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Author | de Jong, T.R.; Neumann, I.D. | ||||
Title | Oxytocin and Aggression | Type | Book Chapter | ||
Year | 2018 | Publication | Behavioral Pharmacology of Neuropeptides: Oxytocin | Abbreviated Journal | |
Volume | Issue | Pages | 175-192 | ||
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Abstract | The neuropeptide oxytocin (OT) has a solid reputation as a facilitator of social interactions such as parental and pair bonding, trust, and empathy. The many results supporting a pro-social role of OT have generated the hypothesis that impairments in the endogenous OT system may lead to antisocial behavior, most notably social withdrawal or pathological aggression. If this is indeed the case, administration of exogenous OT could be the “serenic” treatment that psychiatrists have for decades been searching for. | ||||
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Publisher | Springer International Publishing | Place of Publication | Cham | Editor | Hurlemann, R.; Grinevich, V. |
Language | Summary Language | Original Title | |||
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Series Volume | Series Issue | Edition | |||
ISSN | ISBN | 978-3-319-63739-6 | Medium | ||
Area | Expedition | Conference | |||
Notes | Approved | no | |||
Call Number | Equine Behaviour @ team @ de Jong2018 | Serial | 6424 | ||
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Author | Bosch, O.J.; Nair, H.P.; Ahern, T.H.; Neumann, I.D.; Young, L.J. | ||||
Title | The CRF System Mediates Increased Passive Stress-Coping Behavior Following the Loss of a Bonded Partner in a Monogamous Rodent | Type | Journal Article | ||
Year | 2008 | Publication | Abbreviated Journal | Neuropsychopharmacology | |
Volume | 34 | Issue | 6 | Pages | 1406-1415 |
Keywords | prairie vole; passive stress-coping; forced swim test; tail suspension test; elevated plus-maze; hypothalamo–pituitary–adrenal axis | ||||
Abstract | Social relationships significantly influence physiology and behavior, including the hypothalamo–pituitary–adrenal axis, anxiety, and mental health. Disruption of social bonds through separation or death often results in profound grieving, depression, and physical illness. As the monogamous prairie vole forms enduring, selective pair bonds with the mating partner, they provide an animal model to study the physiological consequences of pair bonding and, thus, the loss of the bonded partner. Male prairie voles were paired with a novel female or male sibling. After 5 days, half of the males of each group were separated from the partner. Elevated plus-maze, forced swim, and tail suspension tests were used to assess anxiety-like and passive stress-coping behaviors indicative of depressive-like behavior. Following 4 days of separation from the female but not the male partner, experimental males displayed increased passive stress-coping. This effect was abolished by long-term intracerebroventricular infusion of a nonselective corticotropin-releasing factor (CRF) receptor antagonist without disrupting the bond itself. Both CRF type 1 and 2 receptors were involved in the emergence of passive stress-coping behavior. Furthermore, pairing with a female was associated with elevated CRF mRNA in the bed nucleus of the stria terminalis, and partner loss elicited a pronounced increase in circulating corticosteroid and adrenal weight. We speculate that the CRF system may mediate an aversive affect following separation from the female partner, which may facilitate proximity seeking between the pair-bonded individuals. Hence, the prairie vole model may provide insights into brain mechanisms involved in the psychopathological consequences of partner loss. |
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Publisher | American College of Neuropsychopharmacology | Place of Publication | Editor | ||
Language | Summary Language | Original Title | |||
Series Editor | Series Title | Abbreviated Series Title | |||
Series Volume | Series Issue | Edition | |||
ISSN | 0893-133x | ISBN | Medium | ||
Area | Expedition | Conference | |||
Notes | Approved | no | |||
Call Number | Equine Behaviour @ team @ | Serial | 5731 | ||
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