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Author |
Hostikka, S.L.; Eddy, R.L.; Byers, M.G.; Hoyhtya, M.; Shows, T.B.; Tryggvason, K. |
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Title |
Identification of a distinct type IV collagen alpha chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome |
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Journal Article |
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Year |
1990 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
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Volume |
87 |
Issue |
4 |
Pages  |
1606-1610 |
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Keywords |
Amino Acid Sequence; Base Sequence; Chromosome Mapping; Cloning, Molecular; Collagen/*genetics; Epitopes/analysis; Female; Fluorescent Antibody Technique; Gene Library; *Genes; Humans; Immunoblotting; Kidney/cytology/*metabolism; Macromolecular Substances; Molecular Sequence Data; Nephritis, Hereditary/*genetics; Oligopeptides/chemical synthesis/immunology; Placenta/metabolism; Pregnancy; Restriction Mapping; Sequence Homology, Nucleic Acid; *X Chromosome |
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Abstract |
We have identified and extensively characterized a type IV collagen alpha chain, referred to as alpha 5(IV). Four overlapping cDNA clones isolated contain an open reading frame for 543 amino acid residues of the carboxyl-terminal end of a collagenous domain, a 229-residue carboxyl-terminal noncollagenous domain, and 1201 base pairs coding for a 3' untranslated region. The collagenous Gly-Xaa-Yaa repeat sequence has five imperfections that coincide with those in the corresponding region of the alpha 1(IV) chain. The noncollagenous domain has 12 conserved cysteine residues and 83% and 63% sequence identity with the noncollagenous domains of the alpha 1(IV) and alpha 2(IV) chains, respectively. The alpha 5(IV) chain has less sequence identity with the putative bovine alpha 3(IV) and alpha 4(IV) chains. Antiserum against an alpha 5(IV) synthetic peptide stained a polypeptide chain of about 185 kDa by immunoblot analysis and immunolocalization of the chain in human kidney was almost completely restricted to the glomerulus. The gene was assigned to the Xq22 locus by somatic cell hybrids and in situ hybridization. This may be identical or close to the locus of the X chromosome-linked Alport syndrome that is believed to be a type IV collagen disease. |
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Biocenter, University of Oulu, Finland |
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0027-8424 |
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PMID:1689491 |
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Call Number |
Equine Behaviour @ team @ |
Serial |
5291 |
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Author |
McDonnell, S.M. |
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Title |
More on self-mutilative behavior in horses |
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Journal Article |
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Year |
1993 |
Publication |
Journal of the American Veterinary Medical Association |
Abbreviated Journal |
J Am Vet Med Assoc |
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Volume |
202 |
Issue |
10 |
Pages |
1545-1546 |
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Keywords |
Animals; Female; Horses/*injuries/psychology; Male; *Self Mutilation |
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0003-1488 |
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PMID:8514553 |
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refbase @ user @ |
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1943 |
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Author |
Fischer, J.; Hammerschmidt, K.; Cheney, D.L.; Seyfarth, R.M. |
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Title |
Acoustic features of male baboon loud calls: influences of context, age, and individuality |
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Journal Article |
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Year |
2002 |
Publication |
The Journal of the Acoustical Society of America |
Abbreviated Journal |
J Acoust Soc Am |
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Volume |
111 |
Issue |
3 |
Pages |
1465-1474 |
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Keywords |
Age Factors; Animal Communication; Animals; Individuality; Male; *Papio; *Social Environment; *Sound Spectrography; *Vocalization, Animal |
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Abstract |
The acoustic structure of loud calls (“wahoos”) recorded from free-ranging male baboons (Papio cynocephalus ursinus) in the Moremi Game Reserve, Botswana, was examined for differences between and within contexts, using calls given in response to predators (alarm wahoos), during male contests (contest wahoos), and when a male had become separated from the group (contact wahoos). Calls were recorded from adolescent, subadult, and adult males. In addition, male alarm calls were compared with those recorded from females. Despite their superficial acoustic similarity, the analysis revealed a number of significant differences between alarm, contest, and contact wahoos. Contest wahoos are given at a much higher rate, exhibit lower frequency characteristics, have a longer “hoo” duration, and a relatively louder “hoo” portion than alarm wahoos. Contact wahoos are acoustically similar to contest wahoos, but are given at a much lower rate. Both alarm and contest wahoos also exhibit significant differences among individuals. Some of the acoustic features that vary in relation to age and sex presumably reflect differences in body size, whereas others are possibly related to male stamina and endurance. The finding that calls serving markedly different functions constitute variants of the same general call type suggests that the vocal production in nonhuman primates is evolutionarily constrained. |
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Department of Psychology, University of Pennsylvania, Philadelphia 19104, USA. fischer@eva.mpg.de |
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0001-4966 |
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PMID:11931324 |
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no |
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Call Number |
refbase @ user @ |
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691 |
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Author |
McDonnell, S.M.; Freeman, D.A.; Cymbaluk, N.F.; Schott, H.C. 2nd; Hinchcliff, K.; Kyle, B. |
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Title |
Behavior of stabled horses provided continuous or intermittent access to drinking water |
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Journal Article |
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Year |
1999 |
Publication |
American Journal of Veterinary Research |
Abbreviated Journal |
Am J Vet Res |
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Volume |
60 |
Issue |
11 |
Pages |
1451-1456 |
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Keywords |
Aggression; Animal Husbandry; Animals; Behavior, Animal/*physiology; Drinking Behavior; Feeding Behavior; Female; Horses/*physiology/*psychology; Housing, Animal; Pregnancy; Pregnancy, Animal/physiology/*psychology; Social Behavior; Videotape Recording; *Water Supply |
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OBJECTIVE: To compare quantitative measures and clinical assessments of behavior as an indication of psychologic well-being of stabled horses provided drinking water continuously or via 1 of 3 intermittent delivery systems. ANIMALS: 22 Quarter Horse (QH) or QH-crossbred mares and 17 Belgian or Belgian-crossbred mares (study 1) and 24 QH or QH-crossbred mares and 18 Belgian or Belgian-crossbred mares (study 2). PROCEDURE: Stabled horses were provided water continuously or via 1 of 3 intermittent water delivery systems in 2 study periods during a 2-year period. Continuous 24-hour videotaped samples were used to compare quantitative measures and clinical assessments of behavior among groups provided water by the various water delivery systems. RESULTS: All horses had clinically normal behavior. Significant differences in well being were not detected among groups provided water by the various delivery systems. CONCLUSIONS AND CLINICAL RELEVANCE: Various continuous and intermittent water delivery systems can provide adequately for the psychologic well-being of stabled horses. |
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New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348, USA |
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0002-9645 |
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Notes |
PMID:10566826 |
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no |
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Call Number |
refbase @ user @ |
Serial |
1928 |
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Author |
Hernandez, J.; Hawkins, D.L. |
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Title |
Training failure among yearling horses |
Type |
Journal Article |
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Year |
2001 |
Publication |
American Journal of Veterinary Research |
Abbreviated Journal |
Am J Vet Res |
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Volume |
62 |
Issue |
9 |
Pages |
1418-1422 |
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Keywords |
Animals; Female; Florida; Horses/*physiology; Lameness, Animal/*economics; Male; Physical Conditioning, Animal/adverse effects/economics; Respiratory Tract Diseases/economics/*veterinary; Statistics, Nonparametric |
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OBJECTIVE: To compare financial returns between pinhooked yearling horses (ie, bought and trained for approximately 5 months with the goal of selling the horse at “2-year-olds in training” sales) that had mild or severe training failure and horses that had planned versus nonplanned training failure. ANIMALS: 40 Thoroughbred pinhooked yearling horses. PROCEDURE: During the period from September 1998 through and April 1999, 20 horses had mild training failure (1 to 11 days lost), and 20 horses had severe training failure (13 to 108 days lost). Horses were assigned to these 2 groups on the basis of frequency distribution (median) of days lost during training. Horses were also categorized on the basis of type of training failure (planned vs nonplanned training failure). The outcome of primary interest was financial return. Median financial returns were compared among groups by use of the Mann-Whitney U test. RESULTS: Median financial returns for horses that had severe training failure ($1,000) were significantly different, compared with horses that had mild training failure ($24,000). Analysis of results also indicated that median returns were significantly different among horses that had planned training failure (-$2,000; eg, horses with radiographic abnormalities detected during routine prepurchase examinations that required surgical treatment, resulting in days lost during training), compared with horses that did not ($10,000). CONCLUSIONS AND CLINICAL RELEVANCE: Training failure has an economic impact on revenues in pinhooked yearling horses. Lameness, planned training failure, respiratory disease, and ringworm were common and important causes of training failure. |
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Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136, USA |
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0002-9645 |
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PMID:11560271 |
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Call Number |
Equine Behaviour @ team @ |
Serial |
4051 |
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Author |
Moses, S.N.; Villate, C.; Ryan, J.D. |
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Title |
An investigation of learning strategy supporting transitive inference performance in humans compared to other species |
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Journal Article |
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Year |
2006 |
Publication |
Neuropsychologia |
Abbreviated Journal |
Neuropsychologia |
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Volume |
44 |
Issue |
8 |
Pages |
1370-1387 |
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Keywords |
Adult; Analysis of Variance; Association Learning/*physiology; *Cognition; *Concept Formation; Female; Humans; *Logic; Male; Pattern Recognition, Visual/physiology; Photic Stimulation/methods; Reaction Time/physiology |
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Abstract |
Generalizations about neural function are often drawn from non-human animal models to human cognition, however, the assumption of cross-species conservation may sometimes be invalid. Humans may use different strategies mediated by alternative structures, or similar structures may operate differently within the context of the human brain. The transitive inference problem, considered a hallmark of logical reasoning, can be solved by non-human species via associative learning rather than logic. We tested whether humans use similar strategies to other species for transitive inference. Results are crucial for evaluating the validity of widely accepted assumptions of similar neural substrates underlying performance in humans and other animals. Here we show that successful transitive inference in humans is unrelated to use of associative learning strategies and is associated with ability to report the hierarchical relationship among stimuli. Our work stipulates that cross-species generalizations must be interpreted cautiously, since performance on the same task may be mediated by different strategies and/or neural systems. |
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Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada. smoses@rotman-baycrest.on.ca |
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0028-3932 |
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Notes |
PMID:16503340 |
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no |
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Call Number |
refbase @ user @ |
Serial |
153 |
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Author |
Walker, M.L.; Becklund, W.W. |
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Title |
Occurrence of a cattle eyeworm, Thelazia gulosa (Nematoda: Thelaziidae), in an imported giraffe in California and T. lacrymalis in a native horse in Maryland |
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Journal Article |
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Year |
1971 |
Publication |
The Journal of Parasitology |
Abbreviated Journal |
J Parasitol |
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57 |
Issue |
6 |
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1362-1363 |
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Animals; *Animals, Zoo; Artiodactyla; California; Ecology; Eye Diseases/epidemiology/*veterinary; Female; Horse Diseases/*epidemiology; Horses; Male; Maryland; Nematode Infections/epidemiology/*veterinary; Spiruroidea/*classification |
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0022-3395 |
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Notes |
PMID:5157171 |
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no |
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Call Number |
Equine Behaviour @ team @ |
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2725 |
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Author |
Cheney, D.; Seyfarth, R.; Smuts, B. |
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Title |
Social relationships and social cognition in nonhuman primates |
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Journal Article |
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Year |
1986 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
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Volume |
234 |
Issue |
4782 |
Pages |
1361-1366 |
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Animals; *Cognition; Female; Male; Pair Bond; Primates/*physiology; *Social Behavior; Social Dominance; Social Perception |
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Complex social relationships among nonhuman primates appear to contribute to individual reproductive success. Experiments with and behavioral observations of natural populations suggest that sophisticated cognitive mechanisms may underlie primate social relationships. Similar capacities are usually less apparent in the nonsocial realm, supporting the view that at least some aspects of primate intelligence evolved to solve the challenges of interacting with conspecifics. |
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0036-8075 |
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PMID:3538419 |
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no |
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refbase @ user @ |
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349 |
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Verheyen, K.; Price, J.; Lanyon, L.; Wood, J. |
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Title |
Exercise distance and speed affect the risk of fracture in racehorses |
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Journal Article |
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Year |
2006 |
Publication |
Bone |
Abbreviated Journal |
Bone |
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Volume |
39 |
Issue |
6 |
Pages |
1322-1330 |
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Keywords |
Animals; Case-Control Studies; Cohort Studies; England; Exertion; Female; Fractures, Bone/etiology/*veterinary; Horse Diseases/*etiology; Horses/*injuries; Male; Physical Conditioning, Animal/adverse effects/methods; Poisson Distribution; Prospective Studies; Regression Analysis; Risk Factors; Running/injuries/physiology |
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In order to gain insight into those training regimens that can minimise the risk of fracture in athletic populations, we conducted a large epidemiological study in racehorses. Thoroughbred racehorses provide a suitable model for studying fracture development and exercise-related risk factors in physically active populations. They represent a homogeneous population, undertaking intensive exercise programmes that are sufficiently heterogeneous to determine those factors that influence injury risk. Daily exercise information was recorded for a cohort of 1178 thoroughbreds that were monitored for up to 2 years. A total of 148 exercise-induced fractures occurred in the study population. Results from a nested case-control study showed a strong interactive effect of exercise distances at different speeds on fracture risk. Horses that exceeded 44 km at canter (< or =14 m/s) and 6 km at gallop (>14 m/s) in a 30-day period were at particularly increased risk of fracture. These distances equate to ca. 7700 bone loading cycles at canter and 880 loading cycles at gallop. Fifty-six fractures occurred in the subset of study horses that were followed since entering training as yearlings, when skeletally immature (n = 335). Cohort analysis of this data set showed that, in previously untrained bones, accumulation of canter exercise increased the risk of fracture (P < or = 0.01), whereas accumulation of high-speed gallop exercise had a protective effect (P < 0.01). However, increasing distances at canter and gallop in short time periods (up to one month) were associated with an increasing fracture risk. All training exercise involves a balance between the risk of fracture inherent in exposure to loading and the beneficial effect that loading has by stimulating bone cells to produce a more robust architecture. Results from our study provide important epidemiological evidence of the effects of physical exercise on bone adaptation and injury risk and can be used to inform the design of safer exercise regimens in physically active populations. |
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Epidemiology Unit, Animal Health Trust, Newmarket, United Kingdom. kverheyen@rvc.ac.uk |
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8756-3282 |
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Notes |
PMID:16926125 |
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Call Number |
Equine Behaviour @ team @ |
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4030 |
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Author |
Alexander, F.; Horner, M.W.; Moss, M.S. |
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Title |
The salivary secretion and clearance in the horse of chloral hydrate and its metabolites |
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Journal Article |
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Year |
1967 |
Publication |
Biochemical pharmacology |
Abbreviated Journal |
Biochem Pharmacol |
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Volume |
16 |
Issue |
7 |
Pages |
1305-1311 |
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Animals; Chloral Hydrate/blood/*metabolism/urine; Chromatography, Gas; Ethanol/blood/urine; Horses; Male; Parotid Gland/metabolism; Saliva/*analysis; Trichloroacetic Acid/blood/urine |
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0006-2952 |
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Notes |
PMID:6053598 |
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Call Number |
refbase @ user @ |
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118 |
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