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	Author	Cheung, C.; Akiyama, T.E.; Ward, J.M.; Nicol, C.J.; Feigenbaum, L.; Vinson, C.; Gonzalez, F.J.
	Title	Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha			Type	Journal Article
	Year	2004	Publication	Cancer research	Abbreviated Journal	Cancer Res
	Volume	64	Issue	11	Pages	3849-3854
	Keywords	Animals; Anticholesteremic Agents/pharmacology; Carcinogens/pharmacology; Cell Division; DNA Replication/drug effects; Fatty Acids/metabolism; Hepatocytes/cytology/drug effects/metabolism/physiology; Humans; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxisome Proliferators/pharmacology; Pyrimidines/pharmacology; Receptors, Cytoplasmic and Nuclear/genetics/physiology; Species Specificity; Transcription Factors/genetics/*physiology
	Abstract	Lipid-lowering fibrate drugs function as agonists for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice. However, humans appear to be resistant to the induction of peroxisome proliferation and the development of liver cancer by fibrate drugs. The molecular basis of this species difference is not known. To examine the mechanism determining species differences in peroxisome proliferator response between mice and humans, a PPARalpha-humanized mouse line was generated in which the human PPARalpha was expressed in liver under control of the tetracycline responsive regulatory system. The PPARalpha-humanized and wild-type mice responded to treatment with the potent PPARalpha ligand Wy-14643 as revealed by induction of genes encoding peroxisomal and mitochondrial fatty acid metabolizing enzymes and resultant decrease of serum triglycerides. However, surprisingly, only the wild-type mice and not the PPARalpha-humanized mice exhibited hepatocellular proliferation as revealed by elevation of cell cycle control genes, increased incorporation of 5-bromo-2'-deoxyuridine into hepatocyte nuclei, and hepatomegaly. These studies establish that following ligand activation, the PPARalpha-mediated pathways controlling lipid metabolism are independent from those controlling the cell proliferation pathways. These findings also suggest that structural differences between human and mouse PPARalpha are responsible for the differential susceptibility to the development of hepatocarcinomas observed after treatment with fibrates. The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators.
	Address	Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0008-5472	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15172993			Approved	no
	Call Number	refbase @ user @			Serial	74
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	Author	Thrower, W.R.
	Title	Aggression in horses			Type	Journal Article
	Year	1970	Publication	Proceedings of the Royal Society of Medicine	Abbreviated Journal	Proc R Soc Med
	Volume	63	Issue	2	Pages	163-167
	Keywords	Aggression; Animals; Behavior, Animal; Breeding; Evolution; Horses; Humans; Species Specificity; Territoriality
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0035-9157	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:5462347			Approved	no
	Call Number	refbase @ user @			Serial	1966
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	Author	Shettleworth, S.J.
	Title	Memory and hippocampal specialization in food-storing birds: challenges for research on comparative cognition			Type	Journal Article
	Year	2003	Publication	Brain, behavior and evolution	Abbreviated Journal	Brain Behav Evol
	Volume	62	Issue	2	Pages	108-116
	Keywords	Animals; Birds/physiology; Cognition/physiology; Color Perception/physiology; Feeding Behavior/physiology; Hippocampus/physiology; Memory/*physiology; Species Specificity
	Abstract	The three-way association among food-storing behavior, spatial memory, and hippocampal enlargement in some species of birds is widely cited as an example of a new 'cognitive ecology' or 'neuroecology.' Whether this relationship is as strong as it first appears and whether it might be evidence for an adaptive specialization of memory and hippocampus in food-storers have recently been the subject of some controversy [Bolhuis and Macphail, 2001; Macphail and Bolhuis, 2001]. These critiques are based on misconceptions about the nature of adaptive specializations in cognition, misconceptions about the uniformity of results to be expected from applying the comparative method to data from a wide range of species, and a narrow view of what kinds of cognitive adaptations are theoretically interesting. New analyses of why food-storers (black-capped chickadees, Poecile Atricapilla) respond preferentially to spatial over color cues when both are relevant in a memory task show that this reflects a relative superiority of spatial memory as compared to memory for color rather than exceptional spatial attention or spatial discrimination ability. New studies of chickadees from more or less harsh winter climates also support the adaptive specialization hypothesis and suggest that within-species comparisons may be especially valuable for unraveling details of the relationships among ecology, memory, and brain in food-storing species.
	Address	Department of Psychology, University of Toronto, Toronto, Ont., M5S 3G3, Canada. shettle@psych.utoronto.ca
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0006-8977	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:12937349			Approved	no
	Call Number	refbase @ user @			Serial	367
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	Author	Bykov, S.; Lednev, I.; Ianoul, A.; Mikhonin, A.; Munro, C.; Asher, S.A.
	Title	Steady-state and transient ultraviolet resonance Raman spectrometer for the 193-270 nm spectral region			Type	Journal Article
	Year	2005	Publication	Applied Spectroscopy	Abbreviated Journal	Appl Spectrosc
	Volume	59	Issue	12	Pages	1541-1552
	Keywords	Animals; Equipment Design; Equipment Failure Analysis; Horses; Kinetics; Metmyoglobin/analysis; Myocardium/metabolism; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet/instrumentation/methods; Spectrum Analysis, Raman/instrumentation/methods
	Abstract	We describe a state-of-the-art tunable ultraviolet (UV) Raman spectrometer for the 193-270 nm spectral region. This instrument allows for steady-state and transient UV Raman measurements. We utilize a 5 kHz Ti-sapphire continuously tunable laser (approximately 20 ns pulse width) between 193 nm and 240 nm for steady-state measurements. For transient Raman measurements we utilize one Coherent Infinity YAG laser to generate nanosecond infrared (IR) pump laser pulses to generate a temperature jump (T-jump) and a second Coherent Infinity YAG laser that is frequency tripled and Raman shifted into the deep UV (204 nm) for transient UV Raman excitation. Numerous other UV excitation frequencies can be utilized for selective excitation of chromophoric groups for transient Raman measurements. We constructed a subtractive dispersion double monochromator to minimize stray light. We utilize a new charge-coupled device (CCD) camera that responds efficiently to UV light, as opposed to the previous CCD and photodiode detectors, which required intensifiers for detecting UV light. For the T-jump measurements we use a second camera to simultaneously acquire the Raman spectra of the water stretching bands (2500-4000 cm(-1)) whose band-shape and frequency report the sample temperature.
	Address	Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0003-7028	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:16390595			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	3767
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	Author	Pichardo, M.
	Title	Valsequillo biostratigraphy. III: Equid ecospecies in Paleoindian sites			Type	Journal Article
	Year	2000	Publication	Anthropologischer Anzeiger; Bericht Uber die Biologisch-Anthropologische Literatur	Abbreviated Journal	Anthropol Anz
	Volume	58	Issue	3	Pages	275-298
	Keywords	Animals; Ecology; Horses/classification; Mexico; *Paleodontology; Species Specificity
	Abstract	Greater precision in North American Pleistocene equid taxonomy makes it now possible to exploit the ubiquitous horse remains in Paleoindian sites as ecological index-fossils. The horses of Central Mexico and the Southern Plains can be sorted by tooth size alone, except for two rare large horses of the Southern Plains. The species endemic to these grasslands and south to Central Mexico are Equus pacificus (large), E. conversidens (small), E. francisci (smallest). The Southern Plains were also occupied by a specialized grazer E. excelsus (Burnet and Sandia caves) and E. occidentalis (Dry and Sandia caves). West of the Rocky Mountains E. occidentalis was dominant. East of the Mississippi River two woodland species are found: E. fraternus and E. littoralis.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0003-5548	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:11082786			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	2648
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	Author	Seyfarth, R.M.; Cheney, D.L.
	Title	Signalers and receivers in animal communication			Type	Journal Article
	Year	2003	Publication	Annual review of psychology	Abbreviated Journal	Annu Rev Psychol
	Volume	54	Issue		Pages	145-173
	Keywords	Affect; Animal Communication; Animals; Arousal; Auditory Perception; Motivation; Social Behavior; Social Environment; Species Specificity; *Vocalization, Animal
	Abstract	In animal communication natural selection favors callers who vocalize to affect the behavior of listeners and listeners who acquire information from vocalizations, using this information to represent their environment. The acquisition of information in the wild is similar to the learning that occurs in laboratory conditioning experiments. It also has some parallels with language. The dichotomous view that animal signals must be either referential or emotional is false, because they can easily be both: The mechanisms that cause a signaler to vocalize do not limit a listener's ability to extract information from the call. The inability of most animals to recognize the mental states of others distinguishes animal communication most clearly from human language. Whereas signalers may vocalize to change a listener's behavior, they do not call to inform others. Listeners acquire information from signalers who do not, in the human sense, intend to provide it.
	Address	Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. seyfarth@psych.upenn.edu
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0066-4308	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:12359915			Approved	no
	Call Number	refbase @ user @			Serial	690
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	Author	Howard, R.W.; Blomquist, G.J.
	Title	Ecological, behavioral, and biochemical aspects of insect hydrocarbons			Type	Journal Article
	Year	2005	Publication	Annual Review of Entomology	Abbreviated Journal	Annu Rev Entomol
	Volume	50	Issue		Pages	371-393
	Keywords	Animals; Behavior, Animal/physiology; Hydrocarbons/metabolism; Insects/physiology; Pheromones/*physiology; Reproduction; Species Specificity
	Abstract	This review covers selected literature from 1982 to the present on some of the ecological, behavioral, and biochemical aspects of hydrocarbon use by insects and other arthropods. Major ecological and behavioral topics are species- and gender-recognition, nestmate recognition, task-specific cues, dominance and fertility cues, chemical mimicry, and primer pheromones. Major biochemical topics include chain length regulation, mechanism of hydrocarbon formation, timing of hydrocarbon synthesis and transport, and biosynthesis of volatile hydrocarbon pheromones of Lepidoptera and Coleoptera. In addition, a section is devoted to future research needs in this rapidly growing area of science.
	Address	USDA-ARS, Manhattan, Kansas 66502, USA. howardks@ksu.edu
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0066-4170	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15355247			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4650
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	Author	Henry, S.; Richard-Yris, M.-A.; Hausberger, M.
	Title	Influence of various early human-foal interferences on subsequent human-foal relationship			Type	Journal Article
	Year	2006	Publication	Developmental psychobiology	Abbreviated Journal	Dev Psychobiol
	Volume	48	Issue	8	Pages	712-718
	Keywords	Animal Husbandry/methods; Animals; Animals, Newborn/psychology; Animals, Suckling/psychology; Behavior, Animal; Female; Handling (Psychology); Horses/psychology; Humans; Mothers/psychology; *Object Attachment; Species Specificity
	Abstract	Whereas the way animals perceive human contact has been particularly examined in pet animals, a small amount of investigations has been done in domestic ungulates. It was nevertheless assumed that, as pet animals, non-aggressive forms of tactile contact were as well rewarding or positive for these species, even though the features of intraspecific relationships in pet animals and domestic ungulates may be to some extent different.We test here the hypothesis that horses may not consider physical handling by humans as a positive event. When comparing different early human-foal interactions, we found that early exposure to a motionless human enhanced slightly foals reactions to humans whereas forced stroking or handling in early life did not improve later human-foal relation. Foals that were assisted during their first suckling (e.g., brought to the dam's teat) even tended to avoid human approach at 2 weeks, and physical contact at 1 month of age.We argue that interspecies differences may exist in how tactile stimulation is perceived. It may be important for the establishment of a bond that a young animal is active in the process and able, through its behavioral responses, to help define what is positive for it. This way of investigation may have important general implications in how we consider the development of social relations, both within and between species.
	Address	UMR CNRS 6552, Ethologie-Evolution-Ecologie, Universite de Rennes 1, Avenue du General Leclerc, Campus de Beaulieu, F-35042 Rennes Cedex, France. severine.henry@univ-rennes1.fr
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0012-1630	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:17111402			Approved	no
	Call Number				Serial	1781
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	Author	Heath-Lange, S.; Ha, J.C.; Sackett, G.P.
	Title	Behavioral measurement of temperament in male nursery-raised infant macaques and baboons			Type	Journal Article
	Year	1999	Publication	American journal of primatology	Abbreviated Journal	Am. J. Primatol.
	Volume	47	Issue	1	Pages	43-50
	Keywords	Age Factors; Animal Technicians; Animals; Animals, Newborn/psychology; Behavior, Animal/physiology; Defecation; Facial Expression; Humans; Irritable Mood; Macaca fascicularis/psychology; Male; Papio/psychology; Sex Characteristics; Species Specificity; Temperament/physiology; Urination; Vocalization, Animal; Weaning
	Abstract	We define temperament as an individual's set of characteristic behavioral responses to novel or challenging stimuli. This study adapted a temperament scale used with rhesus macaques by Schneider and colleagues [American Journal of Primatology 25:137-155, 1991] for use with male pigtailed macaque (Macaca nemestrina, n = 7), longtailed macaque (M. fascicularis, n = 3), and baboon infants (Papio cynocephalus anubis, n = 4). Subjects were evaluated twice weekly for the first 5 months of age during routine removal from their cages for weighing. Behavioral measures were based on the subject's interactions with a familiar human caretaker and included predominant state before capture, response to capture, contact latency, resistance to tester's hold, degree of clinging, attention to environment, defecation/urination, consolability, facial expression, vocalizations, and irritability. Species differences indicated that baboons were more active than macaques in establishing or terminating contact with the tester. Temperament scores decreased over time for the variables Response to Capture and Contact Latency, indicating that as they grew older, subjects became less reactive and more bold in their interactions with the tester. Temperament scores changed slowly with age, with greater change occurring at younger ages. The retention of variability in reactivity between and within species may be advantageous for primates, reflecting the flexibility necessary to survive in a changing environment.
	Address	Department of Psychology and Regional Primate Research Center, University of Washington, Seattle, USA. crgsjh@vmmc.org
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0275-2565	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:9888720			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	4117
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	Author	Harland, M.M.; Stewart, A.J.; Marshall, A.E.; Belknap, E.B.
	Title	Diagnosis of deafness in a horse by brainstem auditory evoked potential			Type	Journal Article
	Year	2006	Publication	The Canadian Veterinary Journal. La Revue Veterinaire Canadienne	Abbreviated Journal	Can Vet J
	Volume	47	Issue	2	Pages	151-154
	Keywords	Acoustic Stimulation/veterinary; Animals; Deafness/congenital/diagnosis/veterinary; Evoked Potentials, Auditory, Brain Stem/physiology; Horse Diseases/congenital/*diagnosis; Horses; Male; Pigmentation/physiology; Sensitivity and Specificity
	Abstract	Deafness was confirmed in a blue-eyed, 3-year-old, overo paint horse by brainstem auditory evoked potential. Congenital inherited deafness associated with lack of facial pigmentation was suspected. Assessment of hearing should be considered, especially in paint horses, at the time of pre-purchase examination. Brainstem auditory evoked potential assessment is well tolerated and accurate.
	Address	Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Wire Road, Auburn, Alabama, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0008-5286	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:16579041			Approved	no
	Call Number	Equine Behaviour @ team @			Serial	5680
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