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| Author | Horn, L.; Range, F.; Huber, L. | ||||
| Title | Dogs’ attention towards humans depends on their relationship, not only on social familiarity | Type | Journal Article | ||
| Year | 2013 | Publication  |
Abbreviated Journal | Animal Cognition | |
| Volume | 16 | Issue | 3 | Pages | 435-443 |
| Keywords | Domestic dogs; Social attention; Social familiarity; Dog–human relationship | ||||
| Abstract | Both in humans and non-human animals, it has been shown that individuals attend more to those they have previously interacted with and/or they are more closely associated with than to unfamiliar individuals. Whether this preference is mediated by mere social familiarity based on exposure or by the specific relationship between the two individuals, however, remains unclear. The domestic dog is an interesting subject in this line of research as it lives in the human environment and regularly interacts with numerous humans, yet it often has a particularly close relationship with its owner. Therefore, we investigated how long dogs (Canis familiaris) would attend to the actions of two familiar humans and one unfamiliar experimenter, while varying whether dogs had a close relationship with only one or both familiar humans. Our data provide evidence that social familiarity by itself cannot account for dogs’ increased attention towards their owners since they only attended more to those familiar humans with whom they also had a close relationship. | ||||
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| Corporate Author | Thesis | ||||
| Publisher | Springer-Verlag | Place of Publication | Editor | ||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 1435-9448 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 5667 | ||
| Permanent link to this record | |||||
| Author | Flauger, B. | ||||
| Title | The introduction of horses into new social groups with special regard to their stress level | Type | Manuscript | ||
| Year | 2011 | Publication |
Abbreviated Journal | ||
| Volume | Issue | Pages | |||
| Keywords | Pferd; Equiden; Eingliederungstechnik; Integrationspferd; Stress; Cortisol; Endokrine Reaktion; Gruppenhaltung; Verletzungsgefahr; Aggression; Futterplatzwahl; Kot; Geruchssinn; Mensch-Pferd Interaktion; horse; equids; introduction technique; integration horse; stress; cortisol; endocrine response; group housing; injury risk; aggression; feeding decision; faecal sample; olfaction; human-horse interaction | ||||
| Abstract | Horses are a highly social species living in complex social systems which should require them to memorise and generalise social experiences and distinguish between familiar and unfamiliar conspecifics. In the main part of my thesis I concentrated on the specific conflict situation of a horse being introduced into a new social group, and investigated its behaviour and stress level. Horses were either introduced (1) immediately, (2) after an observation period, or (3) together with an integration horse after an observation period. Additionally, in the second part of my thesis I arranged several experiments to elaborate additional aspects which could affect the behaviour of horses during introductions. In this study I could describe a simplified method for measuring stress through the analysis of faecal GCMs in horses. An enzyme immunoassay (EIA) for 11-oxoaetiocholanolone using 11-oxoaetiocholanolone-17-CMO: BSA (3?,11-oxo-A EIA) as antigen showed high amounts of immunoreactive substances. The new assay increases the accuracy of the test and lowers the expenses per sample; also storing of samples at room temperature after collection is less critical. This is a big advantage both in the field of wildlife management of equids and in the field of equestrian sports (chapter 1). Comparing the different introduction techniques, the introduction with an integration horse led to significantly less total interactions and lower levels of aggression than the introduction of single horses, both immediately and after several days of observing the new group. Additionally, by observing the behaviour of the horses during everyday sociality I could develop a formula describing the interrelationship between expected aggression level and enclosure size per horse. The curve takes an exponential shape. Starting from a space allowance of 300 m2 and more per horse, the amount of aggressions per hour approaches zero. For the reduction of aggression levels and injury risks in socially kept horses I recommend an enclosure size of at least 300 m2 per horse (chapter 2). I further investigated the stress level of the introduced animals. Horses which were immediately introduced did not show elevated faecal GCMs. In contrast, horses which were introduced after an observation period had slightly elevated values 2 and 3 days after the introduction. For horses introduced together with an integration horse faecal GCMs were significantly above the baseline value on the day of introduction and 1 day after it. These differences between introduction techniques indicate that the introduction event itself is not as stressful as previously assumed. Rather standing together with an integration horse and not being able to integrate immediately into the complete group elicits stress in horses (chapter 3). In the commentary of chapter 4 several studies are discussed which failed to demonstrate social learning in horses. It is argued that they did not consider important aspects which could have an influence, such as the dominance status or the social background of the horses (chapter 4). In chapter 5 a social feeding situation was investigated. The social rank as well as the position of conspecifics affected the feeding strategy of horses. Domestic horses used social cognition and strategic decision making in order to decide where to feed. When possible they tended to return to the same, continuously supplied feeding site and switched to an ?avoidance tendency? in the presence of dominant horses or when another horse was already feeding there (chapter 5). One possibility to recognize group members is through olfactory recognition. In chapter 6 it is shown that horses are able to distinguish their own from their conspecifics? faeces. In addition, they paid most attention to the faeces of those group members from which they received the highest amount of aggressive behaviour (chapter 6). Horses show cognitive abilities because they are able to use humans as local enhancement cues when searching for food, independently of their body posture or gaze consistency when the persons face them. Moreover, they seem to orientate on the attention of familiar persons more than of unfamiliar persons (chapter 7). Altogether, the results of this thesis provide further support for the view that horses show good conflict resolution strategies. They are perfectly able to deal with the conflict situation of being introduced to new group members, and the introduction event itself is not as stressful as previously assumed. It is rather suggested that standing together with an integration horse and not being able to integrate immediately into the complete group elicits stress in horses. All additional experimental set-ups could demonstrate that horses are well capable of social cognition. | ||||
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| Corporate Author | Thesis | Ph.D. thesis | |||
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| Language | Summary Language | Original Title | |||
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| ISSN | ISBN | Medium | |||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ epub18463 | Serial | 5736 | ||
| Permanent link to this record | |||||
| Author | Obergfell, J. | ||||
| Title | Einf lus s v on St ruktur e l ement en auf da s Li eg ev e rha l t en v on Pf e rden in Gruppenha l tung unt e r Be rücks i cht igung de s Ag g r e s s i ons v e rha l t ens | Type | Manuscript | ||
| Year | 2012 | Publication |
Abbreviated Journal | ||
| Volume | Issue | Pages | |||
| Keywords | Pferde, Ruheverhalten, Liegeverhalten, Aggressionsverhalten, Strukturelemente, Rangordnung [horses, rest behavior, lying behavior, aggression behavior, structural elements, rank order] | ||||
| Abstract | Durch die vorliegende Studie wurde der Einfluss von Strukturelementen auf das Liege- und Aggressionsverhalten von Pferden in Gruppenhaltung untersucht. Die Strukturelemente sollten Rückzugsmöglichkeiten bieten, sowie in ihrem Bereich zur Aufhebung der Individualdistanz führen und dadurch die Fläche relativ vergrößern. Für die Versuche stellte das Haupt- und Landesgestüt Marbach drei unabhängige Pferdegruppen mit verschiedener Herdengröße zur Verfügung, die jeweils in Einraum- Innenlaufställen gehalten wurden. Die Datenerfassung fand zwischen 23 und sieben Uhr statt. Insgesamt wurden 366 Stunden Videomaterial ausgewertet. Beim Ruheverhalten wurden mit Hilfe des event-sampling- Verfahrens die Parameter Gesamtliegedauer, Dauer in Seitenlage, Dauer der Einzelphasen in Seitenlage und Abliegehäufigkeit pro Nacht erfasst. Es wurden Versuchsphasen ohne Strukturelemente und mit hängenden Planen als Strukturierung durchgeführt. Im ersten Stall kamen außerdem über einander gestapelte Strohballen zum Einsatz. Diese Art der Strukturierung stellte sich jedoch als nicht praktikabel heraus und führte im Vergleich zu den Planen zu einer signifikanten Verschlechterung der Gesamtliegedauer. In Stall 1 konnte man eine tendenzielle Verbesserung der Parameter Gesamtliegedauer und Gesamtdauer in Seitenlage durch das Anbringen von Planen sehen. In Stall 3 dagegen verschlechterte sich das Ruheverhalten in den Versuchsphasen mit Planen gegenüber den Versuchsphasen ohne Struktur. Die Werte der Gesamtdauer in Seitenlage nahmen signifikant ab. In Stall 2 zeigten sich keine Unterschiede in den verschiedenen Versuchsphasen. Möglicherweise ist die Wirkung der Strukturelemente auf das Liegeverhalten abhängig von der Flächengröße. Stall 1 hatte bezogen auf die Leitlinien des BMELV die größte und Stall 3 die kleinste Fläche. Bei den anderen Parametern des Liegeverhaltens gab es keine signifikanten Unterschiede in den verschiedenen Versuchsphasen. Mit Hilfe des time-sampling-Verfahrens wurde die Anzahl gleichzeitig liegender Pferde und gleichzeitig liegender Pferde in Seitenlage bestimmt. Auch hier zeigten sich keine Unterschiede in den verschiedenen Versuchsphasen. Bei der Gegenüberstellung der Werte der Gesamtliegedauer und der Gesamtdauer in Seitenlage mit dem Alter der Pferde (Stall 1 und Stall 3) und mit dem Integrationszeitpunkt (Stall 1) konnte kein Zusammenhang festgestellt werden. Beim Aggressionsverhalten wurden mit Hilfe des event-sampling-Verfahrens in den Ställen 2 und 3 verschiedene Arten von Aggressionen erfasst, die dann in die drei Intensitätsgrade Low-Level-, Mid-Level- und High-Level- Aggressionen unterteilt wurden. Neben der Anzahl wurde die Dauer der verschiedenen Aggressionen bewertet. Insgesamt konnte eine positive Wirkung der Planen auf das Aggressionsverhalten beobachtet werden. Die Gesamtanzahl an Aggressionen nahm in beiden Ställen tendenziell in den Versuchsphasen mit Planen ab. In Stall 3 konnte, wenn man die Aggressionen stundenweise betrachtet, ein signifikanter Unterschied festgestellt werden. Auch der Hinterhandschlag und die Aggressionen, welche das Ruheverhalten stören, verringerten sich tendenziell nach dem Anbringen von Strukturelementen. In beiden Ställen nahm die relative Häufigkeit von Mid-Level-Aggressionen nach dem Anbringen von Planen zu. Dagegen konnte bei den High-Level-Aggressionen und in Stall 3 bei den Low-Level- Aggressionen eine relative Abnahme beobachtet werden. Sowohl die Anzahl als auch die Dauer der Mid-Level-Aggressionen verringerten sich in Stall 3 stundenweise betrachtet signifikant in den Versuchsphasen mit Planen. In Stall 2 war bei den High-Level- Aggressionen sowohl bei der Dauer als auch bei der Anzahl eine signifikante Abnahme zu sehen. Wenn man das Aggressionsverhalten in Bezug zu der Fläche in den zwei Ställen betrachtet, schien diese vor allem einen Einfluss auf die High-Level-Aggressionen zu nehmen. Mit Hilfe des Rangindex der Pferde im Stall 3 wurde eine Rangordnung aufgestellt. Zwischen dem Platz der Pferde in der Rangordnung und den Parametern des Ruheverhaltens (Gesamtliegedauer, Gesamtdauer in Seitenlage) sowie dem Alter der Pferde konnte kein Zusammenhang festgestellt werden. Zwischen dem Rangindex und der Gesamtanzahl an Aggressionen bestand dagegen ein hoch signifikanter Zusammenhang. Im Rahmen dieser Studie ist das Anbringen von Strukturelementen in Bezug auf das Aggressionsverhalten in Einraum-Innenlaufställen von Pferden zu empfehlen. Die Wirkung auf das Liegeverhalten der Pferde sollte in weiteren Studien untersucht werden. [In this study the influence of structural elements on lying and aggression behavior in horses kept in groups was exanimated. Structural elements should offer the possibility of retreat. Furthermore, within the respective area, the individual distance should be limited, thus increasing the overall space relatively. For the studies the “Haupt- und Landesgestüt Marbach” provided three non-related groups of different sized horses, each kept in separate “Einraum-Innenlaufställen”. Data collection took place between 11 pm and 7 am. Altogether, 366 hours of video material were analyzed. Using the event-sampling-method, the following parameters within the horses´ resting behavior were determined: The total lying period, the total lying period in lateral position, the periods of the single lying in lateral position and the frequency of lying down. Test phases were carried out without structural elements and with hanging canvases as structural elements. In the first stable there were also three bales of straw piled up on top of each other. This kind of structuring emerged as impractical and in comparison to the canvas, led to a significant deterioration to the total period of lying. After the canvases were fixed in the first stable, a slight improvement with the parameters of total lying period and total lying period in the lateral position could be seen. In contrast, the resting behavior in stable 3 worsened in the test phases with the canvases in comparison to the test phases without structural elements. The values for the total lying period in the lateral position decreased significantly. In stable 2, there were no differences in the different test phases. Possibly the effect of the structural elements is dependent of the space. Stable 1 had the largest space and stable 3 the least space referred to the guideline of the BMELV. The other parameters of the lying behavior showed no significant differences in the different test phases. The number of horses lying at the same time, and the number of horses lying at the same time in the lateral position were detected with the aid of the time-sampling-method. There were also no differences between the different test phases. If the values of the total lying period and the total lying period in lateral position were compared to the age of the horses (stable 1 and stable 3) and to the point of integration (stable 1), there was no correlation. Different kinds of aggression were detected by the means of the event-sampling-method in stable 2 and 3 and were subdivided into the three levels of intensity: Low-level-, mid-level and high-level-aggressions. Both the number and the duration of the different aggressions were evaluated. All in all a positive influence of the canvas on the aggression behavior could be observed. In both stables, the total number of aggressions decreased in the test phases with canvases. In stable 3 a significant difference could be detected, if the aggressions were observed per hour. Also hind limb kicks and aggressions disturbing the resting behavior, decreased by trend, after fixing the canvases in the stable. In both stables the relative frequency of mid-level-aggressions increased after the canvases were mounted. In contrast there was a relative decrease at the high-level-aggressions and in stable 3 at the low-levelaggressions. The number and the duration of the mid-level-aggressions in stable 3 decreased, when considered by the hour in the test phases with canvases. In stable 2 a significant decrease in duration and number of high-level-aggressions was observed. When examining aggression behavior in reference to space in the two stables, high-level-aggressions seemed to be mostly influenced. In stable 3 a rank order was established with the aid of the rank index of the horses. There was no correlation between the horses´ rank and the parameters of the resting behavior (the total lying period, the total lying period in lateral position) and between horses´ rank and age. In contrast, there was a high significant correlation between the rank index and the total number of aggressions. In context to this study, structural elements in “Einraum-Innenlaufställen” (BMELV 2009) seem to have a positive influence on the aggression behavior and thus seem to be recommendable. The influence on the lying behavior should be investigated in further studies.] |
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| Corporate Author | Thesis | Ph.D. thesis | |||
| Publisher | Place of Publication | Karlsruhe | Editor | ||
| Language | Summary Language | Original Title | |||
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| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 5772 | ||
| Permanent link to this record | |||||
| Author | A. Wiggins; K. Crowston | ||||
| Title | From Conservation to Crowdsourcing: A Typology of Citizen Science | Type | Conference Article | ||
| Year | 2011 | Publication |
2011 44th Hawaii International Conference on System Sciences | Abbreviated Journal | 2011 44th Hawaii International Conference on System Sciences |
| Volume | Issue | Pages | 1-10 | ||
| Keywords | groupware; natural sciences computing; research and development; social sciences; crowdsourcing; citizen science typology; research collaboration; scientific research projects; virtual collaboration; Communities; Education; Monitoring; Collaboration; Organizations; Biological system modeling; Production | ||||
| Abstract | Citizen science is a form of research collaboration involving members of the public in scientific research projects to address real-world problems. Often organized as a virtual collaboration, these projects are a type of open movement, with collective goals addressed through open participation in research tasks. Existing typologies of citizen science projects focus primarily on the structure of participation, paying little attention to the organizational and macrostructural properties that are important to designing and managing effective projects and technologies. By examining a variety of project characteristics, we identified five types-Action, Conservation, Investigation, Virtual, and Education- that differ in primary project goals and the importance of physical environment to participation. | ||||
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| Publisher | Place of Publication | Editor | |||
| Language | Summary Language | Original Title | |||
| Series Editor | Series Title | Abbreviated Series Title | 2011 44th Hawaii International Conference on System Sciences | ||
| Series Volume | Series Issue | Edition | |||
| ISSN | 1530-1605 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 6430 | ||
| Permanent link to this record | |||||
| Author | Yang, S. | ||||
| Title | Melioidosis research in China | Type | Journal Article | ||
| Year | 2000 | Publication |
Acta Tropica | Abbreviated Journal | Acta Trop |
| Volume | 77 | Issue | 2 | Pages | 157-165 |
| Keywords | Animals; Anti-Bacterial Agents/pharmacology; Burkholderia pseudomallei/drug effects/immunology/*pathogenicity; China/epidemiology; Cross Reactions; Glanders/immunology/microbiology; Horses; Humans; *Melioidosis/epidemiology/immunology/microbiology/veterinary; Seroepidemiologic Studies; Virulence | ||||
| Abstract | Research on melioidosis and its pathogen has been ongoing in China for more than two decades. It has been demonstrated that the natural foci are located predominantly in Hainan, Guangdong and Guangxi province, where there is a good correlation between soil isolation and the serum prevalence of antibodies to Burkholderia pseudomallei. The cases of melioidosis reported up to now are concentrated in the Hainan and Zhanjiang peninsula. Investigations on serotype, virulence, ecology, antibiotic susceptibility, whole cell analysis by gas chromatography, and genetics have led to a new understanding of the pathology of the disease. Immunological cross reactions between Burkholderia mallei and B. pseudomallei and the difference between melioidosis and glanders in horses is discussed. | ||||
| Address | Medical Research Institute, Yan-Ling (510507), Dongguanzhuang Road 91, Guangzhou, People's Republic of China. songyangch@hotmail.com | ||||
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| Language | English | Summary Language | Original Title | ||
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| Series Volume | Series Issue | Edition | |||
| ISSN | 0001-706X | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:11080506 | Approved | no | ||
| Call Number | Equine Behaviour @ team @ | Serial | 2649 | ||
| Permanent link to this record | |||||
| Author | Salmivalli, C.; Lagerspetz, K.; Björkqvist, K.; Österman, K.; Kaukiainen, A. | ||||
| Title | Bullying as a group process: Participant roles and their relations to social status within the group | Type | Journal Article | ||
| Year | 1996 | Publication |
Aggressive Behavior | Abbreviated Journal | Aggr. Behav. |
| Volume | 22 | Issue | 1 | Pages | 1-15 |
| Keywords | aggressive behavior; peer relations; roles; social acceptance; social groups; victimization | ||||
| Abstract | Bullying was investigated as a group process, a social phenomenon taking place in a school setting among 573 Finnish sixth-grade children (286 girls, 287 boys) aged 12–13 years. Different Participant Roles taken by individual children in the bullying process were examined and related to a) self-estimated behavior in bullying situations, b) social acceptance and social rejection, and c) belongingness to one of the five sociometric status groups (popular, rejected, neglected, controversial, and average). The Participant Roles assigned to the subject were Victim, Bully, Reinforcer of the bully, Assistant of the bully, Defender of the victim, and Outsider. There were significant sex differences in the distribution of Participant Roles. Boys were more frequently in the roles of Bully, Reinforcer and Assistant, while the most frequent roles of the girls were those of Defender and Outsider. The subjects were moderately well aware of their Participant Roles, although they underestimated their participation in active bullying behavior and emphasized that they acted as Defenders and Outsiders. The sociometric status of the children was found to be connected to their Participant Roles. © 1996 Wiley-Liss, Inc. | ||||
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| Publisher | Wiley Subscription Services, Inc., A Wiley Company | Place of Publication | Editor | ||
| Language | Summary Language | Original Title | |||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 1098-2337 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 5435 | ||
| Permanent link to this record | |||||
| Author | Romano, N.; Vitale, F.; Alesi, D.R.; Bonura, F.; La Licata, R.; Intonazzo, V.; Dardanoni, G.; Mammina, C. | ||||
| Title | The changing pattern of human immunodeficiency virus type 1 infection in intravenous drug users. Results of a six-year seroprevalence study in Palermo, Italy | Type | Journal Article | ||
| Year | 1992 | Publication |
American Journal of Epidemiology | Abbreviated Journal | Am J Epidemiol |
| Volume | 135 | Issue | 11 | Pages | 1189-1196 |
| Keywords | Acquired Immunodeficiency Syndrome/*epidemiology; Adolescent; Adult; Chi-Square Distribution; Cross-Sectional Studies; Female; HIV Antibodies/blood; HIV Infections/*epidemiology; HIV Seroprevalence/*trends; *Hiv-1; Hepatitis B Antibodies/blood; Hepatitis B Surface Antigens/blood; Heroin; Humans; Incidence; Italy/epidemiology; Logistic Models; Male; Multivariate Analysis; Odds Ratio; Prevalence; Risk Factors; Substance Abuse, Intravenous/*epidemiology; Time Factors | ||||
| Abstract | A cross-sectional seroepidemiologic study was carried out between 1985 and 1990 in 1,567 heterosexual intravenous drug users who had been seen at the AIDS Regional Reference Center in Palermo, Italy, to evaluate the rate of human immunodeficiency virus type 1 (HIV-1) seroprevalence in this group and its long-term trend. Sixty serum samples collected from drug users in 1980 and 1983, before the founding of the Center (1985), were tested as well. Some demographic and behavioral risk factors were studied in a subgroup of intravenous drug users enrolled in 1985, 1987, and 1990 for their possible association with HIV-1. These factors were also studied in relation to hepatitis B virus infection, since both viruses share the same modes of spread. These drug users had a higher prevalence of markers for hepatitis B virus than of HIV-1 antibodies, and the prevalence rates in sera collected declined over time for both infections. The presence of both antibodies to HIV-1 and markers for hepatitis B virus was independently associated with the age of the drug user, the duration of drug use, and the year of serum collection. Antibodies to HIV-1 were observed more frequently in females than in males. No relation was found between education or employment status and the presence of HIV-1 antibodies or hepatitis B virus markers. Although new HIV-1 infections still occur, the decline in seroprevalence observed at the end of the 1980s might be related to modifications in social behavior among newer drug users, partial exhaustion of the susceptible population, and increasing risk awareness in more experienced users. | ||||
| Address | Giuseppe D'Alessandro Department of Hygiene and Microbiology, School of Medicine, University of Palermo, Italy | ||||
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| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0002-9262 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:1626537 | Approved | no | ||
| Call Number | Equine Behaviour @ team @ | Serial | 5258 | ||
| Permanent link to this record | |||||
| Author | Nicol, C.J.; Adachi, M.; Akiyama, T.E.; Gonzalez, F.J. | ||||
| Title | PPARgamma in endothelial cells influences high fat diet-induced hypertension | Type | Journal Article | ||
| Year | 2005 | Publication |
American journal of hypertension : journal of the American Society of Hypertension | Abbreviated Journal | Am J Hypertens |
| Volume | 18 | Issue | 4 Pt 1 | Pages | 549-556 |
| Keywords | Administration, Oral; Animals; Antihypertensive Agents/pharmacology; Blood Pressure/drug effects; Diabetes Mellitus, Type 2/physiopathology; Dietary Fats/*administration & dosage/pharmacology; Dose-Response Relationship, Drug; Endothelial Cells/*metabolism; Female; Heart Rate/drug effects; Hypertension/*etiology; Ligands; Male; Mice; Mice, Knockout; PPAR gamma/*metabolism; Sodium Chloride/administration & dosage/pharmacology; Thiazolidinediones/pharmacology | ||||
| Abstract | BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands improve human hypertension. However, the mechanism and site of this effect remains unknown, confounded by PPARgamma expression in many cell types, including endothelial cells (ECs). METHODS: To evaluate the vascular role of PPARgamma we used a conditional null mouse model. Specific disruption of PPARgamma in ECs was created by crossing Tie2-Cre+ transgenic (T2T+) and PPARgamma-floxed (fl/fl) mice to generate PPARgamma (fl/fl)T2T+ (PPARgamma E-null) mice. Conscious 8- to 12-week-old congenic PPARgamma (fl/fl)Cre- (wild type) and PPARgamma E-null mice were examined for changes in systolic blood pressure (BP) and heart rate (HR), untreated, after 2 months of salt-loading (drinking water), and after treatment for 3 months with high fat (HF) diet alone or supplemented during the last 2 weeks with rosiglitazone (3 mg/kg/d). RESULTS: Untreated PPARgamma E-nulls were phenotypically indistinguishable from wild-type littermates. However, compared to similarly treated wild types, HF-treated PPARgamma E-nulls had significantly elevated systolic BP not seen after normal diet or salt-loading. Despite sex-dependent baseline differences, salt-loaded and HF-treated PPARgamma E-nulls of either sex had significantly elevated HR versus wild types. Interestingly, rosiglitazone improved serum insulin levels, but not HF diet-induced hypertension, in PPARgamma E-null mice. CONCLUSIONS: These results suggest that PPARgamma in ECs not only is an important regulator of hypertension and HR under stressed conditions mimicking those arising in type 2 diabetics, but also mediates the antihypertensive effects of rosiglitazone. These data add evidence supporting a beneficial role for PPARgamma-specific ligands in the treatment of hypertension, and suggest therapeutic strategies targeting ECs may prove useful. | ||||
| Address | Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA | ||||
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| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
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| Series Volume | Series Issue | Edition | |||
| ISSN | 0895-7061 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:15831367 | Approved | no | ||
| Call Number | refbase @ user @ | Serial | 69 | ||
| Permanent link to this record | |||||
| Author | de Waal, F.B.; Uno, H.; Luttrell, L.M.; Meisner, L.F.; Jeannotte, L.A. | ||||
| Title | Behavioral retardation in a macaque with autosomal trisomy and aging mother | Type | Journal Article | ||
| Year | 1996 | Publication |
American journal of mental retardation : AJMR | Abbreviated Journal | Am J Ment Retard |
| Volume | 100 | Issue | 4 | Pages | 378-390 |
| Keywords | Animals; *Behavior, Animal; Brain/physiopathology; Female; Hydrocephalus/complications; Longitudinal Studies; Macaca mulatta/*genetics; Magnetic Resonance Imaging; Male; *Maternal Age; Psychomotor Disorders/*etiology; Social Behavior; Trisomy/*genetics; X Chromosome | ||||
| Abstract | The social development of a female rhesus monkey (Macaca mulatta) was followed from the day of birth until her death, at age 32 months. The subject, born to an older mother, had an extra autosome (karyotype: 43, XX, +18), an affliction that came about spontaneously. MRI scans revealed that she was also hydrocephalic. Compared to 23 female monkeys growing up under identical conditions, the subject showed serious motor deficiencies, a dramatic delay in the development of social behavior, poorly established dominance relationships, and greater than usual dependency on mother and kin. The subject was well-integrated into the social group, however. | ||||
| Address | University of Wisconsin-Madison, USA | ||||
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| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0895-8017 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:8718992 | Approved | no | ||
| Call Number | refbase @ user @ | Serial | 205 | ||
| Permanent link to this record | |||||
| Author | de Waal, F.B.; Seres, M. | ||||
| Title | Propagation of handclasp grooming among captive chimpanzees | Type | Journal Article | ||
| Year | 1997 | Publication |
American journal of primatology | Abbreviated Journal | Am. J. Primatol. |
| Volume | 43 | Issue | 4 | Pages | 339-346 |
| Keywords | Animals; Family Relations; Female; *Grooming; Learning; Male; Pan troglodytes/*psychology; *Social Behavior | ||||
| Abstract | A grooming posture previously reported for two wild chimpanzee (Pan troglodytes) communities developed spontaneously in a captive group of the same species. This offered a unique opportunity to follow the propagation of a new social custom. The posture consists of two partners grasping hands--either both right hands or both left hands--and raising the arms in an A-frame above their heads while mutually grooming with their free hands. The propagation of this pattern was followed over a 5 year period. In the beginning, handclasps were always initiated by the same adult female. This female initiated the posture mainly with her adult female kin. In subsequent years, these relatives became frequent participants in the posture with each other as well as with nonrelatives. Over the years the posture increased in frequency and duration and spread to the majority of adults and also to a few adolescents and older juveniles. The pattern persisted after removal of the apparent originator. | ||||
| Address | Yerkes Primate Center, Emory University, Atlanta, GA 30329, USA. dewaal@emory.edu | ||||
| Corporate Author | Thesis | ||||
| Publisher | Place of Publication | Editor | |||
| Language | English | Summary Language | Original Title | ||
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 0275-2565 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:9403098 | Approved | no | ||
| Call Number | refbase @ user @ | Serial | 202 | ||
| Permanent link to this record | |||||