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Author |
Schmoldt, A.; Benthe, H.F.; Haberland, G. |
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Title |
Digitoxin metabolism by rat liver microsomes |
Type |
Journal Article |
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Year |
1975 |
Publication |
Biochemical pharmacology |
Abbreviated Journal |
Biochem Pharmacol |
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Volume |
24 |
Issue |
17 |
Pages |
1639-1641 |
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Keywords |
Animals; Chromatography, Thin Layer; Digitoxigenin/metabolism; Digitoxin/*metabolism; Hydroxylation; Male; Microsomes, Liver/*metabolism; NADP/metabolism; Rats; Time Factors |
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English |
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0006-2952 |
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PMID:10 |
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Admin @ knut @ |
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20 |
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Author |
Vollmerhaus, B.; Roos, H.; Gerhards, H.; Knospe, C. |
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Title |
[Phylogeny, form and function of canine teeth in the horse] |
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Journal Article |
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Year |
2003 |
Publication |
Anatomia, histologia, embryologia |
Abbreviated Journal |
Anat Histol Embryol |
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Volume |
32 |
Issue |
4 |
Pages |
212-217 |
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Keywords |
Animals; Cuspid/*anatomy & histology/radiography; Evolution; Horses/*anatomy & histology; Male; Phylogeny; *Social Dominance |
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Abstract |
The canine teeth of the horse developed phylogenically from the simple, pointed, short-rooted tooth form of the leaf eating, in pairs living, Eocene horse Hyracotherium and served up to the Oligocene as a means of defense (self preservation). In the Miocene the living conditions of the Merychippus changed and they took to eating grass and adopted as a new behavior the life in a herd. The canine teeth possibly played an important role in fights for social ranking; they changed from a crown form to knife-like shape. In the Pliohippus the canine tooth usually remained in male horses and since the Pliocene, it contributed to the fights between stallions, to ensure that the offspring only came from the strongest animals (preservation of the species). Form and construction of the canine tooth are described and discussed in detail under the above mentioned phylogenic and ethologic aspects. |
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Address |
Institut fur Tieranatomie und Chirurgische Tierklinik der Universitat Munchen, Veterinarstrasse 13, D 80539 Munchen, Deutschland. c-neumueller@anat.vetmed.uni-muenchen.de |
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German |
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Original Title |
[Zur Phylogenie, Form und Funktion der Dentes canini des Pferdes] |
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0340-2096 |
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PMID:12919071 |
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no |
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Call Number |
refbase @ user @ |
Serial |
672 |
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Author |
Houpt, K.A.; Perry, P.J.; Hintz, H.F.; Houpt, T.R. |
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Title |
Effect of meal frequency on fluid balance and behavior of ponies |
Type |
Journal Article |
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Year |
1988 |
Publication |
Physiology & behavior |
Abbreviated Journal |
Physiol. Behav. |
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Volume |
42 |
Issue |
5 |
Pages |
401-407 |
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Keywords |
Animals; Behavior, Animal/*physiology; Blood Proteins/analysis; *Eating; Female; Hematocrit; Horses/blood/*physiology; Osmolar Concentration; *Water-Electrolyte Balance |
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Abstract |
Twelve ponies were fed their total daily ration either as one large meal or divided into six small meals. Pre- and post-feeding behavior was recorded six times a day. Blood samples were taken for 30 min before and two hr after the meal. Plasma protein increased from 7.0 to a peak of 7.3 g/dl with small meals and from 7.3 to 8.1 g/dl with large meals, and returned to pre-feeding levels by 90 min post-feeding. Hematocrit rose from 33.3 to 34.1% with small meals and from 33.0 to 36.0% with large meals. These rapid and short-lived increases indicate a decrease in plasma volume. Plasma osmolality rose with feeding from 283 to 285 mosmoles/kg with small meals and from 281 to 288 mosmoles/kg with large meals. Water availability had no significant effect on blood changes. Digestibility and rate of passage were measured with chromic oxide, but there were no differences. Vocalizing (neighing) and walking occurred more often before than after feeding, while eating bedding and engaging in other oral behaviors were more frequent after feeding. |
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Department of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853 |
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English |
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ISSN |
0031-9384 |
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Notes |
PMID:3393599 |
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no |
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Call Number |
refbase @ user @ |
Serial |
47 |
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Author |
Laut, J.E.; Houpt, K.A.; Hintz, H.F.; Houpt, T.R. |
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Title |
The effects of caloric dilution on meal patterns and food intake of ponies |
Type |
Journal Article |
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Year |
1985 |
Publication |
Physiology & behavior |
Abbreviated Journal |
Physiol. Behav. |
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Volume |
35 |
Issue |
4 |
Pages |
549-554 |
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Keywords |
Animals; Body Weight; *Diet; Energy Intake; *Feeding Behavior; Homeostasis; Horses/*physiology; Male |
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Abstract |
In order to determine if horses will increase their intake in response to caloric dilution, four pony geldings were fed ad lib a mixed grain diet either undiluted (3.4 Mcal/kg of digestible energy) or diluted (wt/wt) with 25% sawdust (2.6 Mcal/kg) or with 50% sawdust (1.7 Mcal/kg). The mean daily caloric intake was 17,457 kcal (3.4 Mcal diet), 17,546 kcal (2.6 Mcal diet) and 12,844 kcal (1.7 Mcal). The mean time spent eating was 246 (3.4 Mcal), 351 (2.6 Mcal), and 408 (1.7 Mcal) minutes/day. Meal size increased and meal frequency decreased with increasing dilution. The median long survivorships of intermeal intervals were 6.4 min (3.4 Mcal), 3.95 min (2.6 Mcal) and 4.91 min (1.7 Mcal). Ponies responded to caloric dilution by increasing the volume of intake to maintain caloric intake when the diet had 25% diluent. When the diet was diluted by 50%, intake was increased, but not at a rate adequate to maintain caloric intake. However, the ponies were able to maintain body weight. |
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English |
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0031-9384 |
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Notes |
PMID:4070429 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
52 |
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Author |
Houpt, K.A.; Parsons, M.S.; Hintz, H.F. |
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Title |
Learning ability of orphan foals, of normal foals and of their mothers |
Type |
Journal Article |
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Year |
1982 |
Publication |
Journal of animal science |
Abbreviated Journal |
J. Anim Sci. |
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Volume |
55 |
Issue |
5 |
Pages |
1027-1032 |
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Keywords |
Age Factors; Animals; Body Weight; Dominance-Subordination; Female; Horses/*physiology; *Learning; *Maternal Deprivation; Mothers/*psychology |
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Abstract |
The maze learning ability of six pony foals that had been weaned at birth was compared to that of six foals reared normally. The foals' learning ability was also compared to their mothers' learning ability at the same task; the correct turn in a single choice point maze. The maze learning test was conducted when the foals were 6 to 8 mo old and after the mothered foals had been weaned. There was no significant difference between the ability of orphaned (weaned at birth) and mothered foals in their ability to learn to turn left (6 +/- .7 and 5.1 +/- .1 trials, respectively) or to learn the reversal, to turn right (6.7 +/- .6 and 6.2 +/- .6 trials, respectively). The orphan foals spent significantly more time in the maze in their first exposure to it than the mothered foals (184 +/- 42 vs 55 +/- 15 s. Mann Whitney U = 7, P less than .05). The mothers of the foals (n = 11) learned to turn left as rapidly as the foals (5.9 +/- .7 trials), but they were slower to learn to turn right (9.8 +/- 1.4 vs 6.4 +/- .4 trials, Mann Whitney U = 33, P less than .05), indicating that the younger horses learned more rapidly. There was no correlation between the trials to criteria of the mare and those of her foal, but there was a significant negative correlation between rank in trials to criteria and age (r = -65, P less than .05) when data from the mare and foal trials were combined. The dominance hierarchy of the mares was determined using a paired feeding test in which two horses competed for one bucket of feed. Although there was no correlation between rank in the hierarchy and maze learning ability, there was a correlation between body weight and rank in the hierarchy (r = .7, P less than .05). This may indicate either that heavier horses are likely to be dominant or that horses high in dominance gain more weight. Maternal deprivation did not appear to seriously retard learning of a simple maze by foals, although the orphans moved more slowly initially. The lack of maternal influence on learning is also reflected in the lack of correlation between the mare's learning ability and that of her foal. Young horses appear to learn more rapidly than older horses. |
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English |
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Abbreviated Series Title |
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ISSN |
0021-8812 |
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Notes |
PMID:7174546 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
58 |
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Author |
Brown, R.F.; Houpt, K.A.; Schryver, H.F. |
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Title |
Stimulation of food intake in horses by diazepam and promazine |
Type |
Journal Article |
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Year |
1976 |
Publication |
Pharmacology, biochemistry, and behavior |
Abbreviated Journal |
Pharmacol Biochem Behav |
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Volume |
5 |
Issue |
4 |
Pages |
495-497 |
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Keywords |
Age Factors; Animals; Diazepam/*pharmacology; Diet; Feeding Behavior/*drug effects; Female; Horses/*physiology; Male; Promazine/*pharmacology; Stimulation, Chemical |
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Abstract |
In two adult horses doses of 0.02-0.03 mg/kg diazepam, intravenously, increased 1 hr intake 54-75% above control levels. Intake was stimulated when the diet was a high grain, calorically dense one and also when the diet was a high fiber, calorically dilute one. Two young rapidly growing weanling horses showed an even more pronounced stimulation of intake. Following diazepam 1 hr intake was increased 105-240% above control lelvels. Promazine at a dose of 0.5 mg/kg also stimulated intake in adult horses, but not as markedly as did diazepam. A transquilizer and a neuroleptic appear to have a stimulatory eff upon short-term intake in horses. |
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English |
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Abbreviated Series Title |
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Series Volume |
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Edition |
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ISSN |
0091-3057 |
ISBN |
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Notes |
PMID:1005496 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
60 |
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Author |
Nicol, C.J.; Brown, S.N.; Glen, E.; Pope, S.J.; Short, F.J.; Warriss, P.D.; Zimmerman, P.H.; Wilkins, L.J. |
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Title |
Effects of stocking density, flock size and management on the welfare of laying hens in single-tier aviaries |
Type |
Journal Article |
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Year |
2006 |
Publication |
British poultry science |
Abbreviated Journal |
Br Poult Sci |
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Volume |
47 |
Issue |
2 |
Pages |
135-146 |
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Keywords |
Animal Husbandry/*methods; *Animal Welfare; Animals; Body Constitution/*physiology; Chickens/*physiology; Crowding; Feathers; Female; *Housing, Animal/standards; Mortality; Organ Size; Oviposition/physiology; Population Density; Population Dynamics; Random Allocation |
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Abstract |
Management practices, stocking rate and flock size may affect laying hen welfare but there have been few replicated studies in commercial non-cage systems that investigate this. This study used a broad range of physical and physiological indicators to assess the welfare of hens in 36 commercial flocks. Six laying period treatments were examined with each treatment replicated 6 times. It was not possible to randomly allocate treatments to houses, so treatment and house were largely confounded. Three stocking rates were compared: 7 birds/m(2) (n = 2450), 9 birds/m(2) (n = 3150) and 12 birds/m(2) in either small (n = 2450) or large (n = 4200) flocks. In addition, at 12 birds/m(2), in both small and large flocks, birds were subjected to either standard (SM) or modified (MM) management. MM flocks had nipple drinkers and no nest-box lights. Bone strength, fracture incidence, heterophil:lymphocyte (H:L) ratio, live weight, organ weights, serum creatine, serum osmolality, muscle pH and faecal corticosterone were measured on samples of birds at the end of the rearing period and at the end of lay. During the laying period, mortality, production and integument condition were recorded at regular intervals. Birds housed at 9 birds/m(2) had higher mortality than birds housed at 12 birds/m(2) by the end of lay, but not higher than birds housed at 7 birds/m(2). Birds housed at 7 and 9 birds/m(2) had lower percent liver weight, and worse plumage condition than most of the 12 bird/m(2) treatments. Modified management tended to improve plumage condition. There were no clear effects of flock size on the welfare indicators recorded. At the end of the rearing period fracture incidence was almost negligible and H:L ratio was within a normal range. By the end of lay fracture incidence was 60% and H:L ratio was high, with no treatment effect for either measure. This, together with information on faecal corticosterone, feather loss and mortality, suggests that the welfare of birds in all treatments was relatively poor by the end of lay. |
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Address |
School of Veterinary Science, University of Bristol, Langford House, Langford BS40 5DU and ADAS Gleadthorpe, Meden Vale, Mansfield, Notts NG20 9PF, England. c.j.nicol@bristol.ac.uk |
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English |
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Series Issue |
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Edition |
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ISSN |
0007-1668 |
ISBN |
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Notes |
PMID:16641024 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
65 |
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Author |
Wilkins, L.J.; Brown, S.N.; Zimmerman, P.H.; Leeb, C.; Nicol, C.J. |
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Title |
Investigation of palpation as a method for determining the prevalence of keel and furculum damage in laying hens |
Type |
Journal Article |
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Year |
2004 |
Publication |
The Veterinary record |
Abbreviated Journal |
Vet. Rec. |
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Volume |
155 |
Issue |
18 |
Pages |
547-549 |
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Keywords |
Animal Husbandry/methods; Animal Welfare; Animals; Bone and Bones/*injuries; Chickens/*injuries; Female; Fractures, Bone/diagnosis/epidemiology/*veterinary; Great Britain/epidemiology; Housing, Animal/standards; Oviposition; Palpation/methods/*veterinary; Poultry Diseases/*diagnosis/epidemiology; Prevalence; Sensitivity and Specificity |
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Abstract |
Old breaks of the keel and furculum were identified by palpation in 500 end-of-lay hens from 10 flocks housed in free-range and barn systems, and the results were compared with the results obtained by a full dissection and inspection. The method was considered to be sufficiently precise to be used as a diagnostic tool although people using it would need to be trained. The results obtained by dissection indicated that 50 to 78 per cent of the birds in the flocks had breaks of the furculum and keel, but no other breaks of bones were detected. |
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Address |
Department of Clinical Veterinary Science, University of Bristol, Bristol BS40 5DU |
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English |
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ISSN |
0042-4900 |
ISBN |
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Notes |
PMID:15559420 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
70 |
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Author |
Jeong, S.; Han, M.; Lee, H.; Kim, M.; Kim, J.; Nicol, C.J.; Kim, B.H.; Choi, J.H.; Nam, K.-H.; Oh, G.T.; Yoon, M. |
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Title |
Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice |
Type |
Journal Article |
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Year |
2004 |
Publication |
Metabolism: clinical and experimental |
Abbreviated Journal |
Metabolism |
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Volume |
53 |
Issue |
10 |
Pages |
1284-1289 |
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Keywords |
Adipose Tissue/*anatomy & histology/drug effects; Animals; Antilipemic Agents/*pharmacology; Body Composition/*drug effects; Body Weight/drug effects; Dietary Fats/*pharmacology; Eating/drug effects; Fatty Acids/metabolism; Female; Gene Expression Regulation/drug effects; Leptin/metabolism; Liver/metabolism; Mice; Mice, Inbred C57BL; Ovariectomy; Procetofen/*pharmacology; RNA, Messenger/biosynthesis/genetics; Receptors, Cytoplasmic and Nuclear/biosynthesis/genetics/metabolism; Transcription Factors/biosynthesis/genetics/metabolism; Weight Gain/*drug effects |
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Abstract |
Our previous study suggested that fenofibrate affects obesity and lipid metabolism in a sexually dimorphic manner in part through the differential activation of hepatic peroxisome proliferator-activated receptor alpha (PPARalpha) in male and female C57BL/6J mice. To determine whether fenofibrate reduces body weight gain and adiposity in female sham-operated (Sham) and ovariectomized (OVX) C57BL/6J mice, the effects of fenofibrate on not only body weight, white adipose tissue (WAT) mass, and food intake, but also the expression of both leptin and PPARalpha target genes were measured. Compared to their respective low-fat diet-fed controls, both Sham and OVX mice exhibited increases in body weight and WAT mass when fed a high-fat diet. Fenofibrate treatment decreased body weight gain and WAT mass in OVX, but not in Sham mice. Furthermore, fenofibrate increased the mRNA levels of PPARalpha target genes encoding peroxisomal enzymes involved in fatty acid beta-oxidation, and reduced apolipoprotein C-III (apo C-III) mRNA, all of which were expressed at higher levels in OVX compared to Sham mice. However, leptin mRNA levels were found to positively correlate with WAT mass, and food intake was not changed in either OVX or Sham mice following fenofibrate treatment. These results suggest that fenofibrate differentially regulates body weight and adiposity due in part to differences in PPARalpha activation, but not to differences in leptin production, between female OVX and Sham mice. |
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Address |
Department of Life Sciences, Mokwon University, Taejon, Korea |
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English |
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ISSN |
0026-0495 |
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Notes |
PMID:15375783 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
72 |
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Author |
Harman, F.S.; Nicol, C.J.; Marin, H.E.; Ward, J.M.; Gonzalez, F.J.; Peters, J.M. |
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Title |
Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis |
Type |
Journal Article |
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Year |
2004 |
Publication |
Nature medicine |
Abbreviated Journal |
Nat Med |
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Volume |
10 |
Issue |
5 |
Pages |
481-483 |
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Keywords |
Animals; Azoxymethane/toxicity; Colonic Neoplasms/etiology/genetics/*prevention & control; Colonic Polyps/etiology/genetics/pathology/prevention & control; Disease Models, Animal; Mice; Mice, Knockout; Mice, Mutant Strains; Phenotype; Receptors, Cytoplasmic and Nuclear/deficiency/genetics/*physiology; Transcription Factors/deficiency/genetics/*physiology |
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Abstract |
Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis. |
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Address |
Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. jmp21@psu.edu |
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English |
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1078-8956 |
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Notes |
PMID:15048110 |
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
77 |
|
| Permanent link to this record |
