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Author |
Cheung, C.; Akiyama, T.E.; Ward, J.M.; Nicol, C.J.; Feigenbaum, L.; Vinson, C.; Gonzalez, F.J. |
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Title |
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha |
Type |
Journal Article |
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Year |
2004 |
Publication |
Cancer research |
Abbreviated Journal |
Cancer Res |
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Volume |
64 |
Issue |
11 |
Pages |
3849-3854 |
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Keywords |
Animals; Anticholesteremic Agents/pharmacology; Carcinogens/pharmacology; Cell Division; DNA Replication/drug effects; Fatty Acids/metabolism; Hepatocytes/cytology/drug effects/metabolism/*physiology; Humans; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxisome Proliferators/pharmacology; Pyrimidines/pharmacology; Receptors, Cytoplasmic and Nuclear/genetics/*physiology; Species Specificity; Transcription Factors/genetics/*physiology |
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Abstract |
Lipid-lowering fibrate drugs function as agonists for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice. However, humans appear to be resistant to the induction of peroxisome proliferation and the development of liver cancer by fibrate drugs. The molecular basis of this species difference is not known. To examine the mechanism determining species differences in peroxisome proliferator response between mice and humans, a PPARalpha-humanized mouse line was generated in which the human PPARalpha was expressed in liver under control of the tetracycline responsive regulatory system. The PPARalpha-humanized and wild-type mice responded to treatment with the potent PPARalpha ligand Wy-14643 as revealed by induction of genes encoding peroxisomal and mitochondrial fatty acid metabolizing enzymes and resultant decrease of serum triglycerides. However, surprisingly, only the wild-type mice and not the PPARalpha-humanized mice exhibited hepatocellular proliferation as revealed by elevation of cell cycle control genes, increased incorporation of 5-bromo-2'-deoxyuridine into hepatocyte nuclei, and hepatomegaly. These studies establish that following ligand activation, the PPARalpha-mediated pathways controlling lipid metabolism are independent from those controlling the cell proliferation pathways. These findings also suggest that structural differences between human and mouse PPARalpha are responsible for the differential susceptibility to the development of hepatocarcinomas observed after treatment with fibrates. The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators. |
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Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA |
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0008-5472 |
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PMID:15172993 |
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no |
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Call Number |
refbase @ user @ |
Serial |
74 |
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Author |
Clark, M.L.; Ayers, M. |
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Title |
Friendship similarity during early adolescence: gender and racial patterns |
Type |
Journal Article |
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Year |
1992 |
Publication |
The Journal of Psychology |
Abbreviated Journal |
J Psychol |
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Volume |
126 |
Issue |
4 |
Pages |
393-405 |
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Keywords |
Achievement; Adolescent; African Americans/*psychology; *Cross-Cultural Comparison; Female; *Gender Identity; Humans; Individuality; *Interpersonal Relations; Male; *Personality Development; Personality Inventory; Sociometric Techniques |
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Abstract |
We studied the relationship of reciprocity, gender, and racial composition (Caucasian, African American, cross-race) of adolescent friendship dyads to similarity and proximity in 136 young adolescents. We found that adolescents selected friends who were of the same gender and race and that female dyads were more similar than male dyads on verbal achievement and several personality dimensions. Caucasian dyads were more similar than African American dyads on verbal achievement, mental alertness, and dominance. African American adolescents had more contact with their best friends outside school, whereas Caucasian adolescent friends had more in-school contact. African American students had fewer reciprocal relationships than the Caucasian students. Cross-race friendships were less reciprocal than same-race friendships. Race and gender were important in determining friendship patterns. Similarity and proximity were more important than reciprocity in understanding early adolescent friendships. |
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Department of Psychology, Virginia Commonwealth University |
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0022-3980 |
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PMID:1403972 |
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Call Number |
Equine Behaviour @ team @ |
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5628 |
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Author |
Collery, L. |
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Title |
Observations of equine animals under farm and feral conditions |
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Journal Article |
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Year |
1974 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
6 |
Issue |
4 |
Pages |
170-173 |
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Keywords |
Aggression; Animals; Animals, Newborn; Breeding; Circadian Rhythm; Feeding Behavior; Female; Horses/*physiology; Housing, Animal; Humans; Male; Pregnancy; Puberty; Reproduction; Sexual Behavior, Animal; Social Dominance |
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0425-1644 |
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PMID:4473340 |
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Call Number |
refbase @ user @ |
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680 |
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Author |
Corr, J.A. |
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Title |
Nuns and monkeys: investigating the behavior of our oldest old |
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Journal Article |
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Year |
2004 |
Publication |
Science of Aging Knowledge Environment : SAGE KE |
Abbreviated Journal |
Sci Aging Knowledge Environ |
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Volume |
2004 |
Issue |
41 |
Pages |
pe38 |
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Keywords |
Aged; Aged, 80 and over/*physiology; Aging/*physiology; Animals; Behavior/*physiology; Humans; Macaca mulatta |
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Abstract |
The use of nonhuman primates, particularly rhesus macaques (Macaca mulatta), as the best model for human physiological and cognitive aging is broadly accepted. Studies employing nonhuman primates to investigate behavioral changes that may occur with increasing age, however, are not common mostly because of the unavailability of appropriate subjects. Recent longitudinal human studies suggest that individual personality might play a large role in aging “successfully” and in the retention of high levels of cognition into old age. As a result of the demographic trend of increasing numbers of aged monkeys and apes in captivity, an opportunity exists to further investigate behavioral aging using the monkey model. |
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Department of Anthropology, Grand Valley State University, Allendale, MI 49401, USA. corrj@gvsu.edu |
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1539-6150 |
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PMID:15483334 |
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no |
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Call Number |
Equine Behaviour @ team @ |
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2828 |
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Author |
Cowell, P.E.; Fitch, R.H.; Denenberg, V.H. |
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Title |
Laterality in animals: relevance to schizophrenia |
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Journal Article |
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Year |
1999 |
Publication |
Schizophrenia Bulletin |
Abbreviated Journal |
Schizophr Bull |
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Volume |
25 |
Issue |
1 |
Pages |
41-62 |
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Keywords |
Adult; Animals; Cognition; *Disease Models, Animal; Functional Laterality/*physiology; Humans; Language; Motor Activity/physiology; Schizophrenia/*physiopathology |
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Abstract |
Anomalies in the laterality of numerous neurocognitive dimensions associated with schizophrenia have been documented, but their role in the etiology and early development of the disorder remain unclear. In the study of normative neurobehavioral organization, animal models have shed much light on the mechanisms underlying and the factors affecting adult patterns of both functional and structural asymmetry. Nonhuman species have more recently been used to investigate the environmental, genetic, and neuroendocrine factors associated with developmental language disorders in humans. We propose that the animal models used to study the basis of lateralization in normative development and language disorders such as dyslexia could be modified to investigate lateralized phenomena in schizophrenia. |
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Dept. of Human Communication Sciences, University of Sheffield, United Kingdom |
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0586-7614 |
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Notes |
PMID:10098913 |
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no |
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Call Number |
Equine Behaviour @ team @ |
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2827 |
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Author |
Cowley, J.J.; Griesel, R.D. |
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Title |
The effect on growth and behaviour of rehabilitating first and second generation low protein rats |
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Journal Article |
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Year |
1966 |
Publication |
Animal Behaviour. |
Abbreviated Journal |
Anim. Behav. |
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Volume |
14 |
Issue |
4 |
Pages |
506-517 |
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Keywords |
Animals; *Behavior, Animal; Diet Therapy; Dietary Proteins; Female; *Growth; Humans; Intelligence; Learning; Male; Mental Retardation/etiology; Protein Deficiency/*therapy; Rats |
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0003-3472 |
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PMID:6008473 |
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Equine Behaviour @ team @ |
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4119 |
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Author |
Crowell-Davis, S.L.; Houpt, K.A. |
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Title |
Coprophagy by foals: effect of age and possible functions |
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Journal Article |
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Year |
1985 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
17 |
Issue |
1 |
Pages |
17-19 |
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Keywords |
*Aging; Animals; *Coprophagia; Deoxycholic Acid/physiology; Female; Horse Diseases/*physiopathology; Horses; Humans; Male; Pheromones/physiology; Time Factors; Urination |
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Abstract |
In colts and fillies observed from birth to 24 weeks old, coprophagy occurred from Weeks 1 to 19. Its frequency was greatest during the first two months. Coprophagy was rarely observed in mares and stallions. Foals usually ate the faeces of their mother but were observed to eat their own and those of a stallion and another unrelated mare. Urination by the foal occurred before, during or after 26 per cent of the coprophagy incidents. It is hypothesised that foals may consume faeces in response to a maternal pheromone which signals the presence of deoxycholic acid or other acids which the foal may be deficient in and which it may require for gut immuno-competence myelination of the nervous system. Such a pheromone may also serve to accelerate growth and sexual maturation. Coprophagy may also provide nutrients and introduce normal bacterial flora to the gut. |
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0425-1644 |
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Notes |
PMID:4038939 |
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no |
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Call Number |
refbase @ user @ |
Serial |
55 |
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Author |
Danchin, E.; Giraldeau, L.-A.; Valone, T.J.; Wagner, R.H. |
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Title |
Public information: from nosy neighbors to cultural evolution |
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Journal Article |
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Year |
2004 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
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Volume |
305 |
Issue |
5683 |
Pages |
487-491 |
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Keywords |
Animals; *Behavior, Animal; Cues; *Cultural Evolution; *Decision Making; Environment; Evolution; Feeding Behavior; Female; Genes; Humans; Male; Reproduction; Sexual Behavior, Animal |
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Abstract |
Psychologists, economists, and advertising moguls have long known that human decision-making is strongly influenced by the behavior of others. A rapidly accumulating body of evidence suggests that the same is true in animals. Individuals can use information arising from cues inadvertently produced by the behavior of other individuals with similar requirements. Many of these cues provide public information about the quality of alternatives. The use of public information is taxonomically widespread and can enhance fitness. Public information can lead to cultural evolution, which we suggest may then affect biological evolution. |
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U.P.M.C. CNRS-UMR7625, Bat A-7e etage-Case 237, 7 quai Saint Bernard, 75252 Paris Cedex 05, France. edanchin@snv.jussieu.fr |
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ISSN |
1095-9203 |
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Notes |
PMID:15273386 |
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Serial |
2131 |
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Author |
Dauphin, G.; Zientara, S.; Zeller, H.; Murgue, B. |
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Title |
West Nile: worldwide current situation in animals and humans |
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Journal Article |
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Year |
2004 |
Publication |
Comparative Immunology, Microbiology and Infectious Diseases |
Abbreviated Journal |
Comp Immunol Microbiol Infect Dis |
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Volume |
27 |
Issue |
5 |
Pages |
343-355 |
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Keywords |
Americas/epidemiology; Animals; Birds/virology; Culex/*virology; *Disease Outbreaks; Disease Reservoirs; Europe/epidemiology; Horses/virology; Humans; Insect Vectors/*virology; Middle East/epidemiology; West Nile Fever/*epidemiology/*veterinary/virology; West Nile virus/*growth & development |
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Abstract |
West Nile (WN) virus is a mosquito-borne flavivirus that is native to Africa, Europe, and Western Asia. It mainly circulates among birds, but can infect many species of mammals, as well as amphibians and reptiles. Epidemics can occur in rural as well as urban areas. Transmission of WN virus, sometimes involving significant mortality in humans and horses, has been documented at erratic intervals in many countries, but never in the New World until it appeared in New York City in 1999. During the next four summers it spread with incredible speed to large portions of 46 US states, and to Canada, Mexico, Central America and the Caribbean. In many respects, WN virus is an outstanding example of a zoonotic pathogen that has leaped geographical barriers and can cause severe disease in human and equine. In Europe, in the past two decades there have been a number of significant outbreaks in several countries. However, very little is known of the ecology and natural history of WN virus transmission in Europe and most WN outbreaks in humans and animals remain unpredictable and difficult to control. |
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AFSSA Alfort, UMR1161 (INRA-AFSSA-ENVA), 22 rue Pierre Curie, BP 63, 94703 Maisons-Alfort Cedex, France |
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0147-9571 |
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PMID:15225984 |
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Call Number |
Equine Behaviour @ team @ |
Serial |
2635 |
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Author |
de Waal, F.B. |
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Title |
The organization of agonistic relations within two captive groups of Java-monkeys (Macaca fascicularis) |
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Journal Article |
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Year |
1977 |
Publication |
Zeitschrift für Tierpsychologie |
Abbreviated Journal |
Z. Tierpsychol. |
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Volume |
44 |
Issue |
3 |
Pages |
225-282 |
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Keywords |
Age Factors; Aggression; Animals; Behavior, Animal/*physiology; Competitive Behavior/*physiology; Fear; Female; Haplorhini; Humans; Macaca/*physiology; Macaca fascicularis/*physiology; Male; Sex Factors; Social Behavior; Social Dominance |
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Abstract |
The paper offers a detailed quantitative descripition of the distribution of agonistic activities over the members of two groups of Java-monkeys (Macaca fascicularis). These groups lived in captivity and were well-established: i.e. they had an extensive network of genealogical relationships. The study pays special attention to agonistic interactions with three or more participants. Its main purpose is an analysis of the way dyadic agonistic relations (e.g. dominance relations) are affected by third group members and the relations among these. The paper presents data on the ontogeny of 'dependent dominance', the 'control role' of the alpha-male, and the functions of different types of alliances. |
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0044-3573 |
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Notes |
PMID:412345 |
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Call Number |
refbase @ user @ |
Serial |
213 |
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