Alexander, F. (1977). The effect of diuretics on the faecal excretion of water and electrolytes in horses. Br J Pharmacol, 60(4), 589–593.
Abstract: 1. The effect on plasma, urinary and faecal electrolytes of frusemide and hydrochlorthiazide was measured in ponies, mean weight 180 kg. 2. The rapid loss in urine of large quantities of sodium had only a small effect on plasma sodium concentration. 3. Faecal sodium excretion was increased substantially after the administration of frusemide. 4. Frusemide increased faecal potassium during the 48 h following administration and faecal water in the 24/48 h period. It also produced a hypopotassaemia. 5. Hydrochlorthiazide increased faecal chloride during the 24 h after administration. 6. Frusemide increased the intestinal transit time of both liquid (polyethylene glycol) and particulate (Cr2O3) markers.
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Alexander, F. (1978). The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse. Equine Vet J, 10(4), 229–234.
Abstract: The effect of morphine, Tinct. opii, loperamide, pethidine and atropine on intestinal transit and the faecal and urinary excretion of water and electrolytes was studied in ponies. The rate of passage of a particulate marker was slowed by morphine, hastened then slowed by loperamide and Tinct. opii, and hastened by atropine. The liquid marker was slowed by Tinct. opii and hastened then slowed by the other drugs. Only loperamide decreased the faecal sodium excretion. This drug also decreased faecal water and weight; it appeared worthy of clinical trial in diarrhoea. Tinct. opii decreased by morphine, pethidine and atropine increased faecal water.
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Alexander, F. (1982). Effect of phenylbutazone on electrolyte metabolism in ponies. Vet. Rec., 110(12), 271–272.
Abstract: Phenylbutazone administered in therapeutic doses to ponies decreased urinary sodium and chloride excretion. The volume and osmolality of the urine was unaffected as was potassium excretion. Faecal excretion of chloride decreased and that of potassium increased, while faecal sodium excretion was unaffected. Plasma pH, bicarbonate and total carbon dioxide decreased after phenylbutazone administration. Packed cell volume, plasma sodium, potassium, carbon dioxide tension and chloride were unchanged.
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Alexander, F., & Benzie, D. (1951). A radiological study of the digestive tract of the foal. Q J Exp Physiol Cogn Med Sci, 36(4), 213–217.
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Alexander, F., & Chowdhury, A. K. (1958). Enzymes in the ileal juice of the horse. Nature, 181(4603), 190.
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Alexander, F., & Collett, R. A. (1974). Pethidine in the horse. Res Vet Sci, 17(1), 136–137.
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Alexander, F., & Collett, R. A. (1974). Proceedings: Some observations on the pharmacokinetics of trimethoprim in the horse. Br J Pharmacol, 52(1), 142p.
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Alexander, F., & Davies, M. E. (1969). Studies on vitamin B12 in the horse. Br. Vet. J., 125(4), 169–176.
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Alexander, F., & Nicholson, J. D. (1968). The blood and saliva clearances of phenobarbitone and pentobarbitone in the horse. Biochem Pharmacol, 17(2), 203–210.
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Alexander, F., Horner, M. W., & Moss, M. S. (1967). The salivary secretion and clearance in the horse of chloral hydrate and its metabolites. Biochem Pharmacol, 16(7), 1305–1311.
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