavior; Technology |
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Abstract |
Half a century of dedicated field research has brought us from ignorance of our closest relatives to the discovery that chimpanzee communities resemble human cultures in possessing suites of local traditions that uniquely identify them. The collaborative effort required to establish this picture parallels the one set up to sequence the chimpanzee genome, and has revealed a complex social inheritance system that complements the genetic picture we are now developing. |
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Address |
Centre for Social Learning and Cognitive Evolution, and Scottish Primate Research Group, School of Psychology, University of St Andrews, St Andrews, Fife KY16 9JP, UK. a.whiten@st-and.ac.uk |
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1476-4687 |
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Notes |
PMID:16136127 |
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no |
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Call Number |
refbase @ user @ |
Serial |
730 |
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Author |
de Waal, F.B.M. |
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Title |
A century of getting to know the chimpanzee |
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Journal Article |
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Year |
2005 |
Publication |
Nature |
Abbreviated Journal |
Nature |
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Volume |
437 |
Issue |
7055 |
Pages |
56-59 |
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Keywords |
Aggression; Animals; Behavior, Animal/*physiology; Competitive Behavior; Cooperative Behavior; Female; Humans; Male; Pan troglodytes/genetics/*physiology/psychology; Sexual Behavior, Animal; *Social Behavior |
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Abstract |
A century of research on chimpanzees, both in their natural habitat and in captivity, has brought these apes socially, emotionally and mentally much closer to us. Parallels and homologues between chimpanzee and human behaviour range from tool-technology and cultural learning to power politics and intercommunity warfare. Few behavioural domains have remained untouched by this increased knowledge, which has dramatically challenged the way we view ourselves. The sequencing of the chimpanzee genome will no doubt bring more surprises and insights. Humans do occupy a special place among the primates, but this place increasingly has to be defined against a backdrop of substantial similarity. |
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Address |
Living Links, Yerkes National Primate Research Center, Emory University, 954 North Gatewood Road, Atlanta, Georgia 30322, USA. dewaal@emory.edu |
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1476-4687 |
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PMID:16136128 |
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no |
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Call Number |
refbase @ user @ |
Serial |
162 |
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