| Records |
| Author |
Polverini, E.; Cugini, G.; Annoni, F.; Abbruzzetti, S.; Viappiani, C.; Gensch, T. |
Title  |
Molten globule formation in apomyoglobin monitored by the fluorescent probe Nile Red |
Type |
Journal Article |
| Year |
2006 |
Publication |
Biochemistry |
Abbreviated Journal |
Biochemistry |
| Volume |
45 |
Issue |
16 |
Pages |
5111-5121 |
| Keywords |
Animals; Apoproteins/*chemistry/*metabolism; Binding Sites; Computer Simulation; Fluorescent Dyes/analysis; Horses; Hydrogen-Ion Concentration; Models, Molecular; Myoglobin/*chemistry/*metabolism; Oxazines/*analysis/chemistry; Protein Binding; Protein Folding; Protein Structure, Tertiary |
| Abstract |
The interaction of nile red (NR) with apomyoglobin (ApoMb) in the native (pH 7) and molten globule (pH 4) states was investigated using experimental and computational methods. NR binds to hydrophobic locations in ApoMb with higher affinity (K(d) = 25 +/- 5 microM) in the native state than in the molten globule state (K(d) = 52 +/- 5 microM). In the molten globule state, NR is located in a more hydrophobic environment. The dye does not bind to the holoprotein, suggesting that the binding site is located at the heme pocket. In addition to monitoring steady-state properties, the fluorescence emission of NR is capable of tracking submillisecond, time-resolved structural rearrangements of the protein, induced by a nanosecond pH jump. Molecular dynamics simulations were run on ApoMb at neutral pH and at pH 4. The structure obtained for the molten globule state is consistent with the experimentally available structural data. The docking of NR with the crystal structure shows that the ligand binds into the binding pocket of the heme group, with an orientation bringing the planar ring system of NR to overlap with the position of two of the heme porphyrin rings in Mb. The docking of NR with the ApoMb structure at pH 4 shows that the dye binds to the heme pocket with a slightly less favorable binding energy, in keeping with the experimental K(d) value. Under these conditions, NR is positioned in a different orientation, reaching a more hydrophobic environment in agreement with the spectroscopic data. |
| Address |
Dipartimento di Fisica, Universita degli Studi di Parma, Viale G. P. Usberti 7/A, 43100 Parma, Italy |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0006-2960 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:16618100 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3763 |
| Permanent link to this record |
| |
|
| |
| Author |
Broad, K.D.; Curley, J.P.; Keverne, E.B. |
| Title |
Mother-infant bonding and the evolution of mammalian social relationships |
Type |
Journal Article |
| Year |
2006 |
Publication |
Philosophical Transactions of the Royal Society B: Biological Sciences |
Abbreviated Journal |
Phil. Trans. Biol. Sci. |
| Volume |
361 |
Issue |
1476 |
Pages |
2199-2214 |
| Keywords |
Endorphin; Maternal behaviour; Olfactory memory; Opioids; Oxytocin; Pair bonding; Prefrontal cortex; Social learning |
| Abstract |
A wide variety of maternal, social and sexual bonding strategies have been described across mammalian species, including humans. Many of the neural and hormonal mechanisms that underpin the formation and maintenance of these bonds demonstrate a considerable degree of evolutionary conservation across a representative range of these species. However, there is also a considerable degree of diversity in both the way these mechanisms are activated and in the behavioural responses that result. In the majority of small-brained mammals (including rodents), the formation of a maternal or partner preference bond requires individual recognition by olfactory cues, activation of neural mechanisms concerned with social reward by these cues and gender-specific hormonal priming for behavioural output. With the evolutionary increase of neocortex seen in monkeys and apes, there has been a corresponding increase in the complexity of social relationships and bonding strategies together with a significant redundancy in hormonal priming for motivated behaviour. Olfactory recognition and olfactory inputs to areas of the brain concerned with social reward are downregulated and recognition is based on integration of multimodal sensory cues requiring an expanded neocortex, particularly the association cortex. This emancipation from olfactory and hormonal determinants of bonding has been succeeded by the increased importance of social learning that is necessitated by living in a complex social world and, especially in humans, a world that is dominated by cultural inheritance. © 2006 The Royal Society. |
| Address |
Sub-Department of Animal Behaviour, University of Cambridge, Madingley, Cambridge CB3 8AA, United Kingdom |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
|
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
|
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
Cited By (since 1996): 6; Export Date: 23 October 2008; Source: Scopus |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4558 |
| Permanent link to this record |
| |
|
| |
| Author |
Wallace, D.G.; Hamilton, D.A.; Whishaw, I.Q. |
| Title |
Movement characteristics support a role for dead reckoning in organizing exploratory behavior |
Type |
Journal Article |
| Year |
2006 |
Publication |
Animal Cognition |
Abbreviated Journal |
Anim. Cogn. |
| Volume |
9 |
Issue |
3 |
Pages |
219-228 |
| Keywords |
Animals; *Association Learning; *Exploratory Behavior; Female; *Motor Activity; *Orientation; Problem Solving; Rats; Rats, Long-Evans; Space Perception; *Spatial Behavior |
| Abstract |
Rat exploration is an organized series of trips. Each exploratory trip involves an outward tour from the refuge followed by a return to the refuge. A tour consists of a sequence of progressions with variable direction and speed concatenated by stops, whereas the return consists of a single direct progression. We have argued that processing self-movement information generated on the tour allows a rat to plot the return to the refuge. This claim has been supported by observing consistent differences between tour and return segments independent of ambient cue availability; however, this distinction was based on differences in movement characteristics derived from multiple progressions and stops on the tour and the single progression on the return. The present study examines movement characteristics of the tour and return progressions under novel-dark and light conditions. Three novel characteristics of progressions were identified: (1) linear speeds and path curvature of exploratory trips are negatively correlated, (2) tour progression maximum linear speed and temporal pacing varies as a function of travel distance, and (3) return progression movement characteristics are qualitatively different from tour progressions of comparable length. These observations support a role for dead reckoning in organizing exploratory behavior. |
| Address |
Psychology Department, Northern Illinois University, DeKalb, IL 60115-2892, USA. dwallace@niu.edu |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1435-9448 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:16767471 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2463 |
| Permanent link to this record |
| |
|
| |
| Author |
Chiesa, A.D.; Pecchia, T.; Tommasi, L.; Vallortigara, G. |
| Title |
Multiple landmarks, the encoding of environmental geometry and the spatial logics of a dual brain |
Type |
Journal Article |
| Year |
2006 |
Publication |
Animal Cognition |
Abbreviated Journal |
Anim. Cogn. |
| Volume |
9 |
Issue |
4 |
Pages |
281-293 |
| Keywords |
Animals; Association Learning/*physiology; Chickens; *Cues; Dominance, Cerebral/*physiology; *Environment; Exploratory Behavior/*physiology; Logic; Space Perception/*physiology; Spatial Behavior/physiology |
| Abstract |
A series of place learning experiments was carried out in young chicks (Gallus gallus) in order to investigate how the geometry of a landmark array and that of a walled enclosure compete when disoriented animals could rely on both of them to re-orient towards the centre of the enclosure. A square-shaped array (four wooden sticks) was placed in the middle of a square-shaped enclosure, the two structures being concentric. Chicks were trained to ground-scratch to search for food hidden in the centre of the enclosure (and the array). To check for effects of array degradation, one, two, three or all landmarks were removed during test trials. Chicks concentrated their searching activity in the central area of the enclosure, but their accuracy was inversely contingent on the number of landmarks removed; moreover, the landmarks still present within the enclosure appeared to influence the shape of the searching patterns. The reduction in the number of landmarks affected the searching strategy of chicks, suggesting that they had focussed mainly on local cues when landmarks were present within the enclosure. When all the landmarks were removed, chicks searched over a larger area, suggesting an absolute encoding of distances from the local cues and less reliance on the relationships provided by the geometry of the enclosure. Under conditions of monocular vision, chicks tended to rely on different strategies to localize the centre on the basis of the eye (and thus the hemisphere) in use, the left hemisphere attending to details of the environment and the right hemisphere attending to the global shape. |
| Address |
Department of Psychology and B.R.A.I.N. Centre for Neuroscience, University of Trieste, via S. Anastasio 12, 34100, Trieste, Italy |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1435-9448 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:16941155 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2443 |
| Permanent link to this record |
| |
|
| |
| Author |
Chase, I.D. |
| Title |
Music notation: a new method for visualizing social interaction in animals and humans |
Type |
Journal Article |
| Year |
2006 |
Publication |
Frontiers in zoology |
Abbreviated Journal |
Front Zool |
| Volume |
3 |
Issue |
|
Pages |
18 |
| Keywords |
|
| Abstract |
ABSTRACT: BACKGROUND: Researchers have developed a variety of techniques for the visual presentation of quantitative data. These techniques can help to reveal trends and regularities that would be difficult to see if the data were left in raw form. Such techniques can be of great help in exploratory data analysis, making apparent the organization of data sets, developing new hypotheses, and in selecting effects to be tested by statistical analysis. Researchers studying social interaction in groups of animals and humans, however, have few tools to present their raw data visually, and it can be especially difficult to perceive patterns in these data. In this paper I introduce a new graphical method for the visual display of interaction records in human and animal groups, and I illustrate this method using data taken on chickens forming dominance hierarchies. RESULTS: This new method presents data in a way that can help researchers immediately to see patterns and connections in long, detailed records of interaction. I show a variety of ways in which this new technique can be used: (1) to explore trends in the formation of both group social structures and individual relationships; (2) to compare interaction records across groups of real animals and between real animals and computer-simulated animal interactions; (3) to search for and discover new types of small-scale interaction sequences; and (4) to examine how interaction patterns in larger groups might emerge from those in component subgroups. In addition, I discuss how this method can be modified and extended for visualizing a variety of different kinds of social interaction in both humans and animals. CONCLUSION: This method can help researchers develop new insights into the structure and organization of social interaction. Such insights can make it easier for researchers to explain behavioural processes, to select aspects of data for statistical analysis, to design further studies, and to formulate appropriate mathematical models and computer simulations. |
| Address |
Department of Sociology, Stony Brook University, Stony Brook, NY 11794-4345, USA. ichase@notes.cc.sunysb.edu |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1742-9994 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:17112384 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
751 |
| Permanent link to this record |
| |
|
| |
| Author |
Teicher, M.H.; Tomoda, A.; Andersen, S.L. |
| Title |
Neurobiological Consequences of Early Stress and Childhood Maltreatment: Are Results from Human and Animal Studies Comparable? |
Type |
Journal Article |
| Year |
2006 |
Publication |
Annals of the New York Academy of Sciences |
Abbreviated Journal |
|
| Volume |
1071 |
Issue |
1 |
Pages |
313-323 |
| Keywords |
adolescence; maltreatment; hippocampus; corpus callosum; translational research; sensitive periods; stress; abuse or neglect |
| Abstract |
Abstract: Recent studies have reported an association between exposure to childhood abuse or neglect and alterations in brain structure or function. One limitation of these studies is that they are correlational and do not provide evidence of a cause–effect relationship. Preclinical studies on the effects of exposure to early life stress can demonstrate causality, and can enrich our understanding of the clinical research if we hypothesize that the consequences of early abuse are predominantly mediated through the induction of stress responses. Exposure to early abuse and early stress has each been associated with the emergence of epileptiform electroencephalogram (EEG) abnormalities, alterations in corpous callosum area, and reduced volume or synaptic density of the hippocampus.Further, there is evidence that different brain regions have unique periods when they are maximally sensitive to the effects of early stress. To date, preclinical studies have guided clinical investigations and will continue to provide important insight into studies on molecular mechanisms and gene–environment interactions. |
| Address |
|
| Corporate Author |
|
Thesis |
|
| Publisher |
Blackwell Publishing Inc |
Place of Publication |
|
Editor |
|
| Language |
|
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1749-6632 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
|
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
5784 |
| Permanent link to this record |
| |
|
| |
| Author |
Lim, M.M.; Young, L.J. |
| Title |
Neuropeptidergic regulation of affiliative behavior and social bonding in animals |
Type |
Journal Article |
| Year |
2006 |
Publication |
Hormones and Behavior |
Abbreviated Journal |
Hormon. Behav. |
| Volume |
50 |
Issue |
4 |
Pages |
506-517 |
| Keywords |
Vasopressin receptor; Oxytocin receptor; Social recognition; Social behavior; Pair bond; Autism; Neuropeptides |
| Abstract |
Social relationships are essential for maintaining human mental health, yet little is known about the brain mechanisms involved in the development and maintenance of social bonds. Animal models are powerful tools for investigating the neurobiological mechanisms regulating the cognitive processes leading to the development of social relationships and for potentially extending our understanding of the human condition. In this review, we discuss the roles of the neuropeptides oxytocin and vasopressin in the regulation of social bonding as well as related social behaviors which culminate in the formation of social relationships in animal models. The formation of social bonds is a hierarchical process involving social motivation and approach, the processing of social stimuli and formation of social memories, and the social attachment itself. Oxytocin and vasopressin have been implicated in each of these processes. Specifically, these peptides facilitate social affiliation and parental nurturing behavior, are essential for social recognition in rodents, and are involved in the formation of selective mother-infant bonds in sheep and pair bonds in monogamous voles. The convergence of evidence from these animal studies makes oxytocin and vasopressin attractive candidates for the neural modulation of human social relationships as well as potential therapeutic targets for the treatment of psychiatric disorders associated with disruptions in social behavior, including autism. |
| Address |
|
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
|
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0018-506x |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
|
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
6416 |
| Permanent link to this record |
| |
|
| |
| Author |
Maple; , M.L.W.; Meredith J. Bashaw; Kimberly Fountain; Sarah Kieschnick; Terry L. |
| Title |
Nocturnal behavior in a group of female African elephants |
Type |
Journal Article |
| Year |
2006 |
Publication |
Zoo Biology |
Abbreviated Journal |
|
| Volume |
25 |
Issue |
3 |
Pages |
173-186 |
| Keywords |
|
| Abstract |
The nocturnal behavior of a stable group of female, African elephants (Loxodonta africana africana) was studied to: (1) examine their behavior as a function of hour of night; (2) qualitatively compare the elephants' activity budgets to those reported in a previous study; and (3) document the presence of aggressive and stereotypic behaviors that might necessitate a change in their management. The elephants were systematically observed at least five times per week for 10 weeks between 17:00 and 08:00. Instantaneous focal samples of behavior, location, and proximity were taken every minute on a rotating basis, and all observed occurrences of social behavior were recorded. The hour of night affected elephant activity: significant relationships were found between hour of night and percent of time they spent feeding, lying, and standing. The overall activity budgets of the elephants were similar to the activity budgets reported in a previous study, although differences were evident in lying, stereotypic, and social behaviors. These differences might be a function of age. Affiliative behaviors accounted for 57% of the elephants' social behaviors, and agonistic behaviors among the elephants occurred infrequently and caused no injuries. Additionally, the elephants used all areas to which they had access. These findings provide compelling evidence that unrestricted social access during the night is the appropriate management strategy for these elephants. The results from the present study also highlight the importance of replicating existing studies and using multiple behavioral measures to make decisions regarding the welfare and management of stable groups of captive elephants. Zoo Biol 25:173-186, 2006. 2006 Wiley-Liss, Inc. |
| Address |
|
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
|
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1098-2361 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
|
Approved |
no |
| Call Number |
refbase @ user @ Maple;2006 |
Serial |
3551 |
| Permanent link to this record |
| |
|
| |
| Author |
Thomas, K.E.; Annest, J.L.; Gilchrist, J.; Bixby-Hammett, D.M. |
| Title |
Non-fatal horse related injuries treated in emergency departments in the United States, 2001-2003 |
Type |
|
| Year |
2006 |
Publication |
British Journal of Sports Medicine |
Abbreviated Journal |
Br J Sports Med |
| Volume |
40 |
Issue |
7 |
Pages |
619-626 |
| Keywords |
Accident Prevention/methods; Accidental Falls/prevention & control; Adolescent; Adult; Aged; Animals; Athletic Injuries/*epidemiology/prevention & control; Child; Child, Preschool; Emergency Service, Hospital/*statistics & numerical data; Female; Head Protective Devices/utilization; Health Promotion; *Horses; Humans; Infant; Male; Middle Aged; Patient Education; Sex Distribution; United States/epidemiology |
| Abstract |
OBJECTIVE: To characterise and provide nationally representative estimates of persons with non-fatal horse related injuries treated in American emergency departments. METHODS: The National Electronic Injury Surveillance System All Injury Program (NEISS-AIP) is a stratified probability sample comprising 66 hospitals. Data on injuries treated in these emergency departments are collected and reported. NEISS-AIP data on all types (horseback riding and otherwise) of non-fatal horse related injuries from 2001 to 2003 were analysed. RESULTS: An estimated 102,904 persons with non-fatal horse related injuries (35.7 per 100,000 population) were treated in American emergency departments each year from 2001 to 2003 inclusive. Non-fatal injury rates were higher for females (41.5 per 100,000) than for males (29.8 per 100,000). Most patients were injured while mounted on a horse (66.1%), commonly from falling or being thrown by the horse; while not mounted, injuries most often resulted from being kicked by the horse. The body parts most often injured were the head/neck region (23.2%), lower extremity (22.2%), and upper extremity (21.5%). The most common principal diagnoses were contusions/abrasions (31.4%) and fractures (25.2%). For each year that was studied, an estimated 11 502 people sustained traumatic brain injuries from horse related incidents. Overall, more than 11% of those injured were admitted to hospital. CONCLUSIONS: Horse related injuries are a public health concern not just for riders but for anyone in close contact with horses. Prevention programmes should target horseback riders and horse caregivers to promote helmet use and educate participants about horse behaviour, proper handling of horses, and safe riding practices. |
| Address |
Office of Statistics and Programming, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. KEThomas@cdc.gov |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1473-0480 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:16611723 |
Approved |
no |
| Call Number |
|
Serial |
1866 |
| Permanent link to this record |
| |
|
| |
| Author |
Schwab, C.; Huber, L. |
| Title |
Obey or not obey? Dogs (Canis familiaris) behave differently in response to attentional states of their owners |
Type |
Journal Article |
| Year |
2006 |
Publication |
Journal of Comparative Psychology (Washington, D.C. : 1983) |
Abbreviated Journal |
J Comp Psychol |
| Volume |
120 |
Issue |
3 |
Pages |
169-175 |
| Keywords |
Animals; *Attention; Awareness; *Bonding, Human-Pet; *Cooperative Behavior; Cues; Dogs/*psychology; Humans; Motivation; *Nonverbal Communication; Social Perception; *Speech Perception; *Verbal Behavior |
| Abstract |
Sixteen domestic dogs (Canis familiaris) were tested in a familiar context in a series of 1-min trials on how well they obeyed after being told by their owner to lie down. Food was used in 1/3 of all trials, and during the trial the owner engaged in 1 of 5 activities. The dogs behaved differently depending on the owner's attention to them. When being watched by the owner, the dogs stayed lying down most often and/or for the longest time compared with when the owner read a book, watched TV, turned his or her back on them, or left the room. These results indicate that the dogs sensed the attentional state of their owners by judging observable behavioral cues such as eye contact and eye, head, and body orientation. |
| Address |
Department for Behavior, Neurobiology and Cognition, University of Vienna, Vienna, Austria. cpriberskyschwab@yahoo.de |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
0735-7036 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:16893253 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4961 |
| Permanent link to this record |
