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Author Branchi, I.; Bichler, Z.; Berger-Sweeney, J.; Ricceri, L. openurl 
  Title Animal models of mental retardation: from gene to cognitive function Type Journal Article
  Year 2003 Publication Neuroscience and Biobehavioral Reviews Abbreviated Journal Neurosci Biobehav Rev  
  Volume 27 Issue 1-2 Pages 141-153  
  Keywords Animals; Animals, Genetically Modified/growth & development; Behavior/physiology; Behavior, Animal; Brain/*growth & development; Cognition/*physiology; *Disease Models, Animal; Environment; Genes; Genetic Diseases, Inborn/physiopathology; Humans; Mental Retardation/classification/*genetics/*physiopathology  
  Abstract About 2-3% of all children are affected by mental retardation, and genetic conditions rank among the leading causes of mental retardation. Alterations in the information encoded by genes that regulate critical steps of brain development can disrupt the normal course of development, and have profound consequences on mental processes. Genetically modified mouse models have helped to elucidate the contribution of specific gene alterations and gene-environment interactions to the phenotype of several forms of mental retardation. Mouse models of several neurodevelopmental pathologies, such as Down and Rett syndromes and X-linked forms of mental retardation, have been developed. Because behavior is the ultimate output of brain, behavioral phenotyping of these models provides functional information that may not be detectable using molecular, cellular or histological evaluations. In particular, the study of ontogeny of behavior is recommended in mouse models of disorders having a developmental onset. Identifying the role of specific genes in neuropathologies provides a framework in which to understand key stages of human brain development, and provides a target for potential therapeutic intervention.  
  Address Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy. branchi@iss.it  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0149-7634 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12732230 Approved no  
  Call Number Equine Behaviour @ team @ Serial 2805  
Permanent link to this record
 

 
Author Cowley, J.J.; Griesel, R.D. openurl 
  Title The effect on growth and behaviour of rehabilitating first and second generation low protein rats Type Journal Article
  Year 1966 Publication Animal Behaviour. Abbreviated Journal Anim. Behav.  
  Volume 14 Issue 4 Pages 506-517  
  Keywords Animals; *Behavior, Animal; Diet Therapy; Dietary Proteins; Female; *Growth; Humans; Intelligence; Learning; Male; Mental Retardation/etiology; Protein Deficiency/*therapy; Rats  
  Abstract  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0003-3472 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:6008473 Approved no  
  Call Number Equine Behaviour @ team @ Serial 4119  
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Author McClearn, G.E. openurl 
  Title Behavioral genetics Type Journal Article
  Year 1971 Publication Behavioral Science Abbreviated Journal Behav Sci  
  Volume 16 Issue 1 Pages 64-81  
  Keywords Amino Acid Metabolism, Inborn Errors; Animals; Aptitude; Behavior, Animal; Chromosome Aberrations; Cognition; Cytogenetics; Female; *Genetics, Behavioral; Genetics, Population; Humans; Intelligence; Mental Retardation; Mice; Models, Biological; Personality; Phenylketonurias; Pregnancy; Research; Schizophrenia; Sex Chromosome Aberrations; Twins  
  Abstract  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0005-7940 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:5105941 Approved no  
  Call Number Equine Behaviour @ team @ Serial 4150  
Permanent link to this record
 

 
Author Morley, K.I.; Montgomery, G.W. openurl 
  Title The genetics of cognitive processes: candidate genes in humans and animals Type Journal Article
  Year 2001 Publication Behavior Genetics Abbreviated Journal Behav Genet  
  Volume 31 Issue 6 Pages 511-531  
  Keywords Animals; *Chromosome Mapping; Drosophila melanogaster; Genetic Markers/*genetics; Humans; Intelligence/*genetics; Mental Retardation/genetics; Mice; Phenotype; Quantitative Trait, Heritable  
  Abstract It has been hypothesized that numerous genes contribute to individual variation in human cognition. An extensive search of the scientific literature was undertaken to identify candidate genes which might contribute to this complex trait. A list of over 150 candidate genes that may influence some aspect of cognition was compiled. Some genes are particularly strong candidates based on evidence for involvement in cognitive processes in humans, mice, and Drosophila melanogaster. This survey confirms that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition.  
  Address Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0001-8244 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:11838530 Approved no  
  Call Number Equine Behaviour @ team @ Serial 4141  
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