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Author |
Harman, F.S.; Nicol, C.J.; Marin, H.E.; Ward, J.M.; Gonzalez, F.J.; Peters, J.M. |
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Title |
Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis |
Type |
Journal Article |
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Year |
2004 |
Publication |
Nature medicine |
Abbreviated Journal |
Nat Med |
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Volume |
10 |
Issue |
5 |
Pages  |
481-483 |
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Keywords |
Animals; Azoxymethane/toxicity; Colonic Neoplasms/etiology/genetics/*prevention & control; Colonic Polyps/etiology/genetics/pathology/prevention & control; Disease Models, Animal; Mice; Mice, Knockout; Mice, Mutant Strains; Phenotype; Receptors, Cytoplasmic and Nuclear/deficiency/genetics/*physiology; Transcription Factors/deficiency/genetics/*physiology |
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Abstract |
Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis. |
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Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. jmp21@psu.edu |
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1078-8956 |
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PMID:15048110 |
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no |
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refbase @ user @ |
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77 |
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Author |
Markman, E.M.; Abelev, M. |
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Title |
Word learning in dogs? |
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Journal Article |
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Year |
2004 |
Publication |
Trends in Cognitive Sciences |
Abbreviated Journal |
Trends. Cognit. Sci. |
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Volume |
8 |
Issue |
11 |
Pages |
479-81; discussion 481 |
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Keywords |
Animals; Association Learning; Dogs; *Learning; *Verbal Learning; *Vocabulary |
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Abstract |
In a recent paper, Kaminski, Call and Fischer report pioneering research on word-learning in a dog. In this commentary we suggest ways of distinguishing referential word use from mere association. We question whether the dog is reasoning by exclusion and, if so, compare three explanations – learned heuristics, default assumptions, and pragmatic reasoning – as they apply to children and might apply to dogs. Kaminski et al.'s work clearly raises important questions about the origins and basis of word learning and social cognition. |
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Department of Psychology, Stanford University, Bldg 420, Stanford, CA 94305-2130, USA |
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1364-6613 |
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PMID:15491899 |
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refbase @ user @ |
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274 |
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Author |
Broucek, J., Uhrincat, M., Kišac, P., Hanus, A.. |
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Title |
Hair Whorl Position as a Predictor of Learning Ability and Locomotor Behavior in Cattle? |
Type |
Journal Article |
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Year |
2004 |
Publication |
ACTA VETERINARIA BRUNENSIS |
Abbreviated Journal |
ACTA VET. BRNO |
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Volume |
73 |
Issue |
4 |
Pages |
455-459 |
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Keywords |
Cattle, hair whorl, reversal learning, open-field |
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Abstract |
The aim of our work was to investigate the hypothesis that the speed of solving the maze tests and
locomotor behavior of heifers in open-field tests are affected by the height location of facial whorl.
Fifty-eight Holstein heifers were used. Maze learning was observed at the age of 15 weeks, and an
open-field test was applied at two ages, 16 weeks and 18 months. Whorl placement was recorded by
one person as each heifer entered the scale. The hair whorl position was determined on the basis of
two patterns: A) hair whorl high, middle and low and B) hair whorl high and low. Heifers with a
high hair whorl were the fastest (77.8 ± 84.3 s) and heifers with a middle hair whorl the slowest (87.3
± 100.3 s) in the A pattern during the maze tests. In the B whorl pattern, heifers with a high hair whorl
ran across the maze in 84.5 ± 95.2 s and heifers with a low hair whorl in 84.1 ± 97.9 s. The number
of crossed squares in a 5-minute open-field test in the A pattern was the non-significantly highest in
heifers with a high hair whorl (43.4) at the age of 16 weeks. In the B whorl pattern, heifers with a
high hair whorl were also more mobile, but neither differences in individual minutes nor in the whole
5 minutes were significant. Heifers with a high hair whorl displayed the strongest locomotory
behavior (37.6 squares) and heifers with a low hair whorl (30.8) were the slowest in the A pattern at
the age of 18 months. The differences were not significant. In the B whorl pattern, heifers with a
high hair whorl crossed more squares, but the difference was not significant in comparison with
heifers with a low hair whorl. We found that the time of traversing the maze and the locomotor
activity in open-field test may not be influenced in the dairy cattle by the height facial whorl position |
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Equine Behaviour @ team @ |
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4321 |
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Author |
Hirota, S.; Suzuki, M.; Watanabe, Y. |
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Title |
Hydrophobic effect of trityrosine on heme ligand exchange during folding of cytochrome c |
Type |
Journal Article |
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Year |
2004 |
Publication |
Biochemical and Biophysical Research Communications |
Abbreviated Journal |
Biochem Biophys Res Commun |
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Volume |
314 |
Issue |
2 |
Pages |
452-458 |
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Keywords |
Amino Acids/chemistry; Animals; Cytochromes c/*chemistry; Heme/*chemistry; Histidine/chemistry; Horses; Hydrogen-Ion Concentration; Kinetics; Ligands; Myocardium/chemistry; Peptides/chemistry; Protein Folding; Spectrophotometry; Spectrum Analysis, Raman; Tyrosine/*analogs & derivatives/*chemistry |
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Abstract |
Effect of a hydrophobic peptide on folding of oxidized cytochrome c (cyt c) is studied with trityrosine. Folding of cyt c was initiated by pH jump from 2.3 (acid-unfolded) to 4.2 (folded). The Soret band of the 2-ms transient absorption spectrum during folding decreased its intensity and red-shifted from 397 to 400 nm by interaction with trityrosine, whereas tyrosinol caused no significant effect. The change in the transient absorption spectrum by interaction with trityrosine was similar to that obtained with 100 mM imidazole, which showed that the population of the intermediate His/His coordinated species increased during folding of cyt c by interaction with trityrosine. The absorption change was biphasic, the fast phase (82+/-9s(-1)) corresponding to the transition from the His/H(2)O to the His/Met coordinated species, whereas the slow phase (24+/-3s(-1)) from His/His to His/Met. By addition of trityrosine, the relative ratio of the slow phase increased, due to increase of the His/His species at the initial stage of folding. According to the resonance Raman spectra of cyt c, the high-spin 6-coordinate and low-spin 6-coordinate species were dominated at pH 2.3 and 4.2, respectively, and these species were not affected by addition of trityrosine. These results demonstrated that the His/His species increased by interaction with trityrosine at the initial stage of cyt c folding, whereas the heme coordination structure was not affected by trityrosine when the protein was completely unfolded or folded. Hydrophobic peptides thus may be useful to study the effects of hydrophobic interactions on protein folding. |
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Address |
Department of Physical Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, 607-8414 Kyoto, Japan. hirota@mb.kyoto-phu.ac.jp |
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0006-291X |
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PMID:14733927 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
3777 |
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Author |
Mellor, P.S.; Hamblin, C. |
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Title |
African horse sickness |
Type |
Journal Article |
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Year |
2004 |
Publication |
Veterinary Research |
Abbreviated Journal |
Vet Res |
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Volume |
35 |
Issue |
4 |
Pages |
445-466 |
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Keywords |
African Horse Sickness/epidemiology/*prevention & control/*transmission/virology; African horse sickness virus/pathogenicity; Animals; Culicidae; Europe/epidemiology; Horses; Insect Vectors |
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Abstract |
African horse sickness virus (AHSV) causes a non-contagious, infectious insect-borne disease of equids and is endemic in many areas of sub-Saharan Africa and possibly Yemen in the Arabian Peninsula. However, periodically the virus makes excursions beyond its endemic areas and has at times extended as far as India and Pakistan in the east and Spain and Portugal in the west. The vectors are certain species of Culicoides biting midge the most important of which is the Afro-Asiatic species C. imicola. This paper describes the effects that AHSV has on its equid hosts, aspects of its epidemiology, and present and future prospects for control. The distribution of AHSV seems to be governed by a number of factors including the efficiency of control measures, the presence or absence of a long term vertebrate reservoir and, most importantly, the prevalence and seasonal incidence of the major vector which is controlled by climate. However, with the advent of climate-change the major vector, C. imicola, has now significantly extended its range northwards to include much of Portugal, Spain, Italy and Greece and has even been recorded from southern Switzerland. Furthermore, in many of these new locations the insect is present and active throughout the entire year. With the related bluetongue virus, which utilises the same vector species of Culicoides this has, since 1998, precipitated the worst outbreaks of bluetongue disease ever recorded with the virus extending further north in Europe than ever before and apparently becoming endemic in that continent. The prospects for similar changes in the epidemiology and distribution of AHSV are discussed. |
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Address |
Institute for Animal Health, Department of Arbovirology, Pirbright Laboratory, Ash Rd., Pirbright, Woking, Surrey, GU24 0NF, United Kingdom. philip.mellor@bbsrc.ac.uk |
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English |
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0928-4249 |
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PMID:15236676 |
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Equine Behaviour @ team @ |
Serial |
2358 |
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Author |
Hausberger, M.; Bruderer, C.; Le Scolan, N.; Pierre, J.-S. |
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Title |
Interplay between environmental and genetic factors in temperament/personality traits in horses (Equus caballus) |
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Journal Article |
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Year |
2004 |
Publication |
Journal of Comparative Psychology |
Abbreviated Journal |
J Comp Psychol |
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Volume |
118 |
Issue |
4 |
Pages |
434-446 |
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Keywords |
*Affect; Animals; Behavior, Animal/*physiology; *Environment; Female; Horses/*psychology; Learning; Male; Memory/physiology |
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Abstract |
The aim of the present study was to broach the question of the relative influence of different genetic and environmental factors on different temperament/personality traits of horses (Equus caballus). The researchers submitted 702 horses to standardized experimental tests and investigated 9 factors, either genetic or environmental. Genetic factors, such as sire or breed, seemed to influence more neophobic reactions, whereas environmental factors, such as the type of work, seemed to play a more dominant role in reactions to social separation or learning abilities. Additive effects were evident, showing how environmental factors may modulate behavioral traits. This study constitutes a first step toward understanding the relative weights of genetic factors and how the environment may intervene in determining individual behavioral characteristics. |
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Ethologie-Evolution-Ecologie, Universite de Rennes 1, Rennes, France. Martine.Hausberger@univ-rennes1.fr |
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Washington, D.C. : 1983 |
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English |
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0735-7036 |
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PMID:15584780 |
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Serial |
1897 |
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Eriksson, E.; Royo, F.; Lyberg, K.; Carlsson, H.-E.; Hau, J. |
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Title |
Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats |
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Journal Article |
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Year |
2004 |
Publication |
Experimental Physiology |
Abbreviated Journal |
Exp. Physiol. |
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Volume |
89 |
Issue |
4 |
Pages |
427-433 |
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Six 8-week-old Sprague-Dawley rats were studied for 9 days divided into three periods of 3 days each: before transferral to metabolism cages, during metabolic cage housing and after return to their home cages. Faeces were collected daily when the animals were housed in their home cages and every 6 h when the animals were housed in metabolic cages during which time urine was also collected every 6 h. The rate of weight gain was slightly reduced during the 3 days in metabolic cages and the animals produced significantly larger amounts of faeces when housed in metabolic cages than when housed in their home cages. The total faecal excretion of corticosterone (nanograms excreted per hour per kilogram body weight) and immunoglobulin A (IgA) (milligrams excreted per hour per kg body weight) quantified by enzyme-linked immunosorbent assays (ELISAs) exhibited a clear diurnal rhythm in the metabolic cage. Urinary excretions of corticosterone and IgA also followed a clear diurnal cycle. The mean daily amounts of corticosterone excreted were not significantly affected by cage change and by housing in metabolic cages. However, the excretion of faecal IgA was significantly reduced during the 3 days after the period in metabolic cages. Taken together the results indicate that metabolic cage housing is mildly stressful for young adult male rats. |
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Blackwell Science Ltd |
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1469-445x |
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Equine Behaviour @ team @ |
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5850 |
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Author |
Subiaul, F.; Cantlon, J.F.; Holloway, R.L.; Terrace, H.S. |
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Title |
Cognitive imitation in rhesus macaques |
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Journal Article |
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Year |
2004 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
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Volume |
305 |
Issue |
5682 |
Pages |
407-410 |
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Animals; *Cognition; *Imitative Behavior; *Learning; Macaca mulatta/*physiology/psychology; Male |
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Abstract |
Experiments on imitation typically evaluate a student's ability to copy some feature of an expert's motor behavior. Here, we describe a type of observational learning in which a student copies a cognitive rule rather than a specific motor action. Two rhesus macaques were trained to respond, in a prescribed order, to different sets of photographs that were displayed on a touch-sensitive monitor. Because the position of the photographs varied randomly from trial to trial, sequences could not be learned by motor imitation. Both monkeys learned new sequences more rapidly after observing an expert execute those sequences than when they had to learn new sequences entirely by trial and error. |
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Department of Anthropology, Columbia University, New York, NY 10027, USA. subiaul@aol.com |
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1095-9203 |
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PMID:15256673 |
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Equine Behaviour @ team @ |
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2839 |
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Author |
Friedrich, A.M.; Zentall, T.R. |
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Title |
Pigeons shift their preference toward locations of food that take more effort to obtain |
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Journal Article |
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Year |
2004 |
Publication |
Behavioural processes |
Abbreviated Journal |
Behav. Process. |
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67 |
Issue |
3 |
Pages |
405-415 |
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Animals; *Behavior, Animal; *Choice Behavior; Columbidae; *Exertion; *Feeding Behavior; Reward |
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Abstract |
Although animals typically prefer to exert less effort rather than more effort to obtain food, the present research shows that requiring greater effort to obtain food at a particular location appears to increase the value of that location. In Experiment 1, pigeons' initial preference for one feeder was significantly reduced by requiring 1 peck to obtain food from that feeder and requiring 30 pecks to obtain food from the other feeder. In Experiment 2, a similar decrease in preference was not found when pigeons received reinforcement from both feeders independently of the amount of effort required. These results are consistent with the within-trial contrast effect proposed by in which the relative hedonic value of a reward depends on the state of the animal immediately prior to the reward. The greater the improvement from that prior state the greater the value of the reinforcer. |
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Department of Psychology, University of Kentucky, Lexington, KY 40506-0044, USA |
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0376-6357 |
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PMID:15518990 |
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Call Number |
refbase @ user @ |
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227 |
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Author |
McGreevy, P. |
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Title |
Equine behavior |
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Journal Article |
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Year |
2004 |
Publication |
Journal of Equine Veterinary Science |
Abbreviated Journal |
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Volume |
24 |
Issue |
9 |
Pages |
397-398 |
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refbase @ user @ |
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1983 |
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