Records |
Author |
Hillidge, C.J.; Lees, P. |
Title |
Cardiac output in the conscious and anaesthetised horse |
Type |
Journal Article |
Year |
1975 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
Volume |
7 |
Issue |
1 |
Pages |
16-21 |
Keywords |
Anesthesia, Inhalation/*veterinary; Animals; Carbon Dioxide/blood; *Cardiac Output/veterinary; *Consciousness; Electrocardiography/veterinary; Ether, Ethyl; Female; Halothane; Heart Rate; Heart Ventricles/physiology; Horses/*physiology; Hydrogen-Ion Concentration; Male; Oxygen/blood; Posture |
Abstract |
Cardiac output in the horse was measured before and at predetermined times during 2-hour periods of thiopentone-halothane and thiopentone-diethyl ether anaesthesia. Left ventricular stroke volume was decreased to a similar extent during anaesthesia with each volatile agent, but a greater reduction in cardiac output occurred during halothane anaesthesia. This finding reflected the differing effects of halothane and ether on heart rate, a slight bradycardia occurring with the former agent while ether produced a small degree of tachycardia. The latter effect was attributed to enhanced sympathoadrenal activity. Changes in cardiac output and stroke volume were considered in relation to other factors, including arterial blood pH and tensions of oxygen and carbon dioxide. Positive correlations between some of these variables and cardiac function were established. With both volatile agents the reductions in stroke volume and cardiac output were related to the duration of anaesthesia, being greatest during the early stages. Possible reasons for the tendency of stroke volume and cardiac output to return towards control levels are discussed. |
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ISSN |
0425-1644 |
ISBN |
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Notes |
PMID:234842 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
102 |
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Author |
Lees, P.; Tavernor, W.D. |
Title |
Influence of halothane and catecholamines on heart rate and rhythm in the horse |
Type |
Journal Article |
Year |
1970 |
Publication |
British journal of pharmacology |
Abbreviated Journal |
Br J Pharmacol |
Volume |
39 |
Issue |
1 |
Pages |
149-159 |
Keywords |
Anesthesia, Inhalation; Animals; Arrhythmia/*chemically induced; Atropine/pharmacology; Catecholamines/*pharmacology; Consciousness; Epinephrine/administration & dosage; Ethers; Female; Halothane/*pharmacology; Heart Rate/*drug effects; Horses; Hypercapnia/physiopathology; Isoproterenol/pharmacology; Male; Norepinephrine/pharmacology; Propranolol/pharmacology |
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Edition |
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ISSN |
0007-1188 |
ISBN |
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Medium |
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Conference |
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Notes |
PMID:5420092 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
103 |
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Author |
Tavernor, W.D.; Lees, P. |
Title |
A pharmacological investigation of the influence of suxamethonium on cardiac function in the horse |
Type |
Journal Article |
Year |
1968 |
Publication |
Experientia |
Abbreviated Journal |
Experientia |
Volume |
24 |
Issue |
6 |
Pages |
582-583 |
Keywords |
Animals; Arrhythmia/chemically induced; Consciousness; Halothane; Heart/innervation; Heart Rate/*drug effects; Horses/*physiology; Oxygen; Propranolol/pharmacology; Receptors, Sensory/drug effects; Stimulation, Chemical; Succinylcholine/antagonists & inhibitors/*pharmacology; Sympathetic Nervous System/physiology; Tachycardia/chemically induced; Thiopental |
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Edition |
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ISSN |
0014-4754 |
ISBN |
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Conference |
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Notes |
PMID:5697737 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
104 |
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Author |
Alexander, F. |
Title |
Effect of phenylbutazone on electrolyte metabolism in ponies |
Type |
Journal Article |
Year |
1982 |
Publication |
The Veterinary record |
Abbreviated Journal |
Vet. Rec. |
Volume |
110 |
Issue |
12 |
Pages |
271-272 |
Keywords |
Animals; Chlorides/metabolism; Electrolytes/*metabolism; Horses/*metabolism; Male; Phenylbutazone/*pharmacology; Sodium/metabolism |
Abstract |
Phenylbutazone administered in therapeutic doses to ponies decreased urinary sodium and chloride excretion. The volume and osmolality of the urine was unaffected as was potassium excretion. Faecal excretion of chloride decreased and that of potassium increased, while faecal sodium excretion was unaffected. Plasma pH, bicarbonate and total carbon dioxide decreased after phenylbutazone administration. Packed cell volume, plasma sodium, potassium, carbon dioxide tension and chloride were unchanged. |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0042-4900 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
PMID:7080416 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
109 |
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Author |
Alexander, F. |
Title |
The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse |
Type |
Journal Article |
Year |
1978 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
Volume |
10 |
Issue |
4 |
Pages |
229-234 |
Keywords |
Animals; Antidiarrheals/*pharmacology; Atropine/pharmacology; Electrolytes/*analysis/urine; Feces/*analysis; Gastrointestinal Motility/*drug effects; Horses/*metabolism/physiology; Loperamide/pharmacology; Male; Meperidine/pharmacology; Morphine/pharmacology; Opium/pharmacology; Water/*analysis |
Abstract |
The effect of morphine, Tinct. opii, loperamide, pethidine and atropine on intestinal transit and the faecal and urinary excretion of water and electrolytes was studied in ponies. The rate of passage of a particulate marker was slowed by morphine, hastened then slowed by loperamide and Tinct. opii, and hastened by atropine. The liquid marker was slowed by Tinct. opii and hastened then slowed by the other drugs. Only loperamide decreased the faecal sodium excretion. This drug also decreased faecal water and weight; it appeared worthy of clinical trial in diarrhoea. Tinct. opii decreased by morphine, pethidine and atropine increased faecal water. |
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Edition |
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ISSN |
0425-1644 |
ISBN |
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Medium |
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Area |
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Conference |
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Notes |
PMID:738263 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
110 |
Permanent link to this record |
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Author |
Alexander, F. |
Title |
The effect of diuretics on the faecal excretion of water and electrolytes in horses |
Type |
Journal Article |
Year |
1977 |
Publication |
British journal of pharmacology |
Abbreviated Journal |
Br J Pharmacol |
Volume |
60 |
Issue |
4 |
Pages |
589-593 |
Keywords |
Animals; Body Water/*metabolism; Chlorides/metabolism; Electrolytes/*metabolism; Feces/*analysis; Furosemide/*pharmacology; Horses; Hydrochlorothiazide/*pharmacology; Male; Potassium/metabolism; Sodium/metabolism; Time Factors |
Abstract |
1. The effect on plasma, urinary and faecal electrolytes of frusemide and hydrochlorthiazide was measured in ponies, mean weight 180 kg. 2. The rapid loss in urine of large quantities of sodium had only a small effect on plasma sodium concentration. 3. Faecal sodium excretion was increased substantially after the administration of frusemide. 4. Frusemide increased faecal potassium during the 48 h following administration and faecal water in the 24/48 h period. It also produced a hypopotassaemia. 5. Hydrochlorthiazide increased faecal chloride during the 24 h after administration. 6. Frusemide increased the intestinal transit time of both liquid (polyethylene glycol) and particulate (Cr2O3) markers. |
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Edition |
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ISSN |
0007-1188 |
ISBN |
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Conference |
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Notes |
PMID:907872 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
111 |
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Author |
Alexander, F.; Collett, R.A. |
Title |
Proceedings: Some observations on the pharmacokinetics of trimethoprim in the horse |
Type |
Journal Article |
Year |
1974 |
Publication |
British journal of pharmacology |
Abbreviated Journal |
Br J Pharmacol |
Volume |
52 |
Issue |
1 |
Pages |
142p |
Keywords |
Animals; Half-Life; Horses/*metabolism; Kinetics; Trimethoprim/*metabolism |
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ISSN |
0007-1188 |
ISBN |
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Conference |
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Notes |
PMID:4451793 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
112 |
Permanent link to this record |
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Author |
Alexander, F.; Collett, R.A. |
Title |
Pethidine in the horse |
Type |
Journal Article |
Year |
1974 |
Publication |
Research in veterinary science |
Abbreviated Journal |
Res Vet Sci |
Volume |
17 |
Issue |
1 |
Pages |
136-137 |
Keywords |
Animals; Half-Life; Horses/*metabolism; Injections, Intravenous/veterinary; Male; Meperidine/administration & dosage/analysis/*metabolism/pharmacology |
Abstract |
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ISSN |
0034-5288 |
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Notes |
PMID:4421117 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
113 |
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Author |
Alexander, F. |
Title |
Multiple fistulation of the horse's large intestine |
Type |
Journal Article |
Year |
1970 |
Publication |
The British veterinary journal |
Abbreviated Journal |
Br. Vet. J. |
Volume |
126 |
Issue |
11 |
Pages |
604-606 |
Keywords |
Animals; Cecum/physiology; Colon/physiology; Horses/*physiology; Intestinal Fistula; Intestine, Large/*physiology; *Intubation, Gastrointestinal; Methods |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0007-1935 |
ISBN |
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Conference |
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Notes |
PMID:5492494 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
115 |
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Author |
Alexander, F.; Davies, M.E. |
Title |
Studies on vitamin B12 in the horse |
Type |
Journal Article |
Year |
1969 |
Publication |
The British veterinary journal |
Abbreviated Journal |
Br. Vet. J. |
Volume |
125 |
Issue |
4 |
Pages |
169-176 |
Keywords |
Animals; Biological Assay; Cattle; Chickens; Feces/analysis; Horses/*metabolism; Humans; Lactobacillus/metabolism; Rabbits; Rats; Sheep; Urine/analysis; Vitamin B 12/*analysis |
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English |
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Series Issue |
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Edition |
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ISSN |
0007-1935 |
ISBN |
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Notes |
PMID:5814055 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
116 |
Permanent link to this record |