| Records |
| Author |
Makarov, V.V.; Bakulov, I.A. |
| Title |
[Zoopathogenic arboviruses, their systematics and ecology] |
Type |
Journal Article |
| Year |
1975 |
Publication  |
Veterinariia |
Abbreviated Journal |
Veterinariia |
| Volume |
|
Issue |
11 |
Pages |
39-41 |
| Keywords |
Animals; Arboviruses/*classification/pathogenicity; Cattle; Deer; Ecology; Horses; Insect Vectors; Sheep; Swine; Turkeys; Viruses/*classification/pathogenicity |
| Abstract |
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| Address |
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| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
Russian |
Summary Language |
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Original Title |
Zoopatogennye arbovirusy--sistematika i ekologiia |
| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0042-4846 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:814685 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2703 |
| Permanent link to this record |
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| Author |
Forbes, A.B. |
| Title |
A review of regional and temporal use of avermectins in cattle and horses worldwide |
Type |
Journal Article |
| Year |
1993 |
Publication |
Veterinary Parasitology |
Abbreviated Journal |
Vet Parasitol |
| Volume |
48 |
Issue |
1-4 |
Pages |
19-28 |
| Keywords |
Animals; Anthelmintics/therapeutic use; Arthropods; Cattle; Cattle Diseases/drug therapy/*prevention & control; Ectoparasitic Infestations/drug therapy/prevention & control/veterinary; Horse Diseases/drug therapy/*prevention & control; Horses; Insecticides; Ivermectin/*analogs & derivatives/*therapeutic use; Nematode Infections/drug therapy/prevention & control/veterinary; Parasitic Diseases/drug therapy/prevention & control; *Parasitic Diseases, Animal |
| Abstract |
Ivermectin and abamectin are two members of the group of parasiticides known as the avermectins; ivermectin was first registered as an injectable treatment for cattle in 1981. Since then, abamectin has been registered for cattle and ivermectin for horses. The relative popularity of the avermectins amongst farmers and veterinarians can be attributed to their spectrum of activity, convenience, wide margin of safety and the improved health and performance of stock following their use. Patterns of use in grazing animals apply equally to the avermectins as to other antiparasitics, particularly anthelmintics; these are based on a knowledge of epidemiology integrated with practical management considerations. For cattle, programs are commonly aimed at control of abomasal nematodes of the genera Ostertagia and Haemonchus. Use of avermectins is largely strategic in cattle, treatments being favored at the end of the period of transmission of these parasites; this frequently coincides with housing, entry into a feedlot or movement to another pasture. Simultaneous control of important ectoparasites at this time is an added benefit. Prophylactic use of avermectins at pasture is primarily targeted at the young first season grazing animal. In horses, a bimonthly treatment schedule during the period of risk has proved effective in helping prevent adverse effects of the main target parasites, including large and small strongyles and stomach bots. These patterns of use can be applied to the evaluation of the potential for avermectin residues in feces to have impact on pasture ecology. The evidence presented suggests that any effects are temporally and spatially limited. After more than a decade of practical use, there is no indication that avermectins have had a significant impact on pasture ecology and the environment. |
| Address |
MERCK AgVet, Rahway, NJ 07065-0912 |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0304-4017 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:8346632 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2665 |
| Permanent link to this record |
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| Author |
Dirikolu, L.; Lehner, A.F.; Karpiesiuk, W.; Hughes, C.; Woods, W.E.; Boyles, J.; Harkins, J.D.; Troppmann, A.; Tobin, T. |
| Title |
Detection, quantification, metabolism, and behavioral effects of selegiline in horses |
Type |
Journal Article |
| Year |
2003 |
Publication |
Veterinary Therapeutics : Research in Applied Veterinary Medicine |
Abbreviated Journal |
Vet Ther |
| Volume |
4 |
Issue |
3 |
Pages |
257-268 |
| Keywords |
Administration, Oral; Animals; Behavior, Animal/drug effects; Female; Horses/*metabolism; Mass Spectrometry/veterinary; Monoamine Oxidase Inhibitors/administration & dosage/blood/*pharmacokinetics/pharmacology/urine; Selegiline/administration & dosage/blood/*pharmacokinetics/pharmacology/urine; Substance Abuse Detection/veterinary |
| Abstract |
Selegiline ([R]-[-]N,alpha-dimethyl-N-2- propynylphenethylamine or l-deprenyl), an irreversible inhibitor of monoamine oxidase, is a classic antidyskinetic and antiparkinsonian agent widely used in human medicine both as monotherapy and as an adjunct to levodopa therapy. Selegiline is classified by the Association of Racing Commissioners International (ARCI) as a class 2 agent, and is considered to have high abuse potential in racing horses. A highly sensitive LC/MS/MS quantitative analytical method has been developed for selegiline and its potential metabolites amphetamine and methamphetamine using commercially available deuterated analogs of these compounds as internal standards. After administering 40 mg of selegiline orally to two horses, relatively low (<60 ng/ml) concentrations of parent selegiline, amphetamine, and methamphetamine were recovered in urine samples. However, relatively high urinary concentrations of another selegiline metabolite were found, tentatively identified as N- desmethylselegiline. This metabolite was synthesized and found to be indistinguishable from the new metabolite recovered from horse urine, thereby confirming the chemical identity of the equine metabolite. Additionally, analysis of urine samples from four horses dosed with 50 mg of selegiline confirmed that N-desmethylselegiline is the major urinary metabolite of selegiline in horses. In related behavior studies, p.o. and i.v. administration of 30 mg of selegiline produced no significant changes in either locomotor activities or heart rates. |
| Address |
Department of Biomedical Sciences, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1528-3593 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:15136987 |
Approved |
no |
| Call Number |
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Serial |
1901 |
| Permanent link to this record |
