Abstract: The article by Zucca and Sovrano (2008, this issue) represents part of a new wave of studies of lateralization in nonhuman species. This work is often in conflict with earlier studies of human cerebral asymmetry and handedness, and the associated claim that these asymmetries are uniquely human, and perhaps even a result of the “speciation event” that led to modern humans. It is now apparent that there are close parallels between human and nonhuman asymmetries, suggesting that they have ancient roots. I argue that asymmetries must be seen in the context of a bilaterally symmetrical body plan, and that there is a balance to be struck between the adaptive advantages of symmetry and asymmetry. In human evolution, systematic asymmetries were incorporated into activities that probably are unique to our species, but the precursors of these asymmetries are increasingly evident in other species, including frogs, fish, birds, and mammals – especially primates.