Records |
Author |
Guo, G.L.; Moffit, J.S.; Nicol, C.J.; Ward, J.M.; Aleksunes, L.A.; Slitt, A.L.; Kliewer, S.A.; Manautou, J.E.; Gonzalez, F.J. |
Title |
Enhanced acetaminophen toxicity by activation of the pregnane X receptor |
Type |
Journal Article |
Year |
2004 |
Publication |
Toxicological sciences : an official journal of the Society of Toxicology |
Abbreviated Journal |
Toxicol Sci |
Volume |
82 |
Issue |
2 |
Pages |
374-380 |
Keywords |
Acetaminophen/pharmacokinetics/*toxicity; Analgesics, Non-Narcotic/pharmacokinetics/*toxicity; Animals; Aryl Hydrocarbon Hydroxylases/biosynthesis; Biotransformation; Blotting, Northern; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Membrane Proteins; Mice; Mice, Knockout; Oxidoreductases, N-Demethylating/biosynthesis; Pregnenolone Carbonitrile/pharmacology; Receptors, Cytoplasmic and Nuclear/*drug effects; Receptors, Steroid/*drug effects; Sulfhydryl Compounds/metabolism |
Abstract |
The pregnane X receptor (PXR) is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Activation of PXR represents an important mechanism for the induction of cytochrome P450 3A (CYP3A) enzymes that can convert acetaminophen (APAP) to its toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI). Therefore, it was hypothesized that activation of PXR plays a major role in APAP-induced hepatotoxicity. Pretreatment with the PXR activator, pregnenolone 16alpha-carbonitrile (PCN), markedly enhanced APAP-induced hepatic injury, as revealed by increased serum ALT levels and hepatic centrilobular necrosis, in wild-type but not in PXR-null mice. Further analysis showed that following PCN treatment, PXR-null mice had lower CYP3A11 expression, decreased NAPQI formation, and increased maintenance of hepatic glutathione content compared to wild-type mice. Thus, these results suggest that PXR plays a critical role in APAP-induced hepatic toxicity, probably by inducing CYP3A11 expression and hence increasing bioactivation. |
Address |
Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA |
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1096-6080 |
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PMID:15456926 |
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no |
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refbase @ user @ |
Serial |
71 |
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Author |
Gentner, T.Q. |
Title |
Neural Systems for Individual Song Recognition in Adult Birds |
Type |
Journal Article |
Year |
2004 |
Publication |
Ann. N.Y. Acad. Sci. |
Abbreviated Journal |
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Volume |
1016 |
Issue |
1 |
Pages |
282-302 |
Keywords |
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Abstract |
The songbird auditory system is an excellent model for neuroethological studies of the mechanisms that govern the perception and cognition of natural stimuli (i.e., song), and the translation of corresponding representations into natural behaviors. One common songbird behavior is the learned recognition of individual conspecific songs. This chapter summarizes the research effort to identify the brain regions and mechanisms mediating individual song recognition in European starlings, a species of songbird. The results of laboratory behavioral studies are reviewed, which show that when adult starlings learn to recognize other individual's songs, they do so by memorizing large sets of song elements, called motifs. Recent data from single neurons in the caudal medial portion of the mesopallium are then reviewed, showing that song recognition learning leads to explicit representation of acoustic features that correspond closely to specific motifs, but only to motifs in the songs that birds have learned to recognize. This suggests that the strength and tuning of high-level auditory object representations, of the sort that presumably underlie many forms of vocal communication, are shaped by each animal's unique experience. |
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10.1196/annals.1298.008 |
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no |
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Equine Behaviour @ team @ |
Serial |
2961 |
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Author |
Huebener, E. |
Title |
Movements of Trunk and Back of the Horse from a Rider's View |
Type |
Journal Article |
Year |
2004 |
Publication |
Tierärztliche Umschau |
Abbreviated Journal |
Tierärztl. Umschau |
Volume |
6 |
Issue |
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Pages |
327 |
Keywords |
walk – trot – canter – pain – damages |
Abstract |
The trunk and back movements of the horse during locomotion determine seat position and leg aids of the rider, this is the basis for horse-oriented and cultivated, sensitive riding. In their tendency these movements could now be derived from the foot sequences of the basic paces. The realizations are verified by video. By translating these movements into diagrams, the author is making an attempt to present the current state of knowledge for non-riding scholars and academically oriented riders alike. The acceptance of the prepared riding knowledge would be improved if one could produce measured values of the horse's back and trunk movements. An appeal of a rider for relevant, scholarly research. |
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German |
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no |
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refbase @ user @ |
Serial |
437 |
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Author |
McBride, S.D.; Hemmings, A.; Robinson, K. |
Title |
A preliminary study on the effect of massage to reduce stress in the horse |
Type |
Journal Article |
Year |
2004 |
Publication |
Journal of Equine Veterinary Science |
Abbreviated Journal |
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Volume |
24 |
Issue |
2 |
Pages |
76-81 |
Keywords |
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Abstract |
The use of massage (as a potential form of acupressure) has long been documented as a human relaxation aid. However, little scientific research has been carried out into its potential use as a form of stress reduction in the horse. This preliminary study investigated the effect of massage at six different sites (thoracic trapezius [withers], mid-brachiocephalicus, cervical ventral serrate and cervical trapezius [mid-neck], proximal gluteal fascia and proximal superficial gluteal [croup], proximal and mid-semitendinosus [second thigh], lateral triceps, proximal extensor carpi radialis and proximal common digital extensor [forearm], proximal brachiocephalicus, proximal splenius and ear [poll and ears) on stress-related behavioral and physiological (heart rate [HR]) measures in the horse. Ten riding school ponies/horses were massaged at each of the six sites (three preferred and three nonpreferred sites of allogrooming (mutual grooming between conspecifics) and changes in HR and behavior were recorded. The results indicated that during massage, all sites except the forearm resulted in a significant reduction in HR (P < .05) with massage at the withers, mid-neck, and croup having the greatest effect (preferred sites of allogrooming). Massage at preferred sites of allogrooming also elicited significantly more (P < .05) positive behavioral responses compared with the three nonpreferred sites. The practical implications of this study are discussed. |
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Equine Behaviour @ team @ |
Serial |
3617 |
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Author |
Corr, J.A. |
Title |
Nuns and monkeys: investigating the behavior of our oldest old |
Type |
Journal Article |
Year |
2004 |
Publication |
Science of Aging Knowledge Environment : SAGE KE |
Abbreviated Journal |
Sci Aging Knowledge Environ |
Volume |
2004 |
Issue |
41 |
Pages |
pe38 |
Keywords |
Aged; Aged, 80 and over/*physiology; Aging/*physiology; Animals; Behavior/*physiology; Humans; Macaca mulatta |
Abstract |
The use of nonhuman primates, particularly rhesus macaques (Macaca mulatta), as the best model for human physiological and cognitive aging is broadly accepted. Studies employing nonhuman primates to investigate behavioral changes that may occur with increasing age, however, are not common mostly because of the unavailability of appropriate subjects. Recent longitudinal human studies suggest that individual personality might play a large role in aging “successfully” and in the retention of high levels of cognition into old age. As a result of the demographic trend of increasing numbers of aged monkeys and apes in captivity, an opportunity exists to further investigate behavioral aging using the monkey model. |
Address |
Department of Anthropology, Grand Valley State University, Allendale, MI 49401, USA. corrj@gvsu.edu |
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English |
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1539-6150 |
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PMID:15483334 |
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no |
Call Number |
Equine Behaviour @ team @ |
Serial |
2828 |
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Author |
Bond III, E.U.; Walker, B.A.; Hutt, M.D.; Reingen, P.H. |
Title |
Reputational Effectiveness in Cross-Functional Working Relationships |
Type |
Journal Article |
Year |
2004 |
Publication |
Journal of Product Innovation Management |
Abbreviated Journal |
‎J. Prod. Innov. Manag. |
Volume |
21 |
Issue |
1 |
Pages |
44-60 |
Keywords |
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Abstract |
The work of innovation management involves cross-functional coordination among specialists and managers with different work orientations, time horizons, professional backgrounds, and values (Ford and Randolph, 1992). While strong connections across functions are critical for new product development success (Green et al., 2000), some managers may be more adept at fostering effective cross-functional relationships than others. In this article, the authors empirically examine the factors that distinguish reputationally effective innovation workers from their less effective peers. Drawing on the work of Tsui (1984, 1994), reputational effectiveness is defined as the degree to which a manager has been responsive to the needs and expectations of constituents. This research examines the relational skills and interaction patterns of more (versus less) reputationally effective managers. A large business unit of a Fortune 500 telecommunications firm provided the context for our study. Using a two-phase approach, the authors first captured the social network patterns of 268 managers from marketing, research and development (R&D), manufacturing, and other business functions that were involved in the new product development process. In addition, the reputational effectiveness of each person who was identified as a member of the network was measured. In the second phase, the authors examined the relational competencies (e.g., role-taking ability, interpersonal control, openness) of the managers who participated in Phase I of the research. As predicted, the results indicate that role-taking ability is related positively to a manager's reputational effectiveness. No support, however, was found for the relationship between interpersonal control and reputational effectiveness. Interestingly, the authors found evidence of an inverse relationship between openness and effectiveness. By sharing too much information?or alternatively information that does not relate to the task at hand?the reputational effectiveness of a manager is damaged. Importantly, the results reveal that the social network characteristics of a reputationally effective manager differ from those of less effective managers. Closeness centrality, a measure of the degree of access one has to other organizational members, was associated strongly with reputational effectiveness. The results demonstrate that managers who are successful in working across functions appreciate the cognitive and emotional perspectives of diverse constituents and develop relationship ties that provide them with ready access to others across the organization. |
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John Wiley & Sons, Ltd (10.1111) |
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0737-6782 |
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doi: 10.1111/j.0737-6782.2004.00053.x |
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Equine Behaviour @ team @ |
Serial |
6540 |
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Author |
Reader S.M., |
Title |
Distinguishing social and asocial learning using diffusion dynamics |
Type |
Journal Article |
Year |
2004 |
Publication |
Learning & Behavior |
Abbreviated Journal |
Learn. Behav. |
Volume |
32 |
Issue |
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Pages |
90-104 |
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Abstract |
Theoretical models predict that the cumulative number of individuals displaying a socially learned novel behavior will follow an accelerating pattern over time, whereas asocial processes have been associated with linear or decelerating functions. This raises the possibility that the shape of the diffusion curve may reveal something about the learning processes involved. If true, this would be particularly useful for identifying social transmission in observational field studies. Published data are reviewed and are found to provide limited support for this view. The use of accelerating curves as a diagnostic is challenging because (1) alternative theoretical models make similar predictions, (2) clear supporting empirical data are lacking, and (3) practical considerations frequently make accurate construction of the diffusion curve difficult. |
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refbase @ user @ |
Serial |
831 |
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Author |
Murphy, J.; Waldmann, T.; Arkins, S. |
Title |
Sex differences in equine learning skills and visuo-spatial ability |
Type |
Journal Article |
Year |
2004 |
Publication |
Applied Animal Behaviour Science |
Abbreviated Journal |
Appl. Anim. Behav. Sci. |
Volume |
87 |
Issue |
1-2 |
Pages |
119-130 |
Keywords |
Horses; Sex differences; Visuo-spatial ability; Learning |
Abstract |
There is evidence of superior visuo-spatial ability in males compared to females in most species investigated to-date. However, no known studies have addressed this issue in the equine. Equine visuo-spatial ability was investigated using a novel test apparatus with a sample of 62 horses (males=34 and females=28) during a series of six tests, where the horses were required to access a food source. The test apparatus consisted of a series of four adjacent stalls, each of which had a feed bin and a moveable barrier. The test apparatus was designed such that the breastplate barriers controlled and limited access by the horses to feed bins in all but one stall during each test. Male horses performed such that there were significant differences (P<0.05) in the ability of the subjects to complete all six tests in a mean time of 30 s or less per test. There were significant differences in mean completion times for male subjects between test 1 and test 2 (P<0.05), test 1 and test 3 (P<0.001), test 1 and test 4 (P<0.05) and test 1 and test 5 (P<0.05). There were no significant differences in mean completion times between any of the six tests for female subjects. Males had a lower mean total number of errors during all tests. Male horses also successfully completed significantly more tests than females (P<0.05). These results provide the first behavioural demonstration of superior visuo-spatial ability in male horses, similar to that reported in other species. |
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Equine Behaviour @ team @ |
Serial |
3560 |
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Author |
Verguts, T.; Fias, W. |
Title |
Representation of Number in Animals and Humans: A Neural Model |
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Journal Article |
Year |
2004 |
Publication |
J. Cogn. Neurosci. |
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Volume |
16 |
Issue |
9 |
Pages |
1493-1504 |
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Abstract |
This article addresses the representation of numerical information conveyed by nonsymbolic and symbolic stimuli. In a first simulation study, we show how number-selective neurons develop when an initially uncommitted neural network is given nonsymbolic stimuli as input (e.g., collections of dots) under unsupervised learning. The resultant network is able to account for the distance and size effects, two ubiquitous effects in numerical cognition. Furthermore, the properties of the network units conform in detail to the characteristics of recently discovered number-selective neurons. In a second study, we simulate symbol learning by presenting symbolic and nonsymbolic input simultaneously. The same number-selective neurons learn to represent the numerical meaning of symbols. In doing so, they show properties reminiscent of the originally available number-selective neurons, but at the same time, the representational efficiency of the neurons is increased when presented with symbolic input. This finding presents a concrete proposal on the linkage between higher order numerical cognition and more primitive numerical abilities and generates specific predictions on the neural substrate of number processing. N1 - |
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Equine Behaviour @ team @ |
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2954 |
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Author |
Zhang, T.-Y.; Parent, C.; Weaver, I.; Meaney, M.J. |
Title |
Maternal programming of individual differences in defensive responses in the rat |
Type |
Journal Article |
Year |
2004 |
Publication |
Annals of the New York Academy of Sciences |
Abbreviated Journal |
Ann N Y Acad Sci |
Volume |
1032 |
Issue |
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Pages |
85-103 |
Keywords |
Adaptation, Biological; Aggression/*physiology; Animals; Evolution; Female; Gene Expression/physiology; Humans; Individuality; *Maternal Behavior; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Stress, Psychological/physiopathology |
Abstract |
This paper describes the results of a series of studies showing that variations in mother-pup interactions program the development of individual differences in behavioral and endocrine stress responses in the rat. These effects are associated with altered expression of genes in brain regions, such as the amygdala, hippocampus, and hypothalamus, that regulate the expression of stress responses. Studies from evolutionary biology suggest that such “maternal effects” are common and often associated with variations in the quality of the maternal environment. Together these findings suggest an epigenetic process whereby the experience of the mother alters the nature of the parent-offspring interactions and thus the phenotype of the offspring. |
Address |
McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 boul. LaSalle, Montreal (Quebec), Canada H4H 1R3 |
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0077-8923 |
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PMID:15677397 |
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Equine Behaviour @ team @ |
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4132 |
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