| Records |
| Author |
Elhay, M.; Newbold, A.; Britton, A.; Turley, P.; Dowsett, K.; Walker, J. |
| Title |
Suppression of behavioural and physiological oestrus in the mare by vaccination against GnRH |
Type |
Journal Article |
| Year |
2007 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
85 |
Issue |
1-2 |
Pages |
39-45 |
| Keywords |
Animals; Antibodies/blood; Estradiol/blood; *Estrus/drug effects/physiology; Female; Gonadotropin-Releasing Hormone/*immunology/*pharmacology; Horses/*physiology; Luteinizing Hormone/blood; Ovulation/*drug effects/physiology; Progesterone/blood; Safety; Sexual Behavior, Animal/drug effects/physiology; Time Factors; Vaccination/veterinary |
| Abstract |
OBJECTIVE: To examine the immunogenicity of an equine immunocontraceptive vaccine and its efficacy in controlling hormone-related behaviour. DESIGN: A total of 24 mares at two sites in Australia were vaccinated with an immunocontraceptive vaccine comprising gonadotrophin releasing hormone (GnRH) conjugated to a carrier protein in immunostimulating complex as an adjuvant. Twelve animals at each site received a placebo of adjuvant alone and served as controls for seasonal oestrus, hormonal and behaviour patterns. Animals were observed for injection site reactions, ovarian and follicular activity, and serum levels of antibody, 17beta-oestradiol and progesterone in the weeks following vaccination. Mares were also examined for oestrous behaviour by teasing with a stallion. RESULTS: All mares responded to vaccination. Two weeks following the second vaccination there was a peak in antibody response to GnRH that declined gradually over the following weeks. Commensurate with the elevated anti-GnRH antibody there was a marked effect on ovarian activity with a reduction in 17beta-oestradiol and progesterone levels in the 24 vaccinated mares. There was also a reduction of oestrus-related behaviour as determined by a teaser stallion. This effect lasted a minimum of 3 months and correlated with the initial level of antibody response. CONCLUSION: Following a conventional two-dose immunisation regime this commercially available equine immunocontraceptive vaccine was effective at inhibiting oestrous behaviour for at least 3 months. This vaccine has a high level of safety since there were no significant local reactions nor were there any adverse systemic responses to vaccination. |
| Address |
Veterinary Medicines Research and Development, Pfizer Animal Health, Parkville, VIC 3052. Martin.Elhay@pfizer.com |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0005-0423 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:17300452 |
Approved |
no |
| Call Number |
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Serial |
1831 |
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| Author |
Lyda, R.O.; Hall, J.R.; Kirkpatrick, J.F. |
| Title |
A comparison of Freund's Complete and Freund's Modified Adjuvants used with a contraceptive vaccine in wild horses (Equus caballus) |
Type |
Journal Article |
| Year |
2005 |
Publication |
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians |
Abbreviated Journal |
J Zoo Wildl Med |
| Volume |
36 |
Issue |
4 |
Pages |
610-616 |
| Keywords |
Animals; Antibody Formation; Contraception, Immunologic/*veterinary; Estrus/drug effects; Female; Freund's Adjuvant/administration & dosage/adverse effects/*immunology; Horses/immunology/*physiology; *Vaccines, Contraceptive; Zona Pellucida/*immunology |
| Abstract |
Fifteen captive wild mares (Equus caballus) were treated with porcine zona pellucida contraceptive vaccine and either Freund's Complete Adjuvant (n = 7) or Freund's Modified Adjuvant (n = 8). All mares received a booster inoculation of porcine zona pellucida plus Freund's Incomplete Adjuvant a month later. Anti-porcine zona pellucida antibodies were measured over 10 mo following the initial inoculation. There were no significant differences in antibody titers at any point during the 10 mo, and seven of the eight mares in the Freund's Modified Adjuvant group were above the 60% level at the end of the study, which is considered to be the contraceptive threshold for horses. There were no significant differences in titers between pregnant and nonpregnant horses, nor was there a significant correlation between age and titers. One local injection site reaction occurred after booster treatment with Freund's Incomplete Adjuvant, and 11 healthy foals were born during the course of the study. These data suggest that Freund's Modified Adjuvant is an acceptable substitute for Freund's Complete Adjuvant in certain free-ranging and captive wildlife species. |
| Address |
Science and Conservation Center, 2100 South Shiloh Road, Billings, Montana 59106, USA |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1042-7260 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:17312717 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
139 |
| Permanent link to this record |
