| |
Records |
Links |
|
Author |
Crosby, M.B.; Zhang, J.; Nowling, T.M.; Svenson, J.L.; Nicol, C.J.; Gonzalez, F.J.; Gilkeson, G.S. |
|
| |
Title |
Inflammatory modulation of PPAR gamma expression and activity |
Type |
Journal Article |
| |
Year |
2006 |
Publication |
Clinical immunology |
Abbreviated Journal |
Clin Immunol |
|
| |
Volume |
118 |
Issue |
2-3 |
Pages |
276-283 |
|
| |
Keywords |
Age Factors; Animals; Cell Line, Transformed; Cells, Cultured; Female; Inflammation Mediators/*physiology; Kidney/metabolism; Mesangial Cells/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type II/biosynthesis/genetics; PPAR gamma/*biosynthesis/*genetics/metabolism; Up-Regulation/immunology |
|
| |
Abstract |
Nitric oxide (NO) production increases with age in the lupus-prone MRL/lpr mouse, paralleling disease activity. One mechanism for excess NO production in MRL/lpr mice may be a defect in down-regulatory mechanisms of the iNOS pathway. A potential modulator of NO is the nuclear hormone receptor peroxisome proliferation activated receptor gamma (PPARgamma). We demonstrate that renal PPARgamma protein expression was altered as disease progressed in MRL/lpr mice, which paralleled increased iNOS protein expression. Additionally, MRL/lpr-derived primary mesangial cells expressed less PPARgamma than BALB/c mesangial cells and produced more NO in response to LPS and IFNgamma. Furthermore, PPARgamma activity was reduced in mesangial cells following exposure to inflammatory mediators. This activity was restored with the addition of a NOS enzyme inhibitor. These results indicate that the activation of inflammatory pathways may lead to reduced activity and expression of PPARgamma, further exacerbating the disease state. |
|
| |
Address |
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA |
|
| |
Corporate Author  |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1521-6616 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:16303334 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
67 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Nicol, C.J.; Davidson, H.P.D.; Harris, P.A.; Waters, A.J.; Wilson, A.D. |
|
| |
Title |
Study of crib-biting and gastric inflammation and ulceration in young horses |
Type |
Journal Article |
| |
Year |
2002 |
Publication |
The Veterinary record |
Abbreviated Journal |
Vet. Rec. |
|
| |
Volume |
151 |
Issue |
22 |
Pages |
658-662 |
|
| |
Keywords |
Animal Husbandry/methods; Animals; Antacids/therapeutic use; *Behavior, Animal; Diet/veterinary; Endoscopy, Gastrointestinal/veterinary; Feces/chemistry; Female; Gastritis/diet therapy/physiopathology/*veterinary; Horse Diseases/diet therapy/*physiopathology/psychology; Horses; Hydrogen-Ion Concentration; Male; Random Allocation; Stereotyped Behavior/*physiology; Stomach Ulcer/diet therapy/physiopathology/*veterinary; Treatment Outcome; Weaning |
|
| |
Abstract |
Nineteen young horses that had recently started to perform the stereotypy of crib-biting were compared with 16 non-stereotypic horses for 14 weeks. After initial observations of their behaviour and an endoscopic examination of the condition of their stomachs, the horses were randomly allocated to a control or an antacid diet At the start of the trial, the stomachs of the crib-biting foals were significantly more ulcerated and inflamed than the stomachs of the normal foals. In addition, the faecal pH of the crib-biting foals (6.05) was significantly lower than that of the normal foals (6.58). The antacid diet resulted in a significant improvement in the condition of the horses' stomachs. The crib-biting behaviour declined in most of the foals, regardless of their diet, but tended to decline to a greater extent in the foals on the antacid diet. |
|
| |
Address |
Department of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5DU |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0042-4900 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:12498408 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
83 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Waters, A.J.; Nicol, C.J.; French, N.P. |
|
| |
Title |
Factors influencing the development of stereotypic and redirected behaviours in young horses: findings of a four year prospective epidemiological study |
Type |
Journal Article |
| |
Year |
2002 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
|
| |
Volume |
34 |
Issue |
6 |
Pages |
572-579 |
|
| |
Keywords |
Age Factors; Animal Husbandry/*methods; Animal Welfare; Animals; *Behavior, Animal; Female; Horse Diseases/epidemiology/prevention & control/*psychology; Horses; Housing, Animal; Longitudinal Studies; Male; Prevalence; Prospective Studies; Risk Factors; *Stereotyped Behavior; Weaning |
|
| |
Abstract |
Stereotypies are invariant and repetitive behaviour patterns that seemingly have no function, which tend to develop in captive animals faced with insoluble problems and may be indicative of reduced welfare. A 4 year prospective study of the factors influencing the development of stereotypic and redirected behaviours (abnormal behaviour) in a population of 225 young Thoroughbred and part-Thoroughbred horses was conducted between 1995 and 1999. Abnormal behaviour affected 34.7% of the population. Multivariable analysis showed that foals of low- or middle-ranking mares were less likely to develop abnormal behaviour than foals of dominant mares (rate ratio (RR) 0.23, P<0.01; RR 0.48, P<0.01, respectively). Weaning by confinement in a stable or barn was associated with an increased rate of development of abnormal behaviour, compared with paddock-weaning (RR 2.19, P<0.05), and housing in barns, rather than at grass after weaning, was associated with a further increase (RR 2.54, P<0.01). Specific stereotypic and redirected behaviours were then considered as separate outcomes. Crib-biting was initiated by 10.5% of horses at median age 20 weeks, weaving by 4.6% of horses at median age 60 weeks, box-walking by 2.3% of horses at median age 64 weeks and wood-chewing by 30.3% of horses at median age 30 weeks. Wood-chewing developed at a lower rate in horses born to subordinate or mid-ranking mares than in horses born to dominant mares (RR 0.29, P<0.01; RR 0.41, P<0.01, respectively), and at a higher rate in horses kept in barns or stables rather than at grass after weaning (RR 4.49, P<0.001; RR 1A6, P<0.001, respectively). Feeding concentrates after weaning was associated with a 4-fold increase in the rate of development of crib-biting (RR 4.12, P = 0.02). The results of this study support the idea that simple changes in feeding, housing and weaning practices could substantially lower the incidence of abnormal behaviour in young horses. |
|
| |
Address |
University of Bristol, Department of Clinical Veterinary Science, Langford, Bristol, UK |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0425-1644 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:12357996 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
84 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
McGreevy, P.D.; French, N.P.; Nicol, C.J. |
|
| |
Title |
The prevalence of abnormal behaviours in dressage, eventing and endurance horses in relation to stabling |
Type |
Journal Article |
| |
Year |
1995 |
Publication |
The Veterinary record |
Abbreviated Journal |
Vet. Rec. |
|
| |
Volume |
137 |
Issue |
2 |
Pages |
36-37 |
|
| |
Keywords |
Animal Husbandry/*methods; Animals; *Behavior, Animal; Horse Diseases/*psychology; Horses; *Physical Conditioning, Animal; Prevalence; Questionnaires; *Stereotyped Behavior |
|
| |
Abstract |
The behaviour of horses competing in different disciplines was studied and the relationship between the time they spent out of the stable and the prevalence of abnormal behaviour was examined. The owners of dressage, eventing and endurance horses were sent a questionnaire and a total of 1101 responses were received, giving data on 1750 horses. The behaviours studied were wood-chewing, weaving, crib-biting/wind-sucking and box-walking. The reported percentage prevalences of abnormal behaviour for the dressage, eventing and endurance horses were 32.5, 30.8 and 19.5, respectively. The relationship between the time spent in the stable and the prevalence of abnormal behaviour was examined by chi 2 tests which showed that there were significant linear trends for the eventing group (P < 0.001) and the dressage group (P < 0.05). It is concluded that the time a horse spends out of the stable is related to the discipline for which it is being trained and in dressage and eventing horses the time spent in a stable is correlated with an increased risk of abnormal behaviour. |
|
| |
Address |
University of Bristol, Department of Clinical Veterinary Science, Langford |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0042-4900 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:8525580 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
89 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Blaisdell, A.P.; Sawa, K.; Leising, K.J.; Waldmann, M.R. |
|
| |
Title |
Causal reasoning in rats |
Type |
Journal Article |
| |
Year |
2006 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
|
| |
Volume |
311 |
Issue |
5763 |
Pages |
1020-1022 |
|
| |
Keywords |
Animals; *Association Learning; Bayes Theorem; *Cognition; Comprehension; Forecasting; Male; Rats; Rats, Long-Evans |
|
| |
Abstract |
Empirical research with nonhuman primates appears to support the view that causal reasoning is a key cognitive faculty that divides humans from animals. The claim is that animals approximate causal learning using associative processes. The present results cast doubt on that conclusion. Rats made causal inferences in a basic task that taps into core features of causal reasoning without requiring complex physical knowledge. They derived predictions of the outcomes of interventions after passive observational learning of different kinds of causal models. These competencies cannot be explained by current associative theories but are consistent with causal Bayes net theories. |
|
| |
Address |
Department of Psychology, University of California, Los Angeles, CA 90095, USA. blaisdell@psych.ucla.edu |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1095-9203 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:16484500 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
154 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Brosnan, S.F.; Freeman, C.; De Waal, F.B.M. |
|
| |
Title |
Partner's behavior, not reward distribution, determines success in an unequal cooperative task in capuchin monkeys |
Type |
Journal Article |
| |
Year |
2006 |
Publication |
American journal of primatology |
Abbreviated Journal |
Am. J. Primatol. |
|
| |
Volume |
68 |
Issue |
7 |
Pages |
713-724 |
|
| |
Keywords |
Animals; Behavior, Animal/*physiology; Cebus/*physiology; *Cooperative Behavior; Female; Food Preferences/physiology; Male; *Reward |
|
| |
Abstract |
It was recently demonstrated that capuchin monkeys notice and respond to distributional inequity, a trait that has been proposed to support the evolution of cooperation in the human species. However, it is unknown how capuchins react to inequitable rewards in an unrestricted cooperative paradigm in which they may freely choose both whether to participate and, within the bounds of their partner's behavior, which reward they will receive for their participation. We tested capuchin monkeys with such a design, using a cooperative barpull, which has been used with great success in the past. Contrary to our expectations, the equity of the reward distribution did not affect success or pulling behavior. However, the behavior of the partner in an unequal situation did affect overall success rates: pairs that had a tendency to alternate which individual received the higher-value food in unequal reward situations were more than twice as successful in obtaining rewards than pairs in which one individual dominated the higher-value food. This ability to equitably distribute rewards in inherently biased cooperative situations has profound implications for activities such as group hunts, in which multiple individuals work together for a single, monopolizable reward. |
|
| |
Address |
Living Links Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. sbrosna@emory.edu |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0275-2565 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:16786518 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
160 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Flack, J.C.; de Waal, F.B.M.; Krakauer, D.C. |
|
| |
Title |
Social structure, robustness, and policing cost in a cognitively sophisticated species |
Type |
Journal Article |
| |
Year |
2005 |
Publication |
The American Naturalist |
Abbreviated Journal |
Am Nat |
|
| |
Volume |
165 |
Issue |
5 |
Pages |
E126-139 |
|
| |
Keywords |
Animals; *Behavior, Animal; Cognition; Conflict (Psychology); Female; Macaca nemestrina/*physiology; Male; Models, Biological; *Social Behavior |
|
| |
Abstract |
Conflict management is one of the primary requirements for social complexity. Of the many forms of conflict management, one of the rarest and most interesting is third-party policing, or intervening impartially to control conflict. Third-party policing should be hard to evolve because policers personally pay a cost for intervening, while the benefits are diffused over the whole group. In this study we investigate the incidence and costs of policing in a primate society. We report quantitative evidence of non-kin policing in the nonhuman primate, the pigtailed macaque. We find that policing is effective at reducing the intensity of or terminating conflict when performed by the most powerful individuals. We define a measure, social power consensus, that predicts effective low-cost interventions by powerful individuals and ineffective, relatively costly interventions by low-power individuals. Finally, we develop a simple probabilistic model to explore whether the degree to which policing can effectively reduce the societal cost of conflict is dependent on variance in the distribution of power. Our data and simple model suggest that third-party policing effectiveness and cost are dependent on power structure and might emerge only in societies with high variance in power. |
|
| |
Address |
Santa Fe Institute, Santa Fe, New Mexico 87501, USA. jflack@santafe.edu |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1537-5323 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:15795848 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
168 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
de Waal, F.B.M. |
|
| |
Title |
Peace lessons from an unlikely source |
Type |
Journal Article |
| |
Year |
2004 |
Publication |
PLoS biology |
Abbreviated Journal |
PLoS. Biol. |
|
| |
Volume |
2 |
Issue |
4 |
Pages |
E101 |
|
| |
Keywords |
Animals; Behavior; Behavior, Animal; Culture; Humans; Interpersonal Relations; Research; Social Conditions; Social Environment; United States; *Violence |
|
| |
Abstract |
|
|
| |
Address |
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. dewaal@emory.edu |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1545-7885 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:15094805 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
174 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
de Waal, F.B.M. |
|
| |
Title |
Animal communication: panel discussion |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
Annals of the New York Academy of Sciences |
Abbreviated Journal |
Ann N Y Acad Sci |
|
| |
Volume |
1000 |
Issue |
|
Pages |
79-87 |
|
| |
Keywords |
Acoustics; Affect; *Animal Communication; Animals |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0077-8923 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:14766621 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
176 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
de Waal, F.B.M. |
|
| |
Title |
Silent invasion: Imanishi's primatology and cultural bias in science |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
Animal cognition |
Abbreviated Journal |
Anim. Cogn. |
|
| |
Volume |
6 |
Issue |
4 |
Pages |
293-299 |
|
| |
Keywords |
Animals; *Behavior, Animal; *Culture; Ecosystem; History, 20th Century; Philosophy; Portraits; *Prejudice; Primates/*psychology; Psychology, Comparative/*history; Research Design/trends |
|
| |
Abstract |
|
|
| |
Address |
Living Links, Yerkes Primate Center, Emory University, Atlanta, GA 30322, USA. dewaal@emory.edu |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1435-9448 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:14551801 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
178 |
|
| Permanent link to this record |
