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Wells, P.G.; Bhuller, Y.; Chen, C.S.; Jeng, W.; Kasapinovic, S.; Kennedy, J.C.; Kim, P.M.; Laposa, R.R.; McCallum, G.P.; Nicol, C.J.; Parman, T.; Wiley, M.J.; Wong, A.W. |
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Title |
Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species |
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Journal Article |
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Year |
2005 |
Publication |
Toxicology and applied pharmacology |
Abbreviated Journal |
Toxicol Appl Pharmacol |
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Volume |
207 |
Issue |
2 Suppl |
Pages |
354-366 |
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Abstract |
Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reactive oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction. This minireview focuses upon several model drugs (phenytoin, thalidomide, methamphetamine), environmental chemicals (benzo[a]pyrene) and gamma irradiation to examine this hypothesis in vivo and in embryo culture using mouse, rat and rabbit models. Embryonic prostaglandin H synthases (PHSs) and lipoxygenases bioactivate xenobiotics to free radical intermediates that initiate ROS formation, resulting in oxidation of proteins, lipids and DNA. Oxidative DNA damage and embryopathies are reduced in PHS knockout mice, and in mice treated with PHS inhibitors, antioxidative enzymes, antioxidants and free radical trapping agents. Thalidomide causes embryonic DNA oxidation in susceptible (rabbit) but not resistant (mouse) species. Embryopathies are increased in mutant mice deficient in the antioxidative enzyme glucose-6-phosphate dehydrogenase (G6PD), or by glutathione (GSH) depletion, or inhibition of GSH peroxidase or GSH reductase. Inducible nitric oxide synthase knockout mice are partially protected. Inhibition of Ras or NF-kB pathways reduces embryopathies, implicating ROS-mediated signal transduction. Atm and p53 knockout mice deficient in DNA damage response/repair are more susceptible to xenobiotic or radiation embryopathies, suggesting a teratological role for DNA damage, consistent with enhanced susceptibility to methamphetamine in ogg1 knockout mice with deficient repair of oxidative DNA damage. Even endogenous embryonic oxidative stress carries a risk, since untreated G6PD- or ATM-deficient mice have increased embryopathies. Thus, embryonic processes regulating the balance of ROS formation, oxidative DNA damage and repair, and ROS-mediated signal transduction may be important determinants of teratological risk. |
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Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada |
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0041-008X |
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PMID:16081118 |
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Call Number |
refbase @ user @ |
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68 |
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Wittig, R.M.; Crockford, C.; Wikberg, E.; Seyfarth, R.M.; Cheney, D.L. |
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Title |
Kin-mediated reconciliation substitutes for direct reconciliation in female baboons |
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Journal Article |
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Year |
2007 |
Publication |
Proceedings. Biological sciences / The Royal Society |
Abbreviated Journal |
Proc Biol Sci |
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Volume |
274 |
Issue |
1613 |
Pages |
1109-1115 |
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It has been hypothesized that group-living mammals engage in reconciliation (post-conflict affiliation between former opponents) to reduce the disruptive costs of aggression and restore opponents' tolerance to baseline levels. Recipients of aggression are sometimes reluctant to tolerate the proximity of a recent opponent, however, in apparent fear that aggression will be renewed. In such cases, reconciliatory behaviour by the aggressor's close kin may substitute for direct reconciliation. We describe a playback experiment with free-ranging baboons (Papio hamadryas ursinus) that examines whether friendly behaviour by the aggressor's kin can substitute for direct reconciliation by the aggressor herself. In the test condition, female subjects who had recently been threatened heard the friendly grunt of one of their aggressor's relatives, mimicking kin-mediated vocal reconciliation. In the control condition, subjects heard the grunt of a dominant female from a different matriline. Subjects responded significantly more strongly in test than in control trials. Moreover, in the next hour they were significantly more likely to tolerate the proximity of both their aggressor and the relative whose grunt they had heard. In contrast, subjects' behaviour towards both control females and other members of their aggressor's matriline was unaffected. We conclude that kin-mediated vocal reconciliation can substitute for direct reconciliation in baboons. |
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Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA |
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0962-8452 |
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PMID:17301022 |
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342 |
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Whiten, A.; van Schaik, C.P. |
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Title |
The evolution of animal 'cultures' and social intelligence |
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Journal Article |
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2007 |
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Philosophical transactions of the Royal Society of London. Series B, Biological sciences |
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Philos Trans R Soc Lond B Biol Sci |
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362 |
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1480 |
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603-620 |
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Decades-long field research has flowered into integrative studies that, together with experimental evidence for the requisite social learning capacities, have indicated a reliance on multiple traditions ('cultures') in a small number of species. It is increasingly evident that there is great variation in manifestations of social learning, tradition and culture among species, offering much scope for evolutionary analysis. Social learning has been identified in a range of vertebrate and invertebrate species, yet sustained traditions appear rarer, and the multiple traditions we call cultures are rarer still. Here, we examine relationships between this variation and both social intelligence-sophisticated information processing adapted to the social domain-and encephalization. First, we consider whether culture offers one particular confirmation of the social ('Machiavellian') intelligence hypothesis that certain kinds of social life (here, culture) select for intelligence: 'you need to be smart to sustain culture'. Phylogenetic comparisons, particularly focusing on our own study animals, the great apes, support this, but we also highlight some paradoxes in a broader taxonomic survey. Second, we use intraspecific variation to address the converse hypothesis that 'culture makes you smart', concluding that recent evidence for both chimpanzees and orang-utans support this proposition. |
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Centre for Social Learning and Cognitive Evolution, School of Psychology, University of St Andrews, St Andrews KY16 9JP, UK |
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0962-8436 |
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PMID:17255007 |
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refbase @ user @ |
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729 |
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Author |
Duncan P, C.P. |
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An unusual choice of habitat helps Camargue horses to avoid blood-sucking horse-flies |
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Year |
1980 |
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Biol Behav |
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5 |
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55-60 |
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Notes |
from Professor Hans Klingels Equine Reference List |
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no |
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1036 |
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Author |
Eisenmann V, G.D.C. |
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Title |
Caractères distinctifs des premières phalanges antérieures et postérieures chez certains équidés actuels et fossiles |
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Journal Article |
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Year |
1974 |
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Bull Soc g?ol France |
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16 |
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352-361 |
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from Professor Hans Klingels Equine Reference List |
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1059 |
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Eisenmann V, G.D.C. |
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Caractères distinctifs entre vrais zèbres et zèbres de Chapman d`après l`étude de 60 têtes osseuses. |
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Journal Article |
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1974 |
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Mammalia |
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38 |
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509-543 |
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from Professor Hans Klingels Equine Reference List |
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no |
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1060 |
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Author |
Eisenmann V, G.C. |
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Title |
Morphologie fonctionelle et environnement chez les périssodactyles. |
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1984 |
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Geobios, Mém sp |
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8 |
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69 |
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from Professor Hans Klingels Equine Reference List |
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no |
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1061 |
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Author |
Eisenmann V, T.J.-C. |
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Title |
Sur la taxinomie du genre Equus |
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1978 |
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Cahiers Analyse Données |
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3 |
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179-201 |
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from Professor Hans Klingels Equine Reference List |
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1063 |
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Author |
Haughton Sh, C.B. |
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Title |
The fossil Equidae of south Africa |
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1931 |
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Abbreviated Journal |
Ann South Afr Mus |
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28 |
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407-427 |
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from Professor Hans Klingels Equine Reference List |
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1166 |
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Author |
Hoyt Df, T.C. |
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Title |
Gait and the energetics of locomotion in horses |
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1981 |
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Nature |
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292 |
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239-240 |
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from Professor Hans Klingels Equine Reference List |
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1205 |
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