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Author (up) Bosch, O.J.; Nair, H.P.; Ahern, T.H.; Neumann, I.D.; Young, L.J. doi  openurl
  Title The CRF System Mediates Increased Passive Stress-Coping Behavior Following the Loss of a Bonded Partner in a Monogamous Rodent Type Journal Article
  Year 2008 Publication Abbreviated Journal Neuropsychopharmacology  
  Volume 34 Issue 6 Pages 1406-1415  
  Keywords prairie vole; passive stress-coping; forced swim test; tail suspension test; elevated plus-maze; hypothalamo–pituitary–adrenal axis  
  Abstract Social relationships significantly influence physiology and behavior, including the hypothalamo–pituitary–adrenal axis, anxiety, and mental

health. Disruption of social bonds through separation or death often results in profound grieving, depression, and physical illness. As the

monogamous prairie vole forms enduring, selective pair bonds with the mating partner, they provide an animal model to study the

physiological consequences of pair bonding and, thus, the loss of the bonded partner. Male prairie voles were paired with a novel female

or male sibling. After 5 days, half of the males of each group were separated from the partner. Elevated plus-maze, forced swim, and tail

suspension tests were used to assess anxiety-like and passive stress-coping behaviors indicative of depressive-like behavior. Following 4

days of separation from the female but not the male partner, experimental males displayed increased passive stress-coping. This effect

was abolished by long-term intracerebroventricular infusion of a nonselective corticotropin-releasing factor (CRF) receptor antagonist

without disrupting the bond itself. Both CRF type 1 and 2 receptors were involved in the emergence of passive stress-coping behavior.

Furthermore, pairing with a female was associated with elevated CRF mRNA in the bed nucleus of the stria terminalis, and partner loss

elicited a pronounced increase in circulating corticosteroid and adrenal weight. We speculate that the CRF system may mediate an

aversive affect following separation from the female partner, which may facilitate proximity seeking between the pair-bonded individuals.

Hence, the prairie vole model may provide insights into brain mechanisms involved in the psychopathological consequences of partner

  Corporate Author Thesis  
  Publisher American College of Neuropsychopharmacology Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0893-133x ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number Equine Behaviour @ team @ Serial 5731  
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