| Records |
| Author |
Branchi, I.; Bichler, Z.; Berger-Sweeney, J.; Ricceri, L. |
| Title |
Animal models of mental retardation: from gene to cognitive function |
Type |
Journal Article |
| Year |
2003 |
Publication |
Neuroscience and Biobehavioral Reviews |
Abbreviated Journal  |
Neurosci Biobehav Rev |
| Volume |
27 |
Issue |
1-2 |
Pages |
141-153 |
| Keywords |
Animals; Animals, Genetically Modified/growth & development; Behavior/physiology; Behavior, Animal; Brain/*growth & development; Cognition/*physiology; *Disease Models, Animal; Environment; Genes; Genetic Diseases, Inborn/physiopathology; Humans; Mental Retardation/classification/*genetics/*physiopathology |
| Abstract |
About 2-3% of all children are affected by mental retardation, and genetic conditions rank among the leading causes of mental retardation. Alterations in the information encoded by genes that regulate critical steps of brain development can disrupt the normal course of development, and have profound consequences on mental processes. Genetically modified mouse models have helped to elucidate the contribution of specific gene alterations and gene-environment interactions to the phenotype of several forms of mental retardation. Mouse models of several neurodevelopmental pathologies, such as Down and Rett syndromes and X-linked forms of mental retardation, have been developed. Because behavior is the ultimate output of brain, behavioral phenotyping of these models provides functional information that may not be detectable using molecular, cellular or histological evaluations. In particular, the study of ontogeny of behavior is recommended in mouse models of disorders having a developmental onset. Identifying the role of specific genes in neuropathologies provides a framework in which to understand key stages of human brain development, and provides a target for potential therapeutic intervention. |
| Address |
Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy. branchi@iss.it |
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Place of Publication |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0149-7634 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:12732230 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2805 |
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| Author |
Milgram, N.W.; Head, E.; Muggenburg, B.; Holowachuk, D.; Murphey, H.; Estrada, J.; Ikeda-Douglas, C.J.; Zicker, S.C.; Cotman, C.W. |
| Title |
Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy |
Type |
Journal Article |
| Year |
2002 |
Publication |
Neuroscience and Biobehavioral Reviews |
Abbreviated Journal |
Neurosci Biobehav Rev |
| Volume |
26 |
Issue |
6 |
Pages |
679-695 |
| Keywords |
Age Factors; Aging/*physiology; Analysis of Variance; Animals; Antioxidants/*pharmacology; Blood Chemical Analysis/methods; Cognition/*physiology; *Diet; Discrimination Learning/*drug effects/*physiology; Distance Perception/drug effects/physiology; Dogs/physiology; Female; Male; Psychomotor Performance/physiology; Retention (Psychology)/drug effects/physiology; Spatial Behavior/*drug effects/*physiology; Task Performance and Analysis; Time Factors; Vitamin E/blood |
| Abstract |
The landmark discrimination learning test can be used to assess the ability to utilize allocentric spatial information to locate targets. The present experiments examined the role of various factors on performance of a landmark discrimination learning task in beagle dogs. Experiments 1 and 2 looked at the effects of age and food composition. Experiments 3 and 4 were aimed at characterizing the cognitive strategies used in performance on this task and in long-term retention. Cognitively equivalent groups of old and young dogs were placed into either a test group maintained on food enriched with a broad-spectrum of antioxidants and mitochondrial cofactors, or a control group maintained on a complete and balanced food formulated for adult dogs. Following a wash-in period, the dogs were tested on a series of problems, in which reward was obtained when the animal responded selectively to the object closest to a thin wooden block, which served as a landmark. In Experiment 1, dogs were first trained to respond to a landmark placed directly on top of coaster, landmark 0 (L0). In the next phase of testing, the landmark was moved at successively greater distances (1, 4 or 10 cm) away from the reward object. Learning varied as a function of age group, food group, and task. The young dogs learned all of the tasks more quickly than the old dogs. The aged dogs on the enriched food learned L0 significantly more rapidly than aged dogs on control food. A higher proportion of dogs on the enriched food learned the task, when the distance was increased to 1cm. Experiment 2 showed that accuracy decreased with increased distance between the reward object and landmark, and this effect was greater in old animals. Experiment 3 showed stability of performance, despite using a novel landmark, and new locations, indicating that dogs learned the landmark concept. Experiment 4 found age impaired long-term retention of the landmark task. These results indicate that allocentric spatial learning is impaired in an age-dependent manner in dogs, and that age also affects performance when the distance between the landmark and target is increased. In addition, these results both support a role of oxidative damage in the development of age-associated cognitive dysfunction and indicate that short-term administration of a food enriched with supplemental antioxidants and mitochondrial cofactors can partially reverse the deleterious effects of aging on cognition. |
| Address |
Life Science Division, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ont., Canada M1C 1A4. milgram@psych.utoronto.ca |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0149-7634 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:12479842 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2806 |
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| Author |
Heschl, A.; Burkart, J. |
| Title |
A new mark test for mirror self-recognition in non-human primates |
Type |
Journal Article |
| Year |
2006 |
Publication |
Primates |
Abbreviated Journal |
Primates |
| Volume |
47 |
Issue |
3 |
Pages |
187-198 |
| Keywords |
Animals; *Behavior, Animal; Callithrix/*physiology; Cognition/*physiology; Discrimination (Psychology)/physiology; Female; Male; Photic Stimulation; *Self Concept |
| Abstract |
For 30 years Gallup's (Science 167:86-87, 1970) mark test, which consists of confronting a mirror-experienced test animal with its own previously altered mirror image, usually a color mark on forehead, eyebrow or ear, has delivered valuable results about the distribution of visual self-recognition in non-human primates. Chimpanzees, bonobos, orangutans and, less frequently, gorillas can learn to correctly understand the reflection of their body in a mirror. However, the standard version of the mark test is good only for positively proving the existence of self-recognition. Conclusive statements about the lack of self-recognition are more difficult because of the methodological constraints of the test. This situation has led to a persistent controversy about the power of Gallup's original technique. We devised a new variant of the test which permits more unequivocal decisions about both the presence and absence of self-recognition. This new procedure was tested with marmoset monkeys (Callithrix jacchus), following extensive training with mirror-related tasks to facilitate performance in the standard mark test. The results show that a slightly altered mark test with a new marking substance (chocolate cream) can help to reliably discriminate between true negative results, indicating a real lack of ability to recognize oneself in a mirror, from false negative results that are due to methodological particularities of the standard test. Finally, an evolutionary hypothesis is put forward as to why many primates can use a mirror instrumentally – i.e. know how to use it for grasping at hidden objects – while failing in the decisive mark test. |
| Address |
Konrad Lorenz Institute for Evolution and Cognition Research, Adolf Lorenz Gasse 2, 3422, Altenberg, Austria. adolf.heschl@uni-graz.at |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0032-8332 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16432640 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2810 |
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| Author |
Barrett, L.; Henzi, P. |
| Title |
The social nature of primate cognition |
Type |
Journal Article |
| Year |
2005 |
Publication |
Proceedings. Biological Sciences / The Royal Society |
Abbreviated Journal |
Proc Biol Sci |
| Volume |
272 |
Issue |
1575 |
Pages |
1865-1875 |
| Keywords |
Animals; Brain/anatomy & histology/*physiology; Cognition/*physiology; *Evolution; Intelligence/*physiology; Primates/*physiology; *Social Behavior |
| Abstract |
The hypothesis that the enlarged brain size of the primates was selected for by social, rather than purely ecological, factors has been strongly influential in studies of primate cognition and behaviour over the past two decades. However, the Machiavellian intelligence hypothesis, also known as the social brain hypothesis, tends to emphasize certain traits and behaviours, like exploitation and deception, at the expense of others, such as tolerance and behavioural coordination, and therefore presents only one view of how social life may shape cognition. This review outlines work from other relevant disciplines, including evolutionary economics, cognitive science and neurophysiology, to illustrate how these can be used to build a more general theoretical framework, incorporating notions of embodied and distributed cognition, in which to situate questions concerning the evolution of primate social cognition. |
| Address |
School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK. louiseb@liv.ac.uk |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0962-8452 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16191591 |
Approved |
no |
| Call Number |
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Serial |
2086 |
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| Author |
Griffin, D.R. |
| Title |
Animals know more than we used to think |
Type |
|
| Year |
2001 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
| Volume |
98 |
Issue |
9 |
Pages |
4833-4834 |
| Keywords |
Animal Communication; Animals; Attention/physiology; Brain/physiology; Choice Behavior/physiology; Cognition/*physiology; Humans; Macaca mulatta/physiology/*psychology; Memory/*physiology; Optic Disk/physiology; Psychological Tests |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0027-8424 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:11320232 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2823 |
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| Author |
Hampton, R.R. |
| Title |
Rhesus monkeys know when they remember |
Type |
Journal Article |
| Year |
2001 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
| Volume |
98 |
Issue |
9 |
Pages |
5359-5362 |
| Keywords |
Animals; Choice Behavior/physiology; Cognition/*physiology; Cues; Food Preferences/psychology; Macaca mulatta/*physiology/*psychology; Male; Memory/*physiology; Probability; Psychological Tests; Reproducibility of Results; Sensitivity and Specificity |
| Abstract |
Humans are consciously aware of some memories and can make verbal reports about these memories. Other memories cannot be brought to consciousness, even though they influence behavior. This conspicuous difference in access to memories is central in taxonomies of human memory systems but has been difficult to document in animal studies, suggesting that some forms of memory may be unique to humans. Here I show that rhesus macaque monkeys can report the presence or absence of memory. Although it is probably impossible to document subjective, conscious properties of memory in nonverbal animals, this result objectively demonstrates an important functional parallel with human conscious memory. Animals able to discern the presence and absence of memory should improve accuracy if allowed to decline memory tests when they have forgotten, and should decline tests most frequently when memory is attenuated experimentally. One of two monkeys examined unequivocally met these criteria under all test conditions, whereas the second monkey met them in all but one case. Probe tests were used to rule out “cueing” by a wide variety of environmental and behavioral stimuli, leaving detection of the absence of memory per se as the most likely mechanism underlying the monkeys' abilities to selectively decline memory tests when they had forgotten. |
| Address |
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Building 49, Room 1B-80, Bethesda, MD 20892, USA. robert@ln.nimh.nih.gov |
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English |
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Series Issue |
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Edition |
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| ISSN |
0027-8424 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:11274360 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2824 |
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| Author |
Rizzolatti, G.; Fogassi, L.; Gallese, V. |
| Title |
Mirrors of the mind |
Type |
Journal Article |
| Year |
2006 |
Publication |
Scientific American |
Abbreviated Journal |
Sci Am |
| Volume |
295 |
Issue |
5 |
Pages |
54-61 |
| Keywords |
Animals; Brain/*physiology; Cognition/*physiology; Discrimination (Psychology)/physiology; Emotions/physiology; Humans; Imitative Behavior; Learning/*physiology; Mental Processes/*physiology; Motor Activity/physiology; Neurons/physiology; Recognition (Psychology); Sensation/physiology |
| Abstract |
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| Address |
Neurosciences Department, University of Parma, Italy |
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English |
Summary Language |
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Edition |
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| ISSN |
0036-8733 |
ISBN |
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| Notes |
PMID:17076084 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2829 |
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| Author |
Hare, B.; Tomasello, M. |
| Title |
Human-like social skills in dogs? |
Type |
Journal Article |
| Year |
2005 |
Publication |
Trends in Cognitive Sciences |
Abbreviated Journal |
Trends. Cognit. Sci. |
| Volume |
9 |
Issue |
9 |
Pages |
439-444 |
| Keywords |
*Animal Communication; Animals; *Behavior, Animal; Cognition/*physiology; Dogs; *Evolution; Humans; *Social Behavior |
| Abstract |
Domestic dogs are unusually skilled at reading human social and communicative behavior--even more so than our nearest primate relatives. For example, they use human social and communicative behavior (e.g. a pointing gesture) to find hidden food, and they know what the human can and cannot see in various situations. Recent comparisons between canid species suggest that these unusual social skills have a heritable component and initially evolved during domestication as a result of selection on systems mediating fear and aggression towards humans. Differences in chimpanzee and human temperament suggest that a similar process may have been an important catalyst leading to the evolution of unusual social skills in our own species. The study of convergent evolution provides an exciting opportunity to gain further insights into the evolutionary processes leading to human-like forms of cooperation and communication. |
| Address |
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany. hare@eva.mpg.de |
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English |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1364-6613 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:16061417 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
546 |
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| Author |
Gomez, J.-C. |
| Title |
Species comparative studies and cognitive development |
Type |
Journal Article |
| Year |
2005 |
Publication |
Trends in Cognitive Sciences |
Abbreviated Journal |
Trends. Cognit. Sci. |
| Volume |
9 |
Issue |
3 |
Pages |
118-125 |
| Keywords |
Animals; Attention/physiology; Brain/*growth & development; Child, Preschool; Cognition/*physiology; Concept Formation/physiology; Dogs; Evolution; Fixation, Ocular; Gorilla gorilla; Humans; Infant; Learning/*physiology; Macaca mulatta; Mental Recall/physiology; Personal Construct Theory; Psychomotor Performance/physiology; Species Specificity |
| Abstract |
The comparative study of infant development and animal cognition brings to cognitive science the promise of insights into the nature and origins of cognitive skills. In this article, I review a recent wave of comparative studies conducted with similar methodologies and similar theoretical frameworks on how two core components of human cognition--object permanence and gaze following--develop in different species. These comparative findings call for an integration of current competing accounts of developmental change. They further suggest that evolution has produced developmental devices capable at the same time of preserving core adaptive components, and opening themselves up to further adaptive change, not only in interaction with the external environment, but also in interaction with other co-developing cognitive systems. |
| Address |
Scottish Primate Research Group, School of Psychology, University of St Andrews, St Andrews, Fife KY15 9JU, UK |
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English |
Summary Language |
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Abbreviated Series Title |
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Edition |
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| ISSN |
1364-6613 |
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Conference |
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| Notes |
PMID:15737820 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2851 |
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| Author |
Matsushima, T.; Izawa, E.-I.; Aoki, N.; Yanagihara, S. |
| Title |
The mind through chick eyes: memory, cognition and anticipation |
Type |
Journal Article |
| Year |
2003 |
Publication |
Zoological Science |
Abbreviated Journal |
Zoolog Sci |
| Volume |
20 |
Issue |
4 |
Pages |
395-408 |
| Keywords |
Animals; Birds/anatomy & histology/*physiology; Brain/anatomy & histology/cytology/physiology; Cognition/*physiology; Memory/*physiology; Perception/physiology |
| Abstract |
To understand the animal mind, we have to reconstruct how animals recognize the external world through their own eyes. For the reconstruction to be realistic, explanations must be made both in their proximate causes (brain mechanisms) as well as ultimate causes (evolutionary backgrounds). Here, we review recent advances in the behavioral, psychological, and system-neuroscience studies accomplished using the domestic chick as subjects. Diverse behavioral paradigms are compared (such as filial imprinting, sexual imprinting, one-trial passive avoidance learning, and reinforcement operant conditioning) in their behavioral characterizations (development, sensory and motor aspects of functions, fitness gains) and relevant brain mechanisms. We will stress that common brain regions are shared by these distinct paradigms, particularly those in the ventral telencephalic structures such as AIv (in the archistriatum) and LPO (in the medial striatum). Neuronal ensembles in these regions could code the chick's anticipation for forthcoming events, particularly the quality/quantity and the temporal proximity of rewards. Without the internal representation of the anticipated proximity in LPO, behavioral tolerance will be lost, and the chick makes impulsive choice for a less optimized option. Functional roles of these regions proved compatible with their anatomical counterparts in the mammalian brain, thus suggesting that the neural systems linking between the memorized past and the anticipated future have remained highly conservative through the evolution of the amniotic vertebrates during the last 300 million years. With the conservative nature in mind, research efforts should be oriented toward a unifying theory, which could explain behavioral deviations from optimized foraging, such as “naive curiosity,” “contra-freeloading,” “Concorde fallacy,” and “altruism.” |
| Address |
Graduate School of Bioagricultural Sciences, Nagoya University, Japan. matusima@agr.nagoya-u.ac.jp |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0289-0003 |
ISBN |
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| Notes |
PMID:12719641 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2858 |
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