Records |
Author |
Tavernor, W.D.; Lees, P. |
Title |
A pharmacological investigation of the influence of suxamethonium on cardiac function in the horse |
Type |
Journal Article |
Year |
1968 |
Publication |
Experientia |
Abbreviated Journal |
Experientia |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
24 |
Issue |
6 |
Pages |
582-583 |
Keywords |
Animals; Arrhythmia/chemically induced; Consciousness; Halothane; Heart/innervation; Heart Rate/*drug effects; Horses/*physiology; Oxygen; Propranolol/pharmacology; Receptors, Sensory/drug effects; Stimulation, Chemical; Succinylcholine/antagonists & inhibitors/*pharmacology; Sympathetic Nervous System/physiology; Tachycardia/chemically induced; Thiopental |
Abstract |
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Address |
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Corporate Author |
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Thesis |
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Publisher |
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Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0014-4754 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
PMID:5697737 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
104 |
Permanent link to this record |
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Author |
Carroll, G.L.; Matthews, N.S.; Hartsfield, S.M.; Slater, M.R.; Champney, T.H.; Erickson, S.W. |
Title |
The effect of detomidine and its antagonism with tolazoline on stress-related hormones, metabolites, physiologic responses, and behavior in awake ponies |
Type |
Journal Article |
Year |
1997 |
Publication |
Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons |
Abbreviated Journal |
Vet Surg |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
26 |
Issue |
1 |
Pages |
69-77 |
Keywords |
Adrenergic alpha-Antagonists/administration & dosage/*pharmacology; Animals; Behavior, Animal/drug effects/physiology; Blood Glucose/metabolism; Blood Pressure/drug effects/physiology; Consciousness/physiology; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine/blood; Fatty Acids, Nonesterified/blood; Female; Heart Rate/drug effects/physiology; Horse Diseases/metabolism/physiopathology/psychology; Horses/blood/metabolism/*physiology; Hydrocortisone/blood; Hypnotics and Sedatives/administration & dosage/*pharmacology; Imidazoles/administration & dosage/*pharmacology; Injections, Intravenous; Male; Norepinephrine/blood; Receptors, Adrenergic, alpha/drug effects/*physiology; Stress/metabolism/physiopathology/veterinary; Time Factors; Tolazoline/administration & dosage/*pharmacology |
Abstract |
Six ponies were used to investigate the effect of tolazoline antagonism of detomidine on physiological responses, behavior, epinephrine, norepinephrine, cortisol, glucose, and free fatty acids in awake ponies. Each pony had a catheter inserted into a jugular vein 1 hour before beginning the study. Awake ponies were administered detomidine (0.04 mg/kg intravenously [i.v.]) followed 20 minutes later by either tolazoline (4.0 mg/kg i.v.) or saline. Blood samples were drawn from the catheter 5 minutes before detomidine administration (baseline), 5 minutes after detomidine administration, 20 minutes before detomidine administration which was immediately before the administration of tolazoline or saline (time [T] = 0), and at 5, 30, and 60 minutes after injections of tolazoline or saline (T = 5, 30, and 60 minutes, respectively). Compared with heart rate at T = 0, tolazoline antagonism increased heart rate 45% at 5 minutes. There was no difference in heart rate between treatments at 30 minutes. Blood pressure remained stable after tolazoline, while it decreased over time after saline. Compared with concentrations at T = 0, tolazoline antagonism of detomidine in awake ponies resulted in a 55% increase in cortisol at 30 minutes and a 52% increase in glucose at 5 minutes. The change in free fatty acids was different for tolazoline and saline over time. Free fatty acids decreased after detomidine administration. Free fatty acids did not change after saline administration. After tolazoline administration, free fatty acids increased transiently. Tolazoline tended to decrease sedation and analgesia at 15 and 60 minutes postantagonism. Antagonism of detomidine-induced physiological and behavioral effects with tolazoline in awake ponies that were not experiencing pain appears to precipitate a stress response as measured by cortisol, glucose, and free fatty acids. If antagonism of an alpha-agonist is contemplated, the potential effect on hormones and metabolites should be considered. |
Address |
Department of Small Animal Medicine and Surgery, Texas A&M University, College Station, USA |
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English |
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Series Editor |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0161-3499 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
PMID:9123816 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
96 |
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Author |
Doherty, T.J.; Frazier, D.L. |
Title |
Effect of intravenous lidocaine on halothane minimum alveolar concentration in ponies |
Type |
Journal Article |
Year |
1998 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
30 |
Issue |
4 |
Pages |
300-303 |
Keywords |
Anesthetics/administration & dosage/blood/*pharmacology; Anesthetics, Inhalation/administration & dosage/*analysis; Animals; Consciousness/drug effects; Dose-Response Relationship, Drug; Halothane/administration & dosage/*analysis; Horses/*physiology; Infusions, Intravenous/veterinary; Lidocaine/administration & dosage/blood/*pharmacology; Male |
Abstract |
This study investigated the effect of lidocaine i.v. on halothane minimum alveolar concentration (MAC) in ponies. Six ponies were anaesthetised with thiopentone and succinylcholine, intubated and anaesthesia maintained with halothane. Ventilation was controlled and blood pressure maintained within clinically acceptable limits. Following a 2 h equilibration period, baseline halothane MAC was determined. The ponies were then given a loading dose of lidocaine (2.5 or 5 mg/kg bwt) or saline over 5 min, followed by a constant infusion of lidocaine (50 or 100 microg/kg/min, or saline, respectively). The halothane MAC was redetermined after a 60 min infusion of lidocaine or saline. The baseline halothane MAC for the control group was mean +/- s.d. 0.94 +/- 0.03%, and no significant decrease occurred following saline infusion. Lidocaine decreased halothane MAC in a dose-dependent fashion (r = 0.86; P < 0.0003). The results indicate that i.v. lidocaine may have a role in equine anaesthesia. |
Address |
Department of Large Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville 37901-1071, USA |
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English |
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Edition |
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ISSN |
0425-1644 |
ISBN |
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Conference |
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Notes |
PMID:9705112 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
95 |
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Author |
Spadavecchia, C.; Arendt-Nielsen, L.; Spadavecchia, L.; Mosing, M.; Auer, U.; van den Hoven, R. |
Title |
Effects of butorphanol on the withdrawal reflex using threshold, suprathreshold and repeated subthreshold electrical stimuli in conscious horses |
Type |
Journal Article |
Year |
2007 |
Publication |
Veterinary anaesthesia and analgesia |
Abbreviated Journal |
Vet Anaesth Analg |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
34 |
Issue |
1 |
Pages |
48-58 |
Keywords |
Analgesics, Opioid/pharmacology; Animals; Butorphanol/*pharmacology; Consciousness; Electric Stimulation; Electromyography; Female; Forelimb/physiology; Horses/*physiology; Male; Pain/veterinary; Pain Threshold/*drug effects; Reflex/*drug effects |
Abstract |
OBJECTIVE: To assess the effects of a single intravenous dose of butorphanol (0.1 mg kg(-1)) on the nociceptive withdrawal reflex (NWR) using threshold, suprathreshold and repeated subthreshold electrical stimuli in conscious horses. STUDY DESIGN: 'Unblinded', prospective experimental study. ANIMALS: Ten adult horses, five geldings and five mares, mean body mass 517 kg (range 487-569 kg). METHODS: The NWR was elicited using single transcutaneous electrical stimulation of the palmar digital nerve. Repeated stimulations were applied to evoke temporal summation. Surface electromyography was performed to record and quantify the responses of the common digital extensor muscle to stimulation and behavioural reactions were scored. Before butorphanol administration and at fixed time points up to 2 hours after injection, baseline threshold intensities for NWR and temporal summation were defined and single suprathreshold stimulations applied. Friedman repeated-measures analysis of variance on ranks and Wilcoxon signed-rank test were used with the Student-Newman-Keul's method applied post-hoc. The level of significance (alpha) was set at 0.05. RESULTS: Butorphanol did not modify either the thresholds for NWR and temporal summation or the reaction scores, but the difference between suprathreshold and threshold reflex amplitudes was reduced when single stimulation was applied. Upon repeated stimulation after butorphanol administration, a significant decrease in the relative amplitude was calculated for both the 30-80 and the 80-200 millisecond intervals after each stimulus, and for the whole post-stimulation interval in the right thoracic limb. In the left thoracic limb a decrease in the relative amplitude was found only in the 30-80 millisecond epoch. CONCLUSION: Butorphanol at 0.1 mg kg(-1) has no direct action on spinal Adelta nociceptive activity but may have some supraspinal effects that reduce the gain of the nociceptive system. CLINICAL RELEVANCE: Butorphanol has minimal effect on sharp immediate Adelta-mediated pain but may alter spinal processing and decrease the delayed sensations of pain. |
Address |
Anesthesiology Section, Department of Clinical Veterinary Sciences, Vetsuisse Faculty, University of Berne, Berne, Switzerland. claudia.spadavecchia@veths.no |
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English |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1467-2987 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
PMID:17238962 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
92 |
Permanent link to this record |
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Author |
Lees, P.; Tavernor, W.D. |
Title |
Influence of halothane and catecholamines on heart rate and rhythm in the horse |
Type |
Journal Article |
Year |
1970 |
Publication |
British journal of pharmacology |
Abbreviated Journal |
Br J Pharmacol |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
39 |
Issue |
1 |
Pages |
149-159 |
Keywords |
Anesthesia, Inhalation; Animals; Arrhythmia/*chemically induced; Atropine/pharmacology; Catecholamines/*pharmacology; Consciousness; Epinephrine/administration & dosage; Ethers; Female; Halothane/*pharmacology; Heart Rate/*drug effects; Horses; Hypercapnia/physiopathology; Isoproterenol/pharmacology; Male; Norepinephrine/pharmacology; Propranolol/pharmacology |
Abstract |
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Thesis |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0007-1188 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
PMID:5420092 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
103 |
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Author |
Morton, D.B. |
Title |
Self-consciousness and animal suffering |
Type |
Journal Article |
Year |
2000 |
Publication |
Biologist (London, England) |
Abbreviated Journal |
Biologist (London) |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
47 |
Issue |
2 |
Pages |
77-80 |
Keywords |
Animal Population Groups/*psychology; Animal Welfare/*standards; Animals; Behavior, Animal; *Consciousness; Dogs; *Ego; Horses/psychology; Pain/psychology/*veterinary; Pan troglodytes/psychology; Parrots; Pongo pygmaeus/psychology; Self Concept |
Abstract |
Animals with relatively highly developed brains are likely to experience some degree of self-awareness and the ability to think. As well as being interesting in its own right, self-consciousness matters from an ethical point of view, since it can give rise to forms of suffering above and beyond the immediate physical sensations of pain or distress. This article surveys the evidence for animal self-consciousness and its implications for animal welfare. |
Address |
Division of Primary Care, Public and Occupational Health, School of Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. d.b.morton@bham.ac.uk |
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English |
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Series Issue |
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Edition |
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ISSN |
0006-3347 |
ISBN |
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Conference |
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Notes |
PMID:11190233 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
618 |
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Author |
Forster, H.V.; Pan, L.G.; Bisgard, G.E.; Flynn, C.; Hoffer, R.E. |
Title |
Changes in breathing when switching from nares to tracheostomy breathing in awake ponies |
Type |
Journal Article |
Year |
1985 |
Publication |
Journal of applied physiology (Bethesda, Md. : 1985) |
Abbreviated Journal |
J Appl Physiol |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
59 |
Issue |
4 |
Pages |
1214-1221 |
Keywords |
Airway Resistance; Animals; Chemoreceptors/physiology; Consciousness; Exertion; Horses/*physiology; Lung Compliance; Pulmonary Gas Exchange; Pulmonary Stretch Receptors/physiology; *Respiration; Respiratory Dead Space; *Tracheotomy |
Abstract |
We assessed the consequences of respiratory unloading associated with tracheostomy breathing (TBr). Three normal and three carotid body-denervated (CBD) ponies were prepared with chronic tracheostomies that at rest reduced physiological dead space (VD) from 483 +/- 60 to 255 +/- 30 ml and lung resistance from 1.5 +/- 0.14 to 0.5 +/- 0.07 cmH2O . l-1 . s. At rest and during steady-state mild-to-heavy exercise arterial PCO2 (PaCO2) was approximately 1 Torr higher during nares breathing (NBr) than during TBr. Pulmonary ventilation and tidal volume (VT) were greater and alveolar ventilation was less during NBr than TBr. Breathing frequency (f) did not differ between NBr and TBr at rest, but f during exercise was greater during TBr than during NBr. These responses did not differ between normal and CBD ponies. We also assessed the consequences of increasing external VD (300 ml) and resistance (R, 0.3 cmH2O . l-1 . s) by breathing through a tube. At rest and during mild exercise tube breathing caused PaCO2 to transiently increase 2-3 Torr, but 3-5 min later PaCO2 usually was within 1 Torr of control. Tube breathing did not cause f to change. When external R was increased 1 cmH2O . l-1 . s by breathing through a conventional air collection system, f did not change at rest, but during exercise f was lower than during unencumbered breathing. These responses did not differ between normal, CBD, and hilar nerve-denervated ponies, and they did not differ when external VD or R were added at either the nares or tracheostomy.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Edition |
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ISSN |
8750-7587 |
ISBN |
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Conference |
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Notes |
PMID:4055600 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
100 |
Permanent link to this record |
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Author |
Spadavecchia, C.; Arendt-Nielsen, L.; Andersen, O.K.; Spadavecchia, L.; Doherr, M.; Schatzmann, U. |
Title |
Comparison of nociceptive withdrawal reflexes and recruitment curves between the forelimbs and hind limbs in conscious horses |
Type |
Journal Article |
Year |
2003 |
Publication |
American journal of veterinary research |
Abbreviated Journal |
Am J Vet Res |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
64 |
Issue |
6 |
Pages |
700-707 |
Keywords |
Animals; Consciousness; Female; Forelimb/*physiology; Hindlimb/*physiology; Horses/*physiology; Male; Nociceptors/physiology; Pain/*physiopathology/*veterinary; Pain Threshold/physiology; Recruitment, Neurophysiological/physiology; Reflex/*physiology |
Abstract |
OBJECTIVE: To compare nociceptive withdrawal reflexes (NWRs) evoked from the distal aspect of the left forelimb and hind limb in conscious standing horses and to investigate NWR recruitment for graded electrical stimulation intensities. ANIMALS: 20 adult horses. PROCEDURE: Surface electromyographic (EMG) activity evoked by transcutaneous electrical stimulation of the digital palmar (or plantar) nerve was recorded from the common digital extensor and cranial tibial muscles. Stimuli consisted of 25-millisecond train-of-5 constant current pulses. Current intensity was gradually increased until NWR threshold intensity was reached. The EMG signal was analyzed for quantification of the NWR. Behavioral responses accompanying the reflex were scored (scale, 0 to 5). The NWR recruitment curves were determined at 0.9, 1.1, 1.2, and 1.3 times the NWR threshold intensity. RESULTS: The NWR threshold was significantly higher for the hind limb (median value, 6.6 mA; range, 3 to 10 mA) than the forelimb (median, 3 mA; range, 1.7 to 5.5 mA). The NWR of the hind limb had a significantly longer latency (median, 122.8 milliseconds; range, 106 to 172 milliseconds), compared with the forelimb (median, 98 milliseconds; range, 86 to 137 milliseconds), and it was associated with significantly stronger behavioral reactions. Gradual increase of NWR amplitude was evident at increasing stimulation intensities and supported by the behavioral observations. CONCLUSIONS AND CLINICAL RELEVANCE: We documented NWRs evoked from the forelimb and hind limb and their recruitment with stimuli of increasing intensity in horses. These results provide a basis for use of NWRs in studies on nociceptive modulation in horses. |
Address |
Department of Clinical Veterinary Sciences, University of Berne, Switzerland |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0002-9645 |
ISBN |
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Expedition |
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Conference |
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Notes |
PMID:12828255 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
93 |
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Author |
Pere, M.C. |
Title |
Maternal and fetal blood levels of glucose, lactate, fructose, and insulin in the conscious pig |
Type |
Journal Article |
Year |
1995 |
Publication |
Journal of Animal Science |
Abbreviated Journal |
J. Anim Sci. |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
73 |
Issue |
10 |
Pages |
2994-2999 |
Keywords |
Animals; Blood Glucose/*analysis; Catheterization/methods/veterinary; Consciousness/physiology; Female; Fetal Blood/*chemistry; Fructose/analysis/*blood; Insulin/analysis/*blood; Lactates/analysis/*blood; Pregnancy; Swine/*blood/physiology |
Abstract |
To study nutrition and metabolism in the fetal pig, a chronic catheterization method was developed that allows blood sampling in arteries and veins, at both the umbilical and uterine sources, in the conscious, unstressed animal. A catheter was inserted in the fetal aorta through a femoral artery, and another one was introduced in the umbilical vein. A catheter was put in a femoral artery of the sow so that its end was in the abdominal aorta. A fourth catheter was placed in a uterine vein draining the fetoplacental unit studied. This procedure was applied to 18 Large White primiparous sows at 99 d of gestation. Blood samples were drawn simultaneously using the four catheters before a meal at 103 d of pregnancy, and glucose, insulin, lactate, and fructose were determinated. Glycemia was 2.5 times higher in the sow than in the fetus. The extraction coefficient of glucose by the fetus amounted to 14% of the umbilical supply. The insulin level in the fetal pig was very low ( < 5 microU/mL). Lactate and fructose seemed to originate from the placenta. Blood lactate was 2.6 times lower in the sow than in the fetus, and its extraction coefficient by the fetus amounted to 8%. Fructose in the fetal blood was 2.3 times higher than that of glucose. Fructose was not utilized by the pig fetus. The present results obtained in the fetal pig are comparable to the conclusions drawn from studies with other species. |
Address |
Station de Recherches Porcines, Institut National de la Recherche Agronomique, Saint-Gilles, France |
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ISSN |
0021-8812 |
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Notes |
PMID:8617670 |
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no |
Call Number |
Equine Behaviour @ team @ |
Serial |
2751 |
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Author |
Kirkwood, J.K. |
Title |
Animal minds and animal welfare |
Type |
Journal Article |
Year |
2000 |
Publication |
The Veterinary Record |
Abbreviated Journal |
Vet. Rec. |
Volume ![sorted by Volume (numeric) field, ascending order (up)](img/sort_asc.gif) |
146 |
Issue |
11 |
Pages |
327 |
Keywords |
*Animal Welfare; Animals; Animals, Domestic/*psychology; *Cognition; Consciousness; Veterinary Medicine/standards |
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English |
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Edition |
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ISSN |
0042-4900 |
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Notes |
PMID:10766123 |
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no |
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Equine Behaviour @ team @ |
Serial |
2856 |
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