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Czeh, B.; Muller-Keuker, J.I.H.; Rygula, R.; Abumaria, N.; Hiemke, C.; Domenici, E.; Fuchs, E. |
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Title |
Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment |
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Journal Article |
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Year |
2006 |
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Abbreviated Journal |
Neuropsychopharmacology |
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Volume |
32 |
Issue |
7 |
Pages |
1490-1503 |
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Keywords |
neurogenesis, stereology, cell number, glia, NG2, hippocampus |
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Abstract |
Profound neuroplastic changes have been demonstrated in various limbic structures after chronic stress exposure and antidepressant treatment in animal models of mood disorders. Here, we examined in rats the effect of chronic social stress and concomitant antidepressant treatment on cell proliferation in the medial prefrontal cortex (mPFC). We also examined possible hemispheric differences. Animals were subjected to 5 weeks of daily social defeat by an aggressive conspecific and received concomitant, daily, oral fluoxetine (10 mg/kg) during the last 4 weeks. Bromodeoxyuridine (BrdU) labeling and quantitative stereological techniques were used to evaluate the treatment effects on proliferation and survival of newborn cells in limbic structures such as the mPFC and the hippocampal dentate gyrus, in comparison with nonlimbic structures such as the primary motor cortex and the subventricular zone. Phenotypic analysis showed that neurogenesis dominated the dentate gyrus, whereas in the mPFC most newborn cells were glia, with smaller numbers of endothelial cells. Chronic stress significantly suppressed cytogenesis in the mPFC and neurogenesis in the dentate gyrus, but had minor effect in nonlimbic structures. Fluoxetine treatment counteracted the inhibitory effect of stress. Hemispheric comparison revealed that the rate of cytogenesis was significantly higher in the left mPFC of control animals, whereas stress inverted this asymmetry, yielding a significantly higher incidence of newborn cells in the right mPFC. Fluoxetine treatment abolished hemispheric asymmetry in both control and stressed animals. These pronounced changes in gliogenesis after chronic stress exposure may relate to the abnormalities of glial cell numbers reported in the frontolimbic areas of depressed patients. |
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0893-133x |
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Equine Behaviour @ team @ |
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5785 |
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Author |
Teicher, M.H.; Tomoda, A.; Andersen, S.L. |
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Title |
Neurobiological Consequences of Early Stress and Childhood Maltreatment: Are Results from Human and Animal Studies Comparable? |
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Journal Article |
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Year |
2006 |
Publication |
Annals of the New York Academy of Sciences |
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Volume |
1071 |
Issue |
1 |
Pages |
313-323 |
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Keywords |
adolescence; maltreatment; hippocampus; corpus callosum; translational research; sensitive periods; stress; abuse or neglect |
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Abstract |
Abstract: Recent studies have reported an association between exposure to childhood abuse or neglect and alterations in brain structure or function. One limitation of these studies is that they are correlational and do not provide evidence of a cause–effect relationship. Preclinical studies on the effects of exposure to early life stress can demonstrate causality, and can enrich our understanding of the clinical research if we hypothesize that the consequences of early abuse are predominantly mediated through the induction of stress responses. Exposure to early abuse and early stress has each been associated with the emergence of epileptiform electroencephalogram (EEG) abnormalities, alterations in corpous callosum area, and reduced volume or synaptic density of the hippocampus.Further, there is evidence that different brain regions have unique periods when they are maximally sensitive to the effects of early stress. To date, preclinical studies have guided clinical investigations and will continue to provide important insight into studies on molecular mechanisms and gene–environment interactions. |
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Blackwell Publishing Inc |
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1749-6632 |
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Equine Behaviour @ team @ |
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5784 |
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Reboreda, J.C.; Clayton, N.S.; Kacelnik, A. |
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Title |
Species and sex differences in hippocampus size in parasitic and non-parasitic cowbirds |
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Journal Article |
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Year |
1996 |
Publication |
Neuroreport |
Abbreviated Journal |
Neuroreport |
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Volume |
7 |
Issue |
2 |
Pages |
505-508 |
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Keywords |
Animals; Birds/*physiology; Female; Hippocampus/*anatomy & histology; Male; Nesting Behavior/*physiology; Sex Characteristics; Species Specificity; Telencephalon/anatomy & histology |
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Abstract |
To test the hypothesis that selection for spatial abilities which require birds to locate and to return accurately to host nests has produced an enlarged hippocampus in brood parasites, three species of cowbird were compared. In shiny cowbirds, females search for host nests without the assistance of the male; in screaming cowbirds, males and females inspect hosts' nests together; in bay-winged cowbirds, neither sex searches because this species is not a brood parasite. As predicted, the two parasitic species had a relatively larger hippocampus than the non-parasitic species. There were no sex differences in relative hippocampus size in screaming or bay-winged cowbirds, but female shiny cowbirds had a larger hippocampus than the male. |
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Instituto de Biologia y Medicina Experimental-CONICET, Buenos Aires, Argentina |
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English |
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0959-4965 |
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PMID:8730816 |
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Call Number |
Equine Behaviour @ team @ |
Serial |
4798 |
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Author |
Dusek, J.A.; Eichenbaum, H. |
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Title |
The hippocampus and memory for orderly stimulus relations |
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Journal Article |
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Year |
1997 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
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Volume |
94 |
Issue |
13 |
Pages |
7109-7114 |
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Keywords |
Animals; Attention; Discrimination (Psychology)/physiology; Hippocampus/anatomy & histology/*physiology; Male; Memory/*physiology; Rats |
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Abstract |
Human declarative memory involves a systematic organization of information that supports generalizations and inferences from acquired knowledge. This kind of memory depends on the hippocampal region in humans, but the extent to which animals also have declarative memory, and whether inferential expression of memory depends on the hippocampus in animals, remains a major challenge in cognitive neuroscience. To examine these issues, we used a test of transitive inference pioneered by Piaget to assess capacities for systematic organization of knowledge and logical inference in children. In our adaptation of the test, rats were trained on a set of four overlapping odor discrimination problems that could be encoded either separately or as a single representation of orderly relations among the odor stimuli. Normal rats learned the problems and demonstrated the relational memory organization through appropriate transitive inferences about items not presented together during training. By contrast, after disconnection of the hippocampus from either its cortical or subcortical pathway, rats succeeded in acquiring the separate discrimination problems but did not demonstrate transitive inference, indicating that they had failed to develop or could not inferentially express the orderly organization of the stimulus elements. These findings strongly support the view that the hippocampus mediates a general declarative memory capacity in animals, as it does in humans. |
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Department of Psychology, Boston University, 64 Cummington Street, Boston, MA 02215, USA |
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0027-8424 |
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Notes |
PMID:9192700 |
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no |
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Call Number |
refbase @ user @ |
Serial |
607 |
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Author |
Hampton, R.R.; Sherry, D.F.; Shettleworth, S.J.; Khurgel, M.; Ivy, G. |
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Title |
Hippocampal volume and food-storing behavior are related in parids |
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Journal Article |
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Year |
1995 |
Publication |
Brain, behavior and evolution |
Abbreviated Journal |
Brain Behav Evol |
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Volume |
45 |
Issue |
1 |
Pages |
54-61 |
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Keywords |
Animals; Appetitive Behavior/*physiology; Birds/*anatomy & histology; Brain Mapping; Evolution; Food Preferences/physiology; Hippocampus/*anatomy & histology; Mental Recall/*physiology; Orientation/*physiology; Predatory Behavior/physiology; Social Environment; Species Specificity |
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The size of the hippocampus has been previously shown to reflect species differences and sex differences in reliance on spatial memory to locate ecologically important resources, such as food and mates. Black-capped chickadees (Parus atricapillus) cached more food than did either Mexican chickadees (P. sclateri) or bridled titmice (P. wollweberi) in two tests of food storing, one conducted in an aviary and another in smaller home cages. Black-capped chickadees were also found to have a larger hippocampus, relative to the size of the telencephalon, than the other two species. Differences in the frequency of food storing behavior among the three species have probably produced differences in the use of hippocampus-dependent memory and spatial information processing to recover stored food, resulting in graded selection for size of the hippocampus. |
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Department of Psychology, University of Toronto, Ontario, Canada |
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0006-8977 |
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PMID:7866771 |
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Call Number |
refbase @ user @ |
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379 |
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Author |
Krebs, J.R.; Clayton, N.S.; Hampton, R.R.; Shettleworth, S.J. |
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Title |
Effects of photoperiod on food-storing and the hippocampus in birds |
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Journal Article |
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Year |
1995 |
Publication |
Neuroreport |
Abbreviated Journal |
Neuroreport |
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Volume |
6 |
Issue |
12 |
Pages |
1701-1704 |
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Keywords |
Animals; Birds; Eating/*physiology; Female; Hippocampus/*physiology; Light; Male; *Photoperiod; Seasons; Telencephalon/physiology; Time Factors |
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Abstract |
Birds that store food have a relatively large hippocampus compared to non-storing species. The hippocampus shows seasonal differences in neurogenesis and volume in black-capped chikadees (Parus atricapillus) taken from the wild at different times of year. We compared hippocampal volumes in black-capped chickadees captured at the same time but differing in food-storing behaviour because of manipulations of photoperiod in the laboratory. Differences in food-storing behaviour were not accompanied by differences in the volume of the hippocampus. Hippocampal volumes also did not differ between two groups of a non-food-storing control species, house sparrows (Passer domesticus), exposed to the same conditions as the chickadees. |
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Edward Grey Institute of Field Ornithology, Department of Zoology, Oxford, UK |
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0959-4965 |
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PMID:8527745 |
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Call Number |
refbase @ user @ |
Serial |
378 |
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Author |
Hampton, R.R.; Shettleworth, S.J. |
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Title |
Hippocampal lesions impair memory for location but not color in passerine birds |
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Journal Article |
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Year |
1996 |
Publication |
Behavioral neuroscience |
Abbreviated Journal |
Behav Neurosci |
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Volume |
110 |
Issue |
4 |
Pages |
831-835 |
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Keywords |
Animals; Appetitive Behavior/physiology; Birds/*physiology; Brain Mapping; Color Perception/*physiology; Discrimination Learning/physiology; Hippocampus/*physiology; Long-Term Potentiation/physiology; Mental Recall/*physiology; Orientation/*physiology; Species Specificity |
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Abstract |
The effects of hippocampal complex lesions on memory for location and color were assessed in black-capped chickadees (Parus atricapillus) and dark-eyed juncos (Junco hyemalis) in operant tests of matching to sample. Before surgery, most birds were more accurate on tests of memory for location than on tests of memory for color. Damage to the hippocampal complex caused a decline in memory for location, whereas memory for color was not affected in the same birds. This dissociation indicates that the avian hippocampus plays an important role in spatial cognition and suggests that this brain structure may play no role in working memory generally. |
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Department of Psychology, University of Toronto, Ontario, Canada |
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0735-7044 |
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PMID:8864273 |
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refbase @ user @ |
Serial |
376 |
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Author |
Shettleworth, S.J. |
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Title |
Memory and hippocampal specialization in food-storing birds: challenges for research on comparative cognition |
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Journal Article |
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Year |
2003 |
Publication |
Brain, behavior and evolution |
Abbreviated Journal |
Brain Behav Evol |
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Volume |
62 |
Issue |
2 |
Pages |
108-116 |
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Keywords |
Animals; Birds/*physiology; Cognition/*physiology; Color Perception/physiology; Feeding Behavior/*physiology; Hippocampus/*physiology; Memory/*physiology; Species Specificity |
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Abstract |
The three-way association among food-storing behavior, spatial memory, and hippocampal enlargement in some species of birds is widely cited as an example of a new 'cognitive ecology' or 'neuroecology.' Whether this relationship is as strong as it first appears and whether it might be evidence for an adaptive specialization of memory and hippocampus in food-storers have recently been the subject of some controversy [Bolhuis and Macphail, 2001; Macphail and Bolhuis, 2001]. These critiques are based on misconceptions about the nature of adaptive specializations in cognition, misconceptions about the uniformity of results to be expected from applying the comparative method to data from a wide range of species, and a narrow view of what kinds of cognitive adaptations are theoretically interesting. New analyses of why food-storers (black-capped chickadees, Poecile Atricapilla) respond preferentially to spatial over color cues when both are relevant in a memory task show that this reflects a relative superiority of spatial memory as compared to memory for color rather than exceptional spatial attention or spatial discrimination ability. New studies of chickadees from more or less harsh winter climates also support the adaptive specialization hypothesis and suggest that within-species comparisons may be especially valuable for unraveling details of the relationships among ecology, memory, and brain in food-storing species. |
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Department of Psychology, University of Toronto, Toronto, Ont., M5S 3G3, Canada. shettle@psych.utoronto.ca |
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0006-8977 |
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PMID:12937349 |
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Call Number |
refbase @ user @ |
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367 |
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