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| Author | Gilmanshin, R.; Callender, R.H.; Dyer, R.B. | ||||
| Title | The core of apomyoglobin E-form folds at the diffusion limit | Type | Journal Article | ||
| Year | 1998 | Publication | Nature Structural Biology | Abbreviated Journal | Nat Struct Biol |
| Volume | 5 | Issue | 5 | Pages  |
363-365 |
| Keywords | Animals; Apoproteins/*chemistry; Diffusion; Horses; Myoglobin/*chemistry; *Protein Folding; Spectroscopy, Fourier Transform Infrared; Temperature | ||||
| Abstract | The E-form of apomyoglobin has been characterized using infrared and fluorescence spectroscopies, revealing a compact core with native like contacts, most probably consisting of 15-20 residues of the A, G and H helices of apomyoglobin. Fast temperature-jump, time-resolved infrared measurements reveal that the core is formed within 96 micros at 46 degrees C, close to the diffusion limit for loop formation. Remarkably, the folding pathway of the E-form is such that the formation of a limited number of native-like contacts is not rate limiting, or that the contacts form on the same time scale expected for diffusion controlled loop formation. | ||||
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| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
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| Series Volume | Series Issue | Edition | |||
| ISSN | 1072-8368 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:9586997 | Approved | no | ||
| Call Number | Equine Behaviour @ team @ | Serial | 3795 | ||
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