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Author Aviad, A.D.; Houpt, J.B. openurl 
  Title The molecular weight of therapeutic hyaluronan (sodium hyaluronate): how significant is it? Type Journal Article
  Year 1994 Publication The Journal of rheumatology Abbreviated Journal J Rheumatol  
  Volume 21 Issue 2 Pages 297-301  
  Keywords Animals; Horse Diseases/drug therapy; Horses; Humans; Hyaluronic Acid/*chemistry/*therapeutic use; Joint Diseases/*drug therapy/veterinary; Molecular Weight; Osteoarthritis/drug therapy/veterinary; Synovial Fluid/drug effects/physiology; Viscosity  
  Abstract Various molecular weight hyaluronic acid (HA) preparations have been injected into joints for the treatment of human and equine osteoarthritis. A therapeutic advantage has been claimed for commercial products with a molecular weight in the range found in normal synovial fluid (SF), compared to lower molecular weight products. But a correlation between molecular weight and efficacy is not borne out by an analysis of the available literature on clinical results. SF viscosity, HA concentration, HA molecular weight and rate of synthesis in joint disease. It is proposed that the beneficial effect of injected HA in joint disease may be due to pharmacological rather than to physical properties.  
  Address Rheumatic Disease Unit, Mount Sinai Hospital, University of Toronto, ON, Canada  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0315-162X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8182640 Approved no  
  Call Number refbase @ user @ Serial (up) 35  
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Author Nicol, C.J.; Davidson, H.P.D.; Harris, P.A.; Waters, A.J.; Wilson, A.D. openurl 
  Title Study of crib-biting and gastric inflammation and ulceration in young horses Type Journal Article
  Year 2002 Publication The Veterinary record Abbreviated Journal Vet. Rec.  
  Volume 151 Issue 22 Pages 658-662  
  Keywords Animal Husbandry/methods; Animals; Antacids/therapeutic use; *Behavior, Animal; Diet/veterinary; Endoscopy, Gastrointestinal/veterinary; Feces/chemistry; Female; Gastritis/diet therapy/physiopathology/*veterinary; Horse Diseases/diet therapy/*physiopathology/psychology; Horses; Hydrogen-Ion Concentration; Male; Random Allocation; Stereotyped Behavior/*physiology; Stomach Ulcer/diet therapy/physiopathology/*veterinary; Treatment Outcome; Weaning  
  Abstract Nineteen young horses that had recently started to perform the stereotypy of crib-biting were compared with 16 non-stereotypic horses for 14 weeks. After initial observations of their behaviour and an endoscopic examination of the condition of their stomachs, the horses were randomly allocated to a control or an antacid diet At the start of the trial, the stomachs of the crib-biting foals were significantly more ulcerated and inflamed than the stomachs of the normal foals. In addition, the faecal pH of the crib-biting foals (6.05) was significantly lower than that of the normal foals (6.58). The antacid diet resulted in a significant improvement in the condition of the horses' stomachs. The crib-biting behaviour declined in most of the foals, regardless of their diet, but tended to decline to a greater extent in the foals on the antacid diet.  
  Address Department of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5DU  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0042-4900 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12498408 Approved no  
  Call Number refbase @ user @ Serial (up) 83  
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Author McGreevy, P.D.; Webster, A.J.; Nicol, C.J. openurl 
  Title Study of the behaviour, digestive efficiency and gut transit times of crib-biting horses Type Journal Article
  Year 2001 Publication The Veterinary record Abbreviated Journal Vet. Rec.  
  Volume 148 Issue 19 Pages 592-596  
  Keywords Animals; Behavior, Animal/*physiology; Case-Control Studies; *Digestion; *Gastrointestinal Motility/drug effects; Horse Diseases/*physiopathology; Horses/*physiology/psychology; Male; Stereotyped Behavior/*physiology; Sulfapyridine/blood; Sulfasalazine/diagnostic use/pharmacology  
  Abstract The spontaneous behaviour and the apparent digestibility of dry matter and fibre and transit times of digesta were compared in four normal horses and four crib-biters. A technique was developed for measuring total gut transit times (TGTT) by using single-stool analysis of the passage of radio-opaque polyethylene markers. Longer TGTT were recorded in the crib-biters than in the normal horses but the orocaecal transit times did not differ. The crib-biters rested less than the normal horses.  
  Address Department of Clinical Veterinary Science, University of Bristol, Langford  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0042-4900 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:11386445 Approved no  
  Call Number refbase @ user @ Serial (up) 86  
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Author King, S.R.B.; Gurnell, J. doi  openurl
  Title Habitat use and spatial dynamics of takhi introduced to Hustai National Park, Mongolia Type Journal Article
  Year 2005 Publication Biological Conservation Abbreviated Journal Biol. Conserva.  
  Volume 124 Issue 2 Pages 277-290  
  Keywords Home range; Habitat use; Equus przewalskii; Takhi; Reintroduction  
  Abstract The successful introduction of captive bred takhi or Przewalski's horse, Equus ferus przewalskii, into Mongolia in the 1990s is a good example of the benefits of ex situ conservation and one of the few examples of the recovery of an animal after it became extinct in the wild. This is also particularly interesting because virtually nothing was known about how takhi lived before they died out, and the introductions have enabled us to study how they have settled, and their ecology and behaviour within their former natural range. In this paper, we describe the movement, home range size and shape, and habitat use of takhi at one of the release areas, the 570 km2 Hustai National Park in Mongolia. Harem home ranges varied between 129 and 2399 ha, with 80% core areas of between 61 and 1196 ha. There was no relationship between range size and harem size, or length of time since release. Initially, harems stayed near their release enclosures, but over time they established home ranges further away. There was little overlap between home ranges of different harems, but neither was there evidence of exclusive range use. The more nutritious vegetation at lower elevations was preferentially selected. Thus the present situation looks good, but, as the population continues to grow, we anticipate that there will be potential problems related to intraspecific competition for water and vegetation resources, and the potential for hybridisation with domestic horses belonging to the local people. We consider the time it may take for takhi to reach carrying capacity within Hustai National Park and emphasise that continual monitoring of the population is essential because interventional management is likely to be required in the future.  
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  Notes Approved no  
  Call Number refbase @ user @ Serial (up) 335  
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Author Linklater, W.L.; Cameron, E.Z.; Stafford, K.J.; Veltman, C.J. url  openurl
  Title Social and spatial structure and range use by Kaimanawa wild horses (Equus caballus: Equidae) Type Journal Article
  Year 2000 Publication New Zealand Journal of Ecology Abbreviated Journal New Zealand J. Ecol.  
  Volume 24 Issue 2 Pages 139-152  
  Keywords Bachelor male; Band; Density; Habitat use; Home range; Management proposals; Micro-climate; Vegetation monitoring; habitat use; home range; mammal; social structure; spatial distribution; New Zealand; Equus caballus  
  Abstract We measured horse density, social structure, habitat use, home ranges and altitudinal micro-climates in the south-western Kaimanawa ranges east of Waiouru, New Zealand. Horse density in the Auahitotara ecological sector averaged 3.6 horses.km-2 and ranged from 0.9 to 5.2 horses.km-2 within different zones. The population's social structure was like that of other feral horse populations with an even adult sex ratio, year round breeding groups (bands) with stable adult membership consisting of 1 to 11 mares, 1 to 4 stallions, and their predispersal offspring, and bachelor groups with unstable membership. Bands and bachelor males were loyal to undefended home ranges with central core use areas. Band home range sizes varied positively with adult band size. Home ranges overlapped entirely with other home ranges. Horses were more likely to occupy north facing aspects, short tussock vegetation and flush zones and avoid high altitudes, southern aspects, steeper slopes, bare ground and forest remnants. Horses were more likely to be on north facing aspects, steeper slopes, in exotic and red tussock grasslands and flush zones during winter and at lower altitudes and on gentler slopes in spring and summer. Seasonal shifts by bands to river basin and stream valley floors in spring and higher altitudes in autumn and winter are attributed to the beginning of foaling and mating in spring and formation of frost inversion layers in winter. Given horse habitat selectivity and the presence of other ungulate herbivores, results from present exclosures are likely to exaggerate the size of horse impacts on range vegetation. Proposals to manage the population by relocation and confinement are likely to modify current social structure and range use behaviour and may lead to the need for more intensive management in the longer term.  
  Address Ecology Group, Institute of Natural Resources, Massey University, Private Bag 11-222, Palmerston North, New Zealand  
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  ISSN 01106465 (Issn) ISBN Medium  
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  Notes Cited By (since 1996): 12; Export Date: 21 April 2007; Source: Scopus; Language of Original Document: English; Correspondence Address: Linklater, W.L.; Ecology Group; Institute of Natural Resources; Massey University; Private Bag 11-222 Palmerston North, New Zealand; email: wlinklater@hotmail.com Approved no  
  Call Number refbase @ user @ Serial (up) 793  
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Author Zehnder, A.M.; Ramer, J.C.; Proudfoot, J.S. openurl 
  Title The use of altrenogest to control aggression in a male Grant's Zebra (Equus burchelli boehmi) Type Journal Article
  Year 2006 Publication Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians Abbreviated Journal J Zoo Wildl Med  
  Volume 37 Issue 1 Pages 61-63  
  Keywords Aggression/*drug effects; Animals; Animals, Zoo; Behavior, Animal/*drug effects; Dose-Response Relationship, Drug; Equidae/*physiology; Female; Horses; Male; Treatment Outcome; Trenbolone/*analogs & derivatives/therapeutic use  
  Abstract A male Grant's Zebra (Equus burchelli boehmi) housed with two mares at the Indianapolis Zoo had a 9-yr history of intermittent aggressive behavior toward mares and other animals. Periods of separation allowed the mares time to heal after sustaining superficial bite wounds. On 26 March 2003, the male (890293) was started on altrenogest at a dosage of 19.8 mg orally once daily to allow reintroduction. The dosage was doubled (40 mg once a day) because of a perceived lack of response. Reintroduction to the mares occurred on 17 May 2003 with no signs of aggression noted. Treatment was reduced to 19.8 mg orally once a day and then discontinued. Altrenogest was restarted at 39.5 mg orally once a day because of the planned introduction of a new mare. There have been no major aggressive displays at this dosage of altrenogest and the dosage has recently been reduced following successful introduction of a new mare.  
  Address University of Florida, 2015 SW 16th Street, Gainesville, Florida 32610, USA  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1042-7260 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17312816 Approved no  
  Call Number Serial (up) 1772  
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Author Kraak, S.B.M. url  doi
openurl 
  Title `Copying mate choice': Which phenomena deserve this term? Type Journal Article
  Year 1996 Publication Behavioural Processes Abbreviated Journal Behav. Process.  
  Volume 36 Issue 1 Pages 99-102  
  Keywords Copying mate choice; Proximate/ultimate causes  
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  Notes Approved no  
  Call Number Serial (up) 1816  
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Author Machnik, M.; Hegger, I.; Kietzmann, M.; Thevis, M.; Guddat, S.; Schanzer, W. doi  openurl
  Title Pharmacokinetics of altrenogest in horses Type Journal Article
  Year 2007 Publication Journal of Veterinary Pharmacology and Therapeutics Abbreviated Journal J Vet Pharmacol Ther  
  Volume 30 Issue 1 Pages 86-90  
  Keywords Administration, Oral; Animals; Chromatography, Liquid/veterinary; Doping in Sports/prevention & control; Horses/*metabolism; Male; Mass Spectrometry/veterinary; Progesterone Congeners/administration & dosage/blood/*pharmacokinetics/urine; Reproducibility of Results; Substance Abuse Detection/veterinary; Trenbolone/administration & dosage/*analogs & derivatives/blood/pharmacokinetics/urine  
  Abstract The Federation Equestre Internationale has permitted the use of altrenogest in mares for the control of oestrus. However, altrenogest is also suspicious to misuse in competition horses for its potential anabolic effects and suppression of typical male behaviour, and thus is a controlled drug. To investigate the pharmacokinetics of altrenogest in horses we conducted an elimination study. Five oral doses of 44 mug/kg altrenogest were administered to 10 horses at a dose interval of 24 h. Following administration blood and urine samples were collected at appropriate intervals. Altrenogest concentrations were measured by liquid chromatography-tandem mass spectrometry. The plasma levels of altrenogest reached maximal concentrations of 23-75 ng/mL. Baseline values were achieved within 3 days after the final administration. Urine peak concentrations of total altrenogest ranged from 823 to 3895 ng/mL. Twelve days after the final administration concentrations were below the limit of detection (ca 2 ng/mL).  
  Address Institute of Biochemistry, German Sport University, Cologne, Germany. m.machnik@biochem.dshs-koeln.de  
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  ISSN 0140-7783 ISBN Medium  
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  Notes PMID:17217407 Approved no  
  Call Number Serial (up) 1841  
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Author Petter-Puchner, A.H.; Froetscher, W.; Krametter-Froetscher, R.; Lorinson, D.; Redl, H.; van Griensven, M. doi  openurl
  Title The long-term neurocompatibility of human fibrin sealant and equine collagen as biomatrices in experimental spinal cord injury Type Journal Article
  Year 2007 Publication Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft fur Toxikologische Pathologie Abbreviated Journal Exp Toxicol Pathol  
  Volume 58 Issue 4 Pages 237-245  
  Keywords Animals; Axotomy; Biocompatible Materials/*therapeutic use; Collagen/*therapeutic use; Fibrin Tissue Adhesive/*therapeutic use; Horses; Humans; Immunohistochemistry; Male; Motor Activity/physiology; Nerve Regeneration/*physiology; Rats; Recovery of Function; Spinal Cord/pathology/physiology; Spinal Cord Injuries/pathology/*therapy; Thoracic Vertebrae  
  Abstract INTRODUCTION: While fibrin sealant (FS) and equine collagen (EC) have been used as scaffold materials in experimental spinal cord injury (SCI), questions concerning neurocompatibility still remain. In this study, we assessed potential adverse effects, as well as functional and histological impact of FS and EC in subtotal hemisection of the thoracic spinal cord (SC) in rats. METHODS: 124 male rats were randomly assigned to four main groups (n=31): Sham (SH), Lesion only (L), fibrin sealant (GFS) and equine collagen group (GEC). SH animals received laminectomy only; all other animals underwent subtotal lateral hemisection at T9. Treatment consisted of application of FS or EC into the lesion gap in GFS and GEC, which was left empty in L. GFS, GEC, L and SH were each further divided into 4 subgroups: One subgroup, consisting of 10 rats was subjected to behavioural and reflex testing before surgery and followed up on days 1,7, 14, 21, 28 post op and then sacrificed. Haemalaun or cresyl violet (CV) was used to identify neutrophils in parasagittal cord sections which were obtained on day 1 (n=7). Sections stained for quantification of microglia/macrophages using ED-1 on day 3 (n=7), day 7 (n=7) and day 28 (n=7 out of 10). Additionally, neural filament (NF) staining was chosen to detect axonal regeneration and the length of ingrowth into FS and EC, Luxol blue for myelination, Von Willebrand factor for vascularisation, and glial fibrillary acidic protein (GFAP) staining for detection of astrocytes in glial scars on day 28. RESULTS: No adverse effects were observed in the treatment groups. Compared to L, GFS and GEC performed significantly better in the Basso, Beattie, Bresnahan (BBB) score and hopping responses. Proprioceptive placing was markedly improved in FS and EC compared to L. Axonal regrowth was found in GFS and GEC--the regrowth in the GFS was accompanied by myelination and vascularisation. Glial scarring occurred in all groups. Discussion Both biomatrices improved functional recovery compared to L and no adverse effects were perceived.  
  Address Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, 1200-Vienna, Austria  
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  ISSN 0940-2993 ISBN Medium  
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  Notes PMID:17118635 Approved no  
  Call Number Serial (up) 1852  
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Author Dirikolu, L.; Lehner, A.F.; Karpiesiuk, W.; Hughes, C.; Woods, W.E.; Boyles, J.; Harkins, J.D.; Troppmann, A.; Tobin, T. openurl 
  Title Detection, quantification, metabolism, and behavioral effects of selegiline in horses Type Journal Article
  Year 2003 Publication Veterinary Therapeutics : Research in Applied Veterinary Medicine Abbreviated Journal Vet Ther  
  Volume 4 Issue 3 Pages 257-268  
  Keywords Administration, Oral; Animals; Behavior, Animal/drug effects; Female; Horses/*metabolism; Mass Spectrometry/veterinary; Monoamine Oxidase Inhibitors/administration & dosage/blood/*pharmacokinetics/pharmacology/urine; Selegiline/administration & dosage/blood/*pharmacokinetics/pharmacology/urine; Substance Abuse Detection/veterinary  
  Abstract Selegiline ([R]-[-]N,alpha-dimethyl-N-2- propynylphenethylamine or l-deprenyl), an irreversible inhibitor of monoamine oxidase, is a classic antidyskinetic and antiparkinsonian agent widely used in human medicine both as monotherapy and as an adjunct to levodopa therapy. Selegiline is classified by the Association of Racing Commissioners International (ARCI) as a class 2 agent, and is considered to have high abuse potential in racing horses. A highly sensitive LC/MS/MS quantitative analytical method has been developed for selegiline and its potential metabolites amphetamine and methamphetamine using commercially available deuterated analogs of these compounds as internal standards. After administering 40 mg of selegiline orally to two horses, relatively low (<60 ng/ml) concentrations of parent selegiline, amphetamine, and methamphetamine were recovered in urine samples. However, relatively high urinary concentrations of another selegiline metabolite were found, tentatively identified as N- desmethylselegiline. This metabolite was synthesized and found to be indistinguishable from the new metabolite recovered from horse urine, thereby confirming the chemical identity of the equine metabolite. Additionally, analysis of urine samples from four horses dosed with 50 mg of selegiline confirmed that N-desmethylselegiline is the major urinary metabolite of selegiline in horses. In related behavior studies, p.o. and i.v. administration of 30 mg of selegiline produced no significant changes in either locomotor activities or heart rates.  
  Address Department of Biomedical Sciences, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA  
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  Series Volume Series Issue Edition  
  ISSN 1528-3593 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15136987 Approved no  
  Call Number Serial (up) 1901  
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