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	Author	Cheung, C.; Akiyama, T.E.; Ward, J.M.; Nicol, C.J.; Feigenbaum, L.; Vinson, C.; Gonzalez, F.J.
	Title	Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha			Type	Journal Article
	Year	2004	Publication	Cancer research	Abbreviated Journal	Cancer Res
	Volume	64	Issue	11	Pages	3849-3854
	Keywords	Animals; Anticholesteremic Agents/pharmacology; Carcinogens/pharmacology; Cell Division; DNA Replication/drug effects; Fatty Acids/metabolism; Hepatocytes/cytology/drug effects/metabolism/physiology; Humans; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxisome Proliferators/pharmacology; Pyrimidines/pharmacology; Receptors, Cytoplasmic and Nuclear/genetics/physiology; Species Specificity; Transcription Factors/genetics/*physiology
	Abstract	Lipid-lowering fibrate drugs function as agonists for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice. However, humans appear to be resistant to the induction of peroxisome proliferation and the development of liver cancer by fibrate drugs. The molecular basis of this species difference is not known. To examine the mechanism determining species differences in peroxisome proliferator response between mice and humans, a PPARalpha-humanized mouse line was generated in which the human PPARalpha was expressed in liver under control of the tetracycline responsive regulatory system. The PPARalpha-humanized and wild-type mice responded to treatment with the potent PPARalpha ligand Wy-14643 as revealed by induction of genes encoding peroxisomal and mitochondrial fatty acid metabolizing enzymes and resultant decrease of serum triglycerides. However, surprisingly, only the wild-type mice and not the PPARalpha-humanized mice exhibited hepatocellular proliferation as revealed by elevation of cell cycle control genes, increased incorporation of 5-bromo-2'-deoxyuridine into hepatocyte nuclei, and hepatomegaly. These studies establish that following ligand activation, the PPARalpha-mediated pathways controlling lipid metabolism are independent from those controlling the cell proliferation pathways. These findings also suggest that structural differences between human and mouse PPARalpha are responsible for the differential susceptibility to the development of hepatocarcinomas observed after treatment with fibrates. The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators.
	Address	Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0008-5472	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15172993			Approved	no
	Call Number	refbase @ user @			Serial	74
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	Author	Hirata, S.
	Title	A note on the responses of chimpanzees (Pan troglodytes) to live self-images on television monitors			Type	Journal Article
	Year	2007	Publication	Behavioural Processes	Abbreviated Journal	Behav. Process.
	Volume	75	Issue	1	Pages	85-90
	Keywords	Animals; Discrimination Learning; Female; Male; Pan troglodytes/psychology; *Self Concept; Self Psychology; Social Behavior; Television
	Abstract	The majority of studies on self-recognition in animals have been conducted using a mirror as the test device; little is known, however, about the responses of non-human primates toward their own images in media other than mirrors. This study provides preliminary data on the reactions of 10 chimpanzees to live self-images projected on two television monitors, each connected to a different video camera. Chimpanzees could see live images of their own faces, which were approximately life-sized, on one monitor. On the other monitor, they could see live images of their whole body, which were approximately one-fifth life-size, viewed diagonally from behind. In addition, several objects were introduced into the test situation. Out of 10 chimpanzees tested, 2 individuals performed self-exploratory behaviors while watching their own images on the monitors. One of these two chimpanzees successively picked up two of the provided objects in front of a monitor, and watched the images of these objects on the monitor. The results indicate that these chimpanzees were able to immediately recognize live images of themselves or objects on the monitors, even though several features of these images differed from those of their previous experience with mirrors.
	Address	Great Ape Research Institute, Hayashibara Biochemical Laboratories Inc., Okayama, Japan. hirata@gari.be.to
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0376-6357	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:17324534			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4145
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	Author	Loveland, K.A.
	Title	Self-recognition in the bottlenose dolphin: ecological considerations			Type	Journal Article
	Year	1995	Publication	Consciousness and Cognition	Abbreviated Journal	Conscious Cogn
	Volume	4	Issue	2	Pages	254-257
	Keywords	Animals; Attention; Awareness; Body Image; Dolphins/psychology; Exploratory Behavior; Female; Male; Self Concept; Social Environment; Species Specificity; Television; *Visual Perception
	Abstract
	Address	Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77025, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1053-8100	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:8521267			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4161
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	Author	Anderson, J.R.
	Title	Self-recognition in dolphins: credible cetaceans; compromised criteria, controls, and conclusions			Type	Journal Article
	Year	1995	Publication	Consciousness and Cognition	Abbreviated Journal	Conscious Cogn
	Volume	4	Issue	2	Pages	239-243
	Keywords	Animal Communication; Animals; Awareness; Discrimination Learning; Dolphins/psychology; Female; Male; Orientation; Self Concept; Social Behavior; Television; *Visual Perception
	Abstract
	Address	Laboratoire de Psychophysiologie, CNRS URA 1295, Universite Louis Pasteur, Strasbourg, France
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1053-8100	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:8521263			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4163
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	Author	Marten, K.; Psarakos, S.
	Title	Using self-view television to distinguish between self-examination and social behavior in the bottlenose dolphin (Tursiops truncatus)			Type	Journal Article
	Year	1995	Publication	Consciousness and Cognition	Abbreviated Journal	Conscious Cogn
	Volume	4	Issue	2	Pages	205-224
	Keywords	Animal Communication; Animals; Attention; Discrimination Learning; Dolphins/psychology; Female; Male; Self Concept; Social Behavior; Television; Visual Perception
	Abstract	In mirror mark tests dolphins twist, posture, and engage in open-mouth and head movements, often repetitive. Because postures and an open mouth are also dolphin social behaviors, we used self-view television as a manipulatable mirror to distinguish between self-examination and social behavior. Two dolphins were exposed to alternating real-time self-view (“mirror mode”) and playback of the same to determine if they distinguished between them. The adult male engaged in elaborate open-mouth behaviors in mirror mode, but usually just watched when played back the same material. Mirror mode behavior was also compared to interacting with real dolphins (controls). Mark tests were conducted, as well as switches from front to side self-views to see if the dolphins turned. They presented marked areas to the self-view television and turned. The results suggest self-examination over social behavior.
	Address	Earthtrust, Kailua, Hawaii 96734, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1053-8100	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:8521259			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4164
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	Author	van Niekerk, H.P.
	Title	Ethological studies within the man-horse relationship			Type	Journal Article
	Year	1980	Publication	Journal of the South African Veterinary Association	Abbreviated Journal	J S Afr Vet Assoc
	Volume	51	Issue	4	Pages	237-238
	Keywords	Animals; Behavior, Animal; Hearing; Horses/*physiology; Humans; Smell; Taste; Touch; Vision
	Abstract	Certain aspects of ethology and the horse's senses are discussed to bring about a better understanding between man and horse. Furthermore the behaviour of horses with respect to housing, feeding, breeding, veterinary treatment and work are considered.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1019-9128	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:7241494			Approved	no
	Call Number	refbase @ user @			Serial	1960
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	Author	Wolfe, J.M.
	Title	Hidden visual processes			Type	Journal Article
	Year	1983	Publication	Scientific American	Abbreviated Journal	Sci Am
	Volume	248	Issue	2	Pages	94-103
	Keywords	Color Perception/physiology; Humans; Motion Perception/physiology; Ocular Physiology; Vision; Visual Perception/physiology
	Abstract	Isoluminant stimulus is an image whose edges are defined only by a change in color, not by change in brightness. The stimulus here is imperfect: the blue parts and the green parts of the image are only as nearly equal in brightness as they can be on the printed page. Moreover, the change in brightness beyond the edge of the page is apparent, and so is the fact that the reader is holding the magazine at reading distance. When such cues are removed under laboratory conditions, subjects faced with an isoluminant stimulus prove unable to bring its edges into focus. This deficiency contributes to making a familiar face hard to recognize. The experiment indicates that the brain process underlying visual accommodation (the focusing of the eyes) cannot “see” color; it is a hidden process distinct from the processes that lead to perception. The image shows Groucho Marx as he appeared in the motion picture Horse Feathers.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0036-8733	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:6836258			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4066
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	Author	Hart, D.; Whitlow, J.W.J.
	Title	The experience of self in the bottlenose dolphin			Type	Journal Article
	Year	1995	Publication	Consciousness and Cognition	Abbreviated Journal	Conscious Cogn
	Volume	4	Issue	2	Pages	244-247
	Keywords	Animal Communication; Animals; Awareness; Body Image; Dolphins/psychology; Female; Humans; Male; Self Concept; Social Behavior; Species Specificity; Television; *Visual Perception
	Abstract	Marten and Psarakos have presented some evidence which suggests that objective self-awareness and possibly representations of self may characterize the dolphins' experience of self. Their research demonstrates the possibility of similarities in the sense of self between primate species and dolphins, although whether dolphins have subjective self-awareness, personal memories, and theories of self--all important facets of the sense of self in humans--was not examined. Clearly, even this limited evidence was difficult to achieve; the difficulties in adapting methods and coding behavior are quite apparent in their report. Future progress, however, may depend upon clarification of what are the necessary components for a sense of self and an explication of how these might be reflected in dolphin behavior. We are mindful of the authors' point (pp. 219 and 220) that the dolphin lives more in an acoustic than a visual environment. Thus, while tasks relying upon vision may reveal the presence or absence of the sense of self in primates, it might well be the case that in dolphins self-related experiences might be better revealed in auditory tasks. But then, what is the nature of human self-awareness in terms of audition? While both conceptual and methodological hurdles remain, Marten and Psarakos have demonstrated that important questions can be asked about the minds and phenomenal worlds of nonanthropoid species.
	Address	Department of Psychology, Rutgers University, Camden, New Jersey 08102, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1053-8100	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:8521264			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4162
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	Author	Hare, B.; Brown, M.; Williamson, C.; Tomasello, M.
	Title	The domestication of social cognition in dogs			Type	Journal Article
	Year	2002	Publication	Science (New York, N.Y.)	Abbreviated Journal	Science
	Volume	298	Issue	5598	Pages	1634-1636
	Keywords	Animals; Animals, Domestic; Behavior, Animal; Cognition; Cues; Dogs; Food; Humans; Memory; Pan troglodytes; Social Behavior; Species Specificity; Vision; Wolves
	Abstract	Dogs are more skillful than great apes at a number of tasks in which they must read human communicative signals indicating the location of hidden food. In this study, we found that wolves who were raised by humans do not show these same skills, whereas domestic dog puppies only a few weeks old, even those that have had little human contact, do show these skills. These findings suggest that during the process of domestication, dogs have been selected for a set of social-cognitive abilities that enable them to communicate with humans in unique ways.
	Address	Department of Anthropology, Harvard University, Cambridge, MA 02138, USA. bhare@fas.harvard.edu
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1095-9203	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:12446914			Approved	no
	Call Number	refbase @ user @			Serial	595
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	Author	Harman, A.M.; Moore, S.; Hoskins, R.; Keller, P.
	Title	Horse vision and an explanation for the visual behaviour originally explained by the 'ramp retina'			Type	Journal Article
	Year	1999	Publication	Equine veterinary journal	Abbreviated Journal	Equine Vet J
	Volume	31	Issue	5	Pages	384-390
	Keywords	Animals; Behavior, Animal; Cell Count; Eye/anatomy & histology; Ganglia, Sensory/cytology; Horses/physiology; Refractive Errors/veterinary; Retina/cytology/physiology; Vision/physiology; Visual Acuity; Visual Fields
	Abstract	Here we provide confirmation that the 'ramp retina' of the horse, once thought to result in head rotating visual behaviour, does not exist. We found a 9% variation in axial length of the eye between the streak region and the dorsal periphery. However, the difference was in the opposite direction to that proposed for the 'ramp retina'. Furthermore, acuity in the narrow, intense visual streak in the inferior retina is 16.5 cycles per degree compared with 2.7 cycles per degree in the periphery. Therefore, it is improbable that the horse rotates its head to focus onto the peripheral retina. Rather, the horse rotates the nose up high to observe distant objects because binocular overlap is oriented down the nose, with a blind area directly in front of the forehead.
	Address	Department of Psychology, University of Western Australia, Nedlands, Australia
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0425-1644	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:10505953			Approved	no
	Call Number	refbase @ user @			Serial	836
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