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| Author | Guo, G.L.; Moffit, J.S.; Nicol, C.J.; Ward, J.M.; Aleksunes, L.A.; Slitt, A.L.; Kliewer, S.A.; Manautou, J.E.; Gonzalez, F.J. | ||||
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Enhanced acetaminophen toxicity by activation of the pregnane X receptor | Type | Journal Article | ||
| Year | 2004 | Publication | Toxicological sciences : an official journal of the Society of Toxicology | Abbreviated Journal | Toxicol Sci |
| Volume | 82 | Issue | 2 | Pages | 374-380 |
| Keywords | Acetaminophen/pharmacokinetics/*toxicity; Analgesics, Non-Narcotic/pharmacokinetics/*toxicity; Animals; Aryl Hydrocarbon Hydroxylases/biosynthesis; Biotransformation; Blotting, Northern; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Membrane Proteins; Mice; Mice, Knockout; Oxidoreductases, N-Demethylating/biosynthesis; Pregnenolone Carbonitrile/pharmacology; Receptors, Cytoplasmic and Nuclear/*drug effects; Receptors, Steroid/*drug effects; Sulfhydryl Compounds/metabolism | ||||
| Abstract | The pregnane X receptor (PXR) is a ligand-activated transcription factor and member of the nuclear receptor superfamily. Activation of PXR represents an important mechanism for the induction of cytochrome P450 3A (CYP3A) enzymes that can convert acetaminophen (APAP) to its toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI). Therefore, it was hypothesized that activation of PXR plays a major role in APAP-induced hepatotoxicity. Pretreatment with the PXR activator, pregnenolone 16alpha-carbonitrile (PCN), markedly enhanced APAP-induced hepatic injury, as revealed by increased serum ALT levels and hepatic centrilobular necrosis, in wild-type but not in PXR-null mice. Further analysis showed that following PCN treatment, PXR-null mice had lower CYP3A11 expression, decreased NAPQI formation, and increased maintenance of hepatic glutathione content compared to wild-type mice. Thus, these results suggest that PXR plays a critical role in APAP-induced hepatic toxicity, probably by inducing CYP3A11 expression and hence increasing bioactivation. | ||||
| Address | Laboratory of Metabolism, CCR, NCI, NIH, Bethesda, Maryland 20892, USA | ||||
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| Language | English | Summary Language | Original Title | ||
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| ISSN | 1096-6080 | ISBN | Medium | ||
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| Notes | PMID:15456926 | Approved | no | ||
| Call Number | refbase @ user @ | Serial | 71 | ||
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| Author | Lensink, J.; Veissier, I.; Boissy, A. | ||||
| Title |
Enhancement of performances in a learning task in suckler calves after weaning and relocation: Motivational versus cognitive control?: A pilot study | Type | Journal Article | ||
| Year | 2006 | Publication | Applied Animal Behaviour Science | Abbreviated Journal | Appl. Anim. Behav. Sci. |
| Volume | 100 | Issue | 3-4 | Pages | 171-181 |
| Keywords | Calves; Weaning; Learning; Cognition; Behavioural test | ||||
| Abstract | Weaning in suckler calves influences performance in a learning task. The aim of the present study was to investigate whether the improved performance after weaning, including relocation, is due to differences in motivation for the reward or in learning abilities. Forty Aubrac calves were used; half of them were weaned from their dams at around eight months, the other half were weaned one month later. After weaning, calves were housed in groups of four in a new setting. From the day after weaning of the last group of calves, the animals were subjected to two tests: (1) an arena test, (2) a T-maze test where one arm led to either a social or a food reward. The T-maze test consisted of three sessions: in Session 1, trials were conducted until the animal acquired the task (i.e. did not take the unrewarded arm on three consecutive trials); in Session 2, the motivation for the reward was assessed via the walking time of the animal to reach the reward; in Session 3, the place of reward was reversed and the animals were trained until they acquired the new task. Calves weaned for one day explored more (P < 0.05) and had lower heart rates during the arena test (P < 0.05) compared to the ones weaned for one month. During the T-maze test, calves weaned for one month versus one day did not differ in their capacities to learn the initial route (Session 1) or in their motivation for either the social or food reward (Session 2). Calves weaned for one day learned significantly faster (P < 0.05) the reversed route (Session 3) than calves weaned for one month. Hence, the better performances at reversal in the T-maze by calves that have just been weaned cannot be accounted for by a higher motivation for the reward. A better cognitive control of their behaviour due to a lower stress state is suggested by our results. | ||||
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| Notes | Approved | no | |||
| Call Number | refbase @ user @ | Serial | 285 | ||
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| Author | Vrba, Elisabeth S. | ||||
| Title |
Environment and evolution: alternative causes of the temporal distribution of evolutionary events | Type | Journal Article | ||
| Year | 1985 | Publication | South African Journal of Science | Abbreviated Journal | S Afr J Anim Sci |
| Volume | 81 | Issue | Pages | 229-236 | |
| Keywords | evolution, paleontology, turnover pulse | ||||
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| Call Number | Equine Behaviour @ team @ | Serial | 5463 | ||
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| Author | Griffiths D.; Dickinson A.; Clayton N. | ||||
| Title |
Episodic memory: what can animals remember about their past? | Type | Journal Article | ||
| Year | 1999 | Publication | Trends in Cognitive Sciences | Abbreviated Journal | Trends. Cognit. Sci. |
| Volume | 3 | Issue | Pages | 74-80 | |
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| Call Number | refbase @ user @ | Serial | 3460 | ||
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| Author | Verrill, S.; McDonnell, S. | ||||
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Equal Outcomes with and without Human-to-Horse Eye Contact When Catching Horses and Ponies in an Open Pasture | Type | Journal Article | ||
| Year | 2008 | Publication | Journal of Equine Veterinary Science | Abbreviated Journal | |
| Volume | 28 | Issue | 5 | Pages | 309-312 |
| Keywords | Horse handling; Horse management; Eye contact; Interspecies interactions; Equine behavior | ||||
| Abstract | Each of 104 horses and ponies was approached for catching at pasture by the same human handler in a standard manner, either maintaining human-to-animal eye contact (EC+; n = 51) or avoiding eye contact (EC-; n = 53). A subset of 74 of these subjects were reevaluated 3 weeks later under similar standard conditions except with the eye contact condition opposite to that used in the first round. Nonparametric statistical methods were used to evaluate between subjects (round 1, n = 104) and within subjects (rounds 1 and 2, n = 74) comparisons of successful or unsuccessful catching outcome with EC+ and EC-. Catching outcomes were similar with eye contact condition. Although this study represents a single handler at one study site, results suggest that human-to-horse eye contact may not be an important influence on catching pastured horses. Certainly, further work is needed to better understand the role of eye contact in horse handling. | ||||
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| ISSN | 0737-0806 | ISBN | Medium | ||
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| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 4711 | ||
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| Author | McDonnell, S.M.; Poulin, A. | ||||
| Title |
Equid play ethogram | Type | Journal Article | ||
| Year | 2002 | Publication | Applied Animal Behaviour Science | Abbreviated Journal | Appl. Anim. Behav. Sci. |
| Volume | 78 | Issue | 2-4 | Pages | 263-290 |
| Keywords | Equine; Pony; Zebra; Donkey; Przewalski horse; Play behavior; Ethogram | ||||
| Abstract | An ethogram of play behavior among equids was developed. Several key English-language studies on equids were reviewed to derive a preliminary inventory of specific behaviors to be included in the ethogram. Our primary observations were based on a herd of semi-feral Shetland-type ponies kept at New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA. Greater than 100 h of direct observation and photo-documentation focused specifically on play in order to identify play behaviors to be added to the preliminary inventory and to obtain detailed descriptions of each behavior. Additionally, these observations were supplemented with photographs obtained during several years of observational study of this herd for other purposes, and with the cumulative equid observational experience and study notes of the principal investigator with other equid species. An initial draft was sent out to 18 equine behavior colleagues for review. A total of 38 individual behaviors classified into four distinct categories were included in the ethogram. These included object play (14 entries), play sexual behavior (3 entries), locomotor play (14 entries) and play fighting (7 entries). All of the behaviors catalogued from direct observation of the herd were also found in the equid literature. The resulting ethogram offers a practical tool as a field guide or reference for quantitative research and other studies of equid play behavior as well as for teaching of equid behavior. | ||||
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| Notes | Approved | no | |||
| Call Number | refbase @ user @ | Serial | 1987 | ||
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| Author | McGreevy, P. | ||||
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Equine behavior | Type | Journal Article | ||
| Year | 2004 | Publication | Journal of Equine Veterinary Science | Abbreviated Journal | |
| Volume | 24 | Issue | 9 | Pages | 397-398 |
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| Call Number | refbase @ user @ | Serial | 1983 | ||
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| Author | Pick, D.F.; Lovell, G.; Brown, S.; Dail, D. | ||||
| Title |
Equine color perception revisited | Type | Journal Article | ||
| Year | 1994 | Publication | Applied Animal Behaviour Science | Abbreviated Journal | Appl. Anim. Behav. Sci. |
| Volume | 42 | Issue | 1 | Pages | 61-65 |
| Keywords | Equine; Color perception; Dichromat | ||||
| Abstract | An attempt to replicate Grzimek (1952; Z. Tierpsychol., 27: 330-338) is reported where a Quarter-Horse mare chose between colored and gray stimuli for food reinforcement. Stimuli varied across a broad range of reflectance values. A double-blind procedure with additional controls for auditory, olfactory, tactile, and position cues was used. The subject could reliably discriminate blue (462 nm) vs. gray, and red (700 nm) vs. gray without regard to reflectance (P<0.001), but could not discriminate green (496 nm) vs. gray. It is suggested that horses are dichromats in a manner similar to swine and cattle. | ||||
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| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 4368 | ||
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| Author | Nicol, C. J. | ||||
| Title |
Equine learning: progress and suggestions for future research | Type | Journal Article | ||
| Year | 2002 | Publication | Applied Animal Behaviour Science | Abbreviated Journal | Appl. Anim. Behav. Sci. |
| Volume | 78 | Issue | 2-4 | Pages | 193-208 |
| Keywords | Learning; Horse; Equine; Discrimination; Training | ||||
| Abstract | Horses are well able to form classical and instrumental associations and so the focus of much recent research has been on the stimulus control of instrumental learning. Horses appear to discriminate using spatial cues more easily than other stimulus features, as indicated both by the speed of initial task acquisition and by the extent to which acquired discriminations can be reversed. Phenomena associated with discrimination learning in laboratory animals, including generalisation and peak shift, have been demonstrated in horses. However, the ability of horses to classify stimuli into categories is more controversial. Although there is some evidence that horses may be able to form categories based on similarities in the physical appearance of different stimuli, there is currently no evidence that they are able to develop abstract concepts. Their performance on social learning tasks has also been poor. Few correlations are observed between the learning ability of individual horses on different tasks, suggesting that it may not be possible to classify individual horses as `good' or `poor' learners. Better learning performance by horses that are naturally calm is probably due to reduced interference in the learning process. Correct handling procedures can lower reactivity levels in horses, and may facilitate learning in some circumstances. Future research on equine learning needs to take into account the complex nature of equine social interaction. Studies on the effects of stress on learning, and on social and spatial cognition, are also particularly needed. | ||||
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| Call Number | refbase @ user @ | Serial | 405 | ||
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| Author | Sackman, J.E.; Houpt, K.A. | ||||
| Title |
Equine Personality: Association with Breed, Use and Husbandry Factors | Type | Journal Article | ||
| Year | 2018 | Publication | Journal of Equine Veterinary Science | Abbreviated Journal | |
| Volume | Issue | Pages | |||
| Keywords | Horse; Personality; Behavior; Breed; Use; Survey | ||||
| Abstract | Abstract Temperament can be defined as innate properties of the nervous system whereas personality includes the complex behavioral traits acquired through life. Association between personality and behavior is important for breeding, selection, and training of horses. For the first time, we evaluated if equine personality components previously identified in Japan and Europe were consistent when applied to American horses. We examined the association of personality with breed, age, sex, management, training, stereotypies and misbehaviors. Materials and Methods The owner directed personality survey consisted of 25 questions. An online version of the survey was created. The principal component analysis (PCA) method was used to associate behavioral traits with personality components. Factor analysis with orthogonal transformation was performed on scores for personality related questions. Results 847 survey responses were used. Quarter horses, “other” breed and Thoroughbred were the most common breeds. Three principal personality components were extracted as each behavioral trait belonged to one of these three components. Arabians, Thoroughbreds, Saddlebreds and Walking horses were the most nervous and Quarter horses, Paints, Appaloosas and Drafts were the least nervous. No trained discipline was significantly associated with any personality component. There were no significant associations between stereotypies and misbehaviors and nervous or curious personality. Conclusions For the first time in predominantly American horses, we have evaluated personality components and their association with breed, age, sex, training discipline and stereotypies. We refute links between personality and trained discipline and confirm the lack of association between nervous personality and stereotypies and misbehaviors. |
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| ISSN | 0737-0806 | ISBN | Medium | ||
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| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 6426 | ||
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