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	Author	Steiner, M.
	Title	Biomechanics of tendon healing			Type	Journal Article
	Year	1982	Publication	Journal of Biomechanics	Abbreviated Journal	J Biomech
	Volume	15	Issue	12	Pages	951-958
	Keywords	Achilles Tendon/injuries; Animals; Biomechanics; Rats; Tendon Injuries/pathology/physiopathology; Tensile Strength; Time Factors; Wound Healing
	Abstract	The biomechanics of tendon healing was investigated with unsutured rat achilles tendons. After two, three, and four weeks of healing tensile parameters were assayed with a bone-muscle-tendon-bone preparation elongated to failure at a controlled physiological strain rate. In the third week of healing, stiffness, strength, and energy absorbing capacity all increased approximately 50%. These changes correlated with early fibroplasia. In the fourth week of healing, strength, energy absorbing capacity and elongation to failure all increased relatively more than stiffness. Histologically, larger fibers with better longitudinal alignment developed during this period. At the end of four weeks the tendon's strength was approximately 25% of normal. To summarize, the return of stiffness in a healing tendon preparation correlated with the presence of fibroplasia and the return of other tensile parameters was a function of the amount and organization of the fibroplasia.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0021-9290	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:7166555			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4448
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	Author	Zhang, T.-Y.; Parent, C.; Weaver, I.; Meaney, M.J.
	Title	Maternal programming of individual differences in defensive responses in the rat			Type	Journal Article
	Year	2004	Publication	Annals of the New York Academy of Sciences	Abbreviated Journal	Ann N Y Acad Sci
	Volume	1032	Issue		Pages	85-103
	Keywords	Adaptation, Biological; Aggression/physiology; Animals; Evolution; Female; Gene Expression/physiology; Humans; Individuality; Maternal Behavior; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Stress, Psychological/physiopathology
	Abstract	This paper describes the results of a series of studies showing that variations in mother-pup interactions program the development of individual differences in behavioral and endocrine stress responses in the rat. These effects are associated with altered expression of genes in brain regions, such as the amygdala, hippocampus, and hypothalamus, that regulate the expression of stress responses. Studies from evolutionary biology suggest that such “maternal effects” are common and often associated with variations in the quality of the maternal environment. Together these findings suggest an epigenetic process whereby the experience of the mother alters the nature of the parent-offspring interactions and thus the phenotype of the offspring.
	Address	McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 boul. LaSalle, Montreal (Quebec), Canada H4H 1R3
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0077-8923	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15677397			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4132
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	Author	Healy, S.D.; Braham, S.R.; Braithwaite, V.A.
	Title	Spatial working memory in rats: no differences between the sexes			Type	Journal Article
	Year	1999	Publication	Proceedings. Biological Sciences / The Royal Society	Abbreviated Journal	Proc Biol Sci
	Volume	266	Issue	1435	Pages	2303-2308
	Keywords	Animals; Estrus/metabolism; Female; Male; Memory/*physiology; Rats; Sex Factors; Swimming
	Abstract	In a number of mammalian species, males appear to have superior spatial abilities to females. The favoured explanations for this cognitive difference are hormonal, with higher testosterone levels in males than females leading to better spatial performance, and evolutionary, where sexual selection has favoured males with increased spatial abilities for either better navigational skills in hunting or to enable an increased territory size. However, an alternative explanation for this sex difference focuses on the role of varying levels of oestrogen in females in spatial cognition (the 'fertility and parental care' hypothesis). One possibility is that varying oestrogen levels result in variation in spatial learning and memory so that, when tested across the oestrous cycle, females perform as well as males on days of low oestrogen but more poorly on days of high oestrogen. If day in the oestrous cycle is not taken into account then, across an experiment, any sex differences found would always produce male superiority. We used a spatial working memory task in a Morris water maze to test the spatial learning and memory abilities of male and female rats. The rats were tested across a number of consecutive days during which the females went through four oestrous cycles. We found no overall sex differences in latencies to reach a submerged platform in a Morris water maze but, on the day of oestrus (low oestrogen), females took an extra swim to learn the platform's location (a 100% increase over the other days in the cycle). Female swim speed also varied across the oestrous cycle but females were no less active on the day of oestrus. These results oppose the predictions of the fertility and parental care hypothesis.
	Address	Department of Psychology, University of Newcastle, UK. s.healey@ed.ac.uk
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0962-8452	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:10629980			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	2818
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	Author	Gibson, B.M.; Shettleworth, S.J.
	Title	Place versus response learning revisited: tests of blocking on the radial maze			Type	Journal Article
	Year	2005	Publication	Behavioral neuroscience	Abbreviated Journal	Behav Neurosci
	Volume	119	Issue	2	Pages	567-586
	Keywords	Animals; Association Learning; Male; Maze Learning; Memory; Rats; Rats, Long-Evans; Reproducibility of Results
	Abstract	Neurobiological and behavioral research indicates that place learning and response learning occur simultaneously, in parallel. Such findings seem to conflict with theories of associative learning in which different cues compete for learning. The authors conducted place+response training on a radial maze and then tested place learning and response learning separately by reconfiguring the maze in various ways. Consistent with the effects of manipulating place and response systems in the brain (M. G. Packard & J. L. McGaugh, 1996), well-trained rats showed strong place learning and strong response learning. Three experiments using associative blocking paradigms indicated that prior response learning interferes with place learning. Blocking and related tests can be used to better understand how memory systems interact during learning.
	Address	Department of Psychology, University of New Hampshire, Durham, NH 03824-3567, USA. bgibson@cisunix.unh.edu
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0735-7044	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15839803			Approved	no
	Call Number	refbase @ user @			Serial	362
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	Author	Zentall, T.R.; Kaiser, D.H.
	Title	Interval timing with gaps: gap ambiguity as an alternative to temporal decay			Type	Journal Article
	Year	2005	Publication	Journal of experimental psychology. Animal behavior processes	Abbreviated Journal	J Exp Psychol Anim Behav Process
	Volume	31	Issue	4	Pages	484-486
	Keywords	Animals; Behavior, Animal; Discrimination (Psychology)/physiology; Memory/physiology; Rats; Time Perception/*physiology
	Abstract	C. V. Buhusi, D. Perera, and W. H. Meck (2005) proposed a hypothesis of timing in rats to account for the results of experiments that have used the peak procedure with gaps. According to this hypothesis, the introduction of a gap causes the animal's memory for the pregap interval to passively decay (subjectively shorten) in direct proportion to the duration and salience of the gap. Thus, animals should pause with short, nonsalient gaps but should reset their clock with longer, salient gaps. The present authors suggest that the ambiguity of the gap (i.e., the similarity between the gap and the intertrial interval in both appearance and relative duration) causes the animal to actively reset the clock and prevents adequate assessments of the fate of timed intervals prior to the gap. Furthermore, when the intertrial interval is discriminable from the gap, the evidence suggests that timed intervals prior to the gap are not lost but are retained in memory.
	Address	Department of Psychology, University of Kentucky, Lexington, KY 40506, USA. zentall@uky.edu
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0097-7403	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:16248734			Approved	no
	Call Number	refbase @ user @			Serial	220
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	Author	Skov-Rackette, S.I.; Shettleworth, S.J.
	Title	What do rats learn about the geometry of object arrays? Tests with exploratory behavior			Type	Journal Article
	Year	2005	Publication	Journal of experimental psychology. Animal behavior processes	Abbreviated Journal	J Exp Psychol Anim Behav Process
	Volume	31	Issue	2	Pages	142-154
	Keywords	Animals; Behavior, Animal; Discrimination Learning; Exploratory Behavior; Female; *Form Perception; Habituation, Psychophysiologic; Male; Rats; Rats, Long-Evans
	Abstract	Six experiments using habituation of exploratory behavior tested whether disoriented rats foraging in a large arena encode the shapes of arrays of objects. Rats did not respond to changes in position of a single object, but they responded to a change in object color and to a change in position of 1 object in a square array, as in previous research (e.g., C. Thinus-Blanc et al., 1987). Rats also responded to an expansion of a square array, suggesting that they encoded sets of interobject distances rather than overall shape. In Experiments 4-6, rats did not respond to changes in sense of a triangular array that maintained interobject distances and angles. Shapes of object arrays are encoded differently from shapes of enclosures.
	Address	Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada. shannon.skov.rackette@utoronto.ca
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0097-7403	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15839772			Approved	no
	Call Number	refbase @ user @			Serial	363
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	Author	Shettleworth, S.J.; Sutton, J.E.
	Title	Multiple systems for spatial learning: dead reckoning and beacon homing in rats			Type	Journal Article
	Year	2005	Publication	Journal of experimental psychology. Animal behavior processes	Abbreviated Journal	J Exp Psychol Anim Behav Process
	Volume	31	Issue	2	Pages	125-141
	Keywords	Animals; Behavior, Animal; Cues; Feeding Behavior; Habituation, Psychophysiologic; Homing Behavior; Learning; Male; Rats; Rats, Long-Evans; Space Perception
	Abstract	Rats homed with food in a large lighted arena. Without visual cues, they used dead reckoning. When a beacon indicated the home, rats could also use the beacon. Homing did not differ in 2 groups of rats, 1 provided with the beacon and 1 without it; tests without the beacon gave no evidence that beacon learning overshadowed dead reckoning (Experiment 1). When the beacon was at the home for 1 group and in random locations for another, there was again no evidence of cue competition (Experiment 2). Dead reckoning experience did not block acquisition of beacon homing (Experiment 3). Beacon learning and dead reckoning do not compete for predictive value but acquire information in parallel and are used hierarchically.
	Address	Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada. shettle@psych.utoronto.ca
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0097-7403	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15839771			Approved	no
	Call Number	refbase @ user @			Serial	364
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	Author	Beckers, T.; Miller, R.R.; De Houwer, J.; Urushihara, K.
	Title	Reasoning rats: forward blocking in Pavlovian animal conditioning is sensitive to constraints of causal inference			Type	Journal Article
	Year	2006	Publication	Journal of experimental psychology. General	Abbreviated Journal	J Exp Psychol Gen
	Volume	135	Issue	1	Pages	92-102
	Keywords	Animals; Association Learning; Cognition; Conditioning, Classical; Cues; Fear; Female; Inhibition (Psychology); Male; Motivation; Problem Solving; Rats; Rats, Sprague-Dawley
	Abstract	Forward blocking is one of the best-documented phenomena in Pavlovian animal conditioning. According to contemporary associative learning theories, forward blocking arises directly from the hardwired basic learning rules that govern the acquisition or expression of associations. Contrary to this view, here the authors demonstrate that blocking in rats is flexible and sensitive to constraints of causal inference, such as violation of additivity and ceiling considerations. This suggests that complex cognitive processes akin to causal inferential reasoning are involved in a well-established Pavlovian animal conditioning phenomenon commonly attributed to the operation of basic associative processes.
	Address	Department of Psychology, Binghamton University, State University of New York, NY, USA. tom.beckers@psy.kuleuven.be
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0096-3445	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:16478318			Approved	no
	Call Number	refbase @ user @			Serial	155
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	Author	Petter-Puchner, A.H.; Froetscher, W.; Krametter-Froetscher, R.; Lorinson, D.; Redl, H.; van Griensven, M.
	Title	The long-term neurocompatibility of human fibrin sealant and equine collagen as biomatrices in experimental spinal cord injury			Type	Journal Article
	Year	2007	Publication	Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft fur Toxikologische Pathologie	Abbreviated Journal	Exp Toxicol Pathol
	Volume	58	Issue	4	Pages	237-245
	Keywords	Animals; Axotomy; Biocompatible Materials/therapeutic use; Collagen/therapeutic use; Fibrin Tissue Adhesive/therapeutic use; Horses; Humans; Immunohistochemistry; Male; Motor Activity/physiology; Nerve Regeneration/physiology; Rats; Recovery of Function; Spinal Cord/pathology/physiology; Spinal Cord Injuries/pathology/*therapy; Thoracic Vertebrae
	Abstract	INTRODUCTION: While fibrin sealant (FS) and equine collagen (EC) have been used as scaffold materials in experimental spinal cord injury (SCI), questions concerning neurocompatibility still remain. In this study, we assessed potential adverse effects, as well as functional and histological impact of FS and EC in subtotal hemisection of the thoracic spinal cord (SC) in rats. METHODS: 124 male rats were randomly assigned to four main groups (n=31): Sham (SH), Lesion only (L), fibrin sealant (GFS) and equine collagen group (GEC). SH animals received laminectomy only; all other animals underwent subtotal lateral hemisection at T9. Treatment consisted of application of FS or EC into the lesion gap in GFS and GEC, which was left empty in L. GFS, GEC, L and SH were each further divided into 4 subgroups: One subgroup, consisting of 10 rats was subjected to behavioural and reflex testing before surgery and followed up on days 1,7, 14, 21, 28 post op and then sacrificed. Haemalaun or cresyl violet (CV) was used to identify neutrophils in parasagittal cord sections which were obtained on day 1 (n=7). Sections stained for quantification of microglia/macrophages using ED-1 on day 3 (n=7), day 7 (n=7) and day 28 (n=7 out of 10). Additionally, neural filament (NF) staining was chosen to detect axonal regeneration and the length of ingrowth into FS and EC, Luxol blue for myelination, Von Willebrand factor for vascularisation, and glial fibrillary acidic protein (GFAP) staining for detection of astrocytes in glial scars on day 28. RESULTS: No adverse effects were observed in the treatment groups. Compared to L, GFS and GEC performed significantly better in the Basso, Beattie, Bresnahan (BBB) score and hopping responses. Proprioceptive placing was markedly improved in FS and EC compared to L. Axonal regrowth was found in GFS and GEC--the regrowth in the GFS was accompanied by myelination and vascularisation. Glial scarring occurred in all groups. Discussion Both biomatrices improved functional recovery compared to L and no adverse effects were perceived.
	Address	Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, 1200-Vienna, Austria
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0940-2993	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:17118635			Approved	no
	Call Number				Serial	1852
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	Author	Zentall, T.R.
	Title	Mental time travel in animals: a challenging question			Type	Journal Article
	Year	2006	Publication	Behavioural processes	Abbreviated Journal	Behav. Process.
	Volume	72	Issue	2	Pages	173-183
	Keywords	Animals; Behavior, Animal; Columbidae; Concept Formation; Conditioning, Operant; Imagination; Memory; Mental Recall; Planning Techniques; Rats; Time Perception; Transfer (Psychology)
	Abstract	Humans have the ability to mentally recreate past events (using episodic memory) and imagine future events (by planning). The best evidence for such mental time travel is personal and thus subjective. For this reason, it is particularly difficult to study such behavior in animals. There is some indirect evidence, however, that animals have both episodic memory and the ability to plan for the future. When unexpectedly asked to do so, animals can report about their recent past experiences (episodic memory) and they also appear to be able to use the anticipation of a future event as the basis for a present action (planning). Thus, the ability to imagine past and future events may not be uniquely human.
	Address	Department of Psychology, University of Kentucky, Lexington, KY 40506-0044, USA. zentall@uky.edu
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0376-6357	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:16466863			Approved	no
	Call Number	refbase @ user @			Serial	218
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