Records |
Author |
Pesenti, M.E.; Spinelli, S.; Bezirard, V.; Briand, L.; Pernollet, J.-C.; Tegoni, M.; Cambillau, C. |
Title |
Structural Basis of the Honey Bee PBP Pheromone and pH-induced Conformational Change |
Type |
Journal Article |
Year |
2008 |
Publication |
Journal of Molecular Biology |
Abbreviated Journal |
J Mol Biol |
Volume |
380 |
Issue |
1 |
Pages |
158-169 |
Keywords |
honeybee; Apis mellifera; pheromone-binding protein; crystal structure; signal transduction |
Abstract |
The behavior of insects and their perception of their surroundings are driven, in a large part, by odorants and pheromones. This is especially true for social insects, such as the honey bee, where the queen controls the development and the caste status of the other individuals. Pheromone perception is a complex phenomenon relying on a cascade of recognition events, initiated in antennae by pheromone recognition by a pheromone-binding protein and finishing with signal transduction at the axon membrane level. With to the objective of deciphering this initial step, we have determined the structures of the bee antennal pheromone-binding protein (ASP1) in the apo form and in complex with the main component of the queen mandibular pheromonal mixture, 9-keto-2(E)-decenoic acid (9-ODA) and with nonpheromonal components. In the apo protein, the C terminus obstructs the binding site. In contrast, ASP1 complexes have different open conformations, depending on the ligand shape, leading to different volumes of the binding cavity. The binding site integrity depends on the C terminus (111-119) conformation, which involves the interplay of two factors; i.e. the presence of a ligand and a low pH. Ligand binding to ASP1 is favored by low pH, opposite to what is observed with other pheromone-binding proteins, such as those of Bombyx mori and Anopheles gambiae. |
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Equine Behaviour @ team @ |
Serial |
4647 |
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Author |
Matzke, S.M.; Oubre, J.L.; Caranto, G.R.; Gentry, M.K.; Galbicka, G. |
Title |
Behavioral and immunological effects of exogenous butyrylcholinesterase in rhesus monkeys |
Type |
Journal Article |
Year |
1999 |
Publication |
Pharmacology, Biochemistry, and Behavior |
Abbreviated Journal |
Pharmacol Biochem Behav |
Volume |
62 |
Issue |
3 |
Pages |
523-530 |
Keywords |
Animals; Antibody Formation/drug effects; Behavior, Animal/*drug effects; Butyrylcholinesterase/*immunology/pharmacokinetics/*pharmacology; Cognition/drug effects; Color Perception/drug effects; Conditioning, Operant/drug effects; Discrimination Learning/drug effects; Half-Life; Horses; Humans; Macaca mulatta; Male |
Abstract |
Although conventional therapies prevent organophosphate (OP) lethality, laboratory animals exposed to such treatments typically display behavioral incapacitation. Pretreatment with purified exogenous human or equine serum butyrylcholinesterase (Eq-BuChE), conversely, has effectively prevented OP lethality in rats and rhesus monkeys, without producing the adverse side effects associated with conventional treatments. In monkeys, however, using a commercial preparation of Eq-BuChE has been reported to incapacitate responding. In the present study, repeated administration of commercially prepared Eq-BuChE had no systematic effect on behavior in rhesus monkeys as measured by a six-item serial probe recognition task, despite 7- to 18-fold increases in baseline BuChE levels in blood. Antibody production induced by the enzyme was slight after the first injection and more pronounced following the second injection. The lack of behavioral effects, the relatively long in vivo half-life, and the previously demonstrated efficacy of BuChE as a biological scavenger for highly toxic OPs make BuChE potentially more effective than current treatment regimens for OP toxicity. |
Address |
Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA |
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English |
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ISSN |
0091-3057 |
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Notes |
PMID:10080246 |
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no |
Call Number |
Equine Behaviour @ team @ |
Serial |
4064 |
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Author |
Hashimoto, C.; Takenaka, O.; Furuichi, T. |
Title |
Matrilineal kin relationship and social behavior of wild bonobos (Pan paniscus): Sequencing the D-loop region of mitochondrial DNA |
Type |
Journal Article |
Year |
1996 |
Publication |
Primates |
Abbreviated Journal |
Primates |
Volume |
37 |
Issue |
3 |
Pages |
305-318-318 |
Keywords |
Biomedical and Life Sciences |
Abstract |
Matrilineal kin-relations among wild bonobos (Pan paniscus) were studied by DNA analysis. Subject individuals were the members of E1 group, living at Wamba, Zaire, which has been studied since 1974. DNA samples were extracted from wadges that bonobos spat out when feeding on sugar cane. The D-loop region of mitochondrial DNA was amplified by the PCR method, and a nucleotide sequence of 350 base pairs was determined for 17 individuals. Nucleotide variations were found at 44 positions of the sequence. Based on these variations, 13 matrilineal units were divided into seven groups, and the mother of an orphan male was determined among several females. These genetic analyses, together with behavioral observation to date, revealed the following facts. High sequence variation in the target region indicated that females transfer between groups of bonobos, which is in agreement with supposition from long-term field studies. For females, there was no relationship between genetic closeness and social closeness that is represented by frequencies of proximity or grooming. After immigration into a new group, females form social associations with senior females without regard to kin relationship. |
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Springer Japan |
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ISSN |
0032-8332 |
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no |
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Equine Behaviour @ team @ |
Serial |
5199 |
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Author |
Imanishi, K. |
Title |
Identification : A process of enculturation in the subhuman society of Macaca fuscata |
Type |
Journal Article |
Year |
1957 |
Publication |
Primates |
Abbreviated Journal |
Primates |
Volume |
1 |
Issue |
1 |
Pages |
1-29-29 |
Keywords |
Biomedical and Life Sciences |
Abstract |
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Publisher |
Springer Japan |
Place of Publication |
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0032-8332 |
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no |
Call Number |
Equine Behaviour @ team @ |
Serial |
5266 |
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Author |
Koyama, N. |
Title |
Playmate relationships among individuals of the Japanese monkey troop in arashiyama |
Type |
Journal Article |
Year |
1985 |
Publication |
Primates |
Abbreviated Journal |
Primates |
Volume |
26 |
Issue |
4 |
Pages |
390-406-406 |
Keywords |
Biomedical and Life Sciences |
Abstract |
Observations of play behavior were made on a troop of Japanese monkeys for five months. The troop consisted of 125 animals during the study period. Only 104 animals were observed playing with the troop members while the other 21 animals were never observed playing with other individuals. Two-member play was the most frequent. On the average, a monkey played with 20.7 individuals. A total of 6,068 play bouts were observed. The frequency of play appeared to be affected by age, sex, and degree of relatedness. One-year-old infant males played most with other members and the frequency of play decreased with age. Between monkeys whose disparity of age was less than two years, 5,763 bouts (95.0% of the total) were observed. Moreover, among sameaged monkeys who comprised 10.6% of the possible pair combinations, 2,739 play bouts (45.1%) were observed. Juvenile males played with same-sexed peers more than with opposite-sexed peers, whereas older juvenile females appeared to play with infants of both sexes. Individuals who were related and similarly-ranked tended to play together. There was no apparent preference for animals to play with the offspring of the highest-ranking female. Dominance rank of infnats and juveniles was primarily affected by rank of their mothers and to a lesser extent by play partners. Dominance rank of older juvenile males is more likely to be affected by play partners than females. It may be a critical time for males when they leave their natal troop and join a new troop. The timing of troop shifting by males seemed to be affected by the presence or absence of play-mates. For male Japanese monkeys, play is very important in developing social bonds. Play may act to perpetuate social bonds, enhance the chance of survival, and may contribute to their future reproductive success. |
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Springer Japan |
Place of Publication |
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0032-8332 |
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no |
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Equine Behaviour @ team @ |
Serial |
5327 |
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Author |
McGrew, W.; Marchant, L. |
Title |
Laterality of hand use pays off in foraging success for wild chimpanzees |
Type |
Journal Article |
Year |
1999 |
Publication |
Primates |
Abbreviated Journal |
Primates |
Volume |
40 |
Issue |
3 |
Pages |
509-513 |
Keywords |
Biomedical and Life Sciences |
Abstract |
The aim of this study was to see if behavioral lateralization in hand use benefits a lateralized organism in nature. We recorded wild chimpanzees (Pan troglodytes schweinfurthii) at Gombe, Tanzania, fishing for termites (Macrotermes spp.), an extractive foraging task using elementary technology. We compared individual apes who were completely lateralized, using only one hand or the other for the task, versus those who were incompletely lateralized, using either hand. Exclusively lateralized individuals were more efficient, that is, gathered more prey per unit effort, but were no different in success or error rate from incompletely lateralized apes. This is the first demonstration of a payoff to laterality of behavioral function in primates in conditions of ecological validity. |
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Springer Japan |
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0032-8332 |
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no |
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Equine Behaviour @ team @ |
Serial |
5368 |
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Author |
Lee, R.D. |
Title |
Rethinking the evolutionary theory of aging: transfers, not births, shape senescence in social species |
Type |
Journal Article |
Year |
2003 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
Proc Natl Acad Sci U S A |
Volume |
100 |
Issue |
16 |
Pages |
9637-9642 |
Keywords |
Adaptation, Physiological; *Aging; Animals; *Biological Evolution; Demography; Economics; Environment; Fertility; Humans; Life Expectancy; Longevity; Models, Theoretical; Parturition; Population Dynamics; Population Growth; Reproduction |
Abstract |
The classic evolutionary theory of aging explains why mortality rises with age: as individuals grow older, less lifetime fertility remains, so continued survival contributes less to reproductive fitness. However, successful reproduction often involves intergenerational transfers as well as fertility. In the formal theory offered here, age-specific selective pressure on mortality depends on a weighted average of remaining fertility (the classic effect) and remaining intergenerational transfers to be made to others. For species at the optimal quantity-investment tradeoff for offspring, only the transfer effect shapes mortality, explaining postreproductive survival and why juvenile mortality declines with age. It also explains the evolution of lower fertility, longer life, and increased investments in offspring. |
Address |
Department of Demography, University of California, 2232 Piedmont Avenue, Berkeley, CA 94720-2120, USA. rlee@demog.berkeley.edu |
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0027-8424 |
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PMID:12878733 |
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no |
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Equine Behaviour @ team @ |
Serial |
5465 |
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Author |
Peltzer, K.; Mabilu, M.G.; Mathoho, S.F.; Nekhwevha, A.P.; Sikhwivhilu, T.; Sinthumule, T.S. |
Title |
Trauma history and severity of gambling involvement among horse-race gamblers in a South African gambling setting |
Type |
Journal Article |
Year |
2006 |
Publication |
Psychological Reports |
Abbreviated Journal |
Psychol Rep |
Volume |
99 |
Issue |
2 |
Pages |
472-476 |
Keywords |
Adult; African Continental Ancestry Group/*psychology/statistics & numerical data; Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Gambling/*psychology; Humans; *Life Change Events; Male; Middle Aged; Personality Inventory; Risk Factors; *Social Environment; Socioeconomic Factors; South Africa; Statistics; Stress Disorders, Post-Traumatic/epidemiology/*psychology |
Abstract |
The purpose of this study was to ascertain the frequency of gambling involvement and the prevalence of problem gambling among horse race gamblers and to discover whether problem gambling in this sample is associated with a history of trauma. Among a sample of 266 South African horse-race gamblers (94% men and 6% women, Mage 46.8 yr., SD = 13.9, range 18-85 years), 31.2% were classified as probable pathological gamblers and 19.9% with problem gambling. Major weekly gambling activities included racetrack betting (82%), purchase of lottery tickets or scratch tickets (35%), purchase of sports lottery tickets (23%), and using casino type games (18%). Trauma history was significantly associated with gambling severity. |
Address |
Human Sciences Research Council, University of Limpopo, Pretoria, South Africa. KPeltzer@hsrc.ac.za |
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0033-2941 |
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PMID:17153816 |
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no |
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1850 |
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Author |
Alexander, F.; Collett, R.A. |
Title |
Pethidine in the horse |
Type |
Journal Article |
Year |
1974 |
Publication |
Research in veterinary science |
Abbreviated Journal |
Res Vet Sci |
Volume |
17 |
Issue |
1 |
Pages |
136-137 |
Keywords |
Animals; Half-Life; Horses/*metabolism; Injections, Intravenous/veterinary; Male; Meperidine/administration & dosage/analysis/*metabolism/pharmacology |
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0034-5288 |
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PMID:4421117 |
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no |
Call Number |
refbase @ user @ |
Serial |
113 |
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Author |
VanDierendonck, M.C. |
Title |
Social relationships in a group of horses without a mature stallion |
Type |
Manuscript |
Year |
2006 |
Publication |
The Importance of Social Relationships in Horses |
Abbreviated Journal |
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Volume |
Chapter 4 |
Issue |
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Pages |
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Keywords |
Feral horses are social animals, which have to rely on survival strategies centered on the formation of cohesive social bonds within their bands. Many problems in the husbandry of social animals such as horses, are due to the fact that the limits of their adaptive abilities are exceeded. Evidence suggests that the fundamental social characteristics of domestic horses have remained relatively unchanged. The social structure, social strategies and social interactions were investigated (3 non-consecutive years, 24 hr per day for several weeks) in long term established groups of domestic horses (mares and geldings of all ages) and a few small introduced groups, kept in (semi)natural environments. The general aim was to investigate the social needs of domestic horses. The social life of domestic horses was characterised by long lasting bonds with preferred partners which were established and maintained by allogrooming, play, proximity and dominance behaviours. Bonding partners were mainly found within the same sex-age group, but adult geldings also bonded with sub-adult mares and geldings. Adult mares were clustered in a group, while the other animals formed a second group. Among the adult mares, subgroups according to reproductive state were formed. Individuals regulated their social network by interfering with interactions between other members of the herd, which in itself is complex. An intervention is a behavioural action of one animal that actively interferes with an ongoing interaction between a dyad with the apparent aim of altering that interaction. This was verified by post-hoc analyses of disturbed and undisturbed interactions. Interventions in allogrooming or play were performed significantly more often when at least one member of the initial dyad was a preferred partner of, or familiar to (within the small introduced bands) the intervener. The stronger the preferred association in allogrooming between the intervener and member(s) of the initial dyad, the higher the probability the intervener would displace one initial member and continue allogrooming with the other. Just five behaviours were extracted which reliably reflected the dominance relations among horses. Aggression with the hind quarters was used both offensively and defensively and therefore not suitable as a reliable parameter. Individual dominance relationships were related to social experience. The implications of these findings for horse husbandry were assessed. It is argued that the execution of affiliative behaviours may be rewarding in itself, and therefore always will be a highly motivated behaviour. It is shown that social positive physical interactions (allogrooming, play) with other horses is an ethological need and therefore indispensable in modern husbandry systems. Ethological needs are so important for the animal that husbandry systems that lack the possibilities to execute such behaviours will cause chronic stress. It is concluded that all horses need physical social contact, and that horses, which lack appropriate social learning experiences during ontogeny, may be hampered in their social functioning later in life. Solutions for problems, including dominance problems, in individual social housing and group housing are presented. |
Abstract |
Feral horses are social animals, which have to rely on survival strategies centered on the formation of cohesive social bonds within their bands. Many problems in the husbandry of social animals such as horses, are due to the fact that the limits of their adaptive abilities are exceeded. Evidence suggests that the fundamental social characteristics of domestic horses have remained relatively unchanged. The social structure, social strategies and social interactions were investigated (3 non-consecutive years, 24 hr per day for several weeks) in long term established groups of domestic horses (mares and geldings of all ages) and a few small introduced groups, kept in (semi)natural environments. The general aim was to investigate the social needs of domestic horses. The social life of domestic horses was characterised by long lasting bonds with preferred partners which were established and maintained by allogrooming, play, proximity and dominance behaviours. Bonding partners were mainly found within the same sex-age group, but adult geldings also bonded with sub-adult mares and geldings. Adult mares were clustered in a group, while the other animals formed a second group. Among the adult mares, subgroups according to reproductive state were formed. Individuals regulated their social network by interfering with interactions between other members of the herd, which in itself is complex. An intervention is a behavioural action of one animal that actively interferes with an ongoing interaction between a dyad with the apparent aim of altering that interaction. This was verified by post-hoc analyses of disturbed and undisturbed interactions. Interventions in allogrooming or play were performed significantly more often when at least one member of the initial dyad was a preferred partner of, or familiar to (within the small introduced bands) the intervener. The stronger the preferred association in allogrooming between the intervener and member(s) of the initial dyad, the higher the probability the intervener would displace one initial member and continue allogrooming with the other. Just five behaviours were extracted which reliably reflected the dominance relations among horses. Aggression with the hind quarters was used both offensively and defensively and therefore not suitable as a reliable parameter. Individual dominance relationships were related to social experience. The implications of these findings for horse husbandry were assessed. It is argued that the execution of affiliative behaviours may be rewarding in itself, and therefore always will be a highly motivated behaviour. It is shown that social positive physical interactions (allogrooming, play) with other horses is an ethological need and therefore indispensable in modern husbandry systems. Ethological needs are so important for the animal that husbandry systems that lack the possibilities to execute such behaviours will cause chronic stress. It is concluded that all horses need physical social contact, and that horses, which lack appropriate social learning experiences during ontogeny, may be hampered in their social functioning later in life. Solutions for problems, including dominance problems, in individual social housing and group housing are presented. |
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Universiteit Utrecht |
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Equine Behaviour @ team @ |
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2369 |
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