| Records |
| Author |
Dunn, M.F.; Branlant, G. |
| Title |
Roles of zinc ion and reduced coenzyme in horse liver alcohol dehydrogenase catalysis. The mechanism of aldehyde activation |
Type |
Journal Article |
| Year |
1975 |
Publication |
Biochemistry |
Abbreviated Journal |
Biochemistry |
| Volume |
14 |
Issue |
14 |
Pages |
3176-3182 |
| Keywords |
*Alcohol Oxidoreductases/metabolism; Aldehydes/*pharmacology; Animals; Binding Sites; Enzyme Activation/drug effects; Horses; Hydrogen-Ion Concentration; Kinetics; Liver/enzymology; *NAD/analogs & derivatives/pharmacology; Oxidation-Reduction; Protein Binding; Spectrophotometry; Spectrophotometry, Ultraviolet; Temperature; *Zinc/pharmacology |
| Abstract |
1,4,5,6-Tetrahydronicotinamide adenine dinucleotide (H2NADH) has been investigated as a reduced coenzyme analog in the reaction between trans-4-N,N-dimethylaminocinnamaldehyde (I) (lambdamax 398 nm, epsilonmax 3.15 X 10-4 M-minus 1 cm-minus 1) and the horse liver alcohol dehydrogenase-NADH complex. These equilibrium binding and temperature-jump kinetic studies establish the following. (i) Substitution of H2NADH for NADH limits reaction to the reversible formation of a new chromophoric species, lambdamax 468 nm, epsilonmax 5.8 x 10-4 M-minus 1 cm-minus 1. This chromophore is demonstrated to be structurally analogous to the transient intermediate formed during the reaction of I with the enzyme-NADH complex [Dunn, M. F., and Hutchison, J. S. (1973), Biochemistry 12, 4882]. (ii) The process of intermediate formation with the enzyme-NADH complex is independent of pH over the range 6.13-10.54. Although studies were limited to the pH range 5.98-8.72, a similar pH independence appears to hold for the H2NADH system. (iii) Within the ternary complex, I is bound within van der Waal's contact distance of the coenzyme nicotinamide ring. (iv) Formation of the transient intermediate does not involve covalent modification of coenzyme. Based on these findings, we conclude that zinc ion has a Lewis acid function in facilitating the chemical activation of the aldehyde carbonyl for reduction, and that reduced coenzyme plays a noncovalent effector role in this substrate activating step. |
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English |
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ISSN  |
0006-2960 |
ISBN |
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Conference |
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| Notes |
PMID:238585 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3817 |
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| Author |
Wang, L.Y. |
| Title |
Host preference of mosquito vectors of Japanese encephalitis |
Type |
Journal Article |
| Year |
1975 |
Publication |
Zhonghua Minguo wei Sheng wu xue za zhi = Chinese Journal of Microbiology |
Abbreviated Journal |
Zhonghua Min Guo Wei Sheng Wu Xue Za Zhi |
| Volume |
8 |
Issue |
4 |
Pages |
274-279 |
| Keywords |
Animals; *Behavior, Animal; Birds/blood; *Culex; Ecology; Encephalitis, Japanese/*transmission; *Feeding Behavior; Female; Humans; *Insect Vectors; Mammals/blood; Species Specificity; Taiwan |
| Abstract |
The host preference of 4 Culex mosquito species collected in Miaoli and Pingtung counties, Taiwan was studied by capillary precipitin method. Antisera to alum-precipitated sera of man, bovine, swine, rabbit, horse, dog, cat, mouse, chicken, duck, and pigeon were produced in rabbits and reacted with 758 mosquito blood meals among which reactions to one or more antisera. Culex annulus and Culex tritaeniorhynchus summorosus showed a great avidity for pig, and Culex fuscocephala for bovine. Culex pipiens fatigans was ornithophilic. None of 110 C. t. summorosus and 2.4% of 223 C. annulus had fed on man. Among 66 samples of C.p. fatigans tested 10.3% had fed on man, while none of 359 C. fuscocephala did. It seems that the latter does not act as a primary vector of Japanese encephalitis. |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0009-4587 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:181218 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2702 |
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| Author |
Nelson, W.A.; Keirans, J.E.; Bell, J.F.; Clifford, C.M. |
| Title |
Host-ectoparasite relationships |
Type |
Journal Article |
| Year |
1975 |
Publication |
Journal of Medical Entomology |
Abbreviated Journal |
J Med Entomol |
| Volume |
12 |
Issue |
2 |
Pages |
143-166 |
| Keywords |
Animal Nutrition Physiology; Animals; Anoplura/physiology; *Arthropods; Birds/parasitology; Chickens/parasitology; Dermacentor/parasitology; Diptera; Ecology; Feeding Behavior; Female; Horses/parasitology; Humans; Male; Mallophaga/physiology; Mice/parasitology; Mites/physiology; Reproduction; Sarcoptes scabiei/physiology; Sheep/parasitology; Skin/parasitology; Ticks/physiology; Toxins, Biological/toxicity; Trombiculidae/physiology |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0022-2585 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:808617 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2704 |
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| Author |
Zentall, T.R; Hogan, D.E. |
| Title |
Key pecking in pigeons produced by pairing keylight with inaccessible grain |
Type |
Journal Article |
| Year |
1975 |
Publication |
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Abbreviated Journal |
J Exp Anal Behav |
| Volume |
23 |
Issue |
2 |
Pages |
199-206 |
| Keywords |
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| Abstract |
In Experiment I, keylight was paired with inaccessible grain delivery (under two conditions of keylight intensity) to determine if autoshaping would occur in the absence of primary reinforcement. In Experiment II, the procedure was repeated with accessible grain, for comparison. In Experiment III, the procedures were repeated with explicitly unpaired presentations of keylight and either inaccessible or accessible grain. The results indicated that key pecking occurred as quickly in the presence of keylight pairings with inaccessible grain as with accessible grain, though (except for one bird) key pecking was not maintained with inaccessible grain. Furthermore, compared to the dim keylight, the bright keylight greatly suppressed key pecking when paired with inaccessible grain, and reduced the rate of key pecking when paired with accessible grain. Little key pecking occurred in groups exposed to explicitly unpaired presentations of keylight (whether bright or dim) and grain (whether accessible or inaccessible). When the birds in Experiment III were retested with explicitly paired presentations of keylight and grain, little key pecking was observed, suggesting suppressive effects of prior explicitly unpaired presentations. It is suggested that the effects of key-brightness manipulation were produced by the association of grain with cues other than the response key, or by distraction produced by partial illumination of the grain hopper. |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0022-5002 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:16811840 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
273 |
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| Author |
Makarov, V.V.; Bakulov, I.A. |
| Title |
[Zoopathogenic arboviruses, their systematics and ecology] |
Type |
Journal Article |
| Year |
1975 |
Publication |
Veterinariia |
Abbreviated Journal |
Veterinariia |
| Volume |
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Issue |
11 |
Pages |
39-41 |
| Keywords |
Animals; Arboviruses/*classification/pathogenicity; Cattle; Deer; Ecology; Horses; Insect Vectors; Sheep; Swine; Turkeys; Viruses/*classification/pathogenicity |
| Abstract |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
Russian |
Summary Language |
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Original Title |
Zoopatogennye arbovirusy--sistematika i ekologiia |
| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0042-4846 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:814685 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2703 |
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| Author |
Sivak, J.G.; Allen, D.B. |
| Title |
An evaluation of the “ramp” retina of the horse eye |
Type |
Journal Article |
| Year |
1975 |
Publication |
Vision Research |
Abbreviated Journal |
Vision Res |
| Volume |
15 |
Issue |
12 |
Pages |
1353-1356 |
| Keywords |
Accommodation, Ocular; Animals; Aqueous Humor/physiology; Cornea/physiology; Freezing; Horses/*anatomy & histology; Lens, Crystalline/anatomy & histology/physiology; Refraction, Ocular; Retina/*anatomy & histology; Vitreous Body/physiology |
| Abstract |
Using a rapid freezing and sectioning technique, the distance between the lens and retina of the horse eye was measured. There is no indication of a ramp retina that could serve accommodation. The pupil axis of the eye coincides with the maximum lens to retina distance. The changes in the lens-retina distance are greater below the axis than above it. Calculations were made of refractive power of the horse eye from measurements of curvature and refractive indices of the ocular tissues. These calculations agree both qualitatively and quantitatively with retinoscopic measurements on live horses. Both show that the refractive state shifts in the direction of hyperopia above and below the axis and that this shift is greater below the axis than above it. Some dynamic accommodative ability in the living eye was observed. |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0042-6989 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:1210017 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3647 |
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| Author |
Wagner, G. |
| Title |
[Flight leadership in flocks of homing pigeons] |
Type |
Journal Article |
| Year |
1975 |
Publication |
Zeitschrift für Tierpsychologie |
Abbreviated Journal |
Z. Tierpsychol. |
| Volume |
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Issue |
39 |
Pages |
61-74 |
| Keywords |
Animals; *Columbidae; *Flight, Animal; *Orientation |
| Abstract |
Groups of 3-5 homing pigeons individually recognizable by different colours of their plumage were followed by helicopter on their way home. In most cases the animals flew together as a group with frequently changing leadership. Flight formations in terms of leadership were noted every minute. It was examined statistically whether the flight order varies at random or whether there are leading and led birds. In 6 out of 7 experiments with groups of 4-5 pigeons flight order was far from random, one or two pigeons proving to be leaders. In only one experiment leadership did not differ from a random distribution. No correlation could be found between the tendency to lead within a group and homing performance of the single pigeon when released individually. |
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Place of Publication |
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| Language |
German |
Summary Language |
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Original Title |
Zur Frage des Flugfuhrens in heimkehrenden Brieftaubengruppen |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0044-3573 |
ISBN |
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Conference |
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| Notes |
PMID:1231423 |
Approved |
no |
| Call Number |
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Serial |
2050 |
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| Author |
Mitchell, D.; Kirschbaum, E.H.; Perry, R.L. |
| Title |
Effects of neophobia and habituation on the poison-induced avoidance of exteroceptive stimuli in the rat |
Type |
Journal Article |
| Year |
1975 |
Publication |
Journal of Experimental Psychology. Animal Behavior Processes |
Abbreviated Journal |
J Exp Psychol Anim Behav Process |
| Volume |
1 |
Issue |
1 |
Pages |
47-55 |
| Keywords |
Animals; Avoidance Learning/*drug effects; *Awareness; *Cognition; Conditioning, Operant; Feeding Behavior/drug effects; *Habituation, Psychophysiologic; Injections, Intraperitoneal; Lithium/administration & dosage/poisoning; Male; Rats; *Taste; Time Factors; *Visual Perception |
| Abstract |
Two experiments on the role of neophobia in poison-induced aversions to exteroceptive stimuli are reported. In Experiment 1, rats were given either 10 or 25 days of habituation to the test situation prior to conditioning. Those animals with the longer habituation period avoided a complex of novel exteroceptive stimuli while those with the shorter habituation period did not. In Experiment 2 rats initially avoided the more novel of two containers, but gradually came to eat equal amounts from both. A single pairing of toxicosis with consumption from either the novel or the familiar container reinstated the avoidance of the novel container in both cases. The results were discussed in terms of an interaction between habituation and conditioning procedures. It was suggested that previously reported differences between interoceptive and exteroceptive conditioning effects may have been influenced by the differential novelty of the two classes of stimuli in the test situation. It was further suggested that non-contingently poisoned control groups should routinely be included in poison avoidance conditioning studies. |
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Place of Publication |
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Editor |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0097-7403 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:1151289 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2791 |
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| Author |
Czerlinski, G.H.; Wagner, M.; Erickson, J.O.; Theorell, H. |
| Title |
Chemical relaxation studies on the system liver alcohol dehydrogenase, NADH and imidazole |
Type |
Journal Article |
| Year |
1975 |
Publication |
Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry |
Abbreviated Journal |
Acta Chem Scand B |
| Volume |
29 |
Issue |
8 |
Pages |
797-810 |
| Keywords |
Alcohol Oxidoreductases/*metabolism; Animals; Computers; Hydrogen-Ion Concentration; Imidazoles/*metabolism; Kinetics; Liver/enzymology/*metabolism; Mathematics; Models, Chemical; NAD/*metabolism; Time Factors |
| Abstract |
Several years ago, Theorell and Czerlinski conducted experiments on the system of horse liver alcohol dehydrogenase, reduced nicotinamide adenine dinucleotide and imidazole, using the first version of the temperature jump apparatus with detection of changes in fluorescence. These early experiments were repeated with improved instrumentation and confirmed the early experiments in general terms. However, the improved detection system allowed to measure a slight concentration dependence of the relaxation time of around 3 ms. Furthermore, the chemical relaxation time was smaller than the one determined earlier (by factor 2). The data were evaluated much more rigorously than before, allowing an appropriate interpretation of the results. The observed relaxation time is largely due to rate constants in an interconversion of ternary complexes, which are faster than three (of the four) dissociation rate constants, determined previously by Theorell and McKinley-McKee.1,2 This fact contributed to earlier difficulties of finding any concentration dependence. However, the binding of imidazole to the binary enzyme-coenzyme complex can be made to couple kinetically into the interconversion rate of the two ternary complexes. The observed signal derives largely from the ternary complex(es). A substantial fluorescence signal change is associated with the observed relaxation process, suggesting a relocation of the imidazole in reference to the nicotinamide moiety of the bound coenzyme. Nine models are considered with two types of coupling of pre-equilibria (none-all). Quantitative evaluations favor the model with two ternary complexes connected by an interconversion outside the four-step (bimolecular) cycle. The ternary complex outside the cycle has much higher fluorescence yield than the one inside. The interconversion equilibrium is near unity for imidazole. If it would be shifted very much to the side of the “dead-end” complex (as in isobutyramide?!), stimulating action could not take place. |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0302-4369 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:882 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
3887 |
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| Author |
Stober, M.; Geiger, J.F. |
| Title |
[Lamenting “moaning” in domestic cattle] |
Type |
Journal Article |
| Year |
1975 |
Publication |
DTW. Deutsche Tierarztliche Wochenschrift |
Abbreviated Journal |
Dtsch Tierarztl Wochenschr |
| Volume |
82 |
Issue |
1 |
Pages |
10-13 |
| Keywords |
Animals; Behavior, Animal; *Cattle; Female; Personality; *Vocalization, Animal |
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Place of Publication |
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Editor |
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| Language |
German |
Summary Language |
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Original Title |
Untersuchungen uber das klagende “Anken” beim Hausrind |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0341-6593 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:1089525 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4173 |
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