Records |
Author |
Hostikka, S.L.; Eddy, R.L.; Byers, M.G.; Hoyhtya, M.; Shows, T.B.; Tryggvason, K. |
Title |
Identification of a distinct type IV collagen alpha chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome |
Type |
Journal Article |
Year |
1990 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
Volume |
87 |
Issue |
4 |
Pages |
1606-1610 |
Keywords |
Amino Acid Sequence; Base Sequence; Chromosome Mapping; Cloning, Molecular; Collagen/*genetics; Epitopes/analysis; Female; Fluorescent Antibody Technique; Gene Library; *Genes; Humans; Immunoblotting; Kidney/cytology/*metabolism; Macromolecular Substances; Molecular Sequence Data; Nephritis, Hereditary/*genetics; Oligopeptides/chemical synthesis/immunology; Placenta/metabolism; Pregnancy; Restriction Mapping; Sequence Homology, Nucleic Acid; *X Chromosome |
Abstract |
We have identified and extensively characterized a type IV collagen alpha chain, referred to as alpha 5(IV). Four overlapping cDNA clones isolated contain an open reading frame for 543 amino acid residues of the carboxyl-terminal end of a collagenous domain, a 229-residue carboxyl-terminal noncollagenous domain, and 1201 base pairs coding for a 3' untranslated region. The collagenous Gly-Xaa-Yaa repeat sequence has five imperfections that coincide with those in the corresponding region of the alpha 1(IV) chain. The noncollagenous domain has 12 conserved cysteine residues and 83% and 63% sequence identity with the noncollagenous domains of the alpha 1(IV) and alpha 2(IV) chains, respectively. The alpha 5(IV) chain has less sequence identity with the putative bovine alpha 3(IV) and alpha 4(IV) chains. Antiserum against an alpha 5(IV) synthetic peptide stained a polypeptide chain of about 185 kDa by immunoblot analysis and immunolocalization of the chain in human kidney was almost completely restricted to the glomerulus. The gene was assigned to the Xq22 locus by somatic cell hybrids and in situ hybridization. This may be identical or close to the locus of the X chromosome-linked Alport syndrome that is believed to be a type IV collagen disease. |
Address |
Biocenter, University of Oulu, Finland |
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English |
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ISSN |
0027-8424 |
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PMID:1689491 |
Approved |
no |
Call Number |
Equine Behaviour @ team @ |
Serial |
5291 |
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Author |
Thompson, J.A.; Brown, S.E. 2nd; Riddle, W.T.; Seahorn, J.C.; Cohen, N.D. |
Title |
Use of a Bayesian risk-mapping technique to estimate spatial risks for mare reproductive loss syndrome in Kentucky |
Type |
Journal Article |
Year |
2005 |
Publication |
American Journal of Veterinary Research |
Abbreviated Journal |
Am J Vet Res |
Volume |
66 |
Issue |
1 |
Pages |
17-20 |
Keywords |
Abortion, Veterinary/*epidemiology; Animals; Bayes Theorem; Female; Geography; Horse Diseases/*epidemiology; Horses; Kentucky/epidemiology; Models, Statistical; Pregnancy; Risk Factors |
Abstract |
OBJECTIVE: To estimate spatial risks associated with mare reproductive loss syndrome (MRLS) during 2001 among horses in a specific study population and partition the herd effects into those attributable to herd location and those that were spatially random and likely attributable to herd management. Animals-Pregnant broodmares from 62 farms in 7 counties in central Kentucky. PROCEDURE: Veterinarians provided the 2001 abortion incidence proportions for each farm included in the study. Farms were georeferenced and data were analyzed by use of a fully Bayesian risk-mapping technique. RESULTS: Large farm-to-farm variation in MRLS incidence proportions was identified. The farm-to-farm variation was largely attributed to spatial location rather than to spatially random herd effects. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicate that there are considerable data to support an ecologic cause and potential ecologic risk factors for MRLS. Veterinary practitioners with more detailed knowledge of the ecology in the 7 counties in Kentucky that were investigated may provide additional data that would assist in the deduction of the causal factor of MRLS via informal geographic information systems analyses and suggest factors for inclusion in further investigations. |
Address |
Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4475, USA. USA |
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English |
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ISSN |
0002-9645 |
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PMID:15691030 |
Approved |
no |
Call Number |
Equine Behaviour @ team @ |
Serial |
2630 |
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Author |
Zhang, T.-Y.; Parent, C.; Weaver, I.; Meaney, M.J. |
Title |
Maternal programming of individual differences in defensive responses in the rat |
Type |
Journal Article |
Year |
2004 |
Publication |
Annals of the New York Academy of Sciences |
Abbreviated Journal |
Ann N Y Acad Sci |
Volume |
1032 |
Issue |
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Pages |
85-103 |
Keywords |
Adaptation, Biological; Aggression/*physiology; Animals; Evolution; Female; Gene Expression/physiology; Humans; Individuality; *Maternal Behavior; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Stress, Psychological/physiopathology |
Abstract |
This paper describes the results of a series of studies showing that variations in mother-pup interactions program the development of individual differences in behavioral and endocrine stress responses in the rat. These effects are associated with altered expression of genes in brain regions, such as the amygdala, hippocampus, and hypothalamus, that regulate the expression of stress responses. Studies from evolutionary biology suggest that such “maternal effects” are common and often associated with variations in the quality of the maternal environment. Together these findings suggest an epigenetic process whereby the experience of the mother alters the nature of the parent-offspring interactions and thus the phenotype of the offspring. |
Address |
McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 boul. LaSalle, Montreal (Quebec), Canada H4H 1R3 |
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English |
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ISSN |
0077-8923 |
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PMID:15677397 |
Approved |
no |
Call Number |
Equine Behaviour @ team @ |
Serial |
4132 |
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Author |
Brennan, P.A. |
Title |
The nose knows who's who: chemosensory individuality and mate recognition in mice |
Type |
Journal Article |
Year |
2004 |
Publication |
Hormones and Behavior |
Abbreviated Journal |
Horm Behav |
Volume |
46 |
Issue |
3 |
Pages |
231-240 |
Keywords |
Animals; Chemoreceptors/physiology; Discrimination Learning/*physiology; Embryo Implantation/physiology; Female; Individuality; Major Histocompatibility Complex/physiology; Male; Mice; Neurons, Afferent/physiology; Nose/cytology/physiology; Perception/physiology; Pregnancy; Pregnancy Maintenance/physiology; Pregnancy, Animal/*physiology; Receptors, Odorant/*physiology; Recognition (Psychology)/*physiology; Sexual Behavior, Animal/*physiology; Smell/*physiology; Urine/physiology; Vomeronasal Organ/cytology/physiology |
Abstract |
Individual recognition is an important component of behaviors, such as mate choice and maternal bonding that are vital for reproductive success. This article highlights recent developments in our understanding of the chemosensory cues and the neural pathways involved in individuality discrimination in rodents. There appear to be several types of chemosensory signal of individuality that are influenced by the highly polymorphic families of major histocompatibility complex (MHC) proteins or major urinary proteins (MUPs). Both have the capability of binding small molecules and may influence the individual profile of these chemosignals in biological fluids such as urine, skin secretions, or saliva. Moreover, these proteins, or peptides associated with them, can be taken up into the vomeronasal organ (VNO) where they can potentially interact directly with the vomeronasal receptors. This is particularly interesting given the expression of major histocompatibility complex Ib proteins by the V2R class of vomeronasal receptor and the highly selective responses of accessory olfactory bulb (AOB) mitral cells to strain identity. These findings are consistent with the role of the vomeronasal system in mediating individual discrimination that allows mate recognition in the context of the pregnancy block effect. This is hypothesized to involve a selective increase in the inhibitory control of mitral cells in the accessory olfactory bulb at the first level of processing of the vomeronasal stimulus. |
Address |
Sub-Department of Animal Behaviour, University of Cambridge, Madingley, Cambridge CB3 8AA, UK. pab23@cus.cam.ac.uk |
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Edition |
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ISSN |
0018-506X |
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PMID:15325224 |
Approved |
no |
Call Number |
Equine Behaviour @ team @ |
Serial |
4191 |
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Author |
Kirkpatrick, J.F.; Turner, A. |
Title |
Absence of effects from immunocontraception on seasonal birth patterns and foal survival among barrier island wild horses |
Type |
Journal Article |
Year |
2003 |
Publication |
Journal of applied animal welfare science : JAAWS |
Abbreviated Journal |
J Appl Anim Welf Sci |
Volume |
6 |
Issue |
4 |
Pages |
301-308 |
Keywords |
Animals; Animals, Newborn; Animals, Wild/*physiology; Birth Rate; Case-Control Studies; Contraception, Immunologic/methods/*veterinary; Egg Proteins/administration & dosage; Female; Horses/*physiology; Maryland/epidemiology; Membrane Glycoproteins/administration & dosage; Population Control; Pregnancy; *Receptors, Cell Surface; *Reproduction; Seasons; Vaccines, Contraceptive/administration & dosage |
Abstract |
Despite a large body of safety data, concern exists that porcine zonae pellucidae (PZP) immunocontraception--used to manage wild horse populations--may cause out-of-season births with resulting foal mortality. Our study at Assateague, Maryland indicated the effects of immunocontraception on season of birth and foal survival between 1990 and 2002 on wild horses from Assateague Island. Among 91 mares never treated, 69 (75.8%) of foals were born in April, May, and June (in season). Among 77 treated mares, 50 (64.9%) were born in season. Of 29 mares foaling within 1 year after treatment (contraceptive failures), 20 (68.9%) were born in season. Of 48 mares treated for greater than 2 years then withdrawn from treatment, 30 (62.5%) of 48 foals were born in season. There were no significant differences (p <.05) between either treatment group or untreated mares. Survival did not differ significantly among foals born in or out of season or among foals born to treated or untreated mares. Data indicate a lack of effect of PZP contraception on season of birth or foal survival on barrier island habitats. |
Address |
Science and Conservation Center Zoo Montana, Billings, Montana 59106, USA. jkirkpatrick@montana.net |
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English |
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ISSN |
1088-8705 |
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PMID:14965784 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
140 |
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Author |
Kirkpatrick, J.F.; Turner, A. |
Title |
Reversibility of action and safety during pregnancy of immunization against porcine zona pellucida in wild mares (Equus caballus) |
Type |
Journal Article |
Year |
2002 |
Publication |
Reproduction (Cambridge, England) Supplement |
Abbreviated Journal |
Reprod Suppl |
Volume |
60 |
Issue |
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Pages |
197-202 |
Keywords |
Animals; *Animals, Wild; Antigens/administration & dosage; Contraception, Immunologic/methods/*veterinary; Egg Proteins/administration & dosage; Female; Fertility; *Horses; Immunization, Secondary/veterinary; Membrane Glycoproteins/administration & dosage; Population Control; Pregnancy; *Receptors, Cell Surface; Safety; Swine; Time Factors; Vaccines, Contraceptive/*administration & dosage |
Abstract |
Contraceptive management of publicly valued wildlife species requires safeguards to ensure that these populations are preserved in a healthy state. In addition, reversibility of contraceptive effects and safety in pregnant animals are major concerns. A population of wild horses has been immunized against porcine zona pellucida (PZP) over a 12 year period on Assateague Island National Seashore, MD (ASIS). Mares initially received one or two 65 microg inoculations and once a year 65 microg booster inoculations, all delivered by dart. All young mares aged > 2 years were treated with PZP for 3 consecutive years regardless of whether they have bred successfully and they were then removed from treatment until they had foaled. All mares vaccinated for 1 or 2 consecutive years became fertile again and 69% of mares treated for 3 consecutive years returned to fertility. All five mares treated for 4 or 5 consecutive years have also returned to fertility, but over longer periods of time. Mares treated for 7 consecutive years have not returned to fertility, but several, while still infertile, have started ovulating again. There was no difference in survival rates between foals born to treated and untreated mares, and PZP treatment of pregnant mares did not affect subsequent fertility of their female offspring. |
Address |
Science and Conservation Center, ZooMontana, Billings 59106, USA. zoolab@wtp.net |
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ISSN |
1477-0415 |
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PMID:12220160 |
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no |
Call Number |
refbase @ user @ |
Serial |
141 |
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Author |
Virga, V.; Houpt, K.A. |
Title |
Prevalence of placentophagia in horses |
Type |
Journal Article |
Year |
2001 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
Volume |
33 |
Issue |
2 |
Pages |
208-210 |
Keywords |
Animals; *Behavior, Animal; Colic/epidemiology/*veterinary; Exploratory Behavior; *Feeding Behavior; Female; Horse Diseases/*epidemiology; Horses; Incidence; New York/epidemiology; *Placenta; Postpartum Period; Pregnancy; Prevalence; Questionnaires |
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Address |
Animal Behavior Clinic, Cornell University Hospital for Animals, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA |
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0425-1644 |
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PMID:11266073 |
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no |
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refbase @ user @ |
Serial |
31 |
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Author |
Houpt, K.A.; Eggleston, A.; Kunkle, K.; Houpt, T.R. |
Title |
Effect of water restriction on equine behaviour and physiology |
Type |
Journal Article |
Year |
2000 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
Volume |
32 |
Issue |
4 |
Pages |
341-344 |
Keywords |
Animals; *Behavior, Animal; Blood Proteins/analysis; Energy Intake; Female; Horse Diseases/physiopathology; Horses/*physiology; Osmolar Concentration; Pregnancy; Stress/veterinary; Video Recording; Water Deprivation/*physiology |
Abstract |
Six pregnant mares were used to determine what level of water restriction causes physiological and/or behavioural changes indicative of stress. Nonlegume hay was fed ad libitum. During the first week of restriction, 5 l water/100 kg bwt was available, during the second week 4 l/100 kg bwt and, during the third week, 3 l/100 kg bwt. Ad libitum water intake was 6.9 l/100 kg bwt; at 3 l/100 kg bwt water intake was 42% of this. Daily hay intake fell significantly with increasing water restriction from 12.9 +/- 0.75 kg to 8.3 +/- 0.54 kg; bodyweight fell significantly for a total loss of 48.5 +/- 8.3 kg in 3 weeks. Daily blood samples were analysed; osmolality rose significantly with increasing water restriction from 282 +/- 0.7 mosmols/kg to 293.3 +/- 0.8 mosmols/kg bwt, but plasma protein and PCV did not change significantly. Cortisol concentrations fell from 8.1 ng/ml to 6.4 ng/ml over the 3 week period. Aldosterone fell from 211.3 +/- 74.2 pg/ml to 92.5 +/- 27.5 pg/ml at the end of the first week. The behaviour of 4 of the 6 mares was recorded 24 h/day for the duration of the study. The only significant difference was in time spent eating, which decreased with increasing water restriction from 46 +/- 3% to 30 +/- 3%. It is concluded that water restriction to 4 l/100 kg bwt dehydrates pregnant mares and may diminish their welfare, but is not life- or pregnancy-threatening. |
Address |
Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA |
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0425-1644 |
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PMID:10952384 |
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no |
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refbase @ user @ |
Serial |
32 |
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Author |
Belonje, P.C.; van Niekerk, C.H. |
Title |
A review of the influence of nutrition upon the oestrous cycle and early pregnancy in the mare |
Type |
Journal Article |
Year |
1975 |
Publication |
Journal of Reproduction and Fertility. Supplement |
Abbreviated Journal |
J Reprod Fertil Suppl |
Volume |
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Issue |
23 |
Pages |
167-169 |
Keywords |
Animals; Body Weight; *Diet; *Estrus; Female; Fertility; Fetal Resorption/prevention & control; Horses/*physiology; Pregnancy |
Abstract |
Attention is drawn to the beneficial effect of improved nutrition during winter and early spring on the ovarian activity of mares. Furthermore, the necessity of an adequate plane of nutrition during early pregnancy to prevent embryonic resorption is stressed. |
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ISSN |
0449-3087 |
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PMID:1060772 |
Approved |
no |
Call Number |
Equine Behaviour @ team @ |
Serial |
2225 |
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Author |
McDonnell, S.M.; Freeman, D.A.; Cymbaluk, N.F.; Schott, H.C. 2nd; Hinchcliff, K.; Kyle, B. |
Title |
Behavior of stabled horses provided continuous or intermittent access to drinking water |
Type |
Journal Article |
Year |
1999 |
Publication |
American Journal of Veterinary Research |
Abbreviated Journal |
Am J Vet Res |
Volume |
60 |
Issue |
11 |
Pages |
1451-1456 |
Keywords |
Aggression; Animal Husbandry; Animals; Behavior, Animal/*physiology; Drinking Behavior; Feeding Behavior; Female; Horses/*physiology/*psychology; Housing, Animal; Pregnancy; Pregnancy, Animal/physiology/*psychology; Social Behavior; Videotape Recording; *Water Supply |
Abstract |
OBJECTIVE: To compare quantitative measures and clinical assessments of behavior as an indication of psychologic well-being of stabled horses provided drinking water continuously or via 1 of 3 intermittent delivery systems. ANIMALS: 22 Quarter Horse (QH) or QH-crossbred mares and 17 Belgian or Belgian-crossbred mares (study 1) and 24 QH or QH-crossbred mares and 18 Belgian or Belgian-crossbred mares (study 2). PROCEDURE: Stabled horses were provided water continuously or via 1 of 3 intermittent water delivery systems in 2 study periods during a 2-year period. Continuous 24-hour videotaped samples were used to compare quantitative measures and clinical assessments of behavior among groups provided water by the various water delivery systems. RESULTS: All horses had clinically normal behavior. Significant differences in well being were not detected among groups provided water by the various delivery systems. CONCLUSIONS AND CLINICAL RELEVANCE: Various continuous and intermittent water delivery systems can provide adequately for the psychologic well-being of stabled horses. |
Address |
New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348, USA |
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0002-9645 |
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PMID:10566826 |
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no |
Call Number |
refbase @ user @ |
Serial |
1928 |
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