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Author Grogan, E.H.; McDonnell, S.M.
Title Behavioral responses to two intranasal vaccine applicators in horses and ponies Type
Year 2005 Publication Journal of the American Veterinary Medical Association Abbreviated Journal J Am Vet Med Assoc
Volume (down) 226 Issue 10 Pages 1689-1693
Keywords Administration, Intranasal; Animals; *Behavior, Animal; Female; Horses/physiology/*psychology; Immunization/instrumentation/methods/*veterinary; Male; Patient Compliance/psychology; Physical Examination/psychology/*veterinary; Vaccines/*administration & dosage; Videotape Recording
Abstract OBJECTIVE: To evaluate behavioral compliance of horses and ponies with simulated intranasal vaccination and assess development of generalized aversion to veterinary manipulations. DESIGN: Clinical trial. ANIMALS: 28 light horse mares, 3 pony geldings, 2 light horse stallions, and 3 pony stallions that had a history of compliance with veterinary procedures. PROCEDURE: Behavioral compliance with 2 intranasal vaccine applicators was assessed. Compliance with standard physical examination procedures was assessed before and after a single experience with either of the applicators or a control manipulation to evaluate development of generalized aversion to veterinary manipulation. RESULTS: In all 30 horses, simulated intranasal vaccination or the control manipulation could be performed without problematic avoidance behavior, and simulated intranasal vaccination did not have any significant effect on duration of or compliance with a standardized physical examination that included manipulation of the ears, nose, and mouth. Results were similar for the 2 intranasal vaccine applicators, and no difference in compliance was seen between horses in which warm versus cold applicators were used. For 3 of the 6 ponies, substantial avoidance behavior was observed in association with simulated intranasal vaccination, and compliance with physical examination procedures decreased after simulated intranasal vaccination. CONCLUSIONS AND CLINICAL RELEVANCE: Although some compliance problems were seen with ponies, neither problems with compliance with simulated intranasal vaccination nor adverse effects on subsequent physical examination were identified in any of the horses. Further study is needed to understand factors involved in practitioner reports of aversion developing in association with intranasal vaccination.
Address Equine Behavior Laboratory, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
Corporate Author Thesis
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Series Volume Series Issue Edition
ISSN 0003-1488 ISBN Medium
Area Expedition Conference
Notes PMID:15906570 Approved no
Call Number Serial 1890
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Author Bobbert, M.F.; Santamaria, S.
Title Contribution of the forelimbs and hindlimbs of the horse to mechanical energy changes in jumping Type Journal Article
Year 2005 Publication The Journal of Experimental Biology Abbreviated Journal J Exp Biol
Volume (down) 208 Issue 2 Pages 249-260
Keywords Animals; Biomechanics; Forelimb/*physiology; Hindlimb/*physiology; Horses/*physiology; Locomotion/*physiology; Muscle, Skeletal/*physiology; Time Factors
Abstract The purpose of the present study was to gain more insight into the contribution of the forelimbs and hindlimbs of the horse to energy changes during the push-off for a jump. For this purpose, we collected kinematic data at 240 Hz from 23 5-year-old Warmbloods (average mass: 595 kg) performing free jumps over a 1.15 m high fence. From these data, we calculated the changes in mechanical energy and the changes in limb length and joint angles. The force carried by the forelimbs and the amount of energy stored was estimated from the distance between elbow and hoof, assuming that this part of the leg behaved as a linear spring. During the forelimb push, the total energy first decreased by 3.2 J kg(-1) and then increased again by 4.2 J kg(-1) to the end of the forelimb push. At the end of the forelimb push, the kinetic energy due to horizontal velocity of the centre of mass was 1.6 J kg(-1) less than at the start, while the effective energy (energy contributing to jump height) was 2.3 J kg(-1) greater. It was investigated to what extent these changes could involve passive spring-like behaviour of the forelimbs. The amount of energy stored and re-utilized in the distal tendons during the forelimb push was estimated to be on average 0.4 J kg(-1) in the trailing forelimb and 0.23 J kg(-1) in the leading forelimb. This means that a considerable amount of energy was first dissipated and subsequently regenerated by muscles, with triceps brachii probably being the most important contributor. During the hindlimb push, the muscles of the leg were primarily producing energy. The total increase in energy was 2.5 J kg(-1) and the peak power output amounted to 71 W kg(-1).
Address Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, van der Boechorstraat 9, NL-1081 BT Amsterdam, The Netherlands. MFBobbert@fbw.vu.nl
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-0949 ISBN Medium
Area Expedition Conference
Notes PMID:15634844 Approved no
Call Number Serial 1895
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Author Wells, P.G.; Bhuller, Y.; Chen, C.S.; Jeng, W.; Kasapinovic, S.; Kennedy, J.C.; Kim, P.M.; Laposa, R.R.; McCallum, G.P.; Nicol, C.J.; Parman, T.; Wiley, M.J.; Wong, A.W.
Title Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species Type Journal Article
Year 2005 Publication Toxicology and applied pharmacology Abbreviated Journal Toxicol Appl Pharmacol
Volume (down) 207 Issue 2 Suppl Pages 354-366
Keywords
Abstract Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reactive oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction. This minireview focuses upon several model drugs (phenytoin, thalidomide, methamphetamine), environmental chemicals (benzo[a]pyrene) and gamma irradiation to examine this hypothesis in vivo and in embryo culture using mouse, rat and rabbit models. Embryonic prostaglandin H synthases (PHSs) and lipoxygenases bioactivate xenobiotics to free radical intermediates that initiate ROS formation, resulting in oxidation of proteins, lipids and DNA. Oxidative DNA damage and embryopathies are reduced in PHS knockout mice, and in mice treated with PHS inhibitors, antioxidative enzymes, antioxidants and free radical trapping agents. Thalidomide causes embryonic DNA oxidation in susceptible (rabbit) but not resistant (mouse) species. Embryopathies are increased in mutant mice deficient in the antioxidative enzyme glucose-6-phosphate dehydrogenase (G6PD), or by glutathione (GSH) depletion, or inhibition of GSH peroxidase or GSH reductase. Inducible nitric oxide synthase knockout mice are partially protected. Inhibition of Ras or NF-kB pathways reduces embryopathies, implicating ROS-mediated signal transduction. Atm and p53 knockout mice deficient in DNA damage response/repair are more susceptible to xenobiotic or radiation embryopathies, suggesting a teratological role for DNA damage, consistent with enhanced susceptibility to methamphetamine in ogg1 knockout mice with deficient repair of oxidative DNA damage. Even endogenous embryonic oxidative stress carries a risk, since untreated G6PD- or ATM-deficient mice have increased embryopathies. Thus, embryonic processes regulating the balance of ROS formation, oxidative DNA damage and repair, and ROS-mediated signal transduction may be important determinants of teratological risk.
Address Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0041-008X ISBN Medium
Area Expedition Conference
Notes PMID:16081118 Approved no
Call Number refbase @ user @ Serial 68
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Author Murray, J.K.; Singer, E.R.; Morgan, K.L.; Proudman, C.J.; French, N.P.
Title Risk factors for cross-country horse falls at one-day events and at two-/three-day events Type Journal Article
Year 2005 Publication The Veterinary Journal Abbreviated Journal
Volume (down) 170 Issue 3 Pages 318-324
Keywords Horse; Eventing; Fall; Cross-country; Risk
Abstract The cross-country phase of eventing competitions has been associated with injuries and fatalities to horses and riders. A case-control study was carried out to identify variables that were associated with increased or decreased risk of a horse fall on the cross-country phase at event competitions. After initial analysis, the dataset was split according to the categories of one-day events as compared to two- or three-day events to establish whether significant risk factors varied between the different types of eventing competitions. Data were collected for 121 cases (horse falls) at one-day events, 59 cases at two- or three-day events and for their 540 matched controls. The data were analysed using conditional logistic regression. The variables of no previous refusals on the course, fences with a landing in water and the combined variable of the angle and the spread of the fence were significantly associated with the risk of a horse fall in both datasets. Additional risk factors for one-day event falls were: fences requiring a take-off from water, a drop landing, the rider's knowledge of their position before the cross-country phase and if the rider received cross-country tuition. Three-day event risk factors in the multivariable model included: the camber of the fence and participation in non-equestrian sports by the rider. This study identified variables that were significantly associated with an increase or a decrease in the risk of a horse fall during the cross-country phase of different types of eventing competitions. Some of these variables are modifiable and the results of this study have been reported to the governing body of the sport of eventing in the UK so that possible interventions might be considered.
Address
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Notes Approved no
Call Number Equine Behaviour @ team @ Serial 3671
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Author Hodgson, D.; Howe, S.; Jeffcott, L.; Reid, S.; Mellor, D.; Higgins, A.
Title Effect of prolonged use of altrenogest on behaviour in mares Type
Year 2005 Publication Veterinary journal (London, England : 1997) Abbreviated Journal Vet J
Volume (down) 169 Issue 1 Pages 113-115
Keywords Administration, Oral; Anabolic Agents/adverse effects/*pharmacology; Animals; Behavior, Animal/*drug effects; Body Constitution/drug effects; Body Weight/drug effects; *Doping in Sports; Female; Horses/*physiology; Social Behavior; Social Dominance; Time Factors; Trenbolone/adverse effects/*analogs & derivatives/*pharmacology
Abstract Erratum in:

Vet J. 2005 May;169(3):321.

Corrected and republished in:

Vet J. 2005 May;169(3):322-5.

Oral administration of altrenogest for oestrus suppression in competition horses is believed to be widespread in some equestrian disciplines, and can be administered continuously for several months during a competition season. To examine whether altrenogest has any anabolic or other potential performance enhancing properties that may give a horse an unfair advantage, we examined the effect of oral altrenogest (0.044 mg/kg), given daily for a period of eight weeks, on social hierarchy, activity budget, body-mass and body condition score of 12 sedentary mares. We concluded that prolonged oral administration of altrenogest at recommended dose rates to sedentary mares resulted in no effect on dominance hierarchies, body mass or condition score.
Address Faculty of Veterinary Science, University of Sydney, Private Mailbag 4, Narellan Delivery Centre, Narellan, NSW 2567, Australia. davidh@camden.usyd.edu.au
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1090-0233 ISBN Medium
Area Expedition Conference
Notes PMID:15683772 Approved no
Call Number refbase @ user @ Serial 671
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Author Spier, S.J.
Title P. McGreevy, Equine Behavior: A Guide for Veterinarians and Equine Scientists, Edinburgh, Saunders (2004) ISBN 0702026344 369 pp. (soft) [pound sign]45 Type Journal Article
Year 2005 Publication The Veterinary Journal Abbreviated Journal
Volume (down) 169 Issue 3 Pages 375-222
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Area Expedition Conference
Notes Approved no
Call Number refbase @ user @ Serial 1982
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Author Flack, J.C.; de Waal, F.B.M.; Krakauer, D.C.
Title Social structure, robustness, and policing cost in a cognitively sophisticated species Type Journal Article
Year 2005 Publication The American Naturalist Abbreviated Journal Am Nat
Volume (down) 165 Issue 5 Pages E126-139
Keywords Animals; *Behavior, Animal; Cognition; Conflict (Psychology); Female; Macaca nemestrina/*physiology; Male; Models, Biological; *Social Behavior
Abstract Conflict management is one of the primary requirements for social complexity. Of the many forms of conflict management, one of the rarest and most interesting is third-party policing, or intervening impartially to control conflict. Third-party policing should be hard to evolve because policers personally pay a cost for intervening, while the benefits are diffused over the whole group. In this study we investigate the incidence and costs of policing in a primate society. We report quantitative evidence of non-kin policing in the nonhuman primate, the pigtailed macaque. We find that policing is effective at reducing the intensity of or terminating conflict when performed by the most powerful individuals. We define a measure, social power consensus, that predicts effective low-cost interventions by powerful individuals and ineffective, relatively costly interventions by low-power individuals. Finally, we develop a simple probabilistic model to explore whether the degree to which policing can effectively reduce the societal cost of conflict is dependent on variance in the distribution of power. Our data and simple model suggest that third-party policing effectiveness and cost are dependent on power structure and might emerge only in societies with high variance in power.
Address Santa Fe Institute, Santa Fe, New Mexico 87501, USA. jflack@santafe.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1537-5323 ISBN Medium
Area Expedition Conference
Notes PMID:15795848 Approved no
Call Number refbase @ user @ Serial 168
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Author Uehara, T.; Yokomizo, H.; Iwasa, Y.
Title Mate-choice copying as Bayesian decision making Type Journal Article
Year 2005 Publication The American naturalist Abbreviated Journal Am Nat
Volume (down) 165 Issue 3 Pages 403-410
Keywords Animals; *Bayes Theorem; *Choice Behavior; Female; Male; *Models, Biological; *Sexual Behavior, Animal
Abstract Mate-choice copying by females has been reported in fishes (e.g., guppies) and lekking birds. Presumably, females assess males' quality using both information from direct observation of males and information acquired by observing other females' choices. Here, we study mathematically the conditions under which mate-choice copying is advantageous on the basis of Bayesian decision theory. A female may observe the mate choice of another female, called the model female, who has performed an optimal choice based on her own judgment. The conditions required for the focal female to choose the same mate as that chosen by the model female should depend on the male's appearance to her, the reliability of her own judgment of male quality, and the reliability of the model females. When three or more females are involved, the optimal mate choice critically depends on whether multiple model females make decisions independently or they themselves copy the choices of others. If two equally reliable females choose different males, the choice of the second female, made knowing the choice of the first, should have a stronger effect on the choice of the third (focal) female. This “last-choice precedence” should be tested experimentally.
Address Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812-8581, Japan. uehara@bio-math.biology.kyushu-u.ac.jp
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1537-5323 ISBN Medium
Area Expedition Conference
Notes PMID:15729669 Approved no
Call Number Serial 1821
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Author Rizhova, L.Y.; Kokorina, E.P.
Title Behavioural asymmetry is involved in regulation of autonomic processes: Left side presentation of food improves reproduction and lactation in cows Type Journal Article
Year 2005 Publication Behavioural Brain Research Abbreviated Journal Behav. Brain. Res.
Volume (down) 161 Issue 1 Pages 75-81
Keywords Behavioural asymmetry; Somatic functions; Reproduction; Lactation
Abstract It is known that the right and left brain hemispheres differ in their ability to regulate autonomic processes in the organism. Direct unilateral stimulation of the brain provokes side-dependent endocrine, immune and other visceral reactions. Since brain hemispheres are mainly involved in the regulation of muscles and sensory organs on the contra lateral side of the body the activation of behavioural asymmetry stimulates the contra lateral half of the brain. The important theoretical and practical question of whether autonomic processes can be regulated via the behavioural asymmetry route remains unexplored. In this study, we report that the chronic presentation of an emotionally important stimulus--food--from the left side, improves reproductive performance in animals in a broad range of feeding conditions. The unilateral presentation of food can also influence lactation, but in this case the side-dependent effects are different under varying feeding conditions. This finding opens a simple practical approach to influence basic somatic functions in the organism.
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Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0166-4328 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5348
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Author Shen, Y.-Q.; Hebert, G.; Lin, L.-Y.; Luo, Y.-L.; Moze, E.; Li, K.-S.; Neveu, P.J.
Title Interleukine-1β and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization Type Journal Article
Year 2005 Publication Journal of Neuroimmunology Abbreviated Journal
Volume (down) 158 Issue 1–2 Pages 14-25
Keywords N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dopamine; Brain; Interleukin-6; Interleukin-1β; Behavioral lateralization
Abstract MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces diminution of the dopamine in nigrostriatal pathway and cognitive deficits in mice. MPTP treatment also increases pro-inflammatory cytokine production in substantia nigra and striatum. Since, pro-inflammatory cytokines influence striatal dopamine content and provoke cognitive impairments, the cognitive defects induced by MPTP may be partly due to brain cytokine induction in other structures than nigrostriatal pathway. Furthermore, behavioral lateralization, as assessed by paw preference, influences cytokine production at the periphery and in the central nervous system. Behavioral lateralization may thus influence brain cytokine levels after MPTP. In order to address these issues, mice selected for paw preference were injected with 25 mg/kg MPTP i.p. for five consecutive days after which striatal dopamine and DOPAC contents were measured by HPLC and IL-1β and IL-6 quantified by ELISA in the striatum, cerebral cortex, hippocampus and hypothalamus. The results showed that MPTP treatment induced dramatic loss of DA in striatum, simultaneously, IL-6 levels decreased in the striatum and increased in hippocampus and hypothalamus, while IL-1β levels decreased in the striatum, cerebral cortex and hippocampus. Interestingly, striatal dopamine turnover under basal conditions as well as striatal IL-1β and IL-6 levels under basal conditions and after MPTP depended on behavioral lateralization. Left pawed mice showed a higher decrease in dopamine turnover and lower cytokine levels as compared to right pawed animals. Behavioral lateralization also influenced IL-6 hippocampal levels under basal conditions and IL-1β cortical levels after MPTP. From these results, it can be concluded that MPTP-induced cognitive defects are accompanied by an alteration of pro-inflammatory cytokine levels in brain structures other than those involved in the nigrostriatal pathway. In addition, MPTP-induced dopamine decrease is influenced by behavioral lateralization, possibly through an effect on brain cytokine levels.
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Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0165-5728 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5781
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