| |
Records |
Links |
|
Author |
Branchi, I.; Bichler, Z.; Berger-Sweeney, J.; Ricceri, L. |
|
| |
Title |
Animal models of mental retardation: from gene to cognitive function |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
Neuroscience and Biobehavioral Reviews |
Abbreviated Journal |
Neurosci Biobehav Rev |
|
| |
Volume |
27 |
Issue |
1-2 |
Pages |
141-153 |
|
| |
Keywords |
Animals; Animals, Genetically Modified/growth & development; Behavior/physiology; Behavior, Animal; Brain/*growth & development; Cognition/*physiology; *Disease Models, Animal; Environment; Genes; Genetic Diseases, Inborn/physiopathology; Humans; Mental Retardation/classification/*genetics/*physiopathology |
|
| |
Abstract |
About 2-3% of all children are affected by mental retardation, and genetic conditions rank among the leading causes of mental retardation. Alterations in the information encoded by genes that regulate critical steps of brain development can disrupt the normal course of development, and have profound consequences on mental processes. Genetically modified mouse models have helped to elucidate the contribution of specific gene alterations and gene-environment interactions to the phenotype of several forms of mental retardation. Mouse models of several neurodevelopmental pathologies, such as Down and Rett syndromes and X-linked forms of mental retardation, have been developed. Because behavior is the ultimate output of brain, behavioral phenotyping of these models provides functional information that may not be detectable using molecular, cellular or histological evaluations. In particular, the study of ontogeny of behavior is recommended in mouse models of disorders having a developmental onset. Identifying the role of specific genes in neuropathologies provides a framework in which to understand key stages of human brain development, and provides a target for potential therapeutic intervention. |
|
| |
Address |
Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy. branchi@iss.it |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0149-7634 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:12732230 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
2805 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Cowell, P.E.; Fitch, R.H.; Denenberg, V.H. |
|
| |
Title |
Laterality in animals: relevance to schizophrenia |
Type |
Journal Article |
| |
Year |
1999 |
Publication |
Schizophrenia Bulletin |
Abbreviated Journal |
Schizophr Bull |
|
| |
Volume |
25 |
Issue |
1 |
Pages |
41-62 |
|
| |
Keywords |
Adult; Animals; Cognition; *Disease Models, Animal; Functional Laterality/*physiology; Humans; Language; Motor Activity/physiology; Schizophrenia/*physiopathology |
|
| |
Abstract |
Anomalies in the laterality of numerous neurocognitive dimensions associated with schizophrenia have been documented, but their role in the etiology and early development of the disorder remain unclear. In the study of normative neurobehavioral organization, animal models have shed much light on the mechanisms underlying and the factors affecting adult patterns of both functional and structural asymmetry. Nonhuman species have more recently been used to investigate the environmental, genetic, and neuroendocrine factors associated with developmental language disorders in humans. We propose that the animal models used to study the basis of lateralization in normative development and language disorders such as dyslexia could be modified to investigate lateralized phenomena in schizophrenia. |
|
| |
Address |
Dept. of Human Communication Sciences, University of Sheffield, United Kingdom |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0586-7614 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:10098913 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
2827 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Pennisi, E. |
|
| |
Title |
Schizophrenia clues from monkeys |
Type |
|
| |
Year |
1997 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
|
| |
Volume |
277 |
Issue |
5328 |
Pages |
900 |
|
| |
Keywords |
Animals; Antipsychotic Agents/pharmacology; Behavior, Animal/drug effects; *Cercopithecus aethiops; Clozapine/pharmacology; Cognition/drug effects; *Disease Models, Animal; Dopamine/*metabolism; Excitatory Amino Acid Antagonists/pharmacology; Memory/drug effects; Phencyclidine/*pharmacology; Prefrontal Cortex/*metabolism; Schizophrenia/chemically induced/drug therapy/*metabolism; Schizophrenic Psychology |
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0036-8075 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:9281070 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
2844 |
|
| Permanent link to this record |
