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	Author	Aviad, A.D.; Houpt, J.B.
	Title	The molecular weight of therapeutic hyaluronan (sodium hyaluronate): how significant is it?			Type	Journal Article
	Year	1994	Publication	The Journal of rheumatology	Abbreviated Journal	J Rheumatol
	Volume	21	Issue	2	Pages	297-301
	Keywords	Animals; Horse Diseases/drug therapy; Horses; Humans; Hyaluronic Acid/chemistry/therapeutic use; Joint Diseases/*drug therapy/veterinary; Molecular Weight; Osteoarthritis/drug therapy/veterinary; Synovial Fluid/drug effects/physiology; Viscosity
	Abstract	Various molecular weight hyaluronic acid (HA) preparations have been injected into joints for the treatment of human and equine osteoarthritis. A therapeutic advantage has been claimed for commercial products with a molecular weight in the range found in normal synovial fluid (SF), compared to lower molecular weight products. But a correlation between molecular weight and efficacy is not borne out by an analysis of the available literature on clinical results. SF viscosity, HA concentration, HA molecular weight and rate of synthesis in joint disease. It is proposed that the beneficial effect of injected HA in joint disease may be due to pharmacological rather than to physical properties.
	Address	Rheumatic Disease Unit, Mount Sinai Hospital, University of Toronto, ON, Canada
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0315-162X	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:8182640			Approved	no
	Call Number	refbase @ user @			Serial	35
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