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Author Crosby, M.B.; Zhang, J.; Nowling, T.M.; Svenson, J.L.; Nicol, C.J.; Gonzalez, F.J.; Gilkeson, G.S. doi  openurl
  Title Inflammatory modulation of PPAR gamma expression and activity Type Journal Article
  Year 2006 Publication Clinical immunology Abbreviated Journal Clin Immunol  
  Volume 118 Issue 2-3 Pages 276-283  
  Keywords Age Factors; Animals; Cell Line, Transformed; Cells, Cultured; Female; Inflammation Mediators/*physiology; Kidney/metabolism; Mesangial Cells/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type II/biosynthesis/genetics; PPAR gamma/*biosynthesis/*genetics/metabolism; Up-Regulation/immunology  
  Abstract Nitric oxide (NO) production increases with age in the lupus-prone MRL/lpr mouse, paralleling disease activity. One mechanism for excess NO production in MRL/lpr mice may be a defect in down-regulatory mechanisms of the iNOS pathway. A potential modulator of NO is the nuclear hormone receptor peroxisome proliferation activated receptor gamma (PPARgamma). We demonstrate that renal PPARgamma protein expression was altered as disease progressed in MRL/lpr mice, which paralleled increased iNOS protein expression. Additionally, MRL/lpr-derived primary mesangial cells expressed less PPARgamma than BALB/c mesangial cells and produced more NO in response to LPS and IFNgamma. Furthermore, PPARgamma activity was reduced in mesangial cells following exposure to inflammatory mediators. This activity was restored with the addition of a NOS enzyme inhibitor. These results indicate that the activation of inflammatory pathways may lead to reduced activity and expression of PPARgamma, further exacerbating the disease state.  
  Address Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1521-6616 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16303334 Approved no  
  Call Number refbase @ user @ Serial 67  
Permanent link to this record
 

 
Author Crosby, M.B.; Svenson, J.L.; Zhang, J.; Nicol, C.J.; Gonzalez, F.J.; Gilkeson, G.S. doi  openurl
  Title Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide Type Journal Article
  Year 2005 Publication The Journal of pharmacology and experimental therapeutics Abbreviated Journal J Pharmacol Exp Ther  
  Volume 312 Issue 1 Pages 69-76  
  Keywords Animals; Cell Line; Gene Expression/drug effects; Macrophages/drug effects/metabolism; Mice; Mice, Inbred C57BL; Nitric Oxide/*metabolism; Nitric Oxide Synthase/*metabolism; Nitric Oxide Synthase Type II; PPAR delta/metabolism; PPAR gamma/*agonists/deficiency; Thiazolidinediones/pharmacology  
  Abstract Peroxisome proliferation-activated receptor (PPAR)gamma agonists inhibit inducible nitric-oxide synthase (iNOS), tumor necrosis factor-alpha, and interleukin-6. Because of these effects, synthetic PPARgamma agonists, including thiazolidinediones, are being studied for their impact on inflammatory disease. The anti-inflammatory concentrations of synthetic PPARgamma agonists range from 10 to 50 microM, whereas their binding affinity for PPARgamma is in the nanomolar range. The specificity of synthetic PPARgamma agonists for PPARgamma at the concentrations necessary for anti-inflammatory effects is thus in question. We report that PPARgamma is not necessary for the inhibition of iNOS by synthetic PPARgamma agonists. RAW 264.7 macrophages possess little PPARgamma, yet lipopolysaccharide (LPS)/interferon (IFN)gamma-induced iNOS was inhibited by synthetic PPARgamma agonists at 20 microM. Endogenous PPARgamma was inhibited by the transfection of a dominant-negative PPARgamma construct into murine mesangial cells. In the transfected cells, synthetic PPARgamma agonists inhibited iNOS production at 10 microM, similar to nontransfected cells. Using cells from PPARgamma Cre/lox conditional knockout mice, baseline and LPS/IFNgamma-induced nitric oxide levels were higher in macrophages lacking PPARgamma versus controls. However, synthetic PPARgamma agonists inhibited iNOS at 10 microM in the PPARgamma-deficient cells, similar to macrophages from wild-type mice. These results indicate that PPARgamma is not necessary for inhibition of iNOS expression by synthetic PPARgamma agonists at concentrations over 10 microM. Intrinsic PPARgamma function, in the absence of synthetic agonists, however, may play a role in inflammatory modulation.  
  Address Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-3565 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15356214 Approved no  
  Call Number refbase @ user @ Serial 73  
Permanent link to this record
 

 
Author Saayman, G.S. openurl 
  Title Behaviour of the adult males in a troop of free-ranging Chacma baboons (Papio ursinus) Type Journal Article
  Year 1971 Publication Folia Primatologica; International Journal of Primatology Abbreviated Journal Folia Primatol (Basel)  
  Volume 15 Issue 1 Pages 36-57  
  Keywords Aggression; Animals; *Behavior, Animal; Female; Grooming; *Haplorhini; Homing Behavior; Humans; Leadership; Male; Papio; Pregnancy; Sex Factors; *Sexual Behavior, Animal; Social Dominance  
  Abstract  
  Address  
  Corporate Author Thesis (up)  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0015-5713 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:5003339 Approved no  
  Call Number Serial 2053  
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Author Sabattini, M.S.; Monath, T.P.; Mitchell, C.J.; Daffner, J.F.; Bowen, G.S.; Pauli, R.; Contigiani, M.S. openurl 
  Title Arbovirus investigations in Argentina, 1977-1980. I. Historical aspects and description of study sites Type Journal Article
  Year 1985 Publication The American Journal of Tropical Medicine and Hygiene Abbreviated Journal Am J Trop Med Hyg  
  Volume 34 Issue 5 Pages 937-944  
  Keywords Animals; Arbovirus Infections/*epidemiology/microbiology; Arboviruses; Argentina; Birds; Cattle; Child; Climate; Ecology; Encephalitis Virus, St. Louis; Encephalitis Virus, Venezuelan Equine; Encephalitis Virus, Western Equine; Encephalitis, St. Louis/epidemiology/microbiology; Encephalomyelitis, Equine/epidemiology/microbiology/veterinary; Encephalomyelitis, Venezuelan Equine/epidemiology/microbiology/veterinary; Geography; Horse Diseases/epidemiology/microbiology; Horses/microbiology; Humans  
  Abstract This is the introductory paper to a series on the ecology of arboviruses in Argentina. Epizootics of equine encephalitis have occurred since at least 1908, principally in the Pampa and Espinal biogeographic zones, with significant economic losses; human cases of encephalitis have been rare or absent. Both western equine and eastern equine encephalitis viruses have been isolated from horses during these epizootics, but the mosquitoes responsible for transmission have not been identified. A number of isolations of Venezuelan equine encephalitis (VEE) virus were reported between 1936 and 1958 in Argentina, but the validity of these findings has been seriously questioned. Nevertheless, serological evidence exists for human infections with a member of the VEE virus complex. Serological surveys conducted in the 1960s indicate a high prevalence of infection of humans and domestic animals with St. Louis encephalitis (SLE), and 2 SLE virus strains have been isolated from rodents. Human disease, however, has rarely been associated with SLE infection. Only 7 isolations of other arboviruses have been described (3 of Maguari, 1 of Aura, 2 of Una, and 1 of an untyped Bunyamwera group virus). In 1977, we began longitudinal field studies in Santa Fe Province, the epicenter of previous equine epizootics, and in 1980 we extended these studies to Chaco and Corrientes provinces. The study sites are described in this paper.  
  Address  
  Corporate Author Thesis (up)  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9637 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:4037184 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2685  
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Author Manning, G.S.; Ratanarat, C. openurl 
  Title Fasciolopsis buski (Lankester, 1857) in Thailand Type Journal Article
  Year 1970 Publication The American Journal of Tropical Medicine and Hygiene Abbreviated Journal Am J Trop Med Hyg  
  Volume 19 Issue 4 Pages 613-619  
  Keywords Adolescent; Adult; Aged; Animals; Buffaloes; Cattle; Child; Child, Preschool; *Disease Reservoirs; Dogs; Ecology; *Fasciolidae; Feces; Female; Health Surveys; Horses; Humans; Infant; Infant, Newborn; Male; Middle Aged; *Plants, Edible; Sex Factors; *Snails; Swine; Thailand; Trematode Infections/*epidemiology  
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  Corporate Author Thesis (up)  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-9637 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:5425498 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2734  
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Author Nelson, G.S. openurl 
  Title Onchocerciasis Type Journal Article
  Year 1970 Publication Advances in Parasitology Abbreviated Journal Adv Parasitol  
  Volume 8 Issue Pages 173-224  
  Keywords Africa; Animals; Anthelmintics/therapeutic use; Artiodactyla; Blindness/etiology; Cattle; Circadian Rhythm; Ddt; Diethylcarbamazine/therapeutic use; Diptera/anatomy & histology/growth & development; Dwarfism/etiology; Ecology; Eye/pathology; Feeding Behavior; Female; Geography; Haplorhini; Hernia, Femoral/etiology; Horses; Humans; Insect Vectors/growth & development; Larva/growth & development; Male; Onchocerca/classification/growth & development; *Onchocerciasis/diagnosis/drug therapy/epidemiology/immunology/pathology/prevention & control/veterinary; Primates; Serologic Tests; Skin/pathology; Skin Tests; Suramin/therapeutic use  
  Abstract  
  Address  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0065-308X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:4997515 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2738  
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Author Honeyman, M.S.; Miller, G.S. url  openurl
  Title The effect of teaching approaches on achievement and satisfaction of field-dependent and field-independent learners in animal science Type Journal Article
  Year 1998 Publication Journal of Animal Science Abbreviated Journal J. Anim Sci.  
  Volume 76 Issue 6 Pages 1710-1715  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 2941  
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Author Halford; G.S.; Halford, J.M . doi  openurl
  Title Secondary reinforcement: signal or substitute reward? A preliminary investigation Type Journal Article
  Year 1969 Publication Abbreviated Journal Aus. J. Psychol  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 3588  
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Author Wolf, M.; van Doorn, G.S.; Leimar, O.; Weissing, F.J. doi  openurl
  Title Life-history trade-offs favour the evolution of animal personalities Type Journal Article
  Year 2007 Publication Nature Abbreviated Journal Nature  
  Volume 447 Issue 7144 Pages 581-584  
  Keywords Aggression/physiology/psychology; Animals; Behavior, Animal/*physiology; *Evolution; Exploratory Behavior/physiology; Models, Biological; Personality/*physiology; Predatory Behavior/physiology; Reproduction/physiology; Risk-Taking; Selection (Genetics)  
  Abstract In recent years evidence has been accumulating that personalities are not only found in humans but also in a wide range of other animal species. Individuals differ consistently in their behavioural tendencies and the behaviour in one context is correlated with the behaviour in multiple other contexts. From an adaptive perspective, the evolution of animal personalities is still a mystery, because a more flexible structure of behaviour should provide a selective advantage. Accordingly, many researchers view personalities as resulting from constraints imposed by the architecture of behaviour (but see ref. 12). In contrast, we show here that animal personalities can be given an adaptive explanation. Our argument is based on the insight that the trade-off between current and future reproduction often results in polymorphic populations in which some individuals put more emphasis on future fitness returns than others. Life-history theory predicts that such differences in fitness expectations should result in systematic differences in risk-taking behaviour. Individuals with high future expectations (who have much to lose) should be more risk-averse than individuals with low expectations. This applies to all kinds of risky situations, so individuals should consistently differ in their behaviour. By means of an evolutionary model we demonstrate that this basic principle results in the evolution of animal personalities. It simultaneously explains the coexistence of behavioural types, the consistency of behaviour through time and the structure of behavioural correlations across contexts. Moreover, it explains the common finding that explorative behaviour and risk-related traits like boldness and aggressiveness are common characteristics of animal personalities.  
  Address Theoretical Biology Group, Centre for Ecological and Evolutionary Studies, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands  
  Corporate Author Thesis (up)  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1476-4687 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17538618 Approved no  
  Call Number Equine Behaviour @ team @ Serial 4098  
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Author Wolf, M.; van Doorn, G.S.; Leimar, O.; Weissing, F.J. doi  openurl
  Title Wolf et al. reply Type Journal Article
  Year 2007 Publication Abbreviated Journal Nature  
  Volume 450 Issue 7167 Pages E5-E6  
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  Series Volume Series Issue Edition  
  ISSN 0028-0836 ISBN Medium  
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  Notes 10.1038/nature06327 Approved no  
  Call Number Equine Behaviour @ team @ Serial 4297  
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