| Records |
| Author |
Branchi, I.; Bichler, Z.; Berger-Sweeney, J.; Ricceri, L. |
Title  |
Animal models of mental retardation: from gene to cognitive function |
Type |
Journal Article |
| Year |
2003 |
Publication |
Neuroscience and Biobehavioral Reviews |
Abbreviated Journal |
Neurosci Biobehav Rev |
| Volume |
27 |
Issue |
1-2 |
Pages |
141-153 |
| Keywords |
Animals; Animals, Genetically Modified/growth & development; Behavior/physiology; Behavior, Animal; Brain/*growth & development; Cognition/*physiology; *Disease Models, Animal; Environment; Genes; Genetic Diseases, Inborn/physiopathology; Humans; Mental Retardation/classification/*genetics/*physiopathology |
| Abstract |
About 2-3% of all children are affected by mental retardation, and genetic conditions rank among the leading causes of mental retardation. Alterations in the information encoded by genes that regulate critical steps of brain development can disrupt the normal course of development, and have profound consequences on mental processes. Genetically modified mouse models have helped to elucidate the contribution of specific gene alterations and gene-environment interactions to the phenotype of several forms of mental retardation. Mouse models of several neurodevelopmental pathologies, such as Down and Rett syndromes and X-linked forms of mental retardation, have been developed. Because behavior is the ultimate output of brain, behavioral phenotyping of these models provides functional information that may not be detectable using molecular, cellular or histological evaluations. In particular, the study of ontogeny of behavior is recommended in mouse models of disorders having a developmental onset. Identifying the role of specific genes in neuropathologies provides a framework in which to understand key stages of human brain development, and provides a target for potential therapeutic intervention. |
| Address |
Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy. branchi@iss.it |
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English |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0149-7634 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:12732230 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2805 |
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| Author |
Griffin, D.R. |
| Title |
Animals know more than we used to think |
Type |
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| Year |
2001 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc. Natl. Acad. Sci. U.S.A. |
| Volume |
98 |
Issue |
9 |
Pages |
4833-4834 |
| Keywords |
Animal Communication; Animals; Attention/physiology; Brain/physiology; Choice Behavior/physiology; Cognition/*physiology; Humans; Macaca mulatta/physiology/*psychology; Memory/*physiology; Optic Disk/physiology; Psychological Tests |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0027-8424 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:11320232 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2823 |
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| Author |
Hubbell, J.A.E.; Muir, W.W. |
| Title |
Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole |
Type |
Journal Article |
| Year |
2006 |
Publication |
Equine Veterinary Journal |
Abbreviated Journal |
Equine Vet J |
| Volume |
38 |
Issue |
3 |
Pages |
238-241 |
| Keywords |
Animals; Behavior, Animal/drug effects/physiology; Dose-Response Relationship, Drug; Double-Blind Method; Horses/*physiology; Hypnotics and Sedatives/*antagonists & inhibitors; Imidazoles/*antagonists & inhibitors/*pharmacology; Infusions, Intravenous/veterinary; Kinetics; Safety; Tolazoline/*pharmacology; Videotape Recording |
| Abstract |
REASONS FOR PERFORMING STUDY: The ability to shorten the duration of sedation would potentially improve safety and utility of detomidine. OBJECTIVES: To determine the effects of tolazoline and atipamezole after detomidine sedation. HYPOTHESIS: Administration of tolazoline or atipamezole would not affect detomidine sedation. METHODS: In a randomised, placebo-controlled, double-blind, descriptive study, detomidine (0.02 mg/kg bwt i.v.) was administered to 6 mature horses on 4 separate occasions. Twenty-five mins later, each horse received one of 4 treatments: Group 1 saline (0.9% i.v.) as a placebo control; Group 2 atipamezole (0.05 mg/kg bwt i.v.); Group 3 atipamezole (0.1 mg/kg bwt i.v.); and Group 4 tolazoline (4.0 mg/kg bwt i.v.). Sedation, muscle relaxation and ataxia were scored by 3 independent observers at 9 time points. Horses were led through an obstacle course at 7 time points. Course completion time was recorded and the ability of the horse to traverse the course was scored by 3 independent observers. Horses were videotaped before, during and after each trip through the obstacle course. RESULTS: Atipamezole and tolazoline administration incompletely antagonised the effects of detomidine, but the time course to recovery was shortened. CONCLUSIONS AND POTENTIAL RELEVANCE: Single bolus administration of atipamezole or tolazoline produced partial reversal of detomidine sedation and may be useful for minimising detomidine sedation. |
| Address |
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, 601 Tharp Street, Columbus, Ohio 43210, USA |
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English |
Summary Language |
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Series Issue |
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Edition |
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| ISSN |
0425-1644 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16706278 |
Approved |
no |
| Call Number |
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Serial |
1869 |
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| Author |
Mulcahy, N.J.; Call, J. |
| Title |
Apes save tools for future use |
Type |
Journal Article |
| Year |
2006 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
| Volume |
312 |
Issue |
5776 |
Pages |
1038-1040 |
| Keywords |
Animals; Association Learning; *Cognition; *Evolution; *Mental Processes; *Pan paniscus; Pan troglodytes; *Pongo pygmaeus |
| Abstract |
Planning for future needs, not just current ones, is one of the most formidable human cognitive achievements. Whether this skill is a uniquely human adaptation is a controversial issue. In a study we conducted, bonobos and orangutans selected, transported, and saved appropriate tools above baseline levels to use them 1 hour later (experiment 1). Experiment 2 extended these results to a 14-hour delay between collecting and using the tools. Experiment 3 showed that seeing the apparatus during tool selection was not necessary to succeed. These findings suggest that the precursor skills for planning for the future evolved in great apes before 14 million years ago, when all extant great ape species shared a common ancestor. |
| Address |
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany |
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Place of Publication |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1095-9203 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16709782 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
466 |
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| Author |
Herrmann, E.; Melis, A.P.; Tomasello, M. |
| Title |
Apes' use of iconic cues in the object-choice task |
Type |
Journal Article |
| Year |
2006 |
Publication |
Animal cognition |
Abbreviated Journal |
Anim. Cogn. |
| Volume |
9 |
Issue |
2 |
Pages |
118-130 |
| Keywords |
Animal Communication; Animals; *Appetitive Behavior; *Choice Behavior; *Cues; Female; Gorilla gorilla; Male; *Nonverbal Communication; Pan paniscus; Pan troglodytes; Pongo pygmaeus; *Problem Solving; Space Perception; Species Specificity; Statistics, Nonparametric |
| Abstract |
In previous studies great apes have shown little ability to locate hidden food using a physical marker placed by a human directly on the target location. In this study, we hypothesized that the perceptual similarity between an iconic cue and the hidden reward (baited container) would help apes to infer the location of the food. In the first two experiments, we found that if an iconic cue is given in addition to a spatial/indexical cue – e.g., picture or replica of a banana placed on the target location – apes (chimpanzees, bonobos, orangutans, gorillas) as a group performed above chance. However, we also found in two further experiments that when iconic cues were given on their own without spatial/indexical information (iconic cue held up by human with no diagnostic spatial/indexical information), the apes were back to chance performance. Our overall conclusion is that although iconic information helps apes in the process of searching hidden food, the poor performance found in the last two experiments is due to apes' lack of understanding of the informative (cooperative) communicative intention of the experimenter. |
| Address |
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany. eherrman@eva.mpg.de |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1435-9448 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16395566 |
Approved |
no |
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Serial |
14 |
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| Author |
Boughner, R.L.; Papini, M.R. |
| Title |
Appetitive latent inhibition in rats: preexposure performance does not predict conditioned performance |
Type |
Journal Article |
| Year |
2006 |
Publication |
Behavioural Processes |
Abbreviated Journal |
Behav. Process. |
| Volume |
72 |
Issue |
1 |
Pages |
42-51 |
| Keywords |
Animals; *Appetitive Behavior; Association Learning; *Conditioning, Classical; *Habituation, Psychophysiologic; Individuality; *Inhibition (Psychology); Male; Motivation; Rats; Rats, Wistar; *Reaction Time |
| Abstract |
Nonreinforced preexposure to a conditioned stimulus impairs subsequent conditioning with that stimulus. The goal of these studies was to assess the extent to which acquisition performance could be predicted from preexposure performance using a correlational approach. For both preexposure and autoshaping, four measures of performance were computed, including overall average lever pressing, lever pressing in the initial session, percentage change in lever pressing, and slopes. These measures were correlated in a large sample of rats trained in an autoshaping situation. None of the three measures of autoshaping performance was consistently predicted by any of the three measures of preexposure performance. These results are consistent with the view that latent inhibition is not reducible to long-term habituation. |
| Address |
Department of Psychology, Texas Christian University, TX 76129, United States |
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Thesis |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0376-6357 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16406375 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4147 |
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| Author |
Rosa, P.A.J.; Azevedo, A.M.; Aires-Barros, M.R. |
| Title |
Application of central composite design to the optimisation of aqueous two-phase extraction of human antibodies |
Type |
Journal Article |
| Year |
2007 |
Publication |
Journal of Chromatography. A |
Abbreviated Journal |
J Chromatogr A |
| Volume |
1141 |
Issue |
1 |
Pages |
50-60 |
| Keywords |
Analysis of Variance; Animals; Antibodies/*chemistry/*isolation & purification; Buffers; Chemical Fractionation/*methods; Horses; Humans; Hydrophobicity; Isoelectric Point; Models, Biological; Molecular Weight; Myoglobin/chemistry/isolation & purification; Osmolar Concentration; Phase Transition; Polyethylene Glycols; Serum Albumin/chemistry/isolation & purification; Sodium Chloride |
| Abstract |
The partition of human antibodies in aqueous two-phase systems (ATPSs) of polyethylene glycol (PEG) and phosphate was systematically studied using first pure proteins systems and then an artificial mixture of proteins containing 1mg/ml human immunoglobulin G (IgG), 10mg/ml serum albumin and 2mg/ml myoglobin. Preliminary results obtained using pure proteins systems indicated that the PEG molecular weight and concentration, the pH value and the salts concentration had a pronounced effect on the partitioning behaviour of all proteins. For high ionic strengths and pH values higher than the isoelectric point (pI) of the contaminant proteins, IgG could be selectively recovered on the top phase. According to these results, a face centred composite design was performed in order to optimise the purification of IgG from the mixture of proteins. The optimal conditions for the isolation of IgG were observed for high concentrations of NaCl and low concentrations of both phase forming components. The best purification was achieved using an ATPS containing 8% (w/w) PEG 3350, 10% (w/w) phosphate pH 6 and 15% (w/w) NaCl. A recovery yield of 101+/-7%, a purity of 99+/-0% and a yield of native IgG of 97+/-4% were obtained. Back extraction studies of IgG to a new phosphate phase were performed and higher yields were obtained using 10% phosphate buffer at pH 6. The total extraction yield was 76% and the purity 100%. |
| Address |
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049-001 Lisbon, Portugal |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0021-9673 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:17196214 |
Approved |
no |
| Call Number |
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Serial |
1842 |
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| Author |
Scheibe, K.M.; Gromann, C. |
| Title |
Application testing of a new three-dimensional acceleration measuring system with wireless data transfer (WAS) for behavior analysis |
Type |
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| Year |
2006 |
Publication |
Behavior research methods |
Abbreviated Journal |
Behav Res Methods |
| Volume |
38 |
Issue |
3 |
Pages |
427-433 |
| Keywords |
Acceleration; Animals; *Behavior, Animal; Cattle; Cattle Diseases/*diagnosis; Computer Communication Networks/*instrumentation; Forelimb/physiopathology; Fractals; Hindlimb/physiopathology; Horse Diseases/*diagnosis; Horses; Imaging, Three-Dimensional/instrumentation/methods/veterinary; Lameness, Animal/*diagnosis; Monitoring, Ambulatory/instrumentation/*methods; Motor Activity; Movement; Pattern Recognition, Automated/methods |
| Abstract |
A wireless acceleration measurement system was applied to free-moving cows and horses. Sensors were available as a collar and a flat box for measuring leg or trunk movements. Results were transmitted simultaneously by radio or stored in an 8-MB internal memory. As analytical procedures, frequency distributions with standard deviations, spectral analyses, and fractal analyses were applied. Bymeans of the collar sensor, basic behavior patterns (standing, grazing, walking, ruminating, drinking, and hay uptake) could be identified in cows. Lameness could be detected in cows and horses by means of the leg sensor. The portion of basic and harmonic spectral components was reduced; the fractal dimension was reduced. The system can be used for the detection and analysis of even small movements of free-moving humans or animals over several hours. It is convenient for the analysis of basic behaviors, emotional reactions, or events causing flight or fright or for comparing different housing elements, such as floors or fences. |
| Address |
Institute for Zoo and Wildlife Research, Berlin, Germany. kscheibe@izw-berlin.de |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1554-351X |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:17186752 |
Approved |
no |
| Call Number |
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Serial |
1775 |
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| Author |
Mills, D.S. |
| Title |
Applying learning theory to the management of the horse: the difference between getting it right and getting it wrong |
Type |
Journal Article |
| Year |
1998 |
Publication |
Equine veterinary journal. Supplement |
Abbreviated Journal |
Equine Vet J Suppl |
| Volume |
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Issue |
27 |
Pages |
44-48 |
| Keywords |
Animals; *Behavior, Animal; Horses/*psychology; *Learning; Reinforcement (Psychology) |
| Abstract |
Horses constantly modify their behaviour as a result of experience. This involves the creation of an association between events or stimuli. The influence of people on the modification and generation of certain behaviour patterns extends beyond the intentional training of the horse. The impact of any action depends on how it is perceived by the horse, rather than the motive of the handler. Negative and positive reinforcement increase the probability of specific behaviours recurring i.e. strengthen the association between events, whereas punishment reduces the probable recurrence of a behaviour without providing specific information about the desired alternative. In this paper the term 'punishers' is used to refer to the physical aids, such as a whip or crop, which may be used to bring about the process of punishment. However, if their application ceases when a specific behaviour occurs they may negatively reinforce that action. Intended 'punishers' may also be rewarding (e.g. for attention seeking behaviour). Therefore, contingency factors (which define the relationship between stimuli, such as the level of reinforcement), contiguity factors (which describe the proximity of events in space or time) and choice of reinforcing stimuli are critical in determining the rate of learning. The many problems associated with the application of punishment in practice lead to confusion by both horse and handler and, possibly, abuse of the former. Most behaviour problems relate to handling and management of the horse and can be avoided or treated with a proper analysis of the factors influencing the behaviour. |
| Address |
De Montfort University Lincoln, School of Agriculture and Horticulture, Caythorpe, Lincs., UK |
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English |
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| Notes |
PMID:10485004 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
845 |
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Sabattini, M.S.; Monath, T.P.; Mitchell, C.J.; Daffner, J.F.; Bowen, G.S.; Pauli, R.; Contigiani, M.S. |
| Title |
Arbovirus investigations in Argentina, 1977-1980. I. Historical aspects and description of study sites |
Type |
Journal Article |
| Year |
1985 |
Publication |
The American Journal of Tropical Medicine and Hygiene |
Abbreviated Journal |
Am J Trop Med Hyg |
| Volume |
34 |
Issue |
5 |
Pages |
937-944 |
| Keywords |
Animals; Arbovirus Infections/*epidemiology/microbiology; Arboviruses; Argentina; Birds; Cattle; Child; Climate; Ecology; Encephalitis Virus, St. Louis; Encephalitis Virus, Venezuelan Equine; Encephalitis Virus, Western Equine; Encephalitis, St. Louis/epidemiology/microbiology; Encephalomyelitis, Equine/epidemiology/microbiology/veterinary; Encephalomyelitis, Venezuelan Equine/epidemiology/microbiology/veterinary; Geography; Horse Diseases/epidemiology/microbiology; Horses/microbiology; Humans |
| Abstract |
This is the introductory paper to a series on the ecology of arboviruses in Argentina. Epizootics of equine encephalitis have occurred since at least 1908, principally in the Pampa and Espinal biogeographic zones, with significant economic losses; human cases of encephalitis have been rare or absent. Both western equine and eastern equine encephalitis viruses have been isolated from horses during these epizootics, but the mosquitoes responsible for transmission have not been identified. A number of isolations of Venezuelan equine encephalitis (VEE) virus were reported between 1936 and 1958 in Argentina, but the validity of these findings has been seriously questioned. Nevertheless, serological evidence exists for human infections with a member of the VEE virus complex. Serological surveys conducted in the 1960s indicate a high prevalence of infection of humans and domestic animals with St. Louis encephalitis (SLE), and 2 SLE virus strains have been isolated from rodents. Human disease, however, has rarely been associated with SLE infection. Only 7 isolations of other arboviruses have been described (3 of Maguari, 1 of Aura, 2 of Una, and 1 of an untyped Bunyamwera group virus). In 1977, we began longitudinal field studies in Santa Fe Province, the epicenter of previous equine epizootics, and in 1980 we extended these studies to Chaco and Corrientes provinces. The study sites are described in this paper. |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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0002-9637 |
ISBN |
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Conference |
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| Notes |
PMID:4037184 |
Approved |
no |
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Equine Behaviour @ team @ |
Serial |
2685 |
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