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Author Camerlink, I.; Menneson, S.; Turner, S.P.; Farish, M.; Arnott, G. url  doi
openurl 
  Title Lateralization influences contest behaviour in domestic pigs Type Journal Article
  Year 2018 Publication Scientific Reports Abbreviated Journal  
  Volume 8 Issue 1 Pages (down) 12116  
  Keywords  
  Abstract Cerebral lateralization, i.e. hemispheric asymmetries in structure and function, relates in many species to a preference to attack from their left. Lateralization increases cognitive capacity, enabling the simultaneous processing of multiple sources of information. Therefore, lateralization may constitute a component of fighting ability (Resource Holding Potential), and/or influence the efficiency of information-gathering during a contest. We hypothesized that lateralization will affect contest outcome and duration, with an advantage for more strongly lateralized individuals. In 52 dyadic contests between weight-matched pigs (Sus scrofa; n = 104; 10 wk age), the direction of orientation towards the opponent was scan sampled every 10 s. Laterality indexes (LI) were calculated for the direction and strength of lateralization. Up to 12.5% of the individuals showed significant lateralization towards either the right or left but lateralization was absent at the population level. In line with our hypothesis, animals showing strong lateralization (irrespective of direction) had a shorter contest duration than animals showing weak lateralization. Winners did not differ from losers in their strength or direction of lateralization. Overall the results suggest that cerebral lateralization may aid in conflict resolution, but does not directly contribute to fighting ability, and will be of value in the study of animal contests.  
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  ISSN 2045-2322 ISBN Medium  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Camerlink2018 Serial 6700  
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Author Ecker, C.; Marquand, A.; Mourao-Miranda, J.; Johnston, P.; Daly, E.M.; Brammer, M.J.; Maltezos, S.; Murphy, C.M.; Robertson, D.; Williams, S.C.; Murphy, D.G.M. url  doi
openurl 
  Title Describing the Brain in Autism in Five Dimensions--Magnetic Resonance Imaging-Assisted Diagnosis of Autism Spectrum Disorder Using a Multiparameter Classification Approach Type Journal Article
  Year 2010 Publication J. Neurosci. Abbreviated Journal J. Neurosci.  
  Volume 30 Issue 32 Pages (down) 10612-10623  
  Keywords  
  Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition with multiple causes, comorbid conditions, and a wide range in the type and severity of symptoms expressed by different individuals. This makes the neuroanatomy of autism inherently difficult to describe. Here, we demonstrate how a multiparameter classification approach can be used to characterize the complex and subtle structural pattern of gray matter anatomy implicated in adults with ASD, and to reveal spatially distributed patterns of discriminating regions for a variety of parameters describing brain anatomy. A set of five morphological parameters including volumetric and geometric features at each spatial location on the cortical surface was used to discriminate between people with ASD and controls using a support vector machine (SVM) analytic approach, and to find a spatially distributed pattern of regions with maximal classification weights. On the basis of these patterns, SVM was able to identify individuals with ASD at a sensitivity and specificity of up to 90% and 80%, respectively. However, the ability of individual cortical features to discriminate between groups was highly variable, and the discriminating patterns of regions varied across parameters. The classification was specific to ASD rather than neurodevelopmental conditions in general (e.g., attention deficit hyperactivity disorder). Our results confirm the hypothesis that the neuroanatomy of autism is truly multidimensional, and affects multiple and most likely independent cortical features. The spatial patterns detected using SVM may help further exploration of the specific genetic and neuropathological underpinnings of ASD, and provide new insights into the most likely multifactorial etiology of the condition.  
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  Notes 10.1523/Jneurosci.5413-09.2010 Approved no  
  Call Number Equine Behaviour @ team @ Serial 5191  
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Author Muscatello, G.; Anderson, G.A.; Gilkerson, J.R.; Browning, G.F. doi  openurl
  Title Associations between the ecology of virulent Rhodococcus equi and the epidemiology of R. equi pneumonia on Australian thoroughbred farms Type Journal Article
  Year 2006 Publication Applied and Environmental Microbiology Abbreviated Journal Appl Environ Microbiol  
  Volume 72 Issue 9 Pages (down) 6152-6160  
  Keywords Actinomycetales Infections/epidemiology/microbiology/*veterinary; Air Microbiology; Animal Husbandry; Animals; Animals, Newborn; Australia/epidemiology; Colony Count, Microbial; DNA, Bacterial/genetics; Ecosystem; Horse Diseases/epidemiology/*microbiology; Horses; Pneumonia, Bacterial/epidemiology/microbiology/*veterinary; Rhodococcus equi/genetics/isolation & purification/*pathogenicity; Soil Microbiology; Virulence  
  Abstract The ecology of virulent strains of Rhodococcus equi on horse farms is likely to influence the prevalence and severity of R. equi pneumonia in foals. This study examined the association between the ecology of virulent R. equi and the epidemiology of R. equi pneumonia by collecting air and soil samples over two breeding seasons (28 farm-year combinations) on Thoroughbred breeding farms with different reported prevalences of R. equi pneumonia. Colony blotting and DNA hybridization were used to detect and measure concentrations of virulent R. equi. The prevalence of R. equi pneumonia was associated with the airborne burden of virulent R. equi (both the concentration and the proportion of R. equi bacteria that were virulent) but was not associated with the burden of virulent R. equi in the soil. Univariable screening and multivariable model building were used to evaluate the effect of environmental and management factors on virulent R. equi burdens. Lower soil moisture concentrations and lower pasture heights were significantly associated with elevated airborne concentrations of virulent R. equi, as were the holding pens and lanes, which typically were sandy, dry, and devoid of pasture cover. Few variables appeared to influence concentrations of virulent R. equi in soil. Acidic soil conditions may have contributed to an elevated proportion of virulent strains within the R. equi population. Environmental management strategies that aim to reduce the level of exposure of susceptible foals to airborne virulent R. equi are most likely to reduce the impact of R. equi pneumonia on endemically affected farms.  
  Address School of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia. mug@unimelb.edu.au  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0099-2240 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16957241 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2622  
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Author Polverini, E.; Cugini, G.; Annoni, F.; Abbruzzetti, S.; Viappiani, C.; Gensch, T. doi  openurl
  Title Molten globule formation in apomyoglobin monitored by the fluorescent probe Nile Red Type Journal Article
  Year 2006 Publication Biochemistry Abbreviated Journal Biochemistry  
  Volume 45 Issue 16 Pages (down) 5111-5121  
  Keywords Animals; Apoproteins/*chemistry/*metabolism; Binding Sites; Computer Simulation; Fluorescent Dyes/analysis; Horses; Hydrogen-Ion Concentration; Models, Molecular; Myoglobin/*chemistry/*metabolism; Oxazines/*analysis/chemistry; Protein Binding; Protein Folding; Protein Structure, Tertiary  
  Abstract The interaction of nile red (NR) with apomyoglobin (ApoMb) in the native (pH 7) and molten globule (pH 4) states was investigated using experimental and computational methods. NR binds to hydrophobic locations in ApoMb with higher affinity (K(d) = 25 +/- 5 microM) in the native state than in the molten globule state (K(d) = 52 +/- 5 microM). In the molten globule state, NR is located in a more hydrophobic environment. The dye does not bind to the holoprotein, suggesting that the binding site is located at the heme pocket. In addition to monitoring steady-state properties, the fluorescence emission of NR is capable of tracking submillisecond, time-resolved structural rearrangements of the protein, induced by a nanosecond pH jump. Molecular dynamics simulations were run on ApoMb at neutral pH and at pH 4. The structure obtained for the molten globule state is consistent with the experimentally available structural data. The docking of NR with the crystal structure shows that the ligand binds into the binding pocket of the heme group, with an orientation bringing the planar ring system of NR to overlap with the position of two of the heme porphyrin rings in Mb. The docking of NR with the ApoMb structure at pH 4 shows that the dye binds to the heme pocket with a slightly less favorable binding energy, in keeping with the experimental K(d) value. Under these conditions, NR is positioned in a different orientation, reaching a more hydrophobic environment in agreement with the spectroscopic data.  
  Address Dipartimento di Fisica, Universita degli Studi di Parma, Viale G. P. Usberti 7/A, 43100 Parma, Italy  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0006-2960 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16618100 Approved no  
  Call Number Equine Behaviour @ team @ Serial 3763  
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Author Harvey, P.H.; Clutton-Brock, T.H.; Mace, G.M. url  openurl
  Title Brain size and ecology in small mammals and primates Type Journal Article
  Year 1980 Publication Proceedings of the National Academy of Sciences Abbreviated Journal PNAS  
  Volume 77 Issue 7 Pages (down) 4387-4389  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 5456  
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Author McComb, K.; Shannon, G.; Durant, S.M.; Sayialel, K.; Slotow, R.; Poole, J.; Moss, C. url  doi
openurl 
  Title Leadership in elephants: the adaptive value of age Type Journal Article
  Year 2011 Publication Proceedings of the Royal Society B: Biological Sciences Abbreviated Journal Proc. R. Soc. Lond. B.  
  Volume 278 Issue 1722 Pages (down) 3270-3276  
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  Abstract The value of age is well recognized in human societies, where older individuals often emerge as leaders in tasks requiring specialized knowledge, but what part do such individuals play in other social species? Despite growing interest in how effective leadership might be achieved in animal social systems, the specific role that older leaders may play in decision-making has rarely been experimentally investigated. Here, we use a novel playback paradigm to demonstrate that in African elephants (Loxodonta africana), age affects the ability of matriarchs to make ecologically relevant decisions in a domain critical to survival—the assessment of predatory threat. While groups consistently adjust their defensive behaviour to the greater threat of three roaring lions versus one, families with younger matriarchs typically under-react to roars from male lions despite the severe danger they represent. Sensitivity to this key threat increases with matriarch age and is greatest for the oldest matriarchs, who are likely to have accumulated the most experience. Our study provides the first empirical evidence that individuals within a social group may derive significant benefits from the influence of an older leader because of their enhanced ability to make crucial decisions about predatory threat, generating important insights into selection for longevity in cognitively advanced social mammals.  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 5652  
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Author Dunn, M.F.; Branlant, G. openurl 
  Title Roles of zinc ion and reduced coenzyme in horse liver alcohol dehydrogenase catalysis. The mechanism of aldehyde activation Type Journal Article
  Year 1975 Publication Biochemistry Abbreviated Journal Biochemistry  
  Volume 14 Issue 14 Pages (down) 3176-3182  
  Keywords *Alcohol Oxidoreductases/metabolism; Aldehydes/*pharmacology; Animals; Binding Sites; Enzyme Activation/drug effects; Horses; Hydrogen-Ion Concentration; Kinetics; Liver/enzymology; *NAD/analogs & derivatives/pharmacology; Oxidation-Reduction; Protein Binding; Spectrophotometry; Spectrophotometry, Ultraviolet; Temperature; *Zinc/pharmacology  
  Abstract 1,4,5,6-Tetrahydronicotinamide adenine dinucleotide (H2NADH) has been investigated as a reduced coenzyme analog in the reaction between trans-4-N,N-dimethylaminocinnamaldehyde (I) (lambdamax 398 nm, epsilonmax 3.15 X 10-4 M-minus 1 cm-minus 1) and the horse liver alcohol dehydrogenase-NADH complex. These equilibrium binding and temperature-jump kinetic studies establish the following. (i) Substitution of H2NADH for NADH limits reaction to the reversible formation of a new chromophoric species, lambdamax 468 nm, epsilonmax 5.8 x 10-4 M-minus 1 cm-minus 1. This chromophore is demonstrated to be structurally analogous to the transient intermediate formed during the reaction of I with the enzyme-NADH complex [Dunn, M. F., and Hutchison, J. S. (1973), Biochemistry 12, 4882]. (ii) The process of intermediate formation with the enzyme-NADH complex is independent of pH over the range 6.13-10.54. Although studies were limited to the pH range 5.98-8.72, a similar pH independence appears to hold for the H2NADH system. (iii) Within the ternary complex, I is bound within van der Waal's contact distance of the coenzyme nicotinamide ring. (iv) Formation of the transient intermediate does not involve covalent modification of coenzyme. Based on these findings, we conclude that zinc ion has a Lewis acid function in facilitating the chemical activation of the aldehyde carbonyl for reduction, and that reduced coenzyme plays a noncovalent effector role in this substrate activating step.  
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  Series Volume Series Issue Edition  
  ISSN 0006-2960 ISBN Medium  
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  Notes PMID:238585 Approved no  
  Call Number Equine Behaviour @ team @ Serial 3817  
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Author Dwan, K.; Altman, D.G.; Arnaiz, J.A.; Bloom, J.; Chan, A.-W.; Cronin, E.; Decullier, E.; Easterbrook, P.J.; Von Elm, E.; Gamble, C.; Ghersi, D.; Ioannidis, J.P.A.; Simes, J.; Williamson, P.R. url  doi
openurl 
  Title Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias Type Journal Article
  Year 2008 Publication Plos One Abbreviated Journal Plos One  
  Volume 3 Issue 8 Pages (down) e3081  
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  Abstract Background The increased use of meta-analysis in systematic reviews of healthcare interventions has highlighted several types of bias that can arise during the completion of a randomised controlled trial. Study publication bias has been recognised as a potential threat to the validity of meta-analysis and can make the readily available evidence unreliable for decision making. Until recently, outcome reporting bias has received less attention. Methodology/Principal Findings We review and summarise the evidence from a series of cohort studies that have assessed study publication bias and outcome reporting bias in randomised controlled trials. Sixteen studies were eligible of which only two followed the cohort all the way through from protocol approval to information regarding publication of outcomes. Eleven of the studies investigated study publication bias and five investigated outcome reporting bias. Three studies have found that statistically significant outcomes had a higher odds of being fully reported compared to non-significant outcomes (range of odds ratios: 2.2 to 4.7). In comparing trial publications to protocols, we found that 40-62% of studies had at least one primary outcome that was changed, introduced, or omitted. We decided not to undertake meta-analysis due to the differences between studies. Conclusions Recent work provides direct empirical evidence for the existence of study publication bias and outcome reporting bias. There is strong evidence of an association between significant results and publication; studies that report positive or significant results are more likely to be published and outcomes that are statistically significant have higher odds of being fully reported. Publications have been found to be inconsistent with their protocols. Researchers need to be aware of the problems of both types of bias and efforts should be concentrated on improving the reporting of trials.  
  Address  
  Corporate Author Thesis  
  Publisher Public Library of Science Place of Publication Editor  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 6644  
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Author Skedros, J.G.; Dayton, M.R.; Sybrowsky, C.L.; Bloebaum, R.D.; Bachus, K.N. doi  openurl
  Title The influence of collagen fiber orientation and other histocompositional characteristics on the mechanical properties of equine cortical bone Type Journal Article
  Year 2006 Publication The Journal of Experimental Biology Abbreviated Journal J Exp Biol  
  Volume 209 Issue Pt 15 Pages (down) 3025-3042  
  Keywords Animals; Biomechanics; Bone and Bones/*physiology; Collagen/*physiology; Forelimb; Horses/*physiology  
  Abstract This study examined relative influences of predominant collagen fiber orientation (CFO), mineralization (% ash), and other microstructural characteristics on the mechanical properties of equine cortical bone. Using strain-mode-specific (S-M-S) testing (compression testing of bone habitually loaded in compression; tension testing of bone habitually loaded in tension), the relative mechanical importance of CFO and other material characteristics were examined in equine third metacarpals (MC3s). This model was chosen since it had a consistent non-uniform strain distribution estimated by finite element analysis (FEA) near mid-diaphysis of a thoroughbred horse, net tension in the dorsal/lateral cortices and net compression in the palmar/medial cortices. Bone specimens from regions habitually loaded in tension or compression were: (1) tested to failure in both axial compression and tension in order to contrast S-M-S vs non-S-M-S behavior, and (2) analyzed for CFO, % ash, porosity, fractional area of secondary osteonal bone, osteon cross-sectional area, and population densities of secondary osteons and osteocyte lacunae. Multivariate multiple regression analyses revealed that in S-M-S compression testing, CFO most strongly influenced total energy (pre-yield elastic energy plus post-yield plastic energy); in S-M-S tension testing CFO most strongly influenced post-yield energy and total energy. CFO was less important in explaining S-M-S elastic modulus, and yield and ultimate stress. Therefore, in S-M-S loading CFO appears to be important in influencing energy absorption, whereas the other characteristics have a more dominant influence in elastic modulus, pre-yield behavior and strength. These data generally support the hypothesis that differentially affecting S-M-S energy absorption may be an important consequence of regional histocompositional heterogeneity in the equine MC3. Data inconsistent with the hypothesis, including the lack of highly longitudinal collagen in the dorsal-lateral ;tension' region, paradoxical histologic organization in some locations, and lack of significantly improved S-M-S properties in some locations, might reflect the absence of a similar habitual strain distribution in all bones. An alternative strain distribution based on in vivo strain measurements, without FEA, on non-Thoroughbreds showing net compression along the dorsal-palmar axis might be more characteristic of the habitual loading of some of the bones that we examined. In turn, some inconsistencies might also reflect the complex torsion/bending loading regime that the MC3 sustains when the animal undergoes a variety of gaits and activities, which may be representative of only a portion of our animals, again reflecting the possibility that not all of the bones examined had similar habitual loading histories.  
  Address Utah Bone and Joint Center, 5323 S. Woodrow Street #202, Salt Lake City, UT 84107, USA. jskedros@utahboneandjoint.com  
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  ISSN 0022-0949 ISBN Medium  
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  Notes PMID:16857886 Approved no  
  Call Number Serial 1868  
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Author A. Lanata; A. Guidi; G. Valenza; P. Baragli; E. P. Scilingo doi  openurl
  Title Quantitative heartbeat coupling measures in human-horse interaction Type Conference Article
  Year 2016 Publication 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Abbreviated Journal 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (E  
  Volume Issue Pages (down) 2696-2699  
  Keywords electrocardiography; medical signal processing; signal classification; time series; Dtw; Hrv; Mpc; Msc; complex biological systems; dynamic time warping; grooming; heart rate variability time series; heartbeat dynamics; human-horse dynamic interaction; magnitude squared coherence; magnitude-phase coupling; mean phase coherence; nearest mean classifier; quantitative heartbeat coupling; real human-animal interaction; time duration; visual-olfactory interaction; Coherence; Couplings; Electrocardiography; Heart rate variability; Horses; Protocols; Time series analysis  
  Abstract Abstract— We present a study focused on a quantitative estimation of a human-horse dynamic interaction. A set of measures based on magnitude and phase coupling between heartbeat dynamics of both humans and horses in three different conditions is reported: no interaction, visual/olfactory interaction and grooming. Specifically, Magnitude Squared Coherence (MSC), Mean Phase Coherence (MPC) and Dynamic Time Warping (DTW) have been used as estimators of the amount of coupling between human and horse through the analysis of their heart rate variability (HRV) time series in a group of eleven human subjects, and one horse. The rationale behind this study is that the interaction of two complex biological systems go towards a coupling process whose dynamical evolution is modulated by the kind and time duration of the interaction itself. We achieved a congruent and consistent

statistical significant difference for all of the three indices. Moreover, a Nearest Mean Classifier was able to recognize the three classes of interaction with an accuracy greater than 70%. Although preliminary, these encouraging results allow a discrimination of three distinct phases in a real human-animal interaction opening to the characterization of the empirically proven relationship between human and horse.
 
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  Series Editor Series Title Abbreviated Series Title 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (E  
  Series Volume Series Issue Edition  
  ISSN 1557-170x ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 6175  
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