| Records |
| Author |
Sluyter F.; Arseneault L.; Moffitt T.E.; Veenema A.H.; de Boer S.; Koolhaas J.M. |
| Title |
Toward an Animal Model for Antisocial Behavior: Parallels Between Mice and Humans: Aggression |
Type |
Journal Article |
| Year |
2003 |
Publication |
Behavior Genetics |
Abbreviated Journal |
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| Volume |
33 |
Issue |
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Pages |
563-574 |
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refbase @ user @ |
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3497 |
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| Author |
Robitaille, J.; Brouillette, C.; Lemieux, S.; Perusse, L.; Gaudet, D.; Vohl, M.C. |
| Title |
Plasma concentrations of apolipoprotein B are modulated by a gene-diet interaction effect between the LFABP T94A polymorphism and dietary fat intake in French-Canadian men |
Type |
Journal Article |
| Year |
2004 |
Publication |
Molecular Genetics and Metabolism |
Abbreviated Journal |
Mol Genet Metabol |
| Volume |
82 |
Issue |
4 |
Pages |
296-303 |
| Keywords |
Apolipoprotein B; Gene-diet interaction; Liver fatty acid-binding protein; Metabolic syndrome |
| Abstract |
Hyperapobetalipoproteinemia is a common feature of the metabolic syndrome and could result from the interaction between genetic and dietary factors. The objective of this study was to verify whether dietary fat intake interacts with the T94A polymorphism of the liver fatty acid-binding protein (LFABP) gene to modulate plasma apolipoprotein (apo) B levels. Dietary fat and saturated fat intakes were obtained by a dietitian-administered food frequency questionnaire and the LFABP T94A genotype was determined by a PCR-RFLP based method in 623 French-Canadian men recruited through the Chicoutimi Lipid Clinic (279 T94/T94, 285 T94/A94, and 59 A94/A94). The LFABP T94A polymorphism was not associated with plasma apo B levels when fat intake was not taken into consideration. However, in a model including the polymorphism, fat intake expressed as a percentage of total energy intake, the interaction term and covariates, the variance in apo B concentrations was partly explained by the LFABP T94A polymorphism (5.24%, p=0.01) and by the LFABP T94A * fat interaction (6.25%, p=0.005). Results were similar when saturated fat replaced fat intake in the model (4.49%, p=0.02 for LFABP T94A and 6.43%, p=0.004 for the interaction). Moreover, in men consuming more than 30% of energy from fat, the odds ratio for having plasma apo B levels above 1.04 g/L for A94 carriers was of 0.40 (p=0.02) compared to T94/T94 homozygotes. Results were similar for carriers of the A94 allele consuming more than 10% of energy from saturated fat (OR: 0.32, p=0.005). In conclusion, T94/T94 exhibit higher apo B levels whereas carriers of the A94 allele seem to be protected against high apo B levels when consuming a high fat and saturated fat diet. These findings reinforce the importance to take into account gene-diet interactions in the prevention and management of the metabolic syndrome. |
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refbase @ user @ |
Serial |
799 |
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| Author |
Kruger, K.; Gaillard, C.; Stranzinger, G.; Rieder, S. |
| Title |
Phylogenetic analysis and species allocation of individual equids using microsatellite data |
Type |
Journal Article |
| Year |
2005 |
Publication |
Journal of Animal Breeding and Genetics |
Abbreviated Journal |
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| Volume |
122 |
Issue |
s1 |
Pages |
78-86 |
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| Abstract |
Summary The taxonomic status of all equid species is not completely unravelled. This is of practical relevance for conservation initiatives of endangered, fragmented equid populations, such as the Asiatic wild asses (in particular Equus hemionus onager and E. hemionus kulan). In this study, a marker panel consisting of 31 microsatellite loci was used to assess species demarcation and phylogeny, as well as allocation of individuals (n = 120) to specific populations of origin (n = 11). Phylogenetic analysis revealed coalescence times comparable with those previously published from fossil records and mtDNA data. Using Bayesian approaches, it was possible to distinguish between the studied equids, although individual assignment levels varied. The observed results support the maintenance of separate captive conservation herds for E. hemionus onager and E. hemionus kulan. The first molecular genetic results for E. hemionus luteus remained contradictory, as they unexpectedly indicated a closer genetic relationship between E. hemionus luteus and E. kiang holderi compared with the other hemiones. |
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no |
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Equine Behaviour @ team @ |
Serial |
2334 |
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| Author |
Poletaeva, I.I.; Popova, N.V.; Romanova, L.G. |
| Title |
Genetic aspects of animal reasoning |
Type |
Journal Article |
| Year |
1993 |
Publication |
Behavior Genetics |
Abbreviated Journal |
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| Volume |
23 |
Issue |
5 |
Pages |
467-475 |
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This paper reviews the investigations of Prof. L. V. Krushinsky and his colleagues into the genetics of complex behaviors in mammals. The ability of animals to extrapolate the direction of a food stimulus movement was investigated in wild and domesticated foxes (including different fur-color mutants), wild brown rats, and laboratory rats and mice. Wild animals (raised in the laboratory) were shown to be superior to their respective domesticated forms on performance of the extrapolation task, especially in their scores for the first presentation, in which no previous experience could be used. Laboratory rats and mice demonstrated a low level of extrapolation performance. This means that only a few laboratory animals were capable of solving the task, i.e., the percentage of correct solutions was equivalent to chance. The brain weight selection program resulted in two mice strains with a 20% (90-mg) difference in brain weight. Ability to solve the extrapolation task was present in low-brain weight mice in generations 7-11 but declined with further selection. Investigation of extrapolation ability in mice with different chromosomal anomalies demonstrated that animals with Robertsonian translocations Rb(8,17) 1lem and Rb(8,17) 6Sic were capable of solving this task in a statistically significant majority of cases, while mice with fusion of other chromosomes, as well as CBA normal karyotype mice, performed no better than expected by chance. Mice with two types of partial trisomies and animals homo- and heterozygous for translocations were also tested. Although mice with T6 trisomy performed no better than expected by chance, animals with trisomy for a chromosome 17 fragment solved the task successfully. Thus, a genetic component underlying the ability to solve the extrapolation task was demonstrated in three animal species. The extrapolation task in animals is considered to reveal a general capacity for elementary reasoning. The genetic basis of this capacity is very complex. |
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no |
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Equine Behaviour @ team @ |
Serial |
3089 |
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| Author |
unknown |
| Title |
Personality and Personality Disorders |
Type |
Book Chapter |
| Year |
1997 |
Publication |
Behavioural Genetics |
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Pages |
195-207 |
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W. H. Freeman and Company |
Place of Publication |
New York |
Editor |
Plomin, R.; DeFries, J.C.; McClearn, G.E.;Rutter, M. |
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3 |
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no |
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Equine Behaviour @ team @ |
Serial |
4283 |
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| Author |
Houpt, K.; Kusunose, R. |
| Title |
Genetics of behaviour. |
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Book Chapter |
| Year |
2000 |
Publication |
The Genetics of the Horse |
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281-306 |
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CABI Publishing |
Place of Publication |
New York |
Editor |
Bowling, A.T., Ruvinsky, A. |
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9780851994291 |
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no |
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Equine Behaviour @ team @ |
Serial |
4821 |
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| Author |
Houpt, K. A.; Kusonose, R. |
| Title |
Genetic of behaviour |
Type |
Book Chapter |
| Year |
2000 |
Publication |
Genetics of the Horse |
Abbreviated Journal |
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Pages |
281-306 |
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Cab Intl |
Place of Publication |
Wallingford Oxfordshire |
Editor |
Bowling,A. T. ; Ruvinsky, A. |
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978-0851994291 |
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no |
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Equine Behaviour @ team @ |
Serial |
5021 |
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| Author |
Oakenfull, E.A.; Lim, H.; Ryder, O. |
| Title |
A survey of equid mitochondrial DNA: Implications for the evolution, genetic diversity and conservation of Equus |
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Journal Article |
| Year |
2000 |
Publication |
Conservation Genetics |
Abbreviated Journal |
Conservat Genet |
| Volume |
1 |
Issue |
4 |
Pages |
341-355 |
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| Abstract |
The evolution, taxonomy and conservation of the genus Equuswere investigated by examining the mitochondrial DNA sequences of thecontrol region and 12S rRNA gene. The phylogenetic analysis of thesesequences provides further evidence that the deepest node in thephylogeny of the extant species is a divergence between twolineages; one leading to the ancestor of modern horses (E.ferus, domestic and przewalskii) and the other to thezebra and ass ancestor, with the later speciation events of the zebrasand asses occurring either as one or more rapid radiations, or withextensive secondary contact after speciation. Examination of the geneticdiversity within species suggested that two of the E. hemionussubspecies (E. h. onager and E. h. kulan) onlyrecently diverged, and perhaps, are insufficiently different to beclassified as separate subspecies. The genetic divergence betweendomestic and wild forms of E. ferus (horse) and E.africanus (African ass) was no greater than expected within anequid species. In E. burchelli (plains zebra) there was anindication of mtDNA divergence between populations increasing withdistance. The implications of these results for equid conservation arediscussed and recommendations are made for conservation action. |
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no |
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Equine Behaviour @ team @ |
Serial |
5039 |
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Hedrick, P.W.; Parker, K.M.; Miller, E.L.; Miller, P.S. |
| Title |
Major Histocompatibility Complex Variation in the Endangered Przewalski's Horse |
Type |
Journal Article |
| Year |
1999 |
Publication |
Genetics |
Abbreviated Journal |
Genetics |
| Volume |
152 |
Issue |
4 |
Pages |
1701-1710 |
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The major histocompatibility complex (MHC) is a fundamental part of the vertebrate immune system, and the high variability in many MHC genes is thought to play an essential role in recognition of parasites. The Przewalski's horse is extinct in the wild and all the living individuals descend from 13 founders, most of whom were captured around the turn of the century. One of the primary genetic concerns in endangered species is whether they have ample adaptive variation to respond to novel selective factors. In examining 14 Przewalski's horses that are broadly representative of the living animals, we found six different class II DRB major histocompatibility sequences. The sequences showed extensive nonsynonymous variation, concentrated in the putative antigen-binding sites, and little synonymous variation. Individuals had from two to four sequences as determined by single-stranded conformation polymorphism (SSCP) analysis. On the basis of the SSCP data, phylogenetic analysis of the nucleotide sequences, and segregation in a family group, we conclude that four of these sequences are from one gene (although one sequence codes for a nonfunctional allele because it contains a stop codon) and two other sequences are from another gene. The position of the stop codon is at the same amino-acid position as in a closely related sequence from the domestic horse. Because other organisms have extensive variation at homologous loci, the Przewalski's horse may have quite low variation in this important adaptive region. N1 - |
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Equine Behaviour @ team @ |
Serial |
5043 |
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| Author |
Aberle, K.S.; Hamann, H.; Drögemüller, C.; Distl, O. |
| Title |
Genetic diversity in German draught horse breeds compared with a group of primitive, riding and wild horses by means of microsatellite DNA markers |
Type |
Journal Article |
| Year |
2004 |
Publication |
Animal Genetics |
Abbreviated Journal |
Anim. Gen. |
| Volume |
35 |
Issue |
4 |
Pages |
270-277 |
| Keywords |
diversity; endangered breeds; genetic variation; horse; microsatellite |
| Abstract |
Summary We compared the genetic diversity and distance among six German draught horse breeds to wild (Przewalski's Horse), primitive (Icelandic Horse, Sorraia Horse, Exmoor Pony) or riding horse breeds (Hanoverian Warmblood, Arabian) by means of genotypic information from 30 microsatellite loci. The draught horse breeds included the South German Coldblood, Rhenish German Draught Horse, Mecklenburg Coldblood, Saxon Thuringa Coldblood, Black Forest Horse and Schleswig Draught Horse. Despite large differences in population sizes, the average observed heterozygosity (Ho) differed little among the heavy horse breeds (0.64�0.71), but was considerably lower than in the Hanoverian Warmblood or Icelandic Horse population. The mean number of alleles (NA) decreased more markedly with declining population sizes of German draught horse breeds (5.2�6.3) but did not reach the values of Hanoverian Warmblood (NA = 6.7). The coefficient of differentiation among the heavy horse breeds showed 11.6% of the diversity between the heavy horse breeds, as opposed to 21.2% between the other horse populations. The differentiation test revealed highly significant genetic differences among all draught horse breeds except the Mecklenburg and Saxon Thuringa Coldbloods. The Schleswig Draught Horse was the most distinct draught horse breed. In conclusion, the study demonstrated a clear distinction among the German draught horse breeds and even among breeds with a very short history of divergence like Rhenish German Draught Horse and its East German subpopulations Mecklenburg and Saxon Thuringa Coldblood. |
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Blackwell Science Ltd |
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1365-2052 |
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no |
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Equine Behaviour @ team @ |
Serial |
5184 |
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