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Author Jafarzadeh A.; Sadeghi M.; Karam G.A.; Vazirinejad R. openurl 
  Title Salivary IgA and IgE levels in healthy subjects: relation to age and gender Type Journal Article
  Year 2010 Publication Braz. oral res. Abbreviated Journal Braz. Oral Res.  
  Volume 24 Issue 1 Pages 21-27  
  Keywords Saliva; Immunoglobulin A; Immunoglobulin E; Adult; Child  
  Abstract It has been reported that the immune system undergoes age and gender changes. The aim of this study was to investigate the age- and gender-dependent changes of salivary IgA and IgE levels among healthy subjects. A total of 203 healthy individuals (aged 1-70 years) were enrolled in the study. Two milliliters of saliva were collected from all participants, and salivary IgA and IgE levels were measured by the ELISA technique. Mean salivary IgA levels were significantly higher in subjects aged 11-20 years as compared to subjects aged 1-10 years (P < 0.01). Mean salivary IgA levels increased with age up to the age of 60 years, and then slightly decreased in subjects aged 61-70 years. The frequency of subjects with detectable levels of salivary IgE and mean salivary IgE levels gradually increased with age, with maximum levels being observed in the 31-40 years age group and not changing significantly thereafter. The mean levels of salivary IgA and IgE in adults were significantly higher than those observed in children (P < 0.00001 and P < 0.05, respectively). No significant differences were observed between men and women regarding both salivary immunoglobulins. These results showed age-dependent changes of the salivary IgA and IgE levels. Gender had no effect on the salivary levels of IgA and IgE.  
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  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 6126  
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