| Records |
| Author |
Li, F.-H.; Zhong, W.-Q.; Wang, Z.; Wang, D.-H. |
| Title |
Rank in a food competition test and humoral immune functions in male Brandt's voles (Lasiopodomys brandtii) |
Type |
Journal Article |
Year  |
2007 |
Publication |
Physiology & behavior |
Abbreviated Journal |
Physiol. Behav. |
| Volume |
90 |
Issue |
2-3 |
Pages |
490-495 |
| Keywords |
Animals; Antibody Formation/*physiology; Arvicolinae/immunology/*physiology; Competitive Behavior/*physiology; *Dominance-Subordination; Feeding Behavior/physiology; Hydrocortisone/blood; Male; *Social Dominance; Spleen/immunology/physiology |
| Abstract |
Social status can influence an animal's immune and reproductive functions, eventually leading to alterations in immunocompetence and reproductive success. Here, we report that rank assessed in a food competition test, considered as an index of social status, has significant influences on humoral immune functions in male Brandt's voles (Lasiopodomys brandtii) living in a group. Our data reveal a negative correlation of the spleen mass and serum antibody levels with social status, as well as a positive correlation of serum cortisol levels with social status. Males winning in food competition had a smaller spleen, a lower level of serum antibodies, and a higher level of serum cortisol than did their conspecific counterparts. These data indicate interactions between social status and humoral immune functions and might illustrate a trade-off between infection risks and reproductive success in male Brandt's voles. |
| Address |
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, The Chinese Academy of Sciences, No. 25 Beisihuan Xilu, Zhongguancun, Haidian, Beijing 100080, China |
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| Language |
English |
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Edition |
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| ISSN |
0031-9384 |
ISBN |
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| Notes |
PMID:17141282 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
804 |
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| Author |
Rapin, V.; Poncet, P.A.; Burger, D.; Mermod, C.; Richard, M.A. |
| Title |
[Measurement of the attention time in the horse] |
Type |
Journal Article |
| Year |
2007 |
Publication |
Schweizer Archiv fur Tierheilkunde |
Abbreviated Journal |
Schweiz Arch Tierheilkd |
| Volume |
149 |
Issue |
2 |
Pages |
77-83 |
| Keywords |
Age Factors; Animals; *Attention/physiology; Conditioning, Operant; Cross-Over Studies; Female; Horses/*physiology; Learning/*physiology; Male; Memory/*physiology; Time Factors |
| Abstract |
A study carried out on 49 horses showed that it is possible to measure the attention time by operant conditioning. After teaching horses an instrumental task using a signal, we were then able to test their attention time by asking them to prolong it increasingly while setting success and failure criteria. Two tests were performed 3 weeks apart. The 2nd test was feasible without relearning, a proof of memory, and was repeatable, a proof of consistency in the attention time. A significant difference was observed between the 3 age groups. Young horses often performed very well during the 1st test but their attention dropped in the 2nd test while older horses were more stable with respect to attention and even increased it slightly. The study shows that there are individual differences but it was not possible to prove a significant influence of breed, gender and paternal influence. Consequently, learning appears to be one of the most interesting approaches for evaluating the attention of horses and for observing their behaviour. |
| Address |
Laboratoire d'Ecoethologie, Universite de Neuchatel, Suisse. veronique.rapin@unine.ch |
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| Language |
French |
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Original Title |
Mesure de la duree d'attention chez le cheval |
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Series Issue |
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Edition |
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| ISSN |
0036-7281 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:17343134 |
Approved |
no |
| Call Number |
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Serial |
1770 |
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| Author |
Robinson, H.C. |
| Title |
Equine interspecies aggression |
Type |
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| Year |
2007 |
Publication |
The Veterinary record |
Abbreviated Journal |
Vet. Rec. |
| Volume |
160 |
Issue |
7 |
Pages |
244 |
| Keywords |
*Aggression; Animals; Behavior, Animal; Equidae; Horses/*physiology/*psychology |
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English |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0042-4900 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:17308028 |
Approved |
no |
| Call Number |
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Serial |
1773 |
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| Author |
Elhay, M.; Newbold, A.; Britton, A.; Turley, P.; Dowsett, K.; Walker, J. |
| Title |
Suppression of behavioural and physiological oestrus in the mare by vaccination against GnRH |
Type |
Journal Article |
| Year |
2007 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
85 |
Issue |
1-2 |
Pages |
39-45 |
| Keywords |
Animals; Antibodies/blood; Estradiol/blood; *Estrus/drug effects/physiology; Female; Gonadotropin-Releasing Hormone/*immunology/*pharmacology; Horses/*physiology; Luteinizing Hormone/blood; Ovulation/*drug effects/physiology; Progesterone/blood; Safety; Sexual Behavior, Animal/drug effects/physiology; Time Factors; Vaccination/veterinary |
| Abstract |
OBJECTIVE: To examine the immunogenicity of an equine immunocontraceptive vaccine and its efficacy in controlling hormone-related behaviour. DESIGN: A total of 24 mares at two sites in Australia were vaccinated with an immunocontraceptive vaccine comprising gonadotrophin releasing hormone (GnRH) conjugated to a carrier protein in immunostimulating complex as an adjuvant. Twelve animals at each site received a placebo of adjuvant alone and served as controls for seasonal oestrus, hormonal and behaviour patterns. Animals were observed for injection site reactions, ovarian and follicular activity, and serum levels of antibody, 17beta-oestradiol and progesterone in the weeks following vaccination. Mares were also examined for oestrous behaviour by teasing with a stallion. RESULTS: All mares responded to vaccination. Two weeks following the second vaccination there was a peak in antibody response to GnRH that declined gradually over the following weeks. Commensurate with the elevated anti-GnRH antibody there was a marked effect on ovarian activity with a reduction in 17beta-oestradiol and progesterone levels in the 24 vaccinated mares. There was also a reduction of oestrus-related behaviour as determined by a teaser stallion. This effect lasted a minimum of 3 months and correlated with the initial level of antibody response. CONCLUSION: Following a conventional two-dose immunisation regime this commercially available equine immunocontraceptive vaccine was effective at inhibiting oestrous behaviour for at least 3 months. This vaccine has a high level of safety since there were no significant local reactions nor were there any adverse systemic responses to vaccination. |
| Address |
Veterinary Medicines Research and Development, Pfizer Animal Health, Parkville, VIC 3052. Martin.Elhay@pfizer.com |
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English |
Summary Language |
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Edition |
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| ISSN |
0005-0423 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:17300452 |
Approved |
no |
| Call Number |
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Serial |
1831 |
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| Author |
Momozawa, Y.; Takeuchi, Y.; Tozaki, T.; Kikusui, T.; Hasegawa, T.; Raudsepp, T.; Chowdhary, B.P.; Kusunose, R.; Mori, Y. |
| Title |
SNP detection and radiation hybrid mapping in horses of nine candidate genes for temperament |
Type |
Journal Article |
| Year |
2007 |
Publication |
Animal Genetics |
Abbreviated Journal |
Anim Genet |
| Volume |
38 |
Issue |
1 |
Pages |
81-83 |
| Keywords |
Animals; *Behavior, Animal; Breeding; Horses/*genetics/physiology; *Polymorphism, Single Nucleotide; Radiation Hybrid Mapping; *Temperament |
| Abstract |
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| Address |
Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo 113-8657, Japan |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0268-9146 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:17257195 |
Approved |
no |
| Call Number |
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Serial |
1834 |
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| Author |
Meral, Y.; Cakiroglu, D.; Sancak, A.A.; Cyftcy, G.; Karabacak, A. |
| Title |
Relationships between serum serotonin and serum lipid levels, and aggression in horses |
Type |
Journal Article |
| Year |
2007 |
Publication |
DTW. Deutsche Tierarztliche Wochenschrift |
Abbreviated Journal |
Dtsch Tierarztl Wochenschr |
| Volume |
114 |
Issue |
1 |
Pages |
30-32 |
| Keywords |
*Aggression; Animals; Behavior, Animal/*physiology; Case-Control Studies; Female; Horses/*blood; Lipids/*blood; Male; Serotonin/*blood |
| Abstract |
Levels of serum serotonin and serum lipids--triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein and very low-density lipoprotein, were determined in normal horses and horses diagnosed with aggression on the basis of a questionnaire survey. Blood serotonin levels in aggressive horses were found to be significantly lower than in non-aggressive horses (P < 0.01), but no association was found with respect to blood lipids. |
| Address |
Department of Internal Diseases, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Samsun, Turkey. ymeral@omu.edu.t |
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English |
Summary Language |
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Edition |
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| ISSN |
0341-6593 |
ISBN |
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Conference |
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| Notes |
PMID:17252934 |
Approved |
no |
| Call Number |
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Serial |
1835 |
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| Author |
Mills, D.S. |
| Title |
Comments about the importance of behaviour to equine clinicians |
Type |
Journal Article |
| Year |
2007 |
Publication |
Equine Veterinary Journal |
Abbreviated Journal |
Equine Vet J |
| Volume |
39 |
Issue |
1 |
Pages |
95 |
| Keywords |
Animals; *Behavior, Animal/physiology; *Clinical Competence; Horses/*physiology; Humans; Veterinarians/*psychology; Veterinary Medicine/*standards |
| Abstract |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0425-1644 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:17228604 |
Approved |
no |
| Call Number |
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Serial |
1839 |
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| Author |
Machnik, M.; Hegger, I.; Kietzmann, M.; Thevis, M.; Guddat, S.; Schanzer, W. |
| Title |
Pharmacokinetics of altrenogest in horses |
Type |
Journal Article |
| Year |
2007 |
Publication |
Journal of Veterinary Pharmacology and Therapeutics |
Abbreviated Journal |
J Vet Pharmacol Ther |
| Volume |
30 |
Issue |
1 |
Pages |
86-90 |
| Keywords |
Administration, Oral; Animals; Chromatography, Liquid/veterinary; Doping in Sports/prevention & control; Horses/*metabolism; Male; Mass Spectrometry/veterinary; Progesterone Congeners/administration & dosage/blood/*pharmacokinetics/urine; Reproducibility of Results; Substance Abuse Detection/veterinary; Trenbolone/administration & dosage/*analogs & derivatives/blood/pharmacokinetics/urine |
| Abstract |
The Federation Equestre Internationale has permitted the use of altrenogest in mares for the control of oestrus. However, altrenogest is also suspicious to misuse in competition horses for its potential anabolic effects and suppression of typical male behaviour, and thus is a controlled drug. To investigate the pharmacokinetics of altrenogest in horses we conducted an elimination study. Five oral doses of 44 mug/kg altrenogest were administered to 10 horses at a dose interval of 24 h. Following administration blood and urine samples were collected at appropriate intervals. Altrenogest concentrations were measured by liquid chromatography-tandem mass spectrometry. The plasma levels of altrenogest reached maximal concentrations of 23-75 ng/mL. Baseline values were achieved within 3 days after the final administration. Urine peak concentrations of total altrenogest ranged from 823 to 3895 ng/mL. Twelve days after the final administration concentrations were below the limit of detection (ca 2 ng/mL). |
| Address |
Institute of Biochemistry, German Sport University, Cologne, Germany. m.machnik@biochem.dshs-koeln.de |
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English |
Summary Language |
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Edition |
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| ISSN |
0140-7783 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:17217407 |
Approved |
no |
| Call Number |
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Serial |
1841 |
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| Author |
Rosa, P.A.J.; Azevedo, A.M.; Aires-Barros, M.R. |
| Title |
Application of central composite design to the optimisation of aqueous two-phase extraction of human antibodies |
Type |
Journal Article |
| Year |
2007 |
Publication |
Journal of Chromatography. A |
Abbreviated Journal |
J Chromatogr A |
| Volume |
1141 |
Issue |
1 |
Pages |
50-60 |
| Keywords |
Analysis of Variance; Animals; Antibodies/*chemistry/*isolation & purification; Buffers; Chemical Fractionation/*methods; Horses; Humans; Hydrophobicity; Isoelectric Point; Models, Biological; Molecular Weight; Myoglobin/chemistry/isolation & purification; Osmolar Concentration; Phase Transition; Polyethylene Glycols; Serum Albumin/chemistry/isolation & purification; Sodium Chloride |
| Abstract |
The partition of human antibodies in aqueous two-phase systems (ATPSs) of polyethylene glycol (PEG) and phosphate was systematically studied using first pure proteins systems and then an artificial mixture of proteins containing 1mg/ml human immunoglobulin G (IgG), 10mg/ml serum albumin and 2mg/ml myoglobin. Preliminary results obtained using pure proteins systems indicated that the PEG molecular weight and concentration, the pH value and the salts concentration had a pronounced effect on the partitioning behaviour of all proteins. For high ionic strengths and pH values higher than the isoelectric point (pI) of the contaminant proteins, IgG could be selectively recovered on the top phase. According to these results, a face centred composite design was performed in order to optimise the purification of IgG from the mixture of proteins. The optimal conditions for the isolation of IgG were observed for high concentrations of NaCl and low concentrations of both phase forming components. The best purification was achieved using an ATPS containing 8% (w/w) PEG 3350, 10% (w/w) phosphate pH 6 and 15% (w/w) NaCl. A recovery yield of 101+/-7%, a purity of 99+/-0% and a yield of native IgG of 97+/-4% were obtained. Back extraction studies of IgG to a new phosphate phase were performed and higher yields were obtained using 10% phosphate buffer at pH 6. The total extraction yield was 76% and the purity 100%. |
| Address |
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049-001 Lisbon, Portugal |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0021-9673 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:17196214 |
Approved |
no |
| Call Number |
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Serial |
1842 |
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| Author |
Petter-Puchner, A.H.; Froetscher, W.; Krametter-Froetscher, R.; Lorinson, D.; Redl, H.; van Griensven, M. |
| Title |
The long-term neurocompatibility of human fibrin sealant and equine collagen as biomatrices in experimental spinal cord injury |
Type |
Journal Article |
| Year |
2007 |
Publication |
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft fur Toxikologische Pathologie |
Abbreviated Journal |
Exp Toxicol Pathol |
| Volume |
58 |
Issue |
4 |
Pages |
237-245 |
| Keywords |
Animals; Axotomy; Biocompatible Materials/*therapeutic use; Collagen/*therapeutic use; Fibrin Tissue Adhesive/*therapeutic use; Horses; Humans; Immunohistochemistry; Male; Motor Activity/physiology; Nerve Regeneration/*physiology; Rats; Recovery of Function; Spinal Cord/pathology/physiology; Spinal Cord Injuries/pathology/*therapy; Thoracic Vertebrae |
| Abstract |
INTRODUCTION: While fibrin sealant (FS) and equine collagen (EC) have been used as scaffold materials in experimental spinal cord injury (SCI), questions concerning neurocompatibility still remain. In this study, we assessed potential adverse effects, as well as functional and histological impact of FS and EC in subtotal hemisection of the thoracic spinal cord (SC) in rats. METHODS: 124 male rats were randomly assigned to four main groups (n=31): Sham (SH), Lesion only (L), fibrin sealant (GFS) and equine collagen group (GEC). SH animals received laminectomy only; all other animals underwent subtotal lateral hemisection at T9. Treatment consisted of application of FS or EC into the lesion gap in GFS and GEC, which was left empty in L. GFS, GEC, L and SH were each further divided into 4 subgroups: One subgroup, consisting of 10 rats was subjected to behavioural and reflex testing before surgery and followed up on days 1,7, 14, 21, 28 post op and then sacrificed. Haemalaun or cresyl violet (CV) was used to identify neutrophils in parasagittal cord sections which were obtained on day 1 (n=7). Sections stained for quantification of microglia/macrophages using ED-1 on day 3 (n=7), day 7 (n=7) and day 28 (n=7 out of 10). Additionally, neural filament (NF) staining was chosen to detect axonal regeneration and the length of ingrowth into FS and EC, Luxol blue for myelination, Von Willebrand factor for vascularisation, and glial fibrillary acidic protein (GFAP) staining for detection of astrocytes in glial scars on day 28. RESULTS: No adverse effects were observed in the treatment groups. Compared to L, GFS and GEC performed significantly better in the Basso, Beattie, Bresnahan (BBB) score and hopping responses. Proprioceptive placing was markedly improved in FS and EC compared to L. Axonal regrowth was found in GFS and GEC--the regrowth in the GFS was accompanied by myelination and vascularisation. Glial scarring occurred in all groups. Discussion Both biomatrices improved functional recovery compared to L and no adverse effects were perceived. |
| Address |
Ludwig Boltzmann Institute of Experimental and Clinical Traumatology, Donaueschingenstrasse 13, 1200-Vienna, Austria |
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English |
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Edition |
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| ISSN |
0940-2993 |
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| Notes |
PMID:17118635 |
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no |
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Serial |
1852 |
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