Equine and Animal Cognition Reference Database -- Query Results

	Equine and Animal Cognition Reference Database Home \| Show All \| Simple Search \| Advanced Search	Login Quick Search: Field: contains: ...
	31-40 of 63 records found matching your query:

Search & Display Options

Select All Deselect All

<< 1 2 3 4 5 6 7 >>

List View

Citations

Details

	Records
	Author	Pierce, M.M.; Nall, B.T.
	Title	Coupled kinetic traps in cytochrome c folding: His-heme misligation and proline isomerization			Type	Journal Article
	Year	2000	Publication	Journal of Molecular Biology	Abbreviated Journal	J Mol Biol
	Volume	298	Issue	5	Pages	955-969
	Keywords	Amino Acid Sequence; Amino Acid Substitution/genetics; Binding Sites; Cytochrome c Group/chemistry/genetics/metabolism; Cytochromes c; Enzyme Stability/drug effects; Fluorescence; Guanidine/pharmacology; Heme/metabolism; Histidine/genetics/metabolism; Hydrogen-Ion Concentration; Isomerism; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation/genetics; Proline/chemistry/metabolism; Protein Conformation/drug effects; Protein Denaturation/drug effects; *Protein Folding; Protein Renaturation; Saccharomyces cerevisiae/enzymology/genetics; Sequence Alignment; Thermodynamics
	Abstract	The effect of His-heme misligation on folding has been investigated for a triple mutant of yeast iso-2 cytochrome c (N26H,H33N,H39K iso-2). The variant contains a single misligating His residue at position 26, a location at which His residues are found in several cytochrome c homologues, including horse, tuna, and yeast iso-1. The amplitude for fast phase folding exhibits a strong initial pH dependence. For GdnHCl unfolded protein at an initial pH<5, the observed refolding at final pH 6 is dominated by a fast phase (tau(2f)=20 ms, alpha(2f)=90 %) that represents folding in the absence of misligation. For unfolded protein at initial pH 6, folding at final pH 6 occurs in a fast phase of reduced amplitude (alpha(2f) approximately 20 %) but the same rate (tau(2f)=20 ms), and in two slower phases (tau(m)=6-8 seconds, alpha(m) approximately 45 %; and tau(1b)=16-20 seconds, alpha(1b) approximately 35 %). Double jump experiments show that the initial pH dependence of the folding amplitudes results from a slow pH-dependent equilibrium between fast and slow folding species present in the unfolded protein. The slow equilibrium arises from coupling of the His protonation equilibrium to His-heme misligation and proline isomerization. Specifically, Pro25 is predominantly in trans in the unligated low-pH unfolded protein, but is constrained in a non-native cis isomerization state by His26-heme misligation near neutral pH. Refolding from the misligated unfolded form proceeds slowly due to the large energetic barrier required for proline isomerization and displacement of the misligated His26-heme ligand.
	Address	Center for Biomolecular Structure, Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0022-2836	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:10801361			Approved	no
	Call Number	refbase @ user @			Serial	3853
Permanent link to this record



	Author	Kirkpatrick, J.F.; Liu, I.M.; Turner, J.W.J.; Naugle, R.; Keiper, R.
	Title	Long-term effects of porcine zonae pellucidae immunocontraception on ovarian function in feral horses (Equus caballus)			Type	Journal Article
	Year	1992	Publication	Journal of reproduction and fertility	Abbreviated Journal	J Reprod Fertil
	Volume	94	Issue	2	Pages	437-444
	Keywords	Animals; Contraception, Immunologic/veterinary; Egg Proteins; Estrogens, Conjugated (USP)/urine; Female; Glycoproteins/pharmacology; Horses/immunology/physiology; Membrane Glycoproteins; Ovary/drug effects/physiology; Progesterone/metabolism; Receptors, Cell Surface; Swine/immunology; Time Factors; Zona Pellucida/immunology
	Abstract	Ten feral mares free-roaming in Maryland, USA, were inoculated with porcine zonae pellucidae (PZP) protein before the breeding season for three consecutive years (1988-90). Ovarian function was monitored for 51 days during the peak of the breeding season after the third annual PZP inoculation, in seven of these mares and in four untreated control mares, by means of urinary oestrone conjugates and nonspecific progesterone metabolites. None of the ten inoculated mares became pregnant in 1990, compared with 55% of 20 control mares, which included two of the four monitored for ovarian function. Three of the untreated mares demonstrated apparent normal ovarian activity, characterized by preovulatory oestrogen peaks, concurrent progesterone nadirs at ovulation, breeding activity, and luteal-phase progesterone increases after ovulation. Two of the seven monitored PZP-treated mares demonstrated ovulatory cycles that did not result in conception. One was pregnant as a result of conception in 1989 and demonstrated a normal, late-gestation, endocrine profile. The remaining four PZP-treated mares revealed no evidence of ovulation, and urinary oestrogen concentrations were significantly depressed. The experiments indicated that (i) a third consecutive annual PZP booster inoculation is greater than 90% effective in preventing pregnancies in mares and (ii) three consecutive years of PZP treatment may interfere with normal ovarian function as shown by markedly depressed oestrogen secretion.
	Address	Deaconess Research Institute, Billings, MT 59102
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0022-4251	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:1317449			Approved	no
	Call Number	refbase @ user @			Serial	145
Permanent link to this record



	Author	Turner, J.W.J.; Kirkpatrick, J.F.
	Title	Androgens, behaviour and fertility control in feral stallions			Type	Journal Article
	Year	1982	Publication	Journal of reproduction and fertility. Supplement	Abbreviated Journal	J Reprod Fertil Suppl
	Volume	32	Issue		Pages	79-87
	Keywords	Animals; Animals, Wild; Copulation/drug effects; Female; Fertility/drug effects; Horses/physiology; Male; Periodicity; Pregnancy; Seasons; Sexual Behavior, Animal/drug effects; Sexual Maturation; Sperm Count; Sperm Motility/drug effects; Testosterone/blood/pharmacology
	Abstract	This field study of feral stallions in Montana and Idaho examines and correlates the seasonal pattern of plasma androgens and specific sociosexual behaviour and reports the effect of a long-acting androgenic steroid on this behaviour and on fertility. Plasma testosterone was measured by competitive protein binding assay in samples obtained by jugular venepuncture from captured animals. In samples taken from 34 sexually mature stallions in 6 different months during the year, a definite seasonal pattern in testosterone was present, with a peak in May (3.04 +/- 0.63 ng/ml) and a nadir in December (1.55 +/- 0.34 ng/ml). Values were less than 2.0 ng/ml in non-breeding months and greater than 2.4 ng/ml in breeding months. Behavioural endpoints measured were (1) stallion scent marking in response to elimination by mares (elimination marking), (2) mounting and (3) copulation. The frequencies of each of these endpoints followed closely the seasonal pattern seen for plasma androgens. In the fertility study microcapsulated testosterone propionate (microTP) was administered i.m. to 10 harem stud stallions 3 months before the 1980 breeding season. In these stallions and in 10 control harem studs, the above behavioural endpoints were examined in the 1980 and 1981 breeding seasons, and foal counts were made in 1981. There were no direct inhibitory or stimulatory effects of microTP treatment on any of the behavioural endpoints in either year. In 1981 foals were produced in 87.5% of the control bands and 28.4% of the microTP-treated bands. These results indicate that microencapsulated testosterone propionate can provide effective fertility control in feral horses without causing significant alterations in sociosexual behaviour.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0449-3087	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:6962905			Approved	no
	Call Number	refbase @ user @			Serial	138
Permanent link to this record



	Author	Loyola, E.G.; Rodriguez, M.H.; Gonzalez, L.; Arredondo, J.I.; Bown, D.N.; Vaca, M.A.
	Title	Effect of indoor residual spraying of DDT and bendiocarb on the feeding patterns of Anopheles pseudopunctipennis in Mexico			Type	Journal Article
	Year	1990	Publication	Journal of the American Mosquito Control Association	Abbreviated Journal	J Am Mosq Control Assoc
	Volume	6	Issue	4	Pages	635-640
	Keywords	Animals; Anopheles/physiology; Carbamates; Cattle; Ddt; Ecology; Enzyme-Linked Immunosorbent Assay; Feeding Behavior/drug effects; Horses; Humans; Insect Vectors; Insecticide Resistance; Insecticides; Mexico; Phenylcarbamates; Seasons
	Abstract	Intense and persistent use of DDT for malaria control has increased resistance and induced exophilic behavior of Anopheles pseudopunctipennis. An evaluation of bendiocarb and DDT to control this species in Sinaloa, Mexico, showed that, in spite of DDT-resistance, both insecticides produced similar effects. Feeding patterns were analyzed to explain these results. Resting mosquitoes were collected over the dry and wet seasons. Anophelines were tested in an ELISA to determine the source of the meals. The human blood index (HBI) ranged from 3.3 to 6.8% in DDT- and from 12.7 to 26.9% in bendiocarb-sprayed houses. Irritability and repellency in DDT-sprayed houses could explain the reduced HBI. In contrast, bendiocarb produced higher mortality. These effects could have affected different components of the vectorial capacity and similarly reduced malaria.
	Address	Center for Malaria Research, Chiapas, Mexico
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	8756-971X	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:2098469			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	2671
Permanent link to this record



	Author	Madigan, J.E.; Bell, S.A.
	Title	Owner survey of headshaking in horses			Type	Journal Article
	Year	2001	Publication	Journal of the American Veterinary Medical Association	Abbreviated Journal	J Am Vet Med Assoc
	Volume	219	Issue	3	Pages	334-337
	Keywords	Animals; Anti-Allergic Agents/therapeutic use; Behavior, Animal/drug effects; Cyproheptadine/therapeutic use; Data Collection; Diagnosis, Differential; Female; Horse Diseases/diagnosis/drug therapy/etiology; Horses; Humans; Male; Questionnaires; Seasons
	Abstract	OBJECTIVE: To determine signalment, history, clinical signs, duration, seasonality, and response to various treatments reported by owners for headshaking in horses. DESIGN: Owner survey. ANIMALS: 109 horses with headshaking. PROCEDURE: Owners of affected horses completed a survey questionnaire. RESULTS: 78 affected horses were geldings, 29 were mares, and 2 were stallions. Mean age of onset was 9 years. Headshaking in 64 horses had a seasonal component, and for most horses, headshaking began in spring and ceased in late summer or fall. The most common clinical signs were shaking the head in a vertical plane, acting like an insect was flying up the nostril, snorting excessively, rubbing the muzzle on objects, having an anxious expression while headshaking, worsening of clinical signs with exposure to sunlight, and improvement of clinical signs at night. Treatment with antihistamines, nonsteroidal anti-inflammatory drugs, corticosteroids, antimicrobials, fly control, chiropractic, and acupuncture had limited success. Sixty-one horses had been treated with cyproheptadine; 43 had moderate to substantial improvement. CONCLUSIONS AND CLINICAL RELEVANCE: Headshaking may have many causes. A large subset of horses have similar clinical signs including shaking the head in a vertical plane, acting as if an insect were flying up the nostrils, and rubbing the muzzle on objects. Seasonality and worsening of clinical signs with exposure to light are also common features of this syndrome. Geldings and Thoroughbreds appear to be overrepresented. Cyproheptadine treatment was beneficial in more than two thirds of treated horses.
	Address	Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0003-1488	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:11497047			Approved	no
	Call Number	refbase @ user @			Serial	1916
Permanent link to this record



	Author	Aronson, L.
	Title	Animal behavior case of the month. Aggression directed toward other horses			Type	Journal Article
	Year	1998	Publication	Journal of the American Veterinary Medical Association	Abbreviated Journal	J Am Vet Med Assoc
	Volume	213	Issue	3	Pages	358-359
	Keywords	Aggression; Animals; Behavior, Animal; Follow-Up Studies; Horse Diseases/diagnosis/drug therapy/psychology; Horses/psychology; Housing, Animal; Hypothyroidism/diagnosis/drug therapy/*veterinary; Male; Physical Examination/veterinary; Thyroxine/blood/therapeutic use
	Abstract
	Address	Department of Surgery, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0003-1488	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:9702222			Approved	no
	Call Number	refbase @ user @			Serial	1935
Permanent link to this record



	Author	Grubb, T.L.; Foreman, J.H.; Benson, G.J.; Thurmon, J.C.; Tranquilli, W.J.; Constable, P.D.; Olson, W.O.; Davis, L.E.
	Title	Hemodynamic effects of calcium gluconate administered to conscious horses			Type	Journal Article
	Year	1996	Publication	Journal of veterinary internal medicine / American College of Veterinary Internal Medicine	Abbreviated Journal	J Vet Intern Med
	Volume	10	Issue	6	Pages	401-404
	Keywords	Animals; Blood Pressure/drug effects/physiology; Calcium/blood; Calcium Gluconate/administration & dosage/pharmacology; Cardiac Output/drug effects/physiology; Consciousness/physiology; Dose-Response Relationship, Drug; Female; Heart Rate/drug effects/physiology; Hemodynamic Processes/drug effects/physiology; Horses/blood/physiology; Infusions, Intravenous; Male; Myocardial Contraction/drug effects/physiology; Respiration/drug effects/physiology; Stroke Volume/drug effects/physiology; Time Factors
	Abstract	Calcium gluconate was administered to conscious horses at 3 different rates (0.1, 0.2, and 0.4 mg/kg/min for 15 minutes each). Serum calcium concentrations and parameters of cardiovascular function were evaluated. All 3 calcium administration rates caused marked increases in both ionized and total calcium concentrations, cardiac index, stroke index, and cardiac contractility (dP/dtmax). Mean arterial pressure and right atrial pressure were unchanged; heart rate decreased markedly during calcium administration. Ionized calcium concentration remained between 54% and 57% of total calcium concentration throughout the study. We conclude that calcium gluconate can safely be administered to conscious horses at 0.1 to 0.4 mg/kg/min and that administration will result in improved cardiac function.
	Address	Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0891-6640	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:8947873			Approved	no
	Call Number	refbase @ user @			Serial	97
Permanent link to this record



	Author	Rietmann, T.R.; Stauffacher, M.; Bernasconi, P.; Auer, J.A.; Weishaupt, M.A.
	Title	The association between heart rate, heart rate variability, endocrine and behavioural pain measures in horses suffering from laminitis			Type	Journal Article
	Year	2004	Publication	Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine	Abbreviated Journal	J Vet Med A Physiol Pathol Clin Med
	Volume	51	Issue	5	Pages	218-225
	Keywords	Animals; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Autonomic Nervous System; Behavior, Animal; Electrophysiology/methods; Endocrine System; Female; Heart Rate; Horse Diseases/blood/drug therapy/physiopathology; Horses; Joint Diseases/physiopathology/veterinary; Male; Pain/physiopathology/veterinary; Pain Measurement/*veterinary; Predictive Value of Tests
	Abstract	The objective of this study was to compare the stress response of horses suffering from laminitis after short- and long-term treatment with the intent to evaluate power spectral analysis of heart rate variability (HRV) for pain monitoring. Data were collected from 19 horses with acute or chronic exacerbating laminitis without known primary disease before and after treatment with non-steroidal anti-inflammatory drugs (NSAID). Recordings were carried out the day after admission to the equine hospital. Measurements were repeated on day 7 of the treatment. The recorded parameters included a clinical orthopaedic index (OLPI: Obel-grade plus hoof tester score), frequency of weight-shifting between contralateral limbs, mean beat-to-beat interval (R-R) duration, standard deviation of continuous R-R intervals, low- (LF) and high-frequency (HF) components of HRV, sympatho-vagal balance (LF/HF), and plasma concentration of cortisol, adrenalin and noradrenalin. The LF represents mainly sympathetic influences on the heart whereas HF is mediated by the parasympathetic tone. Weight-shifting and OLPI decreased significantly with treatment. The LF normalized units (n.u.) decreased after NSAID from 60.41 +/- 21.42 to 51.12 +/- 19.81 and was 49.33 +/- 22.64 on day 7, whereas HF n.u. increased from 35.07 +/- 20.02 to 43.14 +/- 18.30 and was 45.98 +/- 23.00 on day 7. Hormone levels showed no tendency to change with treatment. The OLPI was only correlated with LF/HF, LF and HF (R = 0.57, 0.55 and -0.54 respectively). Significant negative correlations existed between HFn.u. and weight-shifting frequency (R = -0.37), HFn.u. and adrenalin (R = -0.47), and HFn.u. and noradrenalin (R = 0.33). The LFn.u. only correlated positively with adrenalin. Cortisol levels were poorly associated with the other parameters. Determination of the sympatho-vagal influences on cardiac function may offer complementary information for reliable assessment of pain and may represent a valuable alternative method to catecholamine measurements.
	Address	Equine Hospital, Faculty of Veterinary Medicine, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0931-184X	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15315700			Approved	no
	Call Number				Serial	1899
Permanent link to this record



	Author	Tobin, T.; Combie, J.D.
	Title	Performance testing in horses: a review of the role of simple behavioral models in the design of performance experiments			Type	Journal Article
	Year	1982	Publication	Journal of Veterinary Pharmacology and Therapeutics	Abbreviated Journal	J Vet Pharmacol Ther
	Volume	5	Issue	2	Pages	105-118
	Keywords	Analgesics, Opioid/pharmacology; Animals; Apomorphine/pharmacology; Behavior, Animal/drug effects; Dose-Response Relationship, Drug; Fentanyl/pharmacology; Horses/physiology; Methylphenidate/pharmacology; *Models, Biological; Motor Activity/drug effects
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0140-7783	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:6125601			Approved	no
	Call Number	refbase @ user @			Serial	1957
Permanent link to this record



	Author	Lyda, R.O.; Hall, J.R.; Kirkpatrick, J.F.
	Title	A comparison of Freund's Complete and Freund's Modified Adjuvants used with a contraceptive vaccine in wild horses (Equus caballus)			Type	Journal Article
	Year	2005	Publication	Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians	Abbreviated Journal	J Zoo Wildl Med
	Volume	36	Issue	4	Pages	610-616
	Keywords	Animals; Antibody Formation; Contraception, Immunologic/veterinary; Estrus/drug effects; Female; Freund's Adjuvant/administration & dosage/adverse effects/immunology; Horses/immunology/physiology; Vaccines, Contraceptive; Zona Pellucida/*immunology
	Abstract	Fifteen captive wild mares (Equus caballus) were treated with porcine zona pellucida contraceptive vaccine and either Freund's Complete Adjuvant (n = 7) or Freund's Modified Adjuvant (n = 8). All mares received a booster inoculation of porcine zona pellucida plus Freund's Incomplete Adjuvant a month later. Anti-porcine zona pellucida antibodies were measured over 10 mo following the initial inoculation. There were no significant differences in antibody titers at any point during the 10 mo, and seven of the eight mares in the Freund's Modified Adjuvant group were above the 60% level at the end of the study, which is considered to be the contraceptive threshold for horses. There were no significant differences in titers between pregnant and nonpregnant horses, nor was there a significant correlation between age and titers. One local injection site reaction occurred after booster treatment with Freund's Incomplete Adjuvant, and 11 healthy foals were born during the course of the study. These data suggest that Freund's Modified Adjuvant is an acceptable substitute for Freund's Complete Adjuvant in certain free-ranging and captive wildlife species.
	Address	Science and Conservation Center, 2100 South Shiloh Road, Billings, Montana 59106, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1042-7260	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:17312717			Approved	no
	Call Number	refbase @ user @			Serial	139
Permanent link to this record

Select All Deselect All

<< 1 2 3 4 5 6 7 >>

Details

CQL Search | Library Search | Show Record | Extract Citations

Help