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Author Wells, P.G.; Bhuller, Y.; Chen, C.S.; Jeng, W.; Kasapinovic, S.; Kennedy, J.C.; Kim, P.M.; Laposa, R.R.; McCallum, G.P.; Nicol, C.J.; Parman, T.; Wiley, M.J.; Wong, A.W. doi  openurl
  Title Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species Type Journal Article
  Year 2005 Publication Toxicology and applied pharmacology Abbreviated Journal Toxicol Appl Pharmacol  
  Volume 207 Issue 2 Suppl Pages 354-366  
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  Abstract Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reactive oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction. This minireview focuses upon several model drugs (phenytoin, thalidomide, methamphetamine), environmental chemicals (benzo[a]pyrene) and gamma irradiation to examine this hypothesis in vivo and in embryo culture using mouse, rat and rabbit models. Embryonic prostaglandin H synthases (PHSs) and lipoxygenases bioactivate xenobiotics to free radical intermediates that initiate ROS formation, resulting in oxidation of proteins, lipids and DNA. Oxidative DNA damage and embryopathies are reduced in PHS knockout mice, and in mice treated with PHS inhibitors, antioxidative enzymes, antioxidants and free radical trapping agents. Thalidomide causes embryonic DNA oxidation in susceptible (rabbit) but not resistant (mouse) species. Embryopathies are increased in mutant mice deficient in the antioxidative enzyme glucose-6-phosphate dehydrogenase (G6PD), or by glutathione (GSH) depletion, or inhibition of GSH peroxidase or GSH reductase. Inducible nitric oxide synthase knockout mice are partially protected. Inhibition of Ras or NF-kB pathways reduces embryopathies, implicating ROS-mediated signal transduction. Atm and p53 knockout mice deficient in DNA damage response/repair are more susceptible to xenobiotic or radiation embryopathies, suggesting a teratological role for DNA damage, consistent with enhanced susceptibility to methamphetamine in ogg1 knockout mice with deficient repair of oxidative DNA damage. Even endogenous embryonic oxidative stress carries a risk, since untreated G6PD- or ATM-deficient mice have increased embryopathies. Thus, embryonic processes regulating the balance of ROS formation, oxidative DNA damage and repair, and ROS-mediated signal transduction may be important determinants of teratological risk.  
  Address Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada  
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  ISSN 0041-008X ISBN Medium  
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  Notes PMID:16081118 Approved no  
  Call Number refbase @ user @ Serial 68  
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Author Eisenmann V, G.D.C. openurl 
  Title Caractères distinctifs des premières phalanges antérieures et postérieures chez certains équidés actuels et fossiles Type Journal Article
  Year 1974 Publication Abbreviated Journal Bull Soc g?ol France  
  Volume 16 Issue Pages 352-361  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1059  
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Author Eisenmann V, G.D.C. openurl 
  Title Caractères distinctifs entre vrais zèbres et zèbres de Chapman d`après l`étude de 60 têtes osseuses. Type Journal Article
  Year 1974 Publication Abbreviated Journal Mammalia  
  Volume 38 Issue Pages 509-543  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1060  
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Author Eisenmann V, G.C. openurl 
  Title Morphologie fonctionelle et environnement chez les périssodactyles. Type Journal Article
  Year 1984 Publication Abbreviated Journal Geobios, Mém sp  
  Volume 8 Issue Pages 69  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1061  
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Author Fagen Rm, G.T. openurl 
  Title Play behavior and exercise in young ponies Type Journal Article
  Year 1977 Publication Abbreviated Journal Behav Ecol Sociobiol  
  Volume 2 Issue Pages 267-269  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1077  
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Author Green Nf, G.H. openurl 
  Title The wild horse population.... Type Journal Article
  Year 1977 Publication Abbreviated Journal Proc National Wild Horse Forum  
  Volume 1 Issue Pages 59-65  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1125  
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Author Grzimek M, G.B. openurl 
  Title A study of the game of the Serengeti plains Type Journal Article
  Year 1960 Publication Abbreviated Journal Z Säugetierk  
  Volume 25 Issue Pages  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1152  
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Author Penzhorn Bl, G.R. openurl 
  Title Incisor wear in free – ranging Cape mountain zebras Type Journal Article
  Year 1987 Publication Abbreviated Journal S Afr J Wildl Res  
  Volume 17 Issue Pages 99-102  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1461  
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Author Wells Sm, G.-R. openurl 
  Title Social behaviour and relationship in a herd of Carmargue horses Type Journal Article
  Year 1979 Publication Zeitschrift für Tierpsychologie Abbreviated Journal Z. Tierpsychol.  
  Volume 49 Issue Pages 363-380  
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  Notes from Professor Hans Klingels Equine Reference List Approved no  
  Call Number Serial 1700  
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Author White, D.J.; Galef Jr, B.G. url  openurl
  Title Mate choice copying and conspecific cueing in Japanese quail,Coturnix coturnix japonica Type Journal Article
  Year 1999 Publication Animal Behaviour. Abbreviated Journal Anim. Behav.  
  Volume 57 Issue 2 Pages 465-473  
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  Notes Approved no  
  Call Number Serial 1811  
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