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Author |
Gavrilova, O.; Haluzik, M.; Matsusue, K.; Cutson, J.J.; Johnson, L.; Dietz, K.R.; Nicol, C.J.; Vinson, C.; Gonzalez, F.J.; Reitman, M.L. |
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Title |
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass |
Type |
Journal Article |
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Year |
2003 |
Publication |
The Journal of biological chemistry |
Abbreviated Journal |
J Biol Chem |
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Volume |
278 |
Issue |
36 |
Pages |
34268-34276 |
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Keywords  |
Adipose Tissue/*metabolism; Animals; Blotting, Southern; Blotting, Western; Female; Hypoglycemia/genetics; Insulin Resistance/genetics; Lipid Metabolism; Liver/*metabolism; Liver Diseases/genetics/*metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; RNA/metabolism; Receptors, Cytoplasmic and Nuclear/*genetics/*physiology; Recombination, Genetic; Thiazoles/pharmacology; *Thiazolidinediones; Time Factors; Transcription Factors/*genetics/*physiology; Triglycerides/*metabolism |
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Abstract |
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that mediates the antidiabetic effects of thiazolidinediones. PPAR gamma is present in adipose tissue and becomes elevated in fatty livers, but the roles of specific tissues in thiazolidinedione actions are unclear. We studied the function of liver PPAR gamma in both lipoatrophic A-ZIP/F-1 (AZIP) and wild type mice. In AZIP mice, ablation of liver PPAR gamma reduced the hepatic steatosis but worsened the hyperlipidemia, triglyceride clearance, and muscle insulin resistance. Inactivation of AZIP liver PPAR gamma also abolished the hypoglycemic and hypolipidemic effects of rosiglitazone, demonstrating that, in the absence of adipose tissue, the liver is a primary and major site of thiazolidinedione action. In contrast, rosiglitazone remained effective in non-lipoatrophic mice lacking liver PPAR gamma, suggesting that adipose tissue is the major site of thiazolidinedione action in typical mice with adipose tissue. Interestingly, mice without liver PPAR gamma, but with adipose tissue, developed relative fat intolerance, increased adiposity, hyperlipidemia, and insulin resistance. Thus, liver PPAR gamma regulates triglyceride homeostasis, contributing to hepatic steatosis, but protecting other tissues from triglyceride accumulation and insulin resistance. |
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Address |
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. oksanag@bdg10.niddk.nih.gov |
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0021-9258 |
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PMID:12805374 |
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no |
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Call Number |
refbase @ user @ |
Serial |
81 |
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Author |
Manning, G.S.; Ratanarat, C. |
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Title |
Fasciolopsis buski (Lankester, 1857) in Thailand |
Type |
Journal Article |
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Year |
1970 |
Publication |
The American Journal of Tropical Medicine and Hygiene |
Abbreviated Journal |
Am J Trop Med Hyg |
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Volume |
19 |
Issue |
4 |
Pages |
613-619 |
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Keywords |
Adolescent; Adult; Aged; Animals; Buffaloes; Cattle; Child; Child, Preschool; *Disease Reservoirs; Dogs; Ecology; *Fasciolidae; Feces; Female; Health Surveys; Horses; Humans; Infant; Infant, Newborn; Male; Middle Aged; *Plants, Edible; Sex Factors; *Snails; Swine; Thailand; Trematode Infections/*epidemiology |
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0002-9637 |
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PMID:5425498 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2734 |
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Author |
Yamada, T.; Rojanasuphot, S.; Takagi, M.; Wungkobkiat, S.; Hirota, T. |
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Title |
Studies on an epidemic of Japanese encephalitis in the northern region of Thailand in 1969 and 1970 |
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Journal Article |
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Year |
1971 |
Publication |
Biken Journal |
Abbreviated Journal |
Biken J |
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Volume |
14 |
Issue |
3 |
Pages |
267-296 |
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Keywords |
Adolescent; Adult; Animals; Arboviruses/immunology; Buffaloes; Cattle; Chickens; Child; Child, Preschool; Cross Reactions; Culicidae; Dengue Virus/immunology; Disease Outbreaks; Ducks; Ecology; Encephalitis Virus, Japanese/immunology/isolation & purification; Encephalitis, Japanese/cerebrospinal fluid/*epidemiology/immunology/microbiology/mortality; Female; Hemagglutination Inhibition Tests; Hemorrhagic Fevers, Viral/epidemiology; Horses; Humans; Infant; Male; Mice; Neutralization Tests; Swine; Thailand |
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English |
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ISSN |
0006-2324 |
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Notes |
PMID:4400462 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2728 |
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Author |
van der Kolk, J.H.; Nachreiner, R.F.; Schott, H.C.; Refsal, K.R.; Zanella, A.J. |
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Title |
Salivary and plasma concentration of cortisol in normal horses and horses with Cushing's disease |
Type |
Journal Article |
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Year |
2001 |
Publication |
Equine Veterinary Journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
33 |
Issue |
2 |
Pages |
211-213 |
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Keywords |
Adrenal Cortex Function Tests/standards/veterinary; Animals; Cushing Syndrome/diagnosis/metabolism/*veterinary; Female; Horse Diseases/blood/*diagnosis/metabolism; Horses/blood/*metabolism; Hydrocortisone/blood/*metabolism; Male; Predictive Value of Tests; Reference Values; Saliva/*metabolism |
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Address |
Department of Large Animal Medicine and Nutrition, Veterinary Faculty, Utrecht University, The Netherlands |
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English |
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0425-1644 |
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Notes |
PMID:11266074 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
4281 |
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Author |
Carroll, G.L.; Matthews, N.S.; Hartsfield, S.M.; Slater, M.R.; Champney, T.H.; Erickson, S.W. |
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Title |
The effect of detomidine and its antagonism with tolazoline on stress-related hormones, metabolites, physiologic responses, and behavior in awake ponies |
Type |
Journal Article |
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Year |
1997 |
Publication |
Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons |
Abbreviated Journal |
Vet Surg |
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Volume |
26 |
Issue |
1 |
Pages |
69-77 |
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Keywords |
Adrenergic alpha-Antagonists/administration & dosage/*pharmacology; Animals; Behavior, Animal/drug effects/physiology; Blood Glucose/metabolism; Blood Pressure/drug effects/physiology; Consciousness/physiology; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine/blood; Fatty Acids, Nonesterified/blood; Female; Heart Rate/drug effects/physiology; Horse Diseases/metabolism/physiopathology/psychology; Horses/blood/metabolism/*physiology; Hydrocortisone/blood; Hypnotics and Sedatives/administration & dosage/*pharmacology; Imidazoles/administration & dosage/*pharmacology; Injections, Intravenous; Male; Norepinephrine/blood; Receptors, Adrenergic, alpha/drug effects/*physiology; Stress/metabolism/physiopathology/veterinary; Time Factors; Tolazoline/administration & dosage/*pharmacology |
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Abstract |
Six ponies were used to investigate the effect of tolazoline antagonism of detomidine on physiological responses, behavior, epinephrine, norepinephrine, cortisol, glucose, and free fatty acids in awake ponies. Each pony had a catheter inserted into a jugular vein 1 hour before beginning the study. Awake ponies were administered detomidine (0.04 mg/kg intravenously [i.v.]) followed 20 minutes later by either tolazoline (4.0 mg/kg i.v.) or saline. Blood samples were drawn from the catheter 5 minutes before detomidine administration (baseline), 5 minutes after detomidine administration, 20 minutes before detomidine administration which was immediately before the administration of tolazoline or saline (time [T] = 0), and at 5, 30, and 60 minutes after injections of tolazoline or saline (T = 5, 30, and 60 minutes, respectively). Compared with heart rate at T = 0, tolazoline antagonism increased heart rate 45% at 5 minutes. There was no difference in heart rate between treatments at 30 minutes. Blood pressure remained stable after tolazoline, while it decreased over time after saline. Compared with concentrations at T = 0, tolazoline antagonism of detomidine in awake ponies resulted in a 55% increase in cortisol at 30 minutes and a 52% increase in glucose at 5 minutes. The change in free fatty acids was different for tolazoline and saline over time. Free fatty acids decreased after detomidine administration. Free fatty acids did not change after saline administration. After tolazoline administration, free fatty acids increased transiently. Tolazoline tended to decrease sedation and analgesia at 15 and 60 minutes postantagonism. Antagonism of detomidine-induced physiological and behavioral effects with tolazoline in awake ponies that were not experiencing pain appears to precipitate a stress response as measured by cortisol, glucose, and free fatty acids. If antagonism of an alpha-agonist is contemplated, the potential effect on hormones and metabolites should be considered. |
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Address |
Department of Small Animal Medicine and Surgery, Texas A&M University, College Station, USA |
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English |
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ISSN |
0161-3499 |
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Notes |
PMID:9123816 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
96 |
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Author |
Baltic, M.; Jenni-Eiermann, S.; Arlettaz, R.; Palme, R. |
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Title |
A noninvasive technique to evaluate human-generated stress in the black grouse |
Type |
Journal Article |
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Year |
2005 |
Publication |
Annals of the New York Academy of Sciences |
Abbreviated Journal |
Ann N Y Acad Sci |
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Volume |
1046 |
Issue |
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Pages |
81-95 |
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Keywords |
Adrenocorticotropic Hormone/metabolism; Animals; Bird Diseases/*metabolism; Conservation of Natural Resources; Corticosterone/*metabolism; Ecosystem; Feces/*chemistry; Female; Galliformes/*metabolism; Immunoenzyme Techniques/methods/veterinary; Male; Reproducibility of Results; Stress/metabolism/*veterinary; Tritium/diagnostic use |
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Abstract |
The continuous development of tourism and related leisure activities is exerting an increasingly intense pressure on wildlife. In this study, a novel noninvasive method for measuring stress in the black grouse, an endangered, emblematic species of European ecosystems that is currently declining in several parts of its European range, is tested and physiologically validated. A radiometabolism study and an ACTH challenge test were performed on four captive black grouse (two of each sex) in order to get basic information about the metabolism and excretion of corticosterone and to find an appropriate enzyme-immunoassay (EIA) to measure its metabolites in the feces. Peak radioactivity in the droppings was detected within 1 to 2 hours. Injected (3)H-corticosterone was excreted as polar metabolites and by itself was almost absent. A cortisone-EIA was chosen from among seven tested EIAs for different groups of glucocorticoid metabolites, because it cross-reacted with some of the formed metabolites and best reflected the increase of excreted corticosterone metabolites, after the ACTH challenge test. Concentrations of the metabolites from fecal samples collected from snow burrows of free-ranging black grouse were within the same range as in captive birds. The noninvasive method described may be appropriate for evaluating the stress faced by free-living black grouse populations in the wild, particularly in mountain ecosystems where human disturbance, especially by winter sports, is of increasing conservation concern. |
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Address |
Zoological Institute, Division of Conservation Biology, Baltzerstrasse 6, CH-3012 Bern, Switzerland |
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English |
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ISSN |
0077-8923 |
ISBN |
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Notes |
PMID:16055845 |
Approved |
no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
4080 |
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Author |
Cowell, P.E.; Fitch, R.H.; Denenberg, V.H. |
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Title |
Laterality in animals: relevance to schizophrenia |
Type |
Journal Article |
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Year |
1999 |
Publication |
Schizophrenia Bulletin |
Abbreviated Journal |
Schizophr Bull |
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Volume |
25 |
Issue |
1 |
Pages |
41-62 |
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Keywords |
Adult; Animals; Cognition; *Disease Models, Animal; Functional Laterality/*physiology; Humans; Language; Motor Activity/physiology; Schizophrenia/*physiopathology |
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Abstract |
Anomalies in the laterality of numerous neurocognitive dimensions associated with schizophrenia have been documented, but their role in the etiology and early development of the disorder remain unclear. In the study of normative neurobehavioral organization, animal models have shed much light on the mechanisms underlying and the factors affecting adult patterns of both functional and structural asymmetry. Nonhuman species have more recently been used to investigate the environmental, genetic, and neuroendocrine factors associated with developmental language disorders in humans. We propose that the animal models used to study the basis of lateralization in normative development and language disorders such as dyslexia could be modified to investigate lateralized phenomena in schizophrenia. |
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Address |
Dept. of Human Communication Sciences, University of Sheffield, United Kingdom |
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English |
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Abbreviated Series Title |
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ISSN |
0586-7614 |
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Notes |
PMID:10098913 |
Approved |
no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2827 |
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Author |
Crans, W.J.; McNelly, J.; Schulze, T.L.; Main, A. |
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Title |
Isolation of eastern equine encephalitis virus from Aedes sollicitans during an epizootic in southern New Jersey |
Type |
Journal Article |
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Year |
1986 |
Publication |
Journal of the American Mosquito Control Association |
Abbreviated Journal |
J Am Mosq Control Assoc |
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Volume |
2 |
Issue |
1 |
Pages |
68-72 |
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Keywords |
Aedes/*microbiology; Alphavirus/*isolation & purification; Animals; Disease Outbreaks/veterinary; Ecology; Encephalitis Virus, Eastern Equine/*isolation & purification; Encephalomyelitis, Equine/epidemiology/transmission/veterinary; Horse Diseases/epidemiology/transmission; Horses; Insect Vectors/microbiology; New Jersey |
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Abstract |
Eastern equine encephalitis virus (EEE) was isolated from the salt marsh mosquito, Aedes sollicitans, collected from coastal areas of New Jersey on 3 occasions during the late summer and fall of 1982. The isolations were made at a time when local Culiseta melanura were either undergoing a population increase or exhibiting high levels of EEE virus. Although no human cases were reported during the epizootic period, the data lend support to the hypothesis that Ae. sollicitans is capable of functioning as an epidemic vector in the coastal areas of New Jersey where human cases of EEE have been most common. |
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Address |
Mosquito Research and Control, Cook College, Rutgers University, New Brunswick, NJ 08903 |
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English |
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ISSN |
8756-971X |
ISBN |
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Notes |
PMID:2853203 |
Approved |
no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2684 |
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Author |
Hardy, J.L. |
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Title |
The ecology of western equine encephalomyelitis virus in the Central Valley of California, 1945-1985 |
Type |
Journal Article |
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Year |
1987 |
Publication |
The American Journal of Tropical Medicine and Hygiene |
Abbreviated Journal |
Am J Trop Med Hyg |
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Volume |
37 |
Issue |
3 Suppl |
Pages |
18s-32s |
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Keywords |
Aedes/microbiology; Animals; Birds; California; Culex/microbiology; Encephalitis Virus, Western Equine/*physiology; Encephalomyelitis, Equine/*history/microbiology/transmission/veterinary; History, 20th Century; Horse Diseases/history/transmission; Horses; Humans; Insect Vectors/microbiology; Mammals |
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Abstract |
Reeves' concept of the summer transmission cycle of western equine encephalomyelitis virus in 1945 was that the virus was amplified in a silent transmission cycle involving mosquitoes, domestic chickens, and possibly wild birds, from which it could be transmitted tangentially to and cause disease in human and equine populations. Extensive field and laboratory studies done since 1945 in the Central Valley of California have more clearly defined the specific invertebrate and vertebrate hosts involved in the basic virus transmission cycle, but the overall concept remains unchanged. The basic transmission cycle involves Culex tarsalis as the primary vector mosquito species and house finches and house sparrows as the primary amplifying hosts. Secondary amplifying hosts, upon which Cx. tarsalis frequently feeds, include other passerine species, chickens, and possibly pheasants in areas where they are abundant. Another transmission cycle that most likely is initiated from the Cx. tarsalis-wild bird cycle involves Aedes melanimon and the blacktail jackrabbit. Like humans and horses, California ground squirrels, western tree squirrels, and a few other wild mammal species become infected tangentially with the virus but do not contribute significantly to virus amplification. |
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Address |
Department of Biomedical and Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720 |
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English |
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Abbreviated Series Title |
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Edition |
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ISSN |
0002-9637 |
ISBN |
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Notes |
PMID:3318522 |
Approved |
no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2677 |
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Author |
Fulhorst, C.F.; Hardy, J.L.; Eldridge, B.F.; Chiles, R.E.; Reeves, W.C. |
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Title |
Ecology of Jamestown Canyon virus (Bunyaviridae: California serogroup) in coastal California |
Type |
Journal Article |
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Year |
1996 |
Publication |
The American Journal of Tropical Medicine and Hygiene |
Abbreviated Journal |
Am J Trop Med Hyg |
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Volume |
55 |
Issue |
2 |
Pages |
185-189 |
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Keywords |
Aedes/virology; Animals; Antibodies, Viral/blood; California/epidemiology; Cattle; Cattle Diseases/epidemiology; Deer; Dog Diseases/epidemiology; Dogs; Encephalitis Virus, California/immunology/*isolation & purification; Encephalitis, California/epidemiology/*veterinary; Female; Horse Diseases/epidemiology; Horses; Insect Vectors/virology; Lagomorpha; Male; Neutralization Tests/veterinary; Peromyscus; Rodent Diseases/epidemiology; Sigmodontinae |
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Abstract |
This paper reports the first isolation of Jamestown Canyon (JC) virus from coastal California and the results of tests for antibody to JC virus in mammals living in coastal California. The virus isolation was made from a pool of 50 Aedes dorsalis females collected as adults from Morro Bay, San Luis Obispo County, California. The virus isolate was identified by two-way plaque reduction-serum dilution neutralization tests done in Vero cell cultures. Sera from the mammals were tested for antibody to JC virus by a plaque-reduction serum dilution neutralization method. A high prevalence of JC virus-specific antibody was found in horses and cattle sampled from Morro Bay. This finding is additional evidence for the presence of a virus antigenically identical or closely related to JC virus in Morro Bay and indicates that the vectors of the virus in Morro Bay feed on large mammals. A high prevalence of virus-specific antibody was also found in horses sampled from Marin and San Diego counties. This finding suggests that viruses antigenically identical or closely related to JC virus are geographically widespread in coastal California. |
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Address |
School of Public Health, University of California, Berkeley, USA |
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English |
Summary Language |
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Abbreviated Series Title |
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ISSN |
0002-9637 |
ISBN |
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Notes |
PMID:8780458 |
Approved |
no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2656 |
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| Permanent link to this record |
