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| Author | Kalin, N.H.; Shelton, S.E. | ||||
| Title | Nonhuman primate models to study anxiety, emotion regulation, and psychopathology | Type | Journal Article | ||
| Year | 2003 | Publication  |
Annals of the New York Academy of Sciences | Abbreviated Journal | Ann N Y Acad Sci |
| Volume | 1008 | Issue | Pages | 189-200 | |
| Keywords | Affect/*physiology; Amygdala/blood supply; Animals; Anxiety/genetics/*psychology; Brain/*blood supply; Brain Stem/blood supply; Carrier Proteins/genetics; Electroencephalography; *Inhibition (Psychology); Macaca mulatta; Membrane Glycoproteins/genetics; *Membrane Transport Proteins; *Nerve Tissue Proteins; Prefrontal Cortex/blood supply; Serotonin Plasma Membrane Transport Proteins; Social Environment; Temperament; Tomography, Emission-Computed | ||||
| Abstract | This paper demonstrates that the rhesus monkey provides an excellent model to study mechanisms underlying human anxiety and fear and emotion regulation. In previous studies with rhesus monkeys, stable, brain, endocrine, and behavioral characteristics related to individual differences in anxiety were found. It was suggested that, when extreme, these features characterize an anxious endophenotype and that these findings in the monkey are particularly relevant to understanding adaptive and maladaptive anxiety responses in humans. The monkey model is also relevant to understanding the development of human psychopathology. For example, children with extremely inhibited temperament are at increased risk to develop anxiety disorders, and these children have behavioral and biological alterations that are similar to those described in the monkey anxious endophenotype. It is likely that different aspects of the anxious endophenotype are mediated by the interactions of limbic, brain stem, and cortical regions. To understand the brain mechanisms underlying adaptive anxiety responses and their physiological concomitants, a series of studies in monkeys lesioning components of the neural circuitry (amygdala, central nucleus of the amygdala and orbitofrontal cortex) hypothesized to play a role are currently being performed. Initial findings suggest that the central nucleus of the amygdala modulates the expression of behavioral inhibition, a key feature of the endophenotype. In preliminary FDG positron emission tomography (PET) studies, functional linkages were established between the amygdala and prefrontal cortical regions that are associated with the activation of anxiety. | ||||
| Address | Department of Psychiatry, University of Wisconsin-Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53711, USA. nkalin@facstaff.wisc.edu | ||||
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| Language | English | Summary Language | Original Title | ||
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| ISSN | 0077-8923 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:14998885 | Approved | no | ||
| Call Number | Equine Behaviour @ team @ | Serial | 4133 | ||
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| Author | Momozawa, Y.; Takeuchi, Y.; Tozaki, T.; Kikusui, T.; Hasegawa, T.; Raudsepp, T.; Chowdhary, B.P.; Kusunose, R.; Mori, Y. | ||||
| Title | SNP detection and radiation hybrid mapping in horses of nine candidate genes for temperament | Type | Journal Article | ||
| Year | 2007 | Publication |
Animal Genetics | Abbreviated Journal | Anim Genet |
| Volume | 38 | Issue | 1 | Pages | 81-83 |
| Keywords | Animals; *Behavior, Animal; Breeding; Horses/*genetics/physiology; *Polymorphism, Single Nucleotide; Radiation Hybrid Mapping; *Temperament | ||||
| Abstract | |||||
| Address | Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo 113-8657, Japan | ||||
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| Language | English | Summary Language | Original Title | ||
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| ISSN | 0268-9146 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:17257195 | Approved | no | ||
| Call Number | Serial | 1834 | |||
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| Author | h:, M.; Lévy, F.; Fortin, M.; Leterrier, C.; LansadLansade, L. | ||||
| Title | Stress and temperament affect working memory performance for disappearing food in horses, Equus caballus | Type | Journal Article | ||
| Year | 2013 | Publication |
Animal Behaviour | Abbreviated Journal | |
| Volume | 86 | Issue | 6 | Pages | 1233-1240 |
| Keywords | delayed-response task emotion; equid; Equus caballus; fearfulness; individual difference; personality; stress; temperament | ||||
| Abstract | In the present study, we sought to determine the influence of stress and temperament on working memory for disappearing food in horses. After assessment of five dimensions of temperament, we tested working memory of horses using a delayed-response task requiring a choice between two food locations. Delays ranging from 0 to 20 s were tested. The duration of working memory for disappearing food was first characterized without stressors (N = 26). The horses were then divided into two groups and their performance was assessed under stressful (exposure to acute stressors prior to testing, N = 12) or control conditions (N = 12). Results showed that the duration of working memory for disappearing food lasted at least 20 s under nonstressful conditions, and that under stressful conditions this duration lasted less than 12 s. This stress-induced impairment confirms in a nonrodent species that working memory performance is very sensitive to exposure to stressors. In addition, working memory performance in horses is influenced by the temperamental dimension of fearfulness according to the state of stress: fearful horses showed better performance under control conditions and worse performance under stressful conditions than nonfearful horses. These findings are discussed in the context of the Yerkes–Dodson law of stress and performance. | ||||
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| ISSN | 0003-3472 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 5746 | ||
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| Author | Coleman, K.; Tully, L.A.; McMillan, J.L. | ||||
| Title | Temperament correlates with training success in adult rhesus macaques | Type | Journal Article | ||
| Year | 2005 | Publication |
American journal of primatology | Abbreviated Journal | Am. J. Primatol. |
| Volume | 65 | Issue | 1 | Pages | 63-71 |
| Keywords | Animals; Female; *Inhibition (Psychology); *Learning; Macaca mulatta/*psychology; *Reinforcement (Psychology); *Temperament | ||||
| Abstract | In recent years there has been a marked increase in awareness of issues involving the psychological well-being of nonhuman primates (NHPs) used in biomedical research. As a result, many facilities are starting to train primates to voluntarily cooperate with veterinary, husbandry, and research procedures, such as remaining still for blood draws or injections. Such training generally reduces the stress associated with these procedures, resulting in calmer animals and, ultimately, better research models. However, such training requires great investments in time, and there can be vast individual differences in training success. Some animals learn tasks quickly, while others make slower progress in training. In this study, we examined whether temperament, as measured by response to a novel food object, correlated with the amount of time it took to train 20 adult female rhesus macaques to perform a simple task. The monkeys were categorized as “exploratory” (i.e., inspected a novel object placed in the home cage within 10 sec), “moderate” (i.e., inspected the object within 10-180 sec), or “inhibited” (i.e., did not inspect the object within 3 min). We utilized positive reinforcement techniques to train the monkeys to touch a target (PVC pipe shaped like an elbow) hung on their cage. Temperament correlated with training success in this study (Pearson chi2=7.22, df=2, P=0.03). We easily trained over 75% of the animals that inspected the novel food (i.e., exploratory or moderate individuals) to touch the target. However, only 22% of the inhibited monkeys performed the task. By knowing which animals may not respond to conventional training methods, we may be able to develop alternate training techniques to address their specific needs. In addition, these results will allow us to screen monkeys to be assigned to research projects in which they will be trained, with the goal of obtaining the best candidates for those studies. | ||||
| Address | Oregon National Primate Research Center, Beaverton, Oregon 97006, USA. colemank@ohsu.edu | ||||
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| Language | English | Summary Language | Original Title | ||
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| Series Volume | Series Issue | Edition | |||
| ISSN | 0275-2565 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:15645460 | Approved | no | ||
| Call Number | Equine Behaviour @ team @ | Serial | 4112 | ||
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| Author | Heath-Lange, S.; Ha, J.C.; Sackett, G.P. | ||||
| Title | Behavioral measurement of temperament in male nursery-raised infant macaques and baboons | Type | Journal Article | ||
| Year | 1999 | Publication |
American journal of primatology | Abbreviated Journal | Am. J. Primatol. |
| Volume | 47 | Issue | 1 | Pages | 43-50 |
| Keywords | Age Factors; Animal Technicians; Animals; Animals, Newborn/psychology; Behavior, Animal/*physiology; Defecation; Facial Expression; Humans; Irritable Mood; Macaca fascicularis/*psychology; Male; Papio/*psychology; Sex Characteristics; Species Specificity; Temperament/*physiology; Urination; Vocalization, Animal; Weaning | ||||
| Abstract | We define temperament as an individual's set of characteristic behavioral responses to novel or challenging stimuli. This study adapted a temperament scale used with rhesus macaques by Schneider and colleagues [American Journal of Primatology 25:137-155, 1991] for use with male pigtailed macaque (Macaca nemestrina, n = 7), longtailed macaque (M. fascicularis, n = 3), and baboon infants (Papio cynocephalus anubis, n = 4). Subjects were evaluated twice weekly for the first 5 months of age during routine removal from their cages for weighing. Behavioral measures were based on the subject's interactions with a familiar human caretaker and included predominant state before capture, response to capture, contact latency, resistance to tester's hold, degree of clinging, attention to environment, defecation/urination, consolability, facial expression, vocalizations, and irritability. Species differences indicated that baboons were more active than macaques in establishing or terminating contact with the tester. Temperament scores decreased over time for the variables Response to Capture and Contact Latency, indicating that as they grew older, subjects became less reactive and more bold in their interactions with the tester. Temperament scores changed slowly with age, with greater change occurring at younger ages. The retention of variability in reactivity between and within species may be advantageous for primates, reflecting the flexibility necessary to survive in a changing environment. | ||||
| Address | Department of Psychology and Regional Primate Research Center, University of Washington, Seattle, USA. crgsjh@vmmc.org | ||||
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| Language | English | Summary Language | Original Title | ||
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| Series Volume | Series Issue | Edition | |||
| ISSN | 0275-2565 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | PMID:9888720 | Approved | no | ||
| Call Number | Equine Behaviour @ team @ | Serial | 4117 | ||
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| Author | Morton, F.B.; Lee, P.C.; Buchanan-Smith, H.M. | ||||
| Title | Taking personality selection bias seriously in animal cognition research: a case study in capuchin monkeys (Sapajus apella) | Type | Journal Article | ||
| Year | 2013 | Publication |
Abbreviated Journal | Animal Cognition | |
| Volume | 16 | Issue | 4 | Pages | 677-684 |
| Keywords | Platyrrhines; Temperament; Cognitive experiment; Selection bias; Associative learning; Training | ||||
| Abstract | In most experimental work on animal cognition, researchers attempt to control for multiple interacting variables by training subjects prior to testing, allowing subjects to participate voluntarily, and providing subjects with food rewards. However, do such methods encourage selection bias from subjects’ personalities? In this study, we trained eighteen zoo-housed capuchin monkeys (Sapajus apella) for two experiments, under conditions of positive reinforcement (i.e. food rewards) and free-choice participation. Using a combination of behavioral and rater-based methods, we identified and validated five personality dimensions in these capuchins (Assertiveness, Openness, Neuroticism, Sociability, and Attentiveness). Scores on Openness were positively related to individual differences in monkey task participation, reflecting previous work showing that such individuals are often more active, curious, and willing to engage in testing. We also found a negative relationship between scores on Assertiveness and performance on tasks, which may reflect the trade-offs between speed and accuracy in these animals’ decision-making. Highly Assertive individuals (the most sociable within monkey groups) may also prioritize social interactions over engaging in research. Lastly, monkeys that consistently participated and performed well on both tasks showed significantly higher Openness and lower Assertiveness compared to others, mirroring relationships found between personality, participation, and performance among all participants. Participation and performance during training was clearly biased toward individuals with particular personalities (i.e. high Openness, low Assertiveness). Results are discussed in light of the need for careful interpretation of comparative data on animal cognition and the need for researchers to take personality selection bias more seriously. Animal Cognition Animal Cognition Look Inside |
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| Publisher | Springer-Verlag | Place of Publication | Editor | ||
| Language | English | Summary Language | Original Title | ||
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| Series Volume | Series Issue | Edition | |||
| ISSN | 1435-9448 | ISBN | Medium | ||
| Area | Expedition | Conference | |||
| Notes | Approved | no | |||
| Call Number | Equine Behaviour @ team @ | Serial | 5696 | ||
| Permanent link to this record | |||||