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Author Branchi, I.; Bichler, Z.; Berger-Sweeney, J.; Ricceri, L. openurl 
  Title Animal models of mental retardation: from gene to cognitive function Type Journal Article
  Year 2003 Publication Neuroscience and Biobehavioral Reviews Abbreviated Journal Neurosci Biobehav Rev  
  Volume 27 Issue 1-2 Pages 141-153  
  Keywords Animals; Animals, Genetically Modified/growth & development; Behavior/physiology; Behavior, Animal; Brain/*growth & development; Cognition/*physiology; *Disease Models, Animal; Environment; Genes; Genetic Diseases, Inborn/physiopathology; Humans; Mental Retardation/classification/*genetics/*physiopathology  
  Abstract About 2-3% of all children are affected by mental retardation, and genetic conditions rank among the leading causes of mental retardation. Alterations in the information encoded by genes that regulate critical steps of brain development can disrupt the normal course of development, and have profound consequences on mental processes. Genetically modified mouse models have helped to elucidate the contribution of specific gene alterations and gene-environment interactions to the phenotype of several forms of mental retardation. Mouse models of several neurodevelopmental pathologies, such as Down and Rett syndromes and X-linked forms of mental retardation, have been developed. Because behavior is the ultimate output of brain, behavioral phenotyping of these models provides functional information that may not be detectable using molecular, cellular or histological evaluations. In particular, the study of ontogeny of behavior is recommended in mouse models of disorders having a developmental onset. Identifying the role of specific genes in neuropathologies provides a framework in which to understand key stages of human brain development, and provides a target for potential therapeutic intervention.  
  Address Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy. branchi@iss.it  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN (up) 0149-7634 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12732230 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2805  
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Author Breuer, K.; Sutcliffe, M.E.M.; Mercer, J.T.; Rance, K.A.; Beattie, V.E.; Sneddon, I.A.; Edwards, S.A. url  doi
openurl 
  Title The effect of breed on the development of adverse social behaviours in pigs Type Journal Article
  Year 2003 Publication Applied Animal Behaviour Science Abbreviated Journal Appl. Anim. Behav. Sci.  
  Volume 84 Issue 1 Pages 59-74  
  Keywords Pig; Breed; Harmful social behaviour; Ear-biting; Tail-biting; Tail-chew test  
  Abstract Tail-biting and other harmful social behaviours are a common problem on pig farms. The aims of the current experiment were (1) to investigate the genetic component of harmful social behaviours such as tail-biting by assessing breed differences, and (2) to further investigate the reliability and predictability of a test, [`]the tail-chew test', previously identified as potentially being capable of predicting a pig's predisposition for tail- and ear-biting. The behaviour of three pig breeds (Large White (LW), Landrace (LR), Duroc (DR)), with 100 pigs per breed, was observed in a [`]tail-chew test', and by observing the performance of harmful social behaviour directed to pen mates in flat deck pens after weaning. The tail-chew test, carried out on two consecutive days pre-weaning, involved observing the behaviour of individual pigs towards two suspended ropes. Pigs were weaned at 28 days and the occurrence of harmful social behaviour was recorded 4 weeks later over 2 consecutive days (1 h per day) using a group [`]period occurrence' scanning method. Breed had a significant effect on rope-directed behaviour in the tail-chew test and on harmful social behaviour. DR pigs interacted with the ropes in the tail-chew test more often (median 23.0 vs 19.0 and 17.5 times in 20 min, P<0.001) and for longer (31.0 vs 20.0 and 23.2 s, P<0.001) than LR and LW pigs, respectively. Although not significantly different from LW, DR pigs tended to direct more total harmful social behaviour towards pen mates than the other breeds. In particular, DR were observed in more total pig-directed biting of pen mates (median 9.0 vs 6.0 and 7.0, P<0.01) than LR and LW, and tended to nose pen mates more often than the other breeds (13.0 vs 11.0 and 10.0, P=0.06). LR pigs bit the ears of pen mates less often than LW and DR (4.0 vs 5.0 and 6.0, P<0.001). Belly-nosing activity was low, with a median of 0 for all breeds, but LR belly-nosed pen mates more often than Durocs (interquartile ranges 0-2.0 vs 0-1.0 and 0-1.0, P<0.01). The behaviour observed in the tail-chew test on day 1 correlated significantly with that observed on day 2 of the test (e.g. frequency of rope-directed behaviour rs=0.380,P<0.01). There were significant but weak correlations between rope-directed behaviour and the performance of some harmful social behaviours. The significant breed differences indicate some genetic contribution to expression of harmful social behaviours. However, the tail-chew test was found to be of limited ability to predict tail- and ear-biting under commercial conditions.  
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  ISSN (up) 0168-1591 ISBN Medium  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 4979  
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Author Breuer, K.; Hemsworth, P.H.; Coleman, G.J. url  doi
openurl 
  Title The effect of positive or negative handling on the behavioural and physiological responses of nonlactating heifers Type Journal Article
  Year 2003 Publication Applied Animal Behaviour Science Abbreviated Journal Appl. Anim. Behav. Sci.  
  Volume 84 Issue 1 Pages 3-22  
  Keywords Dairy heifer; Fear; Handling; Stress response; Milk production; Stimulus generalisation  
  Abstract This experiment investigated the effects of positive and negative tactile handling on the stress physiology and behaviour of dairy heifers. Forty-eight 5-14-month-old nonlactating Holstein-Friesian heifers were allocated to one of two handling treatments, either positive or negative tactile handling, over four time replicates. Handling was imposed twice daily, 2-5 min per session and involved moving animals individually along a 64 m outdoor route. The negatively handled heifers took longer to approach within 1 and 2 m of a stimulus person in a standard test, than their positively handled counterparts (P<0.001) and had a greater flight distance to an approaching stimulus (P<0.001). The time taken by the heifers to approach within 1 and 2 m of a familiar person was similar to that taken to approach within 1 and 2 m of an unfamiliar person in the standard test (P<0.05). There was a tendency for heifers to have a greater flight distance from the approaching unfamiliar person than from the approaching familiar person (P=0.06). The negatively handled heifers had greater (P<0.05) increases in total cortisol concentrations 5, 10 and 15 min after exposure to a human and had higher (P<0.05) free cortisol concentrations in the afternoon than the positively handled heifers. It is concluded that the nature of the human contact affects the subsequent behavioural response of heifers to humans. This behavioural response may extend to other humans through the process of stimulus generalisation, although there was some evidence of moderate discrimination. Negative handling results in an acute stress response in the presence of humans and also leads to a chronic stress response. Further research into the effect of these stress responses on milk production and welfare in fearful cows in a commercial situation is suggested.  
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  ISSN (up) 0168-1591 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 4980  
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Author Wallner, B.; Brem, G.; Muller, M.; Achmann, R. doi  openurl
  Title Fixed nucleotide differences on the Y chromosome indicate clear divergence between Equus przewalskii and Equus caballus Type Journal Article
  Year 2003 Publication Animal Genetics Abbreviated Journal Anim Genet  
  Volume 34 Issue 6 Pages 453-456  
  Keywords Animals; Base Sequence; DNA, Mitochondrial/genetics; Genetic Variation/*genetics; Horses/classification/*genetics; Male; Molecular Sequence Data; Phylogeny; Probability; Species Specificity; Y Chromosome/*genetics  
  Abstract The phylogenetic relationship between Equus przewalskii and E. caballus is often a matter of debate. Although these taxa have different chromosome numbers, they do not form monophyletic clades in a phylogenetic tree based on mtDNA sequences. Here we report sequence variation from five newly identified Y chromosome regions of the horse. Two fixed nucleotide differences on the Y chromosome clearly display Przewalski's horse and domestic horse as sister taxa. At both positions the Przewalski's horse haplotype shows the ancestral state, in common with the members of the zebra/ass lineage. We discuss the factors that may have led to the differences in mtDNA and Y-chromosomal observations.  
  Address Institut fur Tierzucht und Genetik, Veterinarmedizinische Universitat Wien, Veterinarplatz, Wien, Austria. wallner@i122server.vu-wien.ac.at  
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  Language English Summary Language Original Title  
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  ISSN (up) 0268-9146 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:14687077 Approved no  
  Call Number Equine Behaviour @ team @ Serial 5038  
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Author Maninger, N.; Capitanio, J.P.; Mendoza, S.P.; Mason, W.A. doi  openurl
  Title Personality influences tetanus-specific antibody response in adult male rhesus macaques after removal from natal group and housing relocation Type Journal Article
  Year 2003 Publication American journal of primatology Abbreviated Journal Am. J. Primatol.  
  Volume 61 Issue 2 Pages 73-83  
  Keywords Analysis of Variance; Animals; Antibody Formation; Enzyme-Linked Immunosorbent Assay; Housing, Animal; Immunization, Secondary/*veterinary; Immunoglobulin G/blood; Macaca mulatta/*immunology/physiology; Male; *Personality; Social Behavior; Tetanus Toxoid/*immunology  
  Abstract Previous research has suggested that personality is related to immune function in macaques. Using a prospective design, we examined whether variation in the personality dimension “Sociability” in adult male rhesus macaques (Macaca mulatta) was related to the in vivo secondary antibody response to a tetanus toxoid booster immunization following removal from natal groups and relocation to individual housing. We also explored whether the timing of the immunization following relocation had an impact on the immune response. Blood was sampled at the time of booster immunization, at 14 and 28 days post-immunization, and approximately 9 months post-immunization. Plasma was assayed for tetanus-specific IgG by enzyme-linked immunoassay (ELISA). There was no difference between High- and Low-Sociable animals in antibody levels at the time of the booster immunization. Multivariate analysis of variance (MANOVA) revealed that High-Sociable animals had a significantly higher antibody response following relocation and immunization compared to Low-Sociable animals. There was no effect of timing of the immunization on the immune response. The results confirm that personality factors can affect animals' immune responses, and that the dimension Sociability may be influential in a male's response to social separation and relocation.  
  Address Department of Psychology, and Mind and Behavior Unit, California National Primate Research Center, University of California-Davis, Davis, California 95616, USA. nmaniger@ucdavis.edu  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN (up) 0275-2565 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:14582129 Approved no  
  Call Number Equine Behaviour @ team @ Serial 4114  
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Author Miksovska, J.; Larsen, R.W. openurl 
  Title Photothermal studies of pH induced unfolding of apomyoglobin Type Journal Article
  Year 2003 Publication Journal of Protein Chemistry Abbreviated Journal J Protein Chem  
  Volume 22 Issue 4 Pages 387-394  
  Keywords Acoustics; Animals; Apoproteins/*chemistry/metabolism; Circular Dichroism; Horses; Myocardium/chemistry; Myoglobin/*chemistry/metabolism; Photolysis; Protein Conformation/radiation effects; Protein Denaturation/radiation effects; *Protein Folding; Temperature; Thermodynamics  
  Abstract Conformational dynamic and enthalpy changes associated with pH induced unfolding of apomyoglobin were studied using photoacoustic calorimetry and photothermal beam deflection methods. The transition between the native state and the I intermediate was induced by a nanosecond pH jump from o-nitrobenzaldehyde photolysis. Deconvolution of photoacoustic waves indicates two kinetic processes. The fast phase (T < 50 ns) is characterized by a volume expansion of 8.8 ml mol(-1). This process is followed by a volume contraction of about -22 ml mol(-1) (tau approximately 500 ns). Photothermal beam deflection measurements do not reveal any volume changes on the time scale between approximately 100 micros and 5 ms. We associate the volume contraction with structural changes occurring during the transition between the native state and the I intermediate. The lack of any processes on the ms time scale may indicate the absence of structural events involving larger conformational changes of apomyoglobin after the pH jump.  
  Address Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN (up) 0277-8033 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:13678303 Approved no  
  Call Number Equine Behaviour @ team @ Serial 3780  
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Author Matsushima, T.; Izawa, E.-I.; Aoki, N.; Yanagihara, S. openurl 
  Title The mind through chick eyes: memory, cognition and anticipation Type Journal Article
  Year 2003 Publication Zoological Science Abbreviated Journal Zoolog Sci  
  Volume 20 Issue 4 Pages 395-408  
  Keywords Animals; Birds/anatomy & histology/*physiology; Brain/anatomy & histology/cytology/physiology; Cognition/*physiology; Memory/*physiology; Perception/physiology  
  Abstract To understand the animal mind, we have to reconstruct how animals recognize the external world through their own eyes. For the reconstruction to be realistic, explanations must be made both in their proximate causes (brain mechanisms) as well as ultimate causes (evolutionary backgrounds). Here, we review recent advances in the behavioral, psychological, and system-neuroscience studies accomplished using the domestic chick as subjects. Diverse behavioral paradigms are compared (such as filial imprinting, sexual imprinting, one-trial passive avoidance learning, and reinforcement operant conditioning) in their behavioral characterizations (development, sensory and motor aspects of functions, fitness gains) and relevant brain mechanisms. We will stress that common brain regions are shared by these distinct paradigms, particularly those in the ventral telencephalic structures such as AIv (in the archistriatum) and LPO (in the medial striatum). Neuronal ensembles in these regions could code the chick's anticipation for forthcoming events, particularly the quality/quantity and the temporal proximity of rewards. Without the internal representation of the anticipated proximity in LPO, behavioral tolerance will be lost, and the chick makes impulsive choice for a less optimized option. Functional roles of these regions proved compatible with their anatomical counterparts in the mammalian brain, thus suggesting that the neural systems linking between the memorized past and the anticipated future have remained highly conservative through the evolution of the amniotic vertebrates during the last 300 million years. With the conservative nature in mind, research efforts should be oriented toward a unifying theory, which could explain behavioral deviations from optimized foraging, such as “naive curiosity,” “contra-freeloading,” “Concorde fallacy,” and “altruism.”  
  Address Graduate School of Bioagricultural Sciences, Nagoya University, Japan. matusima@agr.nagoya-u.ac.jp  
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  ISSN (up) 0289-0003 ISBN Medium  
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  Notes PMID:12719641 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2858  
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Author Barker, S.C. openurl 
  Title The Australian paralysis tick may be the missing link in the transmission of Hendra virus from bats to horses to humans Type Journal Article
  Year 2003 Publication Medical Hypotheses Abbreviated Journal Med Hypotheses  
  Volume 60 Issue 4 Pages 481-483  
  Keywords Animals; Chiroptera; *Disease Transmission; Ecology; Hendra Virus/*pathogenicity; Horses; Humans; Models, Theoretical; Polymerase Chain Reaction; Ticks/*virology  
  Abstract Hendra virus is a new virus of the family Paramyxoviridae. This virus was first detected in Queensland, Australia, in 1994; although, it seems that the virus has infected fruit-eating bats (flying-foxes) for a very long time. At least 2 humans and 15 horses have been killed by this virus since it first emerged as a virus that may infect mammals other than flying-foxes. Hendra virus is thought to have moved from flying-foxes to horses, and then from horses to people. There is a reasonably strong hypothesis for horse-to-human transmission: transmission of virus via nasal discharge, saliva and/or urine. In contrast, there is no strong hypothesis for flying-fox-to-human transmission. I present evidence that the Australian paralysis tick, Ixodes holocyclus, which has apparently only recently become a parasite of flying-foxes, may transmit Hendra virus and perhaps related viruses from flying-foxes to horses and other mammals.  
  Address Department of Microbiology and Parisitology, Institute for Molecular Biosciences, ARC Special Research Center for Functional and Applied Genomics, The University of Queensland, Brisbane, Australia. s.barker@imb.uq.edu.au  
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  ISSN (up) 0306-9877 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12615503 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2641  
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Author Vollmerhaus, B.; Roos, H.; Gerhards, H.; Knospe, C. openurl 
  Title [Phylogeny, form and function of canine teeth in the horse] Type Journal Article
  Year 2003 Publication Anatomia, histologia, embryologia Abbreviated Journal Anat Histol Embryol  
  Volume 32 Issue 4 Pages 212-217  
  Keywords Animals; Cuspid/*anatomy & histology/radiography; Evolution; Horses/*anatomy & histology; Male; Phylogeny; *Social Dominance  
  Abstract The canine teeth of the horse developed phylogenically from the simple, pointed, short-rooted tooth form of the leaf eating, in pairs living, Eocene horse Hyracotherium and served up to the Oligocene as a means of defense (self preservation). In the Miocene the living conditions of the Merychippus changed and they took to eating grass and adopted as a new behavior the life in a herd. The canine teeth possibly played an important role in fights for social ranking; they changed from a crown form to knife-like shape. In the Pliohippus the canine tooth usually remained in male horses and since the Pliocene, it contributed to the fights between stallions, to ensure that the offspring only came from the strongest animals (preservation of the species). Form and construction of the canine tooth are described and discussed in detail under the above mentioned phylogenic and ethologic aspects.  
  Address Institut fur Tieranatomie und Chirurgische Tierklinik der Universitat Munchen, Veterinarstrasse 13, D 80539 Munchen, Deutschland. c-neumueller@anat.vetmed.uni-muenchen.de  
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  Language German Summary Language Original Title [Zur Phylogenie, Form und Funktion der Dentes canini des Pferdes]  
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  ISSN (up) 0340-2096 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12919071 Approved no  
  Call Number refbase @ user @ Serial 672  
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Author Visser, E.K.; Van Reenen, C.G.; Rundgren, M.; Zetterqvist, M.; Morgan, K.; Blokhuis, H.J. openurl 
  Title Responses of horses in behavioural tests correlate with temperament assessed by riders Type Journal Article
  Year 2003 Publication Equine Veterinary Journal Abbreviated Journal Equine Vet J  
  Volume 35 Issue 2 Pages 176-183  
  Keywords Adult; Animals; *Behavior, Animal/physiology; Data Interpretation, Statistical; Female; *Handling (Psychology); Heart Rate/*physiology; Horses/physiology/*psychology; Humans; Male; Personality; Temperament/*physiology  
  Abstract REASONS FOR PERFORMING STUDY: Behavioural tests as well as observers' ratings have been used to study horses' temperament. However, the relationship between the ratings and the responses in behavioural tests has not yet been studied in detail. OBJECTIVES: The aim of the present study was to examine this relationship between ratings and responses. METHODS: Eighteen mature Swedish Warmblood horses were subjected to 2 behavioural tests, one relating to novelty (novel object test) and one to handling (handling test). Subsequently, 16 of these horses were ridden by 16 equally experienced students, having no former experience with the horses. Immediately after each ride, the students scored the horse for 10 temperamental traits using a line rating method. RESULTS: It was shown that for each temperamental trait all 16 riders agreed on the ranking of the horses (0.212<W<0.505, P < 0.001). CONCLUSIONS: Correlations between behavioural and heart rate variables in the behavioural tests revealed that horses with a high level of locomotion or much restlessness behaviour exhibited high mean heart rate and low heart rate variability. In particular, heart rate variables in the behavioural tests were found to correlate with riders' rating scores. Furthermore, the underlying components of the handling test, retrieved with a principal component analysis (PCA) correlated with riders' rating scores while the underlying components of the novel object test did not. POTENTIAL CLINICAL RELEVANCE: It is concluded that it is possible for a large panel of assessors to agree upon a horse's temperament and that objective measures from behavioural tests correlate significantly with temperamental traits assessed by a panel of assessors.  
  Address Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.163, NL-3508 TD Utrecht, The Netherlands  
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  ISSN (up) 0425-1644 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12638795 Approved no  
  Call Number Serial 1906  
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