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Author |
Rodier, F. |
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Title |
[Spectral properties of porcine plasminogen: study of the acidic transition (author's transl)] |
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Journal Article |
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Year |
1976 |
Publication |
European journal of biochemistry / FEBS |
Abbreviated Journal |
Eur J Biochem |
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Volume |
63 |
Issue |
2 |
Pages |
553-562 |
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Keywords |
Animals; Binding Sites; Guanidines; Hydrogen-Ion Concentration; *Plasminogen; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Swine; Temperature |
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Abstract |
The acidic transition of porcine plasminogen, prepared by affinity chromatography, was studied by non-destructive methods. These methods are based on the analysis of the behaviour of the tryptophyls under various conditions. The perturbation of the absorption and emission spectra by pH or temperature and the dynamic quenching of the intrinsic fluorescence are used to obtain information on structural changes which affect the environment of these residues. It is shown that by decreasing pH the fluorescence emission spectra are shifted toward the long wavelengths, with a broadening of the fluorescence band. The same effect can be obtained at constant pH by heating the protein solution. In order to analyze these phenomena, it is assumed that the fluorescence intensities at 355 nm and 328 nm reflect the proportion of the tryptophans which are exposed to the solvent, and buried, respectively. The plot of the ratio of the fluorescence intensities at these wavelengths versus pH or temperature leads to a titration curve showing an unmasking of tryptophans. The proportion of exposed tryptophans is measured by the dynamic fluorescence quenching technique and the data analyzed according to Lehrer. The plot of the fraction of exposed tryptophyls versus pH also shows the unmasking of these chromophores. Thermal perturbation of a solution of plaminogen at neutral pH induces a difference absorption spectrum whose amplitudes at the maxima are proportional to the number of exposed aromatic residues. The comparison with a solution of fully denatured plasminogen in 6 M guanidium chloride, where all the tryptophyls are exposed, shows that the percentage of exposure is equal to 59%. This number is significantly higher than the percentage found by the fluorescence quenching technique (20%), indicating that some tryptophyls are located in crevices, exposed to the solvent but not to the iodide. At acidic pH the absorption difference spectra induced by thermal perturbation are not classical, since they show an inversion and a new band between 300 nm and 305 nm. This band is mentioned in the literature as a minor band of tryptophan which appears when this chromophore is located in an asymmetric environment. On plotting the maximum amplitude of these spectra obtained at acidic pH versus temperature, we obtain a curve indicating that two types of antagonistic interactions are involved in the perturbation of the chromophores spectra. The spectrophotometric titration of plasminogen gives classical absorption difference spectra. By plotting the maximum amplitude at 292 nm versus pH, we obtain a titration curve with an apparent pK of 2.9 units. This pK is acidic which respect to the pK value of a normal carboxyl. This low value can be due to a positively charged group in the neighbourhood of a carboxyl, which interacts with one or more chromophores. When the carboxyl becomes protonated, this positively charged group is free and available to perturb the environment of some chromophores... |
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French |
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Proprietes spectrales du plasminogene porcin. Etude de la transition acide |
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0014-2956 |
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PMID:4326 |
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22 |
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Author |
NICOLA J. ROONEY & JOHN W. S. BRADSHAW |
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Title |
Social cognition in the domestic dog: behaviour of spectators towards participants in interspecific games |
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Journal Article |
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Year |
2005 |
Publication |
Animal Behaviour. |
Abbreviated Journal |
Anim. Behav. |
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Volume |
72 |
Issue |
2 |
Pages |
343-352 |
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Abstract |
previous termSocial cognition,next term in particular the derivation of previous termsocialnext term information from observation of interactions between members of a previous termsocialnext term group, has been widely investigated in primates, but it has received little attention in other previous termsocialnext term mammals, although it has been anecdotally reported in the previous termdomestic dog,next term Canis familiaris. We recorded the behaviour of previous termdogsnext term (“spectators”) that had observed controlled interactions between a human and a previous termdognext term (the “demonstrator”) competing for an object, and that were subsequently allowed to interact freely with both participants. When the competitions were playful, as indicated by signals performed by the human, the spectator was more likely to approach the winner first and/or more rapidly, suggesting that winners of games are perceived as desirable previous termsocialnext term partners. When the human did not perform play signals, changing the previous termsocialnext term context from play to contest over a resource, spectators were slower to approach either of the participants, suggesting that participants in contests were less desirable as previous termsocialnext term partners than participants in games. If the previous termdognext term was prevented from seeing the game, it still reacted differently to the winner and the loser, but its behaviour was not the same as after games that it had seen. We conclude that spectator previous termdogsnext term gain information from the players' subsequent behaviour as well as from direct observation of the game. |
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N. J. Rooney, Anthrozoology Institute, School of Clinical Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, U.K. |
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Anthrozoology Institute, University of Bristol, U.K. |
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Admin @ knut @ |
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29 |
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Author |
Zentall, T.R. |
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Title |
The case for a cognitive approach to animal learning and behavior |
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Journal Article |
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Year |
2001 |
Publication |
Behavioral Processes |
Abbreviated Journal |
Behav Processes |
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54 |
Issue |
1-3 |
Pages |
65-78 |
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Abstract |
The dangers of hypothesizing about unobservable cognitive mechanisms are well known to behavior analysts. I propose, however, that carefully fashioned cognitive theories that make predictions that are inconsistent with current behavioral theories can provide useful research tools for the understanding of behavior. Furthermore, even if the results of such research may be accommodated by modifying existing behavioral theories, our understanding of behavior is often advanced by the empirical findings because it is unlikely that the research would have been conducted in the absence of such cognitive hypothesizing. Two examples of the development of emergent relations are described: The first deals with the nature of a pigeon's 'representation' of two stimuli both of which are associated with correct responding to a third in a many-to-one matching task (stimulus equivalence or common representations). The second has to do with transitive inference, the emergent relation between two stimuli mediated by their relation to a common stimulus in a simultaneous discrimination. |
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Department of Psychology, University of Kentucky, 40506-0044, Lexington, KY, USA |
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0376-6357 |
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Notes |
PMID:11369461 |
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no |
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Serial |
25 |
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Author |
Bloom, P. |
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Title |
Behavior. Can a dog learn a word? |
Type |
Journal Article |
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Year |
2004 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
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Volume |
304 |
Issue |
5677 |
Pages |
1605-1606 |
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Keywords |
Animals; Child; Child, Preschool; *Dogs; Humans; *Learning; *Memory; *Vocabulary |
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Department of Psychology, Yale University, Post Office Box 208205, New Haven, CT 06520-8205, USA. paul.bloom@yale.edu |
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1095-9203 |
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PMID:15192205 |
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no |
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28 |
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Author |
Houpt, K.A. |
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Title |
Why horse behaviour is important to the equine clinician |
Type |
Journal Article |
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Year |
2006 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
38 |
Issue |
5 |
Pages |
386-387 |
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Keywords |
Accidents, Occupational/prevention & control; Aggression; Animals; *Behavior, Animal/physiology; Clinical Competence; Fear; Horses/*physiology; Humans; Veterinarians/psychology; Veterinary Medicine/*standards |
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Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA |
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0425-1644 |
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PMID:16986596 |
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no |
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refbase @ user @ |
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30 |
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Author |
Virga, V.; Houpt, K.A. |
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Title |
Prevalence of placentophagia in horses |
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Journal Article |
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Year |
2001 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
33 |
Issue |
2 |
Pages |
208-210 |
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Keywords |
Animals; *Behavior, Animal; Colic/epidemiology/*veterinary; Exploratory Behavior; *Feeding Behavior; Female; Horse Diseases/*epidemiology; Horses; Incidence; New York/epidemiology; *Placenta; Postpartum Period; Pregnancy; Prevalence; Questionnaires |
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Animal Behavior Clinic, Cornell University Hospital for Animals, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA |
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0425-1644 |
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PMID:11266073 |
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no |
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Call Number |
refbase @ user @ |
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31 |
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Author |
Houpt, K.A.; Eggleston, A.; Kunkle, K.; Houpt, T.R. |
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Title |
Effect of water restriction on equine behaviour and physiology |
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Journal Article |
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Year |
2000 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
32 |
Issue |
4 |
Pages |
341-344 |
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Keywords |
Animals; *Behavior, Animal; Blood Proteins/analysis; Energy Intake; Female; Horse Diseases/physiopathology; Horses/*physiology; Osmolar Concentration; Pregnancy; Stress/veterinary; Video Recording; Water Deprivation/*physiology |
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Abstract |
Six pregnant mares were used to determine what level of water restriction causes physiological and/or behavioural changes indicative of stress. Nonlegume hay was fed ad libitum. During the first week of restriction, 5 l water/100 kg bwt was available, during the second week 4 l/100 kg bwt and, during the third week, 3 l/100 kg bwt. Ad libitum water intake was 6.9 l/100 kg bwt; at 3 l/100 kg bwt water intake was 42% of this. Daily hay intake fell significantly with increasing water restriction from 12.9 +/- 0.75 kg to 8.3 +/- 0.54 kg; bodyweight fell significantly for a total loss of 48.5 +/- 8.3 kg in 3 weeks. Daily blood samples were analysed; osmolality rose significantly with increasing water restriction from 282 +/- 0.7 mosmols/kg to 293.3 +/- 0.8 mosmols/kg bwt, but plasma protein and PCV did not change significantly. Cortisol concentrations fell from 8.1 ng/ml to 6.4 ng/ml over the 3 week period. Aldosterone fell from 211.3 +/- 74.2 pg/ml to 92.5 +/- 27.5 pg/ml at the end of the first week. The behaviour of 4 of the 6 mares was recorded 24 h/day for the duration of the study. The only significant difference was in time spent eating, which decreased with increasing water restriction from 46 +/- 3% to 30 +/- 3%. It is concluded that water restriction to 4 l/100 kg bwt dehydrates pregnant mares and may diminish their welfare, but is not life- or pregnancy-threatening. |
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Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA |
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0425-1644 |
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PMID:10952384 |
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no |
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Call Number |
refbase @ user @ |
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32 |
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Author |
Turpeinen, O. |
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Title |
Effect of cholesterol-lowering diet on mortality from coronary heart disease and other causes |
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Journal Article |
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Year |
1979 |
Publication |
Circulation |
Abbreviated Journal |
Circulation |
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Volume |
59 |
Issue |
1 |
Pages |
1-7 |
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Keywords |
Coronary Disease/blood/*mortality/prevention & control; Dairy Products; *Dietary Fats; *Fats, Unsaturated; Finland; Humans; Hypercholesterolemia/complications/*diet therapy/mortality; Male; Middle Aged; Neoplasms/mortality |
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Abstract |
International statistics indicate that there is a close correlation between the consumption of saturated fats (dairy fats and meat fats) and the mortality from coronary heart disease (CHD), and this conception has been confirmed by many epidemiological studies. Such studies alone, however, cannot prove the existence of a cause-and-effect relationship between these two variables; dietary intervention trials are needed. The Finnish Mental Hospital Study was such a trial, conducted in two hospitals near Helsinki in 1959--1971. Practically total replacement of dairy fats by vegetable oils in the diets of these hospitals was followed by a substantial reduction in the mortality of men from CHD. Total mortality also appeared to be reduced. As to the causes of death other than CHD, none was significantly influenced by dietary change. This was also true for malignant neoplasms. To alleviate the burden of CHD on public health, many investigators have recommended important changes in the quantity and quality of dietary fats. |
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0009-7322 |
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PMID:758101 |
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Call Number |
refbase @ user @ |
Serial |
33 |
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Author |
Houpt, K.A. |
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Title |
New perspectives on equine stereotypic behaviour |
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Year |
1995 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
27 |
Issue |
2 |
Pages |
82-83 |
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Animals; Horses/*psychology; Stereotyped Behavior/*physiology |
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0425-1644 |
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PMID:7607153 |
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refbase @ user @ |
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34 |
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Author |
Aviad, A.D.; Houpt, J.B. |
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Title |
The molecular weight of therapeutic hyaluronan (sodium hyaluronate): how significant is it? |
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Journal Article |
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Year |
1994 |
Publication |
The Journal of rheumatology |
Abbreviated Journal |
J Rheumatol |
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21 |
Issue |
2 |
Pages |
297-301 |
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Keywords |
Animals; Horse Diseases/drug therapy; Horses; Humans; Hyaluronic Acid/*chemistry/*therapeutic use; Joint Diseases/*drug therapy/veterinary; Molecular Weight; Osteoarthritis/drug therapy/veterinary; Synovial Fluid/drug effects/physiology; Viscosity |
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Various molecular weight hyaluronic acid (HA) preparations have been injected into joints for the treatment of human and equine osteoarthritis. A therapeutic advantage has been claimed for commercial products with a molecular weight in the range found in normal synovial fluid (SF), compared to lower molecular weight products. But a correlation between molecular weight and efficacy is not borne out by an analysis of the available literature on clinical results. SF viscosity, HA concentration, HA molecular weight and rate of synthesis in joint disease. It is proposed that the beneficial effect of injected HA in joint disease may be due to pharmacological rather than to physical properties. |
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Rheumatic Disease Unit, Mount Sinai Hospital, University of Toronto, ON, Canada |
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0315-162X |
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PMID:8182640 |
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refbase @ user @ |
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35 |
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