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Mitchell, D.; Kirschbaum, E.H.; Perry, R.L. |
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Title  |
Effects of neophobia and habituation on the poison-induced avoidance of exteroceptive stimuli in the rat |
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Journal Article |
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Year |
1975 |
Publication |
Journal of Experimental Psychology. Animal Behavior Processes |
Abbreviated Journal |
J Exp Psychol Anim Behav Process |
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Volume |
1 |
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1 |
Pages |
47-55 |
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Keywords |
Animals; Avoidance Learning/*drug effects; *Awareness; *Cognition; Conditioning, Operant; Feeding Behavior/drug effects; *Habituation, Psychophysiologic; Injections, Intraperitoneal; Lithium/administration & dosage/poisoning; Male; Rats; *Taste; Time Factors; *Visual Perception |
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Abstract |
Two experiments on the role of neophobia in poison-induced aversions to exteroceptive stimuli are reported. In Experiment 1, rats were given either 10 or 25 days of habituation to the test situation prior to conditioning. Those animals with the longer habituation period avoided a complex of novel exteroceptive stimuli while those with the shorter habituation period did not. In Experiment 2 rats initially avoided the more novel of two containers, but gradually came to eat equal amounts from both. A single pairing of toxicosis with consumption from either the novel or the familiar container reinstated the avoidance of the novel container in both cases. The results were discussed in terms of an interaction between habituation and conditioning procedures. It was suggested that previously reported differences between interoceptive and exteroceptive conditioning effects may have been influenced by the differential novelty of the two classes of stimuli in the test situation. It was further suggested that non-contingently poisoned control groups should routinely be included in poison avoidance conditioning studies. |
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0097-7403 |
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PMID:1151289 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2791 |
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Author |
Scherer, W.F.; Madalengoitia, J.; Flores, W.; Acosta, M. |
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Title |
Ecologic studies of Venezuelan encephalitis virus in Peru during 1970-1971 |
Type |
Journal Article |
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Year |
1975 |
Publication |
American Journal of Epidemiology |
Abbreviated Journal |
Am J Epidemiol |
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Volume |
101 |
Issue |
4 |
Pages |
347-355 |
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Keywords |
Animals; Antibodies, Viral; Cricetinae/immunology; Culicidae/microbiology; *Disease Vectors; Ecology; *Encephalitis Virus, Venezuelan Equine/immunology/isolation & purification; Encephalomyelitis, Equine/immunology/microbiology/transmission; Female; Hemagglutination Inhibition Tests; Horses/immunology; Humans; Neutralization Tests; Peru |
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Abstract |
Venezuelan encephalitis (VE) virus has intermittently produced epidemics and equine epizootics on the dry Pacific coastal plain of Peru since at least the 1930's. However, evidence that the virus exists in the Amazon region of Peru to the east of the Andes mountains was not obtained until antibodies were found in human sera collected in 1965, and 10 strains of the virus were isolated in a forest near the city of Iquitos, Peru during February and March 1971. Eight strains came from mosquitoes and two from dead sentinel hamsters. Three hamsters exposed in forests near Iquitos developed VE virus antibodies suggesting that hamster-benign strains also exist there. Antibody tests of equine sera revealed no evidence that VE virus was actively cycling during the late 1950's or 1960's in southern coastal Peru, where equine epizootics had occurred in the 1930's and 1940's. In northern coastal Peru bordering Ecuador, antibodies were present in equine sera, presumably residual from the 1969 outbreak caused by subtype I virus, since neutralizing antibody titers were higher to subtype I virus than to subtypes III or IV. No VE virus was detected in this northern region during the dry season of 1970 by use of sentinel hamsters. The possibility is considered that VE epidemics and equine epizootics on the Pacific coast of Peru are caused by movements of virus in infected vertebrates traversing Andean passes or in infected vertebrates or mosquitoes carried in airplanes from the Amazon region. |
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0002-9262 |
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PMID:235838 |
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Call Number |
Equine Behaviour @ team @ |
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2705 |
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Author |
Niekerk Van Ch, A.W. |
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Title |
Early embryonic development in the horse |
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Journal Article |
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Year |
1975 |
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Abbreviated Journal |
J Reprod Fert Suppl |
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23 |
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495-498 |
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Notes |
from Professor Hans Klingels Equine Reference List |
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no |
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Call Number |
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Serial |
1417 |
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Author |
Schmoldt, A.; Benthe, H.F.; Haberland, G. |
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Title |
Digitoxin metabolism by rat liver microsomes |
Type |
Journal Article |
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Year |
1975 |
Publication |
Biochemical pharmacology |
Abbreviated Journal |
Biochem Pharmacol |
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Volume |
24 |
Issue |
17 |
Pages |
1639-1641 |
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Keywords |
Animals; Chromatography, Thin Layer; Digitoxigenin/metabolism; Digitoxin/*metabolism; Hydroxylation; Male; Microsomes, Liver/*metabolism; NADP/metabolism; Rats; Time Factors |
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0006-2952 |
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PMID:10 |
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Admin @ knut @ |
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20 |
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Author |
Klingel H, |
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Title |
Die soziale Organisation der Equiden |
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Journal Article |
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Year |
1975 |
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Abbreviated Journal |
Verh Dtsch Zool Ges in Karlsruhe |
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71-80 |
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Notes |
from Professor Hans Klingels Equine Reference List |
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no |
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1308 |
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Author |
Douglas Rh, G.O. |
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Title |
Development of the equine fetus and placenta |
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Journal Article |
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Year |
1975 |
Publication |
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Abbreviated Journal |
J Reprod Fert (Suppl) |
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23 |
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495-498 |
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from Professor Hans Klingels Equine Reference List |
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no |
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1023 |
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Author |
Rossdale Pd, |
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Title |
Das Pferd, Fortpflanzung und Entwicklung |
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Journal Article |
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Year |
1975 |
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Karger 1975 |
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from Professor Hans Klingels Equine Reference List |
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no |
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Call Number |
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Serial |
1519 |
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Author |
Czerlinski, G.H.; Wagner, M.; Erickson, J.O.; Theorell, H. |
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Title |
Chemical relaxation studies on the system liver alcohol dehydrogenase, NADH and imidazole |
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Journal Article |
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Year |
1975 |
Publication |
Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry |
Abbreviated Journal |
Acta Chem Scand B |
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Volume |
29 |
Issue |
8 |
Pages |
797-810 |
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Keywords |
Alcohol Oxidoreductases/*metabolism; Animals; Computers; Hydrogen-Ion Concentration; Imidazoles/*metabolism; Kinetics; Liver/enzymology/*metabolism; Mathematics; Models, Chemical; NAD/*metabolism; Time Factors |
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Abstract |
Several years ago, Theorell and Czerlinski conducted experiments on the system of horse liver alcohol dehydrogenase, reduced nicotinamide adenine dinucleotide and imidazole, using the first version of the temperature jump apparatus with detection of changes in fluorescence. These early experiments were repeated with improved instrumentation and confirmed the early experiments in general terms. However, the improved detection system allowed to measure a slight concentration dependence of the relaxation time of around 3 ms. Furthermore, the chemical relaxation time was smaller than the one determined earlier (by factor 2). The data were evaluated much more rigorously than before, allowing an appropriate interpretation of the results. The observed relaxation time is largely due to rate constants in an interconversion of ternary complexes, which are faster than three (of the four) dissociation rate constants, determined previously by Theorell and McKinley-McKee.1,2 This fact contributed to earlier difficulties of finding any concentration dependence. However, the binding of imidazole to the binary enzyme-coenzyme complex can be made to couple kinetically into the interconversion rate of the two ternary complexes. The observed signal derives largely from the ternary complex(es). A substantial fluorescence signal change is associated with the observed relaxation process, suggesting a relocation of the imidazole in reference to the nicotinamide moiety of the bound coenzyme. Nine models are considered with two types of coupling of pre-equilibria (none-all). Quantitative evaluations favor the model with two ternary complexes connected by an interconversion outside the four-step (bimolecular) cycle. The ternary complex outside the cycle has much higher fluorescence yield than the one inside. The interconversion equilibrium is near unity for imidazole. If it would be shifted very much to the side of the “dead-end” complex (as in isobutyramide?!), stimulating action could not take place. |
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0302-4369 |
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PMID:882 |
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Call Number |
refbase @ user @ |
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3887 |
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Author |
Hillidge, C.J.; Lees, P. |
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Title |
Cardiac output in the conscious and anaesthetised horse |
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Journal Article |
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Year |
1975 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
7 |
Issue |
1 |
Pages |
16-21 |
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Keywords |
Anesthesia, Inhalation/*veterinary; Animals; Carbon Dioxide/blood; *Cardiac Output/veterinary; *Consciousness; Electrocardiography/veterinary; Ether, Ethyl; Female; Halothane; Heart Rate; Heart Ventricles/physiology; Horses/*physiology; Hydrogen-Ion Concentration; Male; Oxygen/blood; Posture |
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Abstract |
Cardiac output in the horse was measured before and at predetermined times during 2-hour periods of thiopentone-halothane and thiopentone-diethyl ether anaesthesia. Left ventricular stroke volume was decreased to a similar extent during anaesthesia with each volatile agent, but a greater reduction in cardiac output occurred during halothane anaesthesia. This finding reflected the differing effects of halothane and ether on heart rate, a slight bradycardia occurring with the former agent while ether produced a small degree of tachycardia. The latter effect was attributed to enhanced sympathoadrenal activity. Changes in cardiac output and stroke volume were considered in relation to other factors, including arterial blood pH and tensions of oxygen and carbon dioxide. Positive correlations between some of these variables and cardiac function were established. With both volatile agents the reductions in stroke volume and cardiac output were related to the duration of anaesthesia, being greatest during the early stages. Possible reasons for the tendency of stroke volume and cardiac output to return towards control levels are discussed. |
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ISSN |
0425-1644 |
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PMID:234842 |
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Call Number |
refbase @ user @ |
Serial |
102 |
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Author |
Jallon, J.M.; Risler, Y.; Iwatsubo, M. |
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Title |
Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH |
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Journal Article |
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Year |
1975 |
Publication |
Biochemical and biophysical research communications |
Abbreviated Journal |
Biochem Biophys Res Commun |
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Volume |
67 |
Issue |
4 |
Pages |
1527-1536 |
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Keywords |
Animals; Cattle; Glutamate Dehydrogenase/*metabolism; Ketoglutaric Acids; Kinetics; Liver/*enzymology; Nadp; Oxidation-Reduction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet |
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0006-291X |
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PMID:1038 |
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Admin @ knut @ |
Serial |
21 |
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