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Author Gavrilova, O.; Haluzik, M.; Matsusue, K.; Cutson, J.J.; Johnson, L.; Dietz, K.R.; Nicol, C.J.; Vinson, C.; Gonzalez, F.J.; Reitman, M.L. doi  openurl
  Title Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass Type Journal Article
  Year 2003 Publication The Journal of biological chemistry Abbreviated Journal J Biol Chem  
  Volume 278 Issue 36 Pages 34268-34276  
  Keywords (up) Adipose Tissue/*metabolism; Animals; Blotting, Southern; Blotting, Western; Female; Hypoglycemia/genetics; Insulin Resistance/genetics; Lipid Metabolism; Liver/*metabolism; Liver Diseases/genetics/*metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; RNA/metabolism; Receptors, Cytoplasmic and Nuclear/*genetics/*physiology; Recombination, Genetic; Thiazoles/pharmacology; *Thiazolidinediones; Time Factors; Transcription Factors/*genetics/*physiology; Triglycerides/*metabolism  
  Abstract Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that mediates the antidiabetic effects of thiazolidinediones. PPAR gamma is present in adipose tissue and becomes elevated in fatty livers, but the roles of specific tissues in thiazolidinedione actions are unclear. We studied the function of liver PPAR gamma in both lipoatrophic A-ZIP/F-1 (AZIP) and wild type mice. In AZIP mice, ablation of liver PPAR gamma reduced the hepatic steatosis but worsened the hyperlipidemia, triglyceride clearance, and muscle insulin resistance. Inactivation of AZIP liver PPAR gamma also abolished the hypoglycemic and hypolipidemic effects of rosiglitazone, demonstrating that, in the absence of adipose tissue, the liver is a primary and major site of thiazolidinedione action. In contrast, rosiglitazone remained effective in non-lipoatrophic mice lacking liver PPAR gamma, suggesting that adipose tissue is the major site of thiazolidinedione action in typical mice with adipose tissue. Interestingly, mice without liver PPAR gamma, but with adipose tissue, developed relative fat intolerance, increased adiposity, hyperlipidemia, and insulin resistance. Thus, liver PPAR gamma regulates triglyceride homeostasis, contributing to hepatic steatosis, but protecting other tissues from triglyceride accumulation and insulin resistance.  
  Address Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. oksanag@bdg10.niddk.nih.gov  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0021-9258 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12805374 Approved no  
  Call Number refbase @ user @ Serial 81  
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Author Weik, H.; Altmann, J. openurl 
  Title The effect of L(+)-lactate on rat and horse adipose tissue in vitro Type Journal Article
  Year 1972 Publication Zentralblatt fur Veterinarmedizin. Reihe A Abbreviated Journal Zentralbl Veterinarmed A  
  Volume 19 Issue 6 Pages 514-518  
  Keywords (up) Adipose Tissue/analysis/*drug effects; Animals; Fatty Acids, Nonesterified; Glycerol/metabolism; Horses; Lactates/*pharmacology; Lipid Metabolism; Male; Rats  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0514-7158 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:4626300 Approved no  
  Call Number refbase @ user @ Serial 132  
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Author Hertel, J.; Altmann, H.J.; Drepper, K. openurl 
  Title [Nutritional physiology studies of the horse. II. Raw nutrient studies of the gastrointestinal tract of slaughtered horses] Type Journal Article
  Year 1970 Publication Zeitschrift fur Tierphysiologie, Tierernahrung und Futtermittelkunde Abbreviated Journal Z Tierphysiol Tierernahr Futtermittelkd  
  Volume 26 Issue 3 Pages 169-174  
  Keywords (up) Animal Feed/*analysis; *Animal Nutrition Physiology; Animals; Digestive System/*analysis; Horses/*physiology; Intestines/metabolism; Lipid Metabolism; Proteins/metabolism; Stomach/metabolism  
  Abstract  
  Address  
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  Language German Summary Language Original Title Ernahrungsphysiologische Untersuchungen beim Pferd. II. Rohnahrstoffuntersuchungen im Magen-Darm-Trakt von Schlachtpferden  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0044-3565 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:5516852 Approved no  
  Call Number refbase @ user @ Serial 136  
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