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Author Kirkpatrick, J.F.; Turner, A. openurl 
  Title Reversibility of action and safety during pregnancy of immunization against porcine zona pellucida in wild mares (Equus caballus) Type Journal Article
  Year 2002 Publication Reproduction (Cambridge, England) Supplement Abbreviated Journal Reprod Suppl  
  Volume 60 Issue Pages 197-202  
  Keywords Animals; *Animals, Wild; Antigens/administration & dosage; Contraception, Immunologic/methods/*veterinary; Egg Proteins/administration & dosage; Female; Fertility; *Horses; Immunization, Secondary/veterinary; Membrane Glycoproteins/administration & dosage; Population Control; Pregnancy; *Receptors, Cell Surface; Safety; Swine; Time Factors; Vaccines, Contraceptive/*administration & dosage  
  Abstract Contraceptive management of publicly valued wildlife species requires safeguards to ensure that these populations are preserved in a healthy state. In addition, reversibility of contraceptive effects and safety in pregnant animals are major concerns. A population of wild horses has been immunized against porcine zona pellucida (PZP) over a 12 year period on Assateague Island National Seashore, MD (ASIS). Mares initially received one or two 65 microg inoculations and once a year 65 microg booster inoculations, all delivered by dart. All young mares aged > 2 years were treated with PZP for 3 consecutive years regardless of whether they have bred successfully and they were then removed from treatment until they had foaled. All mares vaccinated for 1 or 2 consecutive years became fertile again and 69% of mares treated for 3 consecutive years returned to fertility. All five mares treated for 4 or 5 consecutive years have also returned to fertility, but over longer periods of time. Mares treated for 7 consecutive years have not returned to fertility, but several, while still infertile, have started ovulating again. There was no difference in survival rates between foals born to treated and untreated mares, and PZP treatment of pregnant mares did not affect subsequent fertility of their female offspring.  
  Address Science and Conservation Center, ZooMontana, Billings 59106, USA. zoolab@wtp.net  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1477-0415 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12220160 Approved no  
  Call Number refbase @ user @ Serial 141  
Permanent link to this record
 

 
Author Turner, A.; Kirkpatrick, J.F. openurl 
  Title Effects of immunocontraception on population, longevity and body condition in wild mares (Equus caballus) Type Journal Article
  Year 2002 Publication Reproduction (Cambridge, England) Supplement Abbreviated Journal Reprod Suppl  
  Volume 60 Issue Pages 187-195  
  Keywords Animals; *Animals, Wild; Antigens/administration & dosage; Body Constitution; Contraception, Immunologic/methods/*veterinary; Egg Proteins/administration & dosage; Female; *Horses; Longevity; Membrane Glycoproteins/administration & dosage; Population Control; Population Dynamics; *Receptors, Cell Surface; Swine; Vaccines, Contraceptive/administration & dosage  
  Abstract Contraception is becoming a common approach for the management of captive and wild ungulates yet there are few data for contraceptive effects on entire populations. Management-level treatment of mares with porcine zona pellucida (PZP) vaccine resulted in zero population growth of the Assateague Island wild horse population within 1 year of initiation of treatment. Contraceptive efficacy was 90% for mares treated twice in the first year and annually thereafter. For mares given a single initial inoculation, contraceptive efficacy was 78%. The effort required to achieve zero population growth decreased, as 95, 83 and 84% of all adult mares were treated in each of the first 3 years, compared with 59 and 52% during the last 2 years. Mortality rates for mares and foals after the initiation of management-level treatments decreased below historic and pretreatment mortality rates of approximately 5%. Two new age classes have appeared among treated animals (21-25 years and > 25 years), indicating an increase in longevity among treated animals. Body condition scores for all horses, all adult mares and non-lactating mares increased significantly between summer 1989 and autumn 1999 but did not change significantly in lactating mares. These results provide reliable data for the construction of realistic models for contraceptive management of free-roaming or captive ungulate populations.  
  Address Assateague Island National Seashore, Berlin, MD 21811, USA  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1477-0415 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12220158 Approved no  
  Call Number refbase @ user @ Serial 142  
Permanent link to this record
 

 
Author Kirkpatrick, J.F.; Turner, J.W.J.; Liu, I.K.; Fayrer-Hosken, R.; Rutberg, A.T. openurl 
  Title Case studies in wildlife immunocontraception: wild and feral equids and white-tailed deer Type Journal Article
  Year 1997 Publication Reproduction, fertility, and development Abbreviated Journal Reprod Fertil Dev  
  Volume 9 Issue 1 Pages 105-110  
  Keywords Animals; Antigens/immunology; Contraception, Immunologic/*veterinary; *Deer; *Equidae; Female; Immunization, Secondary; Pest Control/*methods; Pregnancy; Swine; Vaccines/administration & dosage; Zona Pellucida/immunology  
  Abstract Non-lethal management methods are required for wild equids that are protected by law and for deer inhabiting areas where lethal controls are not legal or safe. Single or multiple inoculations of porcine zona pellucida (PZP) vaccine have been delivered to wild horses and deer by means of darts. Contraceptive efficacy in horses after two inoculations ranged from 90% to 100%, and after a single inoculation ranged from 19% to 28%. Mares given a controlled-release form of the vaccine had foaling rates ranging from 7% to 20%. No detectable changes in social organization or behaviours among treated horses occurred. Contraceptive effects were reversible after 4 consecutive years of treatment but 5-7 years of treatment resulted in ovulation failure and decreased urinary oestrogen concentrations. Among deer, two inoculations were 70-100% effective in preventing fawns, but one inoculation yielded a contraceptive efficacy of < or = 20%, with pregnancies occurring late in the breeding season; a single annual booster inoculation reduced fertility to 20% in the second year. Energy costs of extended breeding seasons were less than those resulting from pregnancy. After two years of treatment, ovaries appeared normal. These studies suggest that PZP immunocontraception can be successfully applied to certain free-roaming populations of wild horses and deer.  
  Address ZooMontana, Billings 59108, USA  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1031-3613 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:9109199 Approved no  
  Call Number refbase @ user @ Serial 143  
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Author Turner, J.W.J.; Liu, I.K.; Kirkpatrick, J.F. openurl 
  Title Remotely delivered immunocontraception in free-roaming feral burros (Equus asinus) Type Journal Article
  Year 1996 Publication Journal of reproduction and fertility Abbreviated Journal J Reprod Fertil  
  Volume 107 Issue 1 Pages 31-35  
  Keywords Animals; *Animals, Wild; Contraception, Immunologic/methods/*veterinary; *Equidae; Feces/chemistry; Female; Pregnancy; Pregnancy Tests; Swine; Zona Pellucida/immunology  
  Abstract Regulation of local overpopulations of free-roaming feral equids is in demand worldwide for ecological balance and habitat preservation. Contraceptive vaccines have proven effective in feral horses, which breed seasonally, but no data are available for equids such as the burro, which is reproductively active all year round. In the present study, 27 individually identified female feral burros (Equus asinus) roaming free in Virgin Islands National Park (St John, US Virgin Islands; Lesser Antilles) were remotely treated with pig zonae pellucidae (PZP) vaccine. Between January and May, 16 burros were darted with a 1 ml emulsion of PZP plus Freund's adjuvant. Ten to twelve months later each treated burro was given a single booster injection of PZP plus adjuvant to maintain contraception through a second year. Eleven adult untreated jennies served as controls. Beginning one year after initial vaccination, these burros were monitored for pregnancy and foal production. Collection of data to determine treatment effect was not begun until 12 months after initial treatment to ensure that pregnancies existing before vaccination were not included. Pregnancy was assessed using previously validated methods for steroid metabolite measurement in fresh faecal samples. None of the PZP-treated burros produced foals between 0 and 12 months after the last inoculation. One PZP-treated burro tested positive for pregnancy at 10 months after the final inoculation. During this same period, six of 11 untreated burros tested pregnancy-positive, and four were observed with foals. There was no difference in pregnancy rates among treated, control and randomly sampled jennies between 12 and 24 months after the last inoculation. The results demonstrate that, in free-roaming feral burros that are reproductively active all year round: (1) burros can be accessed for remotely delivered PZP vaccination; (2) PZP contraception is effective; (3) PZP contraception is reversible; and (4) pregnancy can be reliably detected by faecal steroid analysis.  
  Address Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-4251 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8699431 Approved no  
  Call Number refbase @ user @ Serial 144  
Permanent link to this record
 

 
Author Kirkpatrick, J.F.; Liu, I.M.; Turner, J.W.J.; Naugle, R.; Keiper, R. openurl 
  Title Long-term effects of porcine zonae pellucidae immunocontraception on ovarian function in feral horses (Equus caballus) Type Journal Article
  Year 1992 Publication Journal of reproduction and fertility Abbreviated Journal J Reprod Fertil  
  Volume 94 Issue 2 Pages 437-444  
  Keywords Animals; Contraception, Immunologic/*veterinary; *Egg Proteins; Estrogens, Conjugated (USP)/urine; Female; Glycoproteins/*pharmacology; Horses/immunology/*physiology; *Membrane Glycoproteins; Ovary/drug effects/*physiology; Progesterone/metabolism; *Receptors, Cell Surface; Swine/immunology; Time Factors; Zona Pellucida/*immunology  
  Abstract Ten feral mares free-roaming in Maryland, USA, were inoculated with porcine zonae pellucidae (PZP) protein before the breeding season for three consecutive years (1988-90). Ovarian function was monitored for 51 days during the peak of the breeding season after the third annual PZP inoculation, in seven of these mares and in four untreated control mares, by means of urinary oestrone conjugates and nonspecific progesterone metabolites. None of the ten inoculated mares became pregnant in 1990, compared with 55% of 20 control mares, which included two of the four monitored for ovarian function. Three of the untreated mares demonstrated apparent normal ovarian activity, characterized by preovulatory oestrogen peaks, concurrent progesterone nadirs at ovulation, breeding activity, and luteal-phase progesterone increases after ovulation. Two of the seven monitored PZP-treated mares demonstrated ovulatory cycles that did not result in conception. One was pregnant as a result of conception in 1989 and demonstrated a normal, late-gestation, endocrine profile. The remaining four PZP-treated mares revealed no evidence of ovulation, and urinary oestrogen concentrations were significantly depressed. The experiments indicated that (i) a third consecutive annual PZP booster inoculation is greater than 90% effective in preventing pregnancies in mares and (ii) three consecutive years of PZP treatment may interfere with normal ovarian function as shown by markedly depressed oestrogen secretion.  
  Address Deaconess Research Institute, Billings, MT 59102  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-4251 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1317449 Approved no  
  Call Number refbase @ user @ Serial 145  
Permanent link to this record
 

 
Author Kirkpatrick, J.F.; Shldeler, S.E.; Lasley, B.L.; Turner, J.W.J. openurl 
  Title Pregnancy determination in uncaptured feral horses by means of fecal steroid conjugates Type Journal Article
  Year 1991 Publication Theriogenology Abbreviated Journal Theriogenology  
  Volume 35 Issue 4 Pages 753-760  
  Keywords  
  Abstract This study was carried out to develop an accurate, rapid and inexpensive method for diagnosing pregnancy in uncaptured feral horses by analysis of fecal steroid metabolites and to compare the accuracy of this method with diagnosis by urinary estrone conjugates (E(1)C). Paired urine and fecal samples were collected from 40 sexually mature feral mares during August and October. Urine samples were extracted directly from the soil and analyzed by enzymeimmunoassay (EIA) for E(1)C. Water extracts of fecal samples were assayed by EIA for E(1)C and nonspecific progesterone metabolites (iPdG). Urinary E(1)C, fecal E(1)C and fecal iPdG concentrations for seven mares which produced foals were 3.9 +/- 1.3 (SEM) mug/mg creatinine, 4.2 +/- 0.8 ng/g feces and 1.411 +/- 569.6 ng/g feces, respectively. Urinary E(1)C and fecal E(1)C and iPdG concentrations for the 33 mares which did not produce foals were 0.1 +/- 0.0 mug/mg creatinine and 0.5 +/- 0.1 and 32.8 +/- 4.5 ng/g feces, respectively. These differed (P < 0.01) from values in mares which produced foals.  
  Address Department of Biological Sciences Eastern Montana College Billings, MT 59101 USA  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0093-691X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16726944 Approved no  
  Call Number refbase @ user @ Serial 146  
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Author Kirkpatrick, J.F.; Wiesner, L.; Kenney, R.M.; Ganjam, V.K.; Turner, J.W. openurl 
  Title Seasonal variation in plasma androgens and testosterone in the North American wild horse Type Journal Article
  Year 1977 Publication The Journal of endocrinology Abbreviated Journal J Endocrinol  
  Volume 72 Issue 2 Pages 237-238  
  Keywords Androgens/*blood; Animals; Horses/*blood; Male; *Seasons; Testosterone/*blood  
  Abstract  
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-0795 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:845536 Approved no  
  Call Number refbase @ user @ Serial 148  
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Author Kirkpatrick, J.F.; Vail, R.; Devous, S.; Schwend, S.; Baker, C.B.; Wiesner, L. openurl 
  Title Diurnal variation of plasma testosterone in wild stallions Type Journal Article
  Year 1976 Publication Biology of reproduction Abbreviated Journal Biol Reprod  
  Volume 15 Issue 1 Pages 98-101  
  Keywords Animals; *Circadian Rhythm; Horses/*blood; Male; Montana; Sexual Behavior, Animal; Species Specificity; Testosterone/*blood  
  Abstract  
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-3363 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:986195 Approved no  
  Call Number refbase @ user @ Serial 149  
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Author Hertsch, B.; Becker, C. openurl 
  Title [Occurrence of aseptic necrosis of the palmar and plantar ligament in the horse--a contribution to the differentiation of sesamoid bone diseases] Type Journal Article
  Year 1986 Publication DTW. Deutsche tierarztliche Wochenschrift Abbreviated Journal Dtsch Tierarztl Wochenschr  
  Volume 93 Issue 6 Pages 263-266  
  Keywords Animals; Diagnosis, Differential; Horse Diseases/*pathology; Horses; Ligaments, Articular/*pathology; Osteonecrosis/*pathology; Sesamoid Bones/*pathology  
  Abstract  
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language German Summary Language Original Title Zum Vorkommen der aseptischen Nekrose im Ligamentum palmare bzw. plantare beim Pferd--ein Beitrag zur Differenzierung der Gleichbeinerkrankungen  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0341-6593 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3527654 Approved no  
  Call Number refbase @ user @ Serial 150  
Permanent link to this record
 

 
Author Kraus-Hansen, A.E.; Fackelman, G.E.; Becker, C.; Williams, R.M.; Pipers, F.S. openurl 
  Title Preliminary studies on the vascular anatomy of the equine superficial digital flexor tendon Type Journal Article
  Year 1992 Publication Equine veterinary journal Abbreviated Journal Equine Vet J  
  Volume 24 Issue 1 Pages 46-51  
  Keywords Angiography/veterinary; Animals; Exercise Test/veterinary; Forelimb; Horses/*anatomy & histology/surgery; Microcirculation; Microscopy, Electron, Scanning; Tendons/*blood supply/surgery/ultrastructure  
  Abstract The vascular and microvascular anatomy of normal equine superficial digital flexor tendons was studied by dissection of vinyl-perfused specimens and by microangiography on high detail film. The presence of an extensive intratendinous vascular latticework was confirmed, and a 'nutrient artery' described closely associated with the accessory ligament of the superficial digital flexor tendon (proximal check ligament). Circumferential stripping of the paratenon from the tendon to eliminate afferent vessels was performed bilaterally in three horses and unilaterally in a fourth, followed by a treadmill training regimen. No resulting intratendinous lesions could be documented on gross post mortem and histological examination at three, 10, or 35 days post operatively. There was mild paratendinous proliferation in all instances. In one horse, four intratendinous ligatures were placed within the medial and lateral borders of the contralateral tendon to isolate further from its blood supply a 10 cm segment. Gross lesions at 35 days post operatively included a marked paratendinous response involving the entire 10 cm segment, and a darkened, soft focus within the core of the tendon. Histopathology and electron microscopy demonstrated focal degeneration. It was concluded that the blood supply of the normal equine superficial digital flexor tendon is primarily intratendinous, rather than paratendinous as previously thought. The lesions in one horse similar to those in naturally occurring tendinitis supported a vascular aetiology of the disease, and set the groundwork for studies aimed at the development of a clinically relevant tendinitis model.  
  Address Department of Surgery, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0425-1644 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1555540 Approved no  
  Call Number refbase @ user @ Serial 151  
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