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Author Schmoldt, A.; Benthe, H.F.; Haberland, G. openurl 
  Title Digitoxin metabolism by rat liver microsomes Type Journal Article
  Year 1975 Publication Biochemical pharmacology Abbreviated Journal Biochem Pharmacol  
  Volume 24 Issue 17 Pages 1639-1641  
  Keywords Animals; Chromatography, Thin Layer; Digitoxigenin/metabolism; Digitoxin/*metabolism; Hydroxylation; Male; Microsomes, Liver/*metabolism; NADP/metabolism; Rats; Time Factors  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-2952 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:10 Approved no  
  Call Number Admin @ knut @ Serial 20  
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Author Jallon, J.M.; Risler, Y.; Iwatsubo, M. openurl 
  Title Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH Type Journal Article
  Year 1975 Publication Biochemical and biophysical research communications Abbreviated Journal Biochem Biophys Res Commun  
  Volume 67 Issue 4 Pages 1527-1536  
  Keywords Animals; Cattle; Glutamate Dehydrogenase/*metabolism; Ketoglutaric Acids; Kinetics; Liver/*enzymology; Nadp; Oxidation-Reduction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-291X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1038 Approved no  
  Call Number Admin @ knut @ Serial 21  
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Author Rodier, F. openurl 
  Title [Spectral properties of porcine plasminogen: study of the acidic transition (author's transl)] Type Journal Article
  Year 1976 Publication European journal of biochemistry / FEBS Abbreviated Journal Eur J Biochem  
  Volume 63 Issue 2 Pages 553-562  
  Keywords Animals; Binding Sites; Guanidines; Hydrogen-Ion Concentration; *Plasminogen; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Swine; Temperature  
  Abstract The acidic transition of porcine plasminogen, prepared by affinity chromatography, was studied by non-destructive methods. These methods are based on the analysis of the behaviour of the tryptophyls under various conditions. The perturbation of the absorption and emission spectra by pH or temperature and the dynamic quenching of the intrinsic fluorescence are used to obtain information on structural changes which affect the environment of these residues. It is shown that by decreasing pH the fluorescence emission spectra are shifted toward the long wavelengths, with a broadening of the fluorescence band. The same effect can be obtained at constant pH by heating the protein solution. In order to analyze these phenomena, it is assumed that the fluorescence intensities at 355 nm and 328 nm reflect the proportion of the tryptophans which are exposed to the solvent, and buried, respectively. The plot of the ratio of the fluorescence intensities at these wavelengths versus pH or temperature leads to a titration curve showing an unmasking of tryptophans. The proportion of exposed tryptophans is measured by the dynamic fluorescence quenching technique and the data analyzed according to Lehrer. The plot of the fraction of exposed tryptophyls versus pH also shows the unmasking of these chromophores. Thermal perturbation of a solution of plaminogen at neutral pH induces a difference absorption spectrum whose amplitudes at the maxima are proportional to the number of exposed aromatic residues. The comparison with a solution of fully denatured plasminogen in 6 M guanidium chloride, where all the tryptophyls are exposed, shows that the percentage of exposure is equal to 59%. This number is significantly higher than the percentage found by the fluorescence quenching technique (20%), indicating that some tryptophyls are located in crevices, exposed to the solvent but not to the iodide. At acidic pH the absorption difference spectra induced by thermal perturbation are not classical, since they show an inversion and a new band between 300 nm and 305 nm. This band is mentioned in the literature as a minor band of tryptophan which appears when this chromophore is located in an asymmetric environment. On plotting the maximum amplitude of these spectra obtained at acidic pH versus temperature, we obtain a curve indicating that two types of antagonistic interactions are involved in the perturbation of the chromophores spectra. The spectrophotometric titration of plasminogen gives classical absorption difference spectra. By plotting the maximum amplitude at 292 nm versus pH, we obtain a titration curve with an apparent pK of 2.9 units. This pK is acidic which respect to the pK value of a normal carboxyl. This low value can be due to a positively charged group in the neighbourhood of a carboxyl, which interacts with one or more chromophores. When the carboxyl becomes protonated, this positively charged group is free and available to perturb the environment of some chromophores...  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language French Summary Language Original Title Proprietes spectrales du plasminogene porcin. Etude de la transition acide  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0014-2956 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:4326 Approved no  
  Call Number Admin @ knut @ Serial 22  
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Author Houpt, K.A. openurl 
  Title Why horse behaviour is important to the equine clinician Type Journal Article
  Year 2006 Publication Equine veterinary journal Abbreviated Journal Equine Vet J  
  Volume 38 Issue 5 Pages 386-387  
  Keywords Accidents, Occupational/prevention & control; Aggression; Animals; *Behavior, Animal/physiology; Clinical Competence; Fear; Horses/*physiology; Humans; Veterinarians/psychology; Veterinary Medicine/*standards  
  Abstract  
  Address Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0425-1644 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16986596 Approved no  
  Call Number refbase @ user @ Serial 30  
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Author Virga, V.; Houpt, K.A. openurl 
  Title Prevalence of placentophagia in horses Type Journal Article
  Year 2001 Publication Equine veterinary journal Abbreviated Journal Equine Vet J  
  Volume 33 Issue 2 Pages 208-210  
  Keywords Animals; *Behavior, Animal; Colic/epidemiology/*veterinary; Exploratory Behavior; *Feeding Behavior; Female; Horse Diseases/*epidemiology; Horses; Incidence; New York/epidemiology; *Placenta; Postpartum Period; Pregnancy; Prevalence; Questionnaires  
  Abstract  
  Address Animal Behavior Clinic, Cornell University Hospital for Animals, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0425-1644 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:11266073 Approved no  
  Call Number refbase @ user @ Serial 31  
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Author Houpt, K.A.; Eggleston, A.; Kunkle, K.; Houpt, T.R. openurl 
  Title Effect of water restriction on equine behaviour and physiology Type Journal Article
  Year 2000 Publication Equine veterinary journal Abbreviated Journal Equine Vet J  
  Volume 32 Issue 4 Pages 341-344  
  Keywords Animals; *Behavior, Animal; Blood Proteins/analysis; Energy Intake; Female; Horse Diseases/physiopathology; Horses/*physiology; Osmolar Concentration; Pregnancy; Stress/veterinary; Video Recording; Water Deprivation/*physiology  
  Abstract Six pregnant mares were used to determine what level of water restriction causes physiological and/or behavioural changes indicative of stress. Nonlegume hay was fed ad libitum. During the first week of restriction, 5 l water/100 kg bwt was available, during the second week 4 l/100 kg bwt and, during the third week, 3 l/100 kg bwt. Ad libitum water intake was 6.9 l/100 kg bwt; at 3 l/100 kg bwt water intake was 42% of this. Daily hay intake fell significantly with increasing water restriction from 12.9 +/- 0.75 kg to 8.3 +/- 0.54 kg; bodyweight fell significantly for a total loss of 48.5 +/- 8.3 kg in 3 weeks. Daily blood samples were analysed; osmolality rose significantly with increasing water restriction from 282 +/- 0.7 mosmols/kg to 293.3 +/- 0.8 mosmols/kg bwt, but plasma protein and PCV did not change significantly. Cortisol concentrations fell from 8.1 ng/ml to 6.4 ng/ml over the 3 week period. Aldosterone fell from 211.3 +/- 74.2 pg/ml to 92.5 +/- 27.5 pg/ml at the end of the first week. The behaviour of 4 of the 6 mares was recorded 24 h/day for the duration of the study. The only significant difference was in time spent eating, which decreased with increasing water restriction from 46 +/- 3% to 30 +/- 3%. It is concluded that water restriction to 4 l/100 kg bwt dehydrates pregnant mares and may diminish their welfare, but is not life- or pregnancy-threatening.  
  Address Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0425-1644 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:10952384 Approved no  
  Call Number refbase @ user @ Serial 32  
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Author Turpeinen, O. openurl 
  Title Effect of cholesterol-lowering diet on mortality from coronary heart disease and other causes Type Journal Article
  Year 1979 Publication Circulation Abbreviated Journal Circulation  
  Volume 59 Issue 1 Pages 1-7  
  Keywords Coronary Disease/blood/*mortality/prevention & control; Dairy Products; *Dietary Fats; *Fats, Unsaturated; Finland; Humans; Hypercholesterolemia/complications/*diet therapy/mortality; Male; Middle Aged; Neoplasms/mortality  
  Abstract International statistics indicate that there is a close correlation between the consumption of saturated fats (dairy fats and meat fats) and the mortality from coronary heart disease (CHD), and this conception has been confirmed by many epidemiological studies. Such studies alone, however, cannot prove the existence of a cause-and-effect relationship between these two variables; dietary intervention trials are needed. The Finnish Mental Hospital Study was such a trial, conducted in two hospitals near Helsinki in 1959--1971. Practically total replacement of dairy fats by vegetable oils in the diets of these hospitals was followed by a substantial reduction in the mortality of men from CHD. Total mortality also appeared to be reduced. As to the causes of death other than CHD, none was significantly influenced by dietary change. This was also true for malignant neoplasms. To alleviate the burden of CHD on public health, many investigators have recommended important changes in the quantity and quality of dietary fats.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0009-7322 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:758101 Approved no  
  Call Number refbase @ user @ Serial 33  
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Author Houpt, K.A. openurl 
  Title New perspectives on equine stereotypic behaviour Type Editorial
  Year 1995 Publication Equine veterinary journal Abbreviated Journal Equine Vet J  
  Volume 27 Issue 2 Pages 82-83  
  Keywords Animals; Horses/*psychology; Stereotyped Behavior/*physiology  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0425-1644 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:7607153 Approved no  
  Call Number refbase @ user @ Serial 34  
Permanent link to this record
 

 
Author Aviad, A.D.; Houpt, J.B. openurl 
  Title The molecular weight of therapeutic hyaluronan (sodium hyaluronate): how significant is it? Type Journal Article
  Year 1994 Publication The Journal of rheumatology Abbreviated Journal J Rheumatol  
  Volume 21 Issue 2 Pages 297-301  
  Keywords Animals; Horse Diseases/drug therapy; Horses; Humans; Hyaluronic Acid/*chemistry/*therapeutic use; Joint Diseases/*drug therapy/veterinary; Molecular Weight; Osteoarthritis/drug therapy/veterinary; Synovial Fluid/drug effects/physiology; Viscosity  
  Abstract Various molecular weight hyaluronic acid (HA) preparations have been injected into joints for the treatment of human and equine osteoarthritis. A therapeutic advantage has been claimed for commercial products with a molecular weight in the range found in normal synovial fluid (SF), compared to lower molecular weight products. But a correlation between molecular weight and efficacy is not borne out by an analysis of the available literature on clinical results. SF viscosity, HA concentration, HA molecular weight and rate of synthesis in joint disease. It is proposed that the beneficial effect of injected HA in joint disease may be due to pharmacological rather than to physical properties.  
  Address Rheumatic Disease Unit, Mount Sinai Hospital, University of Toronto, ON, Canada  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0315-162X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8182640 Approved no  
  Call Number refbase @ user @ Serial 35  
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Author Houpt, K.A.; Feldman, J. openurl 
  Title Animal behavior case of the month. Aggression toward a neonatal foal by its dam Type Journal Article
  Year 1993 Publication Journal of the American Veterinary Medical Association Abbreviated Journal J Am Vet Med Assoc  
  Volume 203 Issue 9 Pages 1279-1280  
  Keywords Animals; Animals, Newborn; *Behavior, Animal; Female; Follow-Up Studies; Horses/*psychology; *Maternal Behavior; Rejection (Psychology); Restraint, Physical/veterinary  
  Abstract  
  Address Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up)  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0003-1488 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:8253618 Approved no  
  Call Number refbase @ user @ Serial 36  
Permanent link to this record
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