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Author Bosch, O.J.; Nair, H.P.; Ahern, T.H.; Neumann, I.D.; Young, L.J.
Title The CRF System Mediates Increased Passive Stress-Coping Behavior Following the Loss of a Bonded Partner in a Monogamous Rodent Type Journal Article
Year 2008 Publication Abbreviated Journal Neuropsychopharmacology
Volume 34 Issue 6 Pages 1406-1415
Keywords prairie vole; passive stress-coping; forced swim test; tail suspension test; elevated plus-maze; hypothalamo–pituitary–adrenal axis
Abstract Social relationships significantly influence physiology and behavior, including the hypothalamo–pituitary–adrenal axis, anxiety, and mental

health. Disruption of social bonds through separation or death often results in profound grieving, depression, and physical illness. As the

monogamous prairie vole forms enduring, selective pair bonds with the mating partner, they provide an animal model to study the

physiological consequences of pair bonding and, thus, the loss of the bonded partner. Male prairie voles were paired with a novel female

or male sibling. After 5 days, half of the males of each group were separated from the partner. Elevated plus-maze, forced swim, and tail

suspension tests were used to assess anxiety-like and passive stress-coping behaviors indicative of depressive-like behavior. Following 4

days of separation from the female but not the male partner, experimental males displayed increased passive stress-coping. This effect

was abolished by long-term intracerebroventricular infusion of a nonselective corticotropin-releasing factor (CRF) receptor antagonist

without disrupting the bond itself. Both CRF type 1 and 2 receptors were involved in the emergence of passive stress-coping behavior.

Furthermore, pairing with a female was associated with elevated CRF mRNA in the bed nucleus of the stria terminalis, and partner loss

elicited a pronounced increase in circulating corticosteroid and adrenal weight. We speculate that the CRF system may mediate an

aversive affect following separation from the female partner, which may facilitate proximity seeking between the pair-bonded individuals.

Hence, the prairie vole model may provide insights into brain mechanisms involved in the psychopathological consequences of partner

loss.
Address
Corporate Author Thesis
Publisher American College of Neuropsychopharmacology Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0893-133x ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial (up) 5731
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Author de Jong, T.R.; Neumann, I.D.
Title Oxytocin and Aggression Type Book Chapter
Year 2018 Publication Behavioral Pharmacology of Neuropeptides: Oxytocin Abbreviated Journal
Volume Issue Pages 175-192
Keywords
Abstract The neuropeptide oxytocin (OT) has a solid reputation as a facilitator of social interactions such as parental and pair bonding, trust, and empathy. The many results supporting a pro-social role of OT have generated the hypothesis that impairments in the endogenous OT system may lead to antisocial behavior, most notably social withdrawal or pathological aggression. If this is indeed the case, administration of exogenous OT could be the “serenic” treatment that psychiatrists have for decades been searching for.
Address
Corporate Author Thesis
Publisher Springer International Publishing Place of Publication Cham Editor Hurlemann, R.; Grinevich, V.
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 978-3-319-63739-6 Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ de Jong2018 Serial (up) 6424
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